{ "uniprot_canonical_ac": "Q8BIW9-1", "uniprot_ac": "Q8BIW9", "uniprot_id": "CTF18_MOUSE", "mass": { "chemical_mass": 108137.0, "monoisotopic_mass": 108137.0 }, "refseq": { "ac": "XP_006524080", "name": "chromosome transmission fidelity protein 18 homolog isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006524080" }, "gene_names": [ { "name": "Chtf18", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8BIW9", "id": "Q8BIW9" }, { "name": "6030457M03Rik; Chl12; CTF18", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663384", "id": "NP_663384" }, { "name": "Chtf18", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663384", "id": "NP_663384" }, { "name": "Ctf18", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8BIW9", "id": "Q8BIW9" } ], "protein_names": [ { "name": "Chromosome transmission fidelity protein 18 homolog", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8BIW9" }, { "name": "Chl12 homolog; CTF18, chromosome transmission fidelity factor 18 homolog", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663384", "id": "NP_663384" }, { "name": "chromosome transmission fidelity protein 18 homolog isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006524080", "id": "XP_006524080" }, { "name": "chromosome transmission fidelity protein 18 homolog", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663384", "id": "NP_663384" } ], "function": [ { "annotation": "CHTF18 ensures the quantity and quality of the ovarian reservedagger.", "evidence": [ { "database": "RefSeq", "id": "NP_663384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663384" }, { "database": "PubMed", "id": "32219340", "url": "https://glygen.org/publication/PubMed/32219340" } ] }, { "annotation": "Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. Interacts with and stimulates DNA polymerase POLH. During DNA repair synthesis, involved in loading DNA polymerase POLE at the sites of local damage.", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9#function" }, { "database": "UniProtKB", "id": "Q8WVB6", "url": "https://www.uniprot.org/uniprot/Q8WVB6#function" } ] }, { "annotation": "These findings demonstrate essential roles for CHTF18 in mammalian spermatogenesis and meiosis, and suggest that CHTF18 may function during the double-strand break repair pathway to promote the formation of crossovers.", "evidence": [ { "database": "RefSeq", "id": "NP_663384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663384" }, { "database": "PubMed", "id": "23133398", "url": "https://glygen.org/publication/PubMed/23133398" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Chtf18", "url": "https://www.uniprot.org/uniprot/Q8BIW9", "locus": { "chromosome": "17", "start_pos": 25937900, "end_pos": 25946393, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000019214", "url": "https://www.ensembl.org/id/ENSMUSG00000019214" } ] } } ], "crossref": [ { "id": "ENSMUSG00000019214", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000019214", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00009", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00009", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd18140", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd18140", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "214901", "url": "https://www.ncbi.nlm.nih.gov/gene/214901", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003959", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003959", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:214901", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:214901", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2384887", "url": "http://www.informatics.jax.org/marker/MGI:2384887", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q8BIW9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8BIW9", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "SYEDPMV", "url": "https://omabrowser.org/oma/group/SYEDPMV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "6297at2759", "url": "http://www.orthodb.org/?query=6297at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23389", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23389", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23389:SF33", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23389:SF33", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46765", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46765", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46765:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46765:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00004", "url": "http://pfam.xfam.org/family/PF00004", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8BIW9", "url": "http://purl.obolibrary.org/obo/PR_Q8BIW9", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-174411", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-174411", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_663384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663384", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0R4J0I4", "url": "https://www.uniprot.org/uniprot/A0A0R4J0I4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0R4J0I4-1", "url": "https://www.uniprot.org/uniprot/A0A0R4J0I4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PVJ3", "url": "https://www.uniprot.org/uniprot/E9PVJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PVJ3-1", "url": "https://www.uniprot.org/uniprot/E9PVJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9Q2M3", "url": "https://www.uniprot.org/uniprot/E9Q2M3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9Q2M3-1", "url": "https://www.uniprot.org/uniprot/E9Q2M3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6YVH6", "url": "https://www.uniprot.org/uniprot/F6YVH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6YVH6-1", "url": "https://www.uniprot.org/uniprot/F6YVH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6ZBE7", "url": "https://www.uniprot.org/uniprot/F6ZBE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6ZBE7-1", "url": "https://www.uniprot.org/uniprot/F6ZBE7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8BIW9-1", "url": "https://www.uniprot.org/uniprot/Q8BIW9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEDYEEDLYGVEDDFQNQFAAELEVLAELEGTRDQAPPGTLQTPASRPPLTFEEAIAGGDTVPRPCPAGSPGNVNRNTRKNVRRDQPAPSSPMVKRPRLDVVKKLNFEPDMEELLYPDSPPGDITPPPSPEVFPEMLDAGYSDANADKDLMQTLPSPRNRNPVLRRPPILEDYINVTSTSGERAFLVLRADLIGPGVQNPLLDVHWRGCGQLDLLGVPFASLKEQVDSKRRQQLLEDAQQLSDTLHSLRSEGEEAVLEGPPAEEPAPGQNTAQHCLWVDEFAPQHYTELLSDDFTNRCLLKWLKLWDLVVFGRERPARKPRPGVETTRVGKEATAPGKWKSHEQALEEMLEAELDPSQRPRQKVALLCGPPGLGKTTLAHVVARHAGYCVVEMNASDDRSPEAFRTRIEAATQMESVLGVGGRPNCLVIDEIDGAPTAAINVLLGILNRKGPQEADQGGTAVAAGGRRRRAEGGLLTRPIICICNDQFTPSLRQLKQQALLLHVPPTLPSRLVQRLQEISLQHGMRSDPGALVALCEKTDNDIRACINTLQFLYGRGRRELSVKAVQTTHVGLKDQRKGLFSVWQEVFQLPRTQRRIVGQDLMLPAHALLLSNGDKGSLTLASQRFYHILRVTTSAGEHEKVVQGLFDNFLRLRLRDSSLSTVCCALDWLAFDDLLEQAAHRGQSFQLLCYLPFVPAAFHVLFASSHVPRITFPSSQQEAQTRMSQTRNHIQTLVSGMAPTTRSRATPQALVLDTLCLLLDVLAPKLRPVSTQLYSAHEKQQLSCLVGTMLAYSLTYHQERTPDGQYLYKLEPNVEEVCRFPELPARKPLTYQAKQLIAREIEMEKMRRAEALAWARSGPQVDQGSSGPASLWTDSGEKGTRQPAPRNHEQRLEHIMKRATVQEQPERDFFGRVVIRKVAVPSREVEAPQKDADEWRMGVAVGRSEVWFRFNEGVSNAVRRSLYIRDLL", "length": 969, "header": "sp|Q8BIW9-1|CTF18_MOUSE Isoform 1 of Chromosome transmission fidelity protein 18 homolog OS=Mus musculus OX=10090 GN=Chtf18 PE=1 SV=2 CANONICAL=Q8BIW9-1" }, "isoforms": [ { "isoform_ac": "A0A0R4J0I4-1", "url": "", "sequence": { "sequence": "MEDYEEDLYGVEDDFQNQFAAELEVLAELEGTRDQAPPGTLQTPASRPPLTFEEAIAGGDTVPRPCPAGSPGNVNRNTRKNVRRDQPAPSSPMVKRPRLDVVKKLNFEPDMEELLYPDSPPGDITPPPSPEVFPEMLDAGYSDANADKDLMQTLPSPRNRNPVLRRPPILEDYINVTSTSGERAFLVLRADLIGPGVQNPLLDVHWRGCGQLDLLGVPFASLKEQVDSKRRQQLLEDAQQLSDTLHSLRSEGEEAVLEGPPAEEPAPGQNTAQHCLWVDEFAPQHYTELLSDDFTNRCLLKWLKLWDLVVFGRERPARKPRPGVETTRVGKEATAPGKWKSHEQALEEMLEAELDPSQRPRQKVALLCGPPGLGKTTLAHVVARHAGYCVVEMNASDDRSPEAFRTRIEAATQMESVLGVGGRPNCLVIDEIDGAPTAAINVLLGILNRKGPQEADQGGTAVAAGGRRRRAEGGLLTRPIICICNDQFTPSLRQLKQQALLLHVPPTLPSRLVQRLQEISLQHGMRSDPGALVALCEKTDNDIRACINTLQFLYGRGRRELSVKAVQTTHVGLKDQRKGLFSVWQEVFQLPRTQRRIVGQDLMLPAHALLLSNGDKGSLTLASQRFYHILRVTTSAGEHEKVVQGLFDNFLRLRLRDSSLSTVCCALDWLAFDDLLEQAAHRGQSFQLLCYLPFVPAAFHVLFASSHVPRITFPSSQQEAQTRMSQTRNHIQTLVSGMAPTTRSRATPQALVLDTLCLLLDVLAPKLRPVSTQLYSAHEKQQLSCLVGTMLAYSLTYHQERTPDGQYLYKLEPNVEEVCRFPELPARKPLTYQAKQLIAREIEMEKMRRAEALAWARSGPQVDQGSSGPASLWTDSGEKGTRQPVPRNHEQRLEHIMTRATVQEQPERDFFGRVVIRKVAVPSREVEAPQKDADEWRMGVAVGRSEVWFRFNEGVSNAVRRSLYIRDLL", "length": 969, "header": "tr|A0A0R4J0I4-1|CTF18_MOUSE Computationally mapped isoform of Chromosome transmission fidelity protein 18 homolog OS=Mus musculus OX=10090 GN=Chtf18 PE=1 SV=1 CANONICAL=Q8BIW9-1" }, "locus": { "chromosome": "17", "start_pos": 25946311, "end_pos": 25938125, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000048054.14", "url": "https://www.ensembl.org/id/ENSMUST00000048054.14" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000043896.8", "url": "https://www.ensembl.org/id/ENSMUSP00000043896.8" } ] } }, { "isoform_ac": "E9PVJ3-1", "url": "", "sequence": { "sequence": "MEDYEEDLYGVEDDFQNQFAAELEVLAELEAGTRDQAPPGTLQTPASRPPLTFEEAIAGGDTVPRPCPAGSPGNVNRNTRKNVRRDQPAPSSPMVKRPRLDVVKKLNFEPDMEELLYPDSPPGDITPPPSPEVFPEMLDAGYSDANADKDLMQTLPSPRNRNPVLRRPPILEDYINVTSTSGERAFLVLRADLIGPGVQNPLLDVHWRGCGQLDLLGVPFASLKEQVDSKRRQQLLEDAQQLSDTLHSLRSEGEEAVLEGPPAEEPAPGQNTAQHCLWVDEFAPQHYTELLSDDFTNRCLLKWLKLWDLVVFGRERPARKPRPGVETTRVGKEATAPGKWKSHEQALEEMLEAELDPSQRPRQKVALLCGPPGLGKTTLAHVVARHAGYCVVEMNASDDRSPEAFRTRIEAATQMESVLGVGGRPNCLVIDEIDGAPTAAINVLLGILNRKGPQEADQGGTAVAAGGRRRRAEGGLLTRPIICICNDQFTPSLRQLKQQALLLHVPPTLPSRLVQRLQEISLQHGMRSDPGALVALCEKTDNDIRACINTLQFLYGRGRRELSVKAVQTTHVGLKDQRKGLFSVWQEVFQLPRTQRRIVGQDLMLPAHALLLSNGDKGSLTLASQRFYHILRVTTSAGEHEKVVQGLFDNFLRLRLRDSSLSTVCCALDWLAFDDLLEQAAHRGQSFQLLCYLPFVPAAFHVLFASSHVPRITFPSSQQEAQTRMSQTRNHIQTLVSGMAPTTRSRATPQALVLDTLCLLLDVLAPKLRPVSTQLYSAHEKQQLSCLVGTMLAYSLTYHQERTPDGQYLYKLEPNVEEVCRFPELPARKPLTYQAKQLIAREIEMEKMRRAEALAWARSGPQVDQGSSGPASLWTDSGEKGTRQPVPRNHEQRLEHIMTRATVQEQPERDFFGRVVIRKVAVPSREVEAPQKDADEWRMGVAVGRSEVWFRFNEGVSNAVRRSLYIRDLL", "length": 970, "header": "tr|E9PVJ3-1|CTF18_MOUSE Computationally mapped isoform of Chromosome transmission fidelity protein 18 homolog OS=Mus musculus OX=10090 GN=Chtf18 PE=1 SV=2 CANONICAL=Q8BIW9-1" }, "locus": { "chromosome": "17", "start_pos": 25946311, "end_pos": 25938125, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000170070.3", "url": "https://www.ensembl.org/id/ENSMUST00000170070.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000131768.3", "url": "https://www.ensembl.org/id/ENSMUSP00000131768.3" } ] } }, { "isoform_ac": "E9Q2M3-1", "url": "", "sequence": { "sequence": "MEDYEEDLYGVEDDFQNQFAAELEVLAELEAGTRDQAPPGTLQTPASRPPLTFEEAIAGGDTVPRPCPAGSPGNVNRNTRKNVRRDQPAPSSPMVKRPRLDVVKKLNFEPDMEELLYPDSPPGDITPPPSPEVFPEMLDAGYSDANADKDLMQTLPSPRNRNPVLRRPPILEDYINVTSTSGERAFLVLRADLIGPGVQNPLLDVHWRGCGQLDLLGVPFASLKEQVDSKRRQQLLEDAQQLSDTLHSLRSEGEEAVLEGPPAEEPAPGQNTAQHCLWVDEFAPQHYTELLSDDFTNRCLLKWLKLWDLVVFGRERPARKPRPGVETTRVGKEATAPGKWKSHEQALEEMLEAELDPSQRPRQKD", "length": 365, "header": "tr|E9Q2M3-1|CTF18_MOUSE Computationally mapped isoform of Chromosome transmission fidelity protein 18 homolog OS=Mus musculus OX=10090 GN=Chtf18 PE=1 SV=1 CANONICAL=Q8BIW9-1" }, "locus": { "chromosome": "17", "start_pos": 25946311, "end_pos": 25943047, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000170575.8", "url": "https://www.ensembl.org/id/ENSMUST00000170575.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000131366.2", "url": "https://www.ensembl.org/id/ENSMUSP00000131366.2" } ] } }, { "isoform_ac": "F6YVH6-1", "url": "", "sequence": { "sequence": "XVDQGSSGPASLWTDSGEKGTRQPVPRNHEQRLEHIMTRATVQEQPERDFFGRVVIRKVAVPSRGVEAPQKDADEWRMGVAVGRSEVWFRFNEGVSNAVRRSLYIRDLL", "length": 109, "header": "tr|F6YVH6-1|CTF18_MOUSE Computationally mapped isoform of Chromosome transmission fidelity protein 18 homolog OS=Mus musculus OX=10090 GN=Chtf18 PE=1 SV=1 CANONICAL=Q8BIW9-1" }, "locus": { "chromosome": "17", "start_pos": 25938759, "end_pos": 25938124, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000169767.2", "url": "https://www.ensembl.org/id/ENSMUST00000169767.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000129694.2", "url": "https://www.ensembl.org/id/ENSMUSP00000129694.2" } ] } }, { "isoform_ac": "F6ZBE7-1", "url": "", "sequence": { "sequence": "SRATPQALVLDTLCLLLDVLAPKLRPVSTQLYSAHEKQQLSCLVGTMLAYSLTYHQERTPDGQYLYKLEPNVEEVCRFPELPARKPLTYQAKQLIAREIEMEKMRRAEALAWARSGPQDIRSHWLPQGMD", "length": 130, "header": "tr|F6ZBE7-1|CTF18_MOUSE Computationally mapped isoform of Chromosome transmission fidelity protein 18 homolog OS=Mus musculus OX=10090 GN=Chtf18 PE=1 SV=1 CANONICAL=Q8BIW9-1" }, "locus": { "chromosome": "17", "start_pos": 25939875, "end_pos": 25938072, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000167940.2", "url": "https://www.ensembl.org/id/ENSMUST00000167940.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000131349.2", "url": "https://www.ensembl.org/id/ENSMUSP00000131349.2" } ] } }, { "isoform_ac": "Q8BIW9-1", "url": "", "sequence": { "sequence": "MEDYEEDLYGVEDDFQNQFAAELEVLAELEGTRDQAPPGTLQTPASRPPLTFEEAIAGGDTVPRPCPAGSPGNVNRNTRKNVRRDQPAPSSPMVKRPRLDVVKKLNFEPDMEELLYPDSPPGDITPPPSPEVFPEMLDAGYSDANADKDLMQTLPSPRNRNPVLRRPPILEDYINVTSTSGERAFLVLRADLIGPGVQNPLLDVHWRGCGQLDLLGVPFASLKEQVDSKRRQQLLEDAQQLSDTLHSLRSEGEEAVLEGPPAEEPAPGQNTAQHCLWVDEFAPQHYTELLSDDFTNRCLLKWLKLWDLVVFGRERPARKPRPGVETTRVGKEATAPGKWKSHEQALEEMLEAELDPSQRPRQKVALLCGPPGLGKTTLAHVVARHAGYCVVEMNASDDRSPEAFRTRIEAATQMESVLGVGGRPNCLVIDEIDGAPTAAINVLLGILNRKGPQEADQGGTAVAAGGRRRRAEGGLLTRPIICICNDQFTPSLRQLKQQALLLHVPPTLPSRLVQRLQEISLQHGMRSDPGALVALCEKTDNDIRACINTLQFLYGRGRRELSVKAVQTTHVGLKDQRKGLFSVWQEVFQLPRTQRRIVGQDLMLPAHALLLSNGDKGSLTLASQRFYHILRVTTSAGEHEKVVQGLFDNFLRLRLRDSSLSTVCCALDWLAFDDLLEQAAHRGQSFQLLCYLPFVPAAFHVLFASSHVPRITFPSSQQEAQTRMSQTRNHIQTLVSGMAPTTRSRATPQALVLDTLCLLLDVLAPKLRPVSTQLYSAHEKQQLSCLVGTMLAYSLTYHQERTPDGQYLYKLEPNVEEVCRFPELPARKPLTYQAKQLIAREIEMEKMRRAEALAWARSGPQVDQGSSGPASLWTDSGEKGTRQPAPRNHEQRLEHIMKRATVQEQPERDFFGRVVIRKVAVPSREVEAPQKDADEWRMGVAVGRSEVWFRFNEGVSNAVRRSLYIRDLL", "length": 969, "header": "sp|Q8BIW9-1|CTF18_MOUSE Isoform 1 of Chromosome transmission fidelity protein 18 homolog OS=Mus musculus OX=10090 GN=Chtf18 PE=1 SV=2 CANONICAL=Q8BIW9-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q8BIW9", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8BIW9" }, { "id": "25153642", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25153642" } ] } ], "phosphorylation": [ { "start_pos": 221, "end_pos": 221, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "site_lbl": "Ser221" }, { "start_pos": 51, "end_pos": 51, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "site_lbl": "Thr51" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Disruption of CHTF18 causes defective meiotic recombination in male mice.", "journal": "PLoS genetics", "date": "2012", "authors": "Berkowitz KM, Sowash AR, Koenig LR, Urcuyo D, Khan F, Yang F, Wang PJ, Jongens TA, Kaestner KH", "evidence": [ { "database": "RefSeq", "id": "NP_663384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663384" } ], "reference": [ { "type": "PubMed", "id": "23133398", "url": "https://glygen.org/publication/PubMed/23133398" } ] }, { "title": "Changes in metabolic chemical reporter structure yield a selective probe of O-GlcNAc modification.", "journal": "Journal of the American Chemical Society", "date": "2014", "authors": "Chuh KN, Zaro BW, Piller F, Piller V, Pratt MR", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8BIW9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8BIW9" } ], "reference": [ { "type": "PubMed", "id": "25153642", "url": "https://glygen.org/publication/PubMed/25153642" } ] }, { "title": "CHTF18 ensures the quantity and quality of the ovarian reservedagger.", "journal": "Biology of reproduction", "date": "2020", "authors": "Holton RA, Harris AM, Mukerji B, Singh T, Dia F, Berkowitz KM", "evidence": [ { "database": "RefSeq", "id": "NP_663384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_663384" } ], "reference": [ { "type": "PubMed", "id": "32219340", "url": "https://glygen.org/publication/PubMed/32219340" } ] } ], "pathway": [ { "id": "mmu:214901", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:214901", "resource": "KEGG Pathway" }, { "id": "R-MMU-174411", "name": "Polymerase switching on the C-strand of the telomere", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-174411", "resource": "Reactome", "description": "Polymerase switching on the C-strand of the telomere" } ], "orthologs": [ { "uniprot_canonical_ac": "D4AC99-1", "protein_name": "Chromosome transmission fidelity factor 18", "gene_name": "Chtf18", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MEDYEEDLYGVEDDFQNQFAAELEVLAELEAGTGDLAPSETLQTPASRPPLTFEEAIAGGDIVPRPCPAGSSGNDSRNTRKNVRRDQPAPSSPMVKRPRLDVVKRLNFEPDKEELLYPDSPPGDITPPPSPEVFPEMWDAGPSDAGADNGLMQALPSPRNPVLRRPPVLEDYINVTSTCGERAFLVLRADLTGTGVQNHLPDVQWRGRGQLDLLGVPFTSLKEQVDNKRRQQLLEEAQQLSDTLHSLRSEGEEAMLEGPPEEEPGPGQETAQHCLWVDEFAPQHYTELLSDDFTNRCLLKWLKLWDLVVFGHERPARKPRPGVEPTRVGKEAPAPGKWKSHEQVLEEMLEAELDPSRRPRQKVALLCGPPGLGKTTLAHVVARHAGYCVVEMNASDDRSPEAFRTRIEAATQMESVLGAGGRPNCLVIDEIDGAPTAAINVLLSILNRKGPQEAEQGGTAVAAAGGRRRRAEGGLLTRPIICICNDQFTPSLRQLKQQALLLHVPPTLPSRLVQRLQEISLQHGMRSDPGALAALCEKTDNDIRACINTLQFLYGRGQRELSVKDVQTTHVGLKDQRKGLFSVWQEVFQLPRAQRRLVGQDLMLPTHALLLNDSDKGSLTLASQRFYHILRVTTSAGEHEKVVQGLFDNFLRLRLRDSSLGTVCCALDWLAFDDLLEQAAHHGQSFQLLRYLPFLPAAFHVLFASSHVPRITFPSSQQEAQTRLSQTRNHIQTLVSGMAPATRSRATPQALVLDTLCLLLDVLSPKLRPVSTQLYSAREKQQLSSLVGTMLAYSLTYHQERTPDGQYLYRLEPNVEEVCRFPELPARKPLTYQAKQLIAREIEMEKMWRAEALAWTGGGPQVDQGPSGPANLRTDSGEKGTRQPAPRNHEQRLEHIMKRAAVQEQVCCGGRGRVGLEQSDEQRVGLAPSPKEPPVAPRKWAVVSRRTPSHRPCSEASEPLTWERPGYACLSTGNLMTLFSASLRGTSLDVWSSGKWQSQAKVCMGHRREGGSGGVG", "length": 1016 }, "evidence": [ { "id": "45236963", "url": "http://www.informatics.jax.org/homology/45236963", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8WVB6-1", "protein_name": "Chromosome transmission fidelity protein 18 homolog", "gene_name": "CHTF18", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MEDYEQELCGVEDDFHNQFAAELEVLAELEGASTPSPSGVPLFTAGRPPRTFEEALARGDAASSPAPAASVGSSQGGARKRQVDADLQPAGSLPHAPRIKRPRLQVVKRLNFRSEEMEEPPPPDSSPTDITPPPSPEDLAELWGHGVSEAAADVGLTRASPAARNPVLRRPPILEDYVHVTSTEGVRAYLVLRADPMAPGVQGSLLHVPWRGGGQLDLLGVSLASLKKQVDGERRERLLQEAQKLSDTLHSLRSGEEEAAQPLGAPEEEPTDGQDASSHCLWVDEFAPRHYTELLSDDFTNRCLLKWLKLWDLVVFGHERPSRKPRPSVEPARVSKEATAPGKWKSHEQVLEEMLEAGLDPSQRPKQKVALLCGPPGLGKTTLAHVIARHAGYSVVEMNASDDRSPEVFRTRIEAATQMESVLGAGGKPNCLVIDEIDGAPVAAINVLLSILNRKGPQEVGPQGPAVPSGGGRRRRAEGGLLMRPIICICNDQFAPSLRQLKQQAFLLHFPPTLPSRLVQRLQEVSLRQGMRADPGVLAALCEKTDNDIRACINTLQFLYSRGQRELSVRDVQATRVGLKDQRRGLFSVWQEVFQLPRAQRRRVGQDPALPADTLLLGDGDAGSLTSASQRFYRVLHAAASAGEHEKVVQGLFDNFLRLRLRDSSLGAVCVALDWLAFDDLLAGAAHHSQSFQLLRYPPFLPVAFHVLFASSHTPRITFPSSQQEAQNRMSQMRNLIQTLVSGIAPATRSRATPQALLLDALCLLLDILAPKLRPVSTQLYSTREKQQLASLVGTMLAYSLTYRQERTPDGQYIYRLEPNVEELCRFPELPARKPLTYQTKQLIAREIEVEKMRRAEASARVENSPQVDGSPPGLEGLLGGIGEKGVHRPAPRNHEQRLEHIMRRAAREEQPEKDFFGRVVVRSTAVPSAGDTAPEQDSVERRMGTAVGRSEVWFRFNEGVSNAVRRSLYIRDLL", "length": 975 }, "evidence": [ { "id": "45236963", "url": "http://www.informatics.jax.org/homology/45236963", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" }, { "name": "DNA clamp loader activity", "id": "GO:0003689", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003689", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" }, { "name": "single-stranded DNA helicase activity", "id": "GO:0017116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017116", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" }, { "name": "male germ cell nucleus", "id": "GO:0001673", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001673", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" }, { "name": "Ctf18 RFC-like complex", "id": "GO:0031390", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031390", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" }, { "name": "DNA replication", "id": "GO:0006260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006260", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" }, { "name": "germ cell development", "id": "GO:0007281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007281", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" }, { "name": "male meiotic nuclear division", "id": "GO:0007140", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007140", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" }, { "name": "positive regulation of DNA-directed DNA polymerase activity", "id": "GO:1900264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900264", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" }, { "name": "reciprocal meiotic recombination", "id": "GO:0007131", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007131", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" }, { "name": "negative regulation of chromosome segregation", "id": "GO:0051985", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051985", "evidence": [ { "database": "UniProtKB", "id": "Q8BIW9", "url": "https://www.uniprot.org/uniprot/Q8BIW9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 175, "end_pos": 177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }