{ "uniprot_canonical_ac": "Q8BIK4-1", "uniprot_ac": "Q8BIK4", "uniprot_id": "DOCK9_MOUSE", "mass": { "chemical_mass": 235312.0, "monoisotopic_mass": 235312.0 }, "refseq": { "ac": "NP_001074508", "name": "dedicator of cytokinesis protein 9 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074508" }, "gene_names": [ { "name": "Dock9", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8BIK4", "id": "Q8BIK4" }, { "name": "B230309H04Rik; D14Wsu89e; mKIAA1058; Zizimin1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121780", "id": "NP_001121780" }, { "name": "D14Wsu89e", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8BIK4", "id": "Q8BIK4" }, { "name": "Dock9", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121780", "id": "NP_001121780" }, { "name": "Kiaa1058", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8BIK4", "id": "Q8BIK4" }, { "name": "Ziz1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8BIK4", "id": "Q8BIK4" } ], "protein_names": [ { "name": "Dedicator of cytokinesis protein 9", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8BIK4" }, { "name": "Cdc42 guanine nucleotide exchange factor zizimin-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8BIK4" }, { "name": "Zizimin-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8BIK4" }, { "name": "dedicator of cytokinesis protein 9 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074508", "id": "NP_001074508" }, { "name": "dedicator of cytokinesis protein 9 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598835", "id": "NP_598835" }, { "name": "dedicator of cytokinesis protein 9 isoform 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121779", "id": "NP_001121779" }, { "name": "dedicator of cytokinesis protein 9 isoform 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121780", "id": "NP_001121780" }, { "name": "dedicator of cytokinesis protein 9 isoform 5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334525", "id": "NP_001334525" }, { "name": "dedicator of cytokinesis protein 9; cdc42 guanine nucleotide exchange factor zizimin-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121779", "id": "NP_001121779" } ], "function": [ { "annotation": "Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/beta-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001121779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121779" }, { "database": "PubMed", "id": "32917852", "url": "https://glygen.org/publication/PubMed/32917852" }, { "database": "RefSeq", "id": "NP_598835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598835" }, { "database": "RefSeq", "id": "NP_001121780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121780" }, { "database": "RefSeq", "id": "NP_001334525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334525" }, { "database": "RefSeq", "id": "NP_001074508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074508" } ] }, { "annotation": "Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:25851601). Overexpression induces filopodia formation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4#function" }, { "database": "UniProtKB", "id": "Q9BZ29", "url": "https://www.uniprot.org/uniprot/Q9BZ29#function" }, { "database": "PubMed", "id": "25851601", "url": "https://glygen.org/publication/PubMed/25851601" } ] }, { "annotation": "Thus, these results suggest that Zizimin1 plays an important role in dendrite growth in hippocampal neurons through activation of Cdc42.", "evidence": [ { "database": "RefSeq", "id": "NP_001121779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121779" }, { "database": "PubMed", "id": "19156867", "url": "https://glygen.org/publication/PubMed/19156867" }, { "database": "RefSeq", "id": "NP_598835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598835" }, { "database": "RefSeq", "id": "NP_001121780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121780" }, { "database": "RefSeq", "id": "NP_001334525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334525" }, { "database": "RefSeq", "id": "NP_001074508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074508" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Dock9", "url": "https://www.uniprot.org/uniprot/Q8BIK4", "locus": { "chromosome": "14", "start_pos": 121779458, "end_pos": 122035249, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000025558", "url": "https://www.ensembl.org/id/ENSMUSG00000025558" } ] } } ], "crossref": [ { "id": "ENSMUSG00000025558", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000025558", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd08697", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08697", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11698", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11698", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13267", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13267", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "105445", "url": "https://www.ncbi.nlm.nih.gov/gene/105445", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021816", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021816", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR026791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR026791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027007", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027007", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037809", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037809", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043161", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043161", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043162", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043162", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046769", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046769", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046773", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046773", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:105445", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:105445", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "106321", "url": "http://www.informatics.jax.org/marker/MGI:106321", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "YRQDNNK", "url": "https://omabrowser.org/oma/group/YRQDNNK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5480873at2759", "url": "http://www.orthodb.org/?query=5480873at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23317", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23317", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23317:SF77", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23317:SF77", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "http://pfam.xfam.org/family/PF00169", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF06920", "url": "http://pfam.xfam.org/family/PF06920", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF11878", "url": "http://pfam.xfam.org/family/PF11878", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14429", "url": "http://pfam.xfam.org/family/PF14429", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF20421", "url": "http://pfam.xfam.org/family/PF20421", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF20422", "url": "http://pfam.xfam.org/family/PF20422", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8BIK4", "url": "http://purl.obolibrary.org/obo/PR_Q8BIK4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013148", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-9013149", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013149", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-983231", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983231", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "A0A1D5RLB8", "url": "https://www.uniprot.org/uniprot/A0A1D5RLB8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5RLB8-1", "url": "https://www.uniprot.org/uniprot/A0A1D5RLB8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5RLE0", "url": "https://www.uniprot.org/uniprot/A0A1D5RLE0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5RLE0-1", "url": "https://www.uniprot.org/uniprot/A0A1D5RLE0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5RMM1", "url": "https://www.uniprot.org/uniprot/A0A1D5RMM1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A1D5RMM1-1", "url": "https://www.uniprot.org/uniprot/A0A1D5RMM1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BG77", "url": "https://www.uniprot.org/uniprot/A0A571BG77", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BG77-1", "url": "https://www.uniprot.org/uniprot/A0A571BG77-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A5F8MPL9", "url": "https://www.uniprot.org/uniprot/A0A5F8MPL9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A5F8MPL9-1", "url": "https://www.uniprot.org/uniprot/A0A5F8MPL9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9QMR2", "url": "https://www.uniprot.org/uniprot/E9QMR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9QMR2-1", "url": "https://www.uniprot.org/uniprot/E9QMR2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8VPN7", "url": "https://www.uniprot.org/uniprot/F8VPN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8VPN7-1", "url": "https://www.uniprot.org/uniprot/F8VPN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8BIK4-1", "url": "https://www.uniprot.org/uniprot/Q8BIK4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8BIK4-2", "url": "https://www.uniprot.org/uniprot/Q8BIK4-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8BIK4-3", "url": "https://www.uniprot.org/uniprot/Q8BIK4-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGCTTSVILFKGIRTVFERNCAYMCKQPGESNALEYTAYNWSKEDSELSIAFCLAKPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYLRSTVPANAEEEAQSLFVTECIKTYNSDWHLVTYKYEDYSGEFRQLPNKVPKLDKLPVHVYEVDEEADKDEDAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKILQLNFEAAMQEKRNGDPHEDDEQSKLEGSGSGLDSYLPELAKSTREAEIKLKSESRVKLFYLDPDTQKLDFSSAEPEVKPFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLAPTSPALMNGGQSPPAFQDALHTAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMRSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAARTLFKDTSGNLDKNARFSAIYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDSVSCDFPNYLNSSYIPMRQFETCSKSPITFEVEEFVPCIPKHTQPYTVYSNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSALAAVLHHQQNPEFYDEIKIELPAQLHERHHLLFTFFHVSCDNSTKGSTKKKDAVETQVGFSWLPLLKDGRVLTSEQHIPVSANLPSGYLGYQELGMGRHYGPEVKWVEGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQASGSELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKFAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENNKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAISMLKNLLIKHSFDDRYNSRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNPGSIVKDEALAVPAGNPLMTPQKGNTLDHSLHKDLLGAISGIASPYTASTPNINSVRNADSRGSLISTDSGNSLPDRNPEKSNSLDKQQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWNKASTAELMDFFTISEVCLHQFQYMGKRYIARTGMMHARLQQLGSLDNSVTFNHSYGHSEADVVHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMALKNVFTALRSLIYKFPSAFYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRIIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKGMFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQAAQYQFTDSETDVEGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKFAYIQVTHVTPFFDEKELQERRTEFERCHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSDIMREQMG", "length": 2055, "header": "sp|Q8BIK4-1|DOCK9_MOUSE Isoform 1 of Dedicator of cytokinesis protein 9 OS=Mus musculus OX=10090 GN=Dock9 PE=1 SV=2 CANONICAL=Q8BIK4-1" }, "isoforms": [ { "isoform_ac": "A0A1D5RLB8-1", "url": "", "sequence": { "sequence": "MTPQKGNTLDHSLHKDLLGAISGIASPYTASTPNINSVRNADSRGSLISTDSGNSLPDRNPEKSNSLDKQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWNKASTAELMDFFTISEVCLHQFQYMGKRYIASLTKCVTLPPAWEPGGVGTHRS", "length": 166, "header": "tr|A0A1D5RLB8-1|A0A1D5RLB8_MOUSE Computationally mapped isoform of Dedicator of cytokinesis 9 OS=Mus musculus OX=10090 GN=Dock9 PE=1 SV=1 CANONICAL=Q8BIK4-1" }, "locus": { "chromosome": "14", "start_pos": 121842656, "end_pos": 121829331, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000212416.2", "url": "https://www.ensembl.org/id/ENSMUST00000212416.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000148303.2", "url": "https://www.ensembl.org/id/ENSMUSP00000148303.2" } ] } }, { "isoform_ac": "A0A1D5RLE0-1", "url": "", "sequence": { "sequence": "MGCTTSVILFKGIRTVFERNCAYMCKQPGESNALEYTAYNWSKEDSELSIAFCLAKPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYLRSTVPANAEEEAQSLFVTECIKTYNSDWHLVTYKYEDYSGEFRQLPNKVPKLDKLPVHVYEVDEEADKDEDAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKILQLNFEAAMQEKRNGDPHEDDEQSKLEGSGSGLDSYLPELAKSTREAEIKLKSESRVKLFYLDPDTQKLDFSSAEPEVKPFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLTPTSPALMNGGQSPPAFQDALHTAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMRSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAARTLFKDTSGNLDKNARFSAIYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDSVSCDFPNYLNSSYIPMRQFETCSKSPITFEVEEFVPCIPKHTQPYTVYSNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSALAAVLHHQQNPEFYDEIKIELPAQLHERHHLLFTFFHVSCDNSTKGSTKKKDAVETQVGFSWLPLLKDGRVLTSEQHIPVSANLPSGYLGYQELGMGRHYGPEVKWVEGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQASGSELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKFAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENNKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAISMLKNLLIKHSFDDRYNSRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNPGSIVKDEALAVPAGNPLMTPQKGNTLDHSLHKDLLGAISGIASPYTASTPNINSVRNADSRGSLISTDSGNSLPDRNPEKSNSLDKQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWNKASTAELMDFFTISEVCLHQFQYMGKRYIARTGMMHARLQQLGSLDNSVTFNHSYGHSEADVVHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMALKNVFTALRSLIYKFPSAFYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRIIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKGMFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQAAGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKFAYIQVTHVTPFFDEKELQERRTEFERCHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSDIMREQMG", "length": 2042, "header": "tr|A0A1D5RLE0-1|DOCK9_MOUSE Computationally mapped isoform of Dedicator of cytokinesis protein 9 OS=Mus musculus OX=10090 GN=Dock9 PE=1 SV=1 CANONICAL=Q8BIK4-1" }, "locus": { "chromosome": "14", "start_pos": 121975874, "end_pos": 121781988, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000212376.3", "url": "https://www.ensembl.org/id/ENSMUST00000212376.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000148328.2", "url": "https://www.ensembl.org/id/ENSMUSP00000148328.2" } ] } }, { "isoform_ac": "A0A1D5RMM1-1", "url": "", "sequence": { "sequence": "MQAEKYRTSGRSDKKELVIESPLQYKDAAQADVEAESSTLAKPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYLRSTVPANAEEEAQSLFVTECIKTYNSDWHLVTYKYEDYSGEFRQLPNKVPKLDKLPVHVYEVDEEADKDEDAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKILQLNFEAAMQEKRNGDPHEDDEQSKLEGSGSGLDSYLPELAKSTREAEIKLKSESRVKLFYLDPDTQKLDFSSAEPEVKPFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLTPTSPALMNGGQSPPAFQDALHTAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMRSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAARTLFKDTSGNLDKNARFSAIYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDSVSCDFPNYLNSSYIPMRQFETCSKSPITFEVEEFVPCIPKHTQPYTVYSNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSALAAVLHHQQNPEFYDEIKIELPAQLHERHHLLFTFFHVSCDNSTKGSTKKKDAVETQVGFSWLPLLKDGRVLTSEQHIPVSANLPSGYLGYQELGMGRHYGPEVKWVEGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQASGSELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKFAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENNKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAISMLKNLLIKHSFDDRYNSRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNPGSIVKDEALAVPAGNPLMTPQKGNTLDHSLHKDLLGAISGIASPYTASTPNINSVRNADSRGSLISTDSGNSLPDRNPEKSNSLDKQQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWNKASTAELMDFFTISEVCLHQFQYMGKRYIARNQEGLGPIGHDRKSQTLPVSRNRTGMMHARLQQLGSLDNSVTFNHSYGHSEADVVHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMALKNVFTALRSLIYKFPSAFYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRIIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKGMFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKFAYIQVTHVTPFFDEKELQERRTEFERCHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSDIMREQICPLEEKTSVLPNSLHIFNAISGTPTSTVVQGLTSSSSVV", "length": 2088, "header": "tr|A0A1D5RMM1-1|A0A1D5RMM1_MOUSE Computationally mapped isoform of Dedicator of cytokinesis 9 OS=Mus musculus OX=10090 GN=Dock9 PE=1 SV=1 CANONICAL=Q8BIK4-1" }, "locus": { "chromosome": "14", "start_pos": 121935725, "end_pos": 121780918, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000212181.2", "url": "https://www.ensembl.org/id/ENSMUST00000212181.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000148834.2", "url": "https://www.ensembl.org/id/ENSMUSP00000148834.2" } ] } }, { "isoform_ac": "A0A571BG77-1", "url": "", "sequence": { "sequence": "XSPYTASTPNINSVRNADSRGSLISTDSGNSLPDRNPEKSNSLDKRDKLLRRHSACVVRSAEEEESCPSARRHRITVDFSLLTVPPLPEETLHVAPQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSD", "length": 133, "header": "tr|A0A571BG77-1|DOCK9_MOUSE Computationally mapped isoform of Dedicator of cytokinesis protein 9 OS=Mus musculus OX=10090 GN=Dock9 PE=1 SV=1 CANONICAL=Q8BIK4-1" }, "locus": { "chromosome": "14", "start_pos": 121837233, "end_pos": 121835054, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000238406.2", "url": "https://www.ensembl.org/id/ENSMUST00000238406.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158723.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158723.2" } ] } }, { "isoform_ac": "A0A5F8MPL9-1", "url": "", "sequence": { "sequence": "MGCTTSVILFKGIRTVFERNCAYMCKQPGESNALEYTAYNWSKEDSELSIAFCLAKPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYLRSTVPANAEEEAQSLFVTECIKTYNSDWHLVTYKYEDYSGEFRQLPNKVPKLDKLPVHVYEVDEEADKDEDAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKILQLNFEAAMQEKRNGDPHEDDEQSKLEGSGSGLDSYLPELAKSTREAEIKLKSESRVKLFYLDPDTQKLDFSSAEPEVKPFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLTPTSPALMNGGQSPPAFQDALHTAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMRSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAARTLFKDTSGNLDKNARFSAIYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDSVSCDFPNYLNSSYIPMRQFETCSKSPITFEVEEFVPCIPKHTQPYTVYSNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSALAAVLHHQQNPEFYDEIKIELPAQLHERHHLLFTFFHVSCDNSTKGSTKKKDAVETQVGFSWLPLLKDGRVLTSEQHIPVSANLPSGYLGYQELGMGRHYGPEVKWVEGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQASGSELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKFAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENNKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAISMLKNLLIKHSFDDRYNSRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNPGSIVKDEALAVPAGNPLMTPQKGNTLDHSLHKDLLGAISGIASPYTASTPNINSVRNADSRGSLISTDSGNSLPDRNPEKSNSLDKQQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWNKASTAELMDFFTISEVCLHQFQYMGKRYIARTGMMHARLQQLGSLDNSVTFNHSYGHSEADVVHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMALKNVFTALRSLIYKFPSAFYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRIIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKGMFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQAAQYQFTDSETDVEGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKFAYIQVTHVTPFFDEKELQERRTEFERCHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSDIMREQMG", "length": 2055, "header": "tr|A0A5F8MPL9-1|A0A5F8MPL9_MOUSE Computationally mapped isoform of Dedicator of cytokinesis 9 OS=Mus musculus OX=10090 GN=Dock9 PE=1 SV=1 CANONICAL=Q8BIK4-1" }, "locus": { "chromosome": "14", "start_pos": 121975874, "end_pos": 121781988, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000239077.2", "url": "https://www.ensembl.org/id/ENSMUST00000239077.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000159030.2", "url": "https://www.ensembl.org/id/ENSMUSP00000159030.2" } ] } }, { "isoform_ac": "E9QMR2-1", "url": "", "sequence": { "sequence": "MAQQQLPVSTETRKFTRALSKPGTAAELRQSVSEVVRGSVLLAKPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYLRSTVPANAEEEAQSLFVTECIKTYNSDWHLVTYKYEDYSGEFRQLPNKVPKLDKLPVHVYEVDEEADKDEDAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKILQLNFEAAMQEKRNGDPHEDDEQSKLEGSGSGLDSYLPELAKSTREAEIKLKSESRVKLFYLDPDTQKLDFSSAEPEVKPFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLTPTSPALMNGGQSPPAFQDALHTAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMRSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAARTLFKDTSGNLDKNARFSAIYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDSVSCDFPNYLNSSYIPMRQFETCSKSPITFEVEEFVPCIPKHTQPYTVYSNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSALAAVLHHQQNPEFYDEIKIELPAQLHERHHLLFTFFHVSCDNSTKGSTKKKDAVETQVGFSWLPLLKDGRVLTSEQHIPVSANLPSGYLGYQELGMGRHYGPEVKWVEGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQASGSELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKFAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENNKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAISMLKNLLIKHSFDDRYNSRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNPGSIVKDEALAVPAGNPLMTPQKGNTLDHSLHKDLLGAISGIASPYTASTPNINSVRNADSRGSLISTDSGNSLPDRNPEKSNSLDKQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWNKASTAELMDFFTISEVCLHQFQYMGKRYIASVRKISSVLGISVDNGYGHSEADVVHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMALKNVFTALRSLIYKFPSAFYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRIIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKGMFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKFAYIQVTHVTPFFDEKELQERRTEFERCHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSDIMREQICPLEEKTSVLPNSLHIFNAISGTPTSTVVQGLTSSSSVV", "length": 2058, "header": "tr|E9QMR2-1|DOCK9_MOUSE Computationally mapped isoform of Dedicator of cytokinesis protein 9 OS=Mus musculus OX=10090 GN=Dock9 PE=1 SV=1 CANONICAL=Q8BIK4-1" }, "locus": { "chromosome": "14", "start_pos": 122035027, "end_pos": 121780918, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000100299.11", "url": "https://www.ensembl.org/id/ENSMUST00000100299.11" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000097872.4", "url": "https://www.ensembl.org/id/ENSMUSP00000097872.4" } ] } }, { "isoform_ac": "F8VPN7-1", "url": "", "sequence": { "sequence": "MQAEKYRTSGRSDKKELVIESPLQYKDAAQADVEAESSTLAKPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYLRSTVPANAEEEAQSLFVTECIKTYNSDWHLVTYKYEDYSGEFRQLPNKVPKLDKLPVHVYEVDEEADKDEDAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKILQLNFEAAMQEKRNGDPHEDDEQSKLEGSGSGLDSYLPELAKSTREAEIKLKSESRVKLFYLDPDTQKLDFSSAEPEVKPFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLTPTSPALMNGGQSPPAFQDALHTAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMRSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAARTLFKDTSGNLDKNARFSAIYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDSVSCDFPNYLNSSYIPMRQFETCSKSPITFEVEEFVPCIPKHTQPYTVYSNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSALAAVLHHQQNPEFYDEIKIELPAQLHERHHLLFTFFHVSCDNSTKGSTKKKDAVETQVGFSWLPLLKDGRVLTSEQHIPVSANLPSGYLGYQELGMGRHYGPEVKWVEGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQASGSELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKFAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENNKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAISMLKNLLIKHSFDDRYNSRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNPGSIVKDEALAVPAGNPLMTPQKGNTLDHSLHKDLLGAISGIASPYTASTPNINSVRNADSRGSLISTDSGNSLPDRNPEKSNSLDKQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWNKASTAELMDFFTISEVCLHQFQYMGKRYIARNQEGLGPIGHDRKSQTLPVSRNRTGMMHARLQQLGSLDNSVTFNHSYGHSEADVVHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMALKNVFTALRSLIYKFPSAFYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRIIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKEADLALQREPPAFPYSHSTCQRKSWGGMFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKFAYIQVTHVTPFFDEKELQERRTEFERCHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSDIMREQICPLEEKTSVLPNSLHIFNAISGTPTSTVVQGLTSSSSVV", "length": 2113, "header": "tr|F8VPN7-1|F8VPN7_MOUSE Computationally mapped isoform of Dedicator of cytokinesis 9 OS=Mus musculus OX=10090 GN=Dock9 PE=1 SV=1 CANONICAL=Q8BIK4-1" }, "locus": { "chromosome": "14", "start_pos": 121935725, "end_pos": 121780918, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000040700.9", "url": "https://www.ensembl.org/id/ENSMUST00000040700.9" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000047881.8", "url": "https://www.ensembl.org/id/ENSMUSP00000047881.8" } ] } }, { "isoform_ac": "Q8BIK4-1", "url": "", "sequence": { "sequence": "MGCTTSVILFKGIRTVFERNCAYMCKQPGESNALEYTAYNWSKEDSELSIAFCLAKPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYLRSTVPANAEEEAQSLFVTECIKTYNSDWHLVTYKYEDYSGEFRQLPNKVPKLDKLPVHVYEVDEEADKDEDAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKILQLNFEAAMQEKRNGDPHEDDEQSKLEGSGSGLDSYLPELAKSTREAEIKLKSESRVKLFYLDPDTQKLDFSSAEPEVKPFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLAPTSPALMNGGQSPPAFQDALHTAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMRSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAARTLFKDTSGNLDKNARFSAIYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDSVSCDFPNYLNSSYIPMRQFETCSKSPITFEVEEFVPCIPKHTQPYTVYSNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSALAAVLHHQQNPEFYDEIKIELPAQLHERHHLLFTFFHVSCDNSTKGSTKKKDAVETQVGFSWLPLLKDGRVLTSEQHIPVSANLPSGYLGYQELGMGRHYGPEVKWVEGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQASGSELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKFAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENNKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAISMLKNLLIKHSFDDRYNSRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNPGSIVKDEALAVPAGNPLMTPQKGNTLDHSLHKDLLGAISGIASPYTASTPNINSVRNADSRGSLISTDSGNSLPDRNPEKSNSLDKQQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWNKASTAELMDFFTISEVCLHQFQYMGKRYIARTGMMHARLQQLGSLDNSVTFNHSYGHSEADVVHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMALKNVFTALRSLIYKFPSAFYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRIIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKGMFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQAAQYQFTDSETDVEGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKFAYIQVTHVTPFFDEKELQERRTEFERCHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSDIMREQMG", "length": 2055, "header": "sp|Q8BIK4-1|DOCK9_MOUSE Isoform 1 of Dedicator of cytokinesis protein 9 OS=Mus musculus OX=10090 GN=Dock9 PE=1 SV=2 CANONICAL=Q8BIK4-1" }, "locus": {} }, { "isoform_ac": "Q8BIK4-2", "url": "", "sequence": { "sequence": "MGCTTSVILFKGIRTVFERNCAYMCKQPGESNALEYTAYNWSKEDSELSIAFCLAKPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYLRSTVPANAEEEAQSLFVTECIKTYNSDWHLVTYKYEDYSGEFRQLPNKVPKLDKLPVHVYEVDEEADKDEDAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVIQNNRVRRFAFELKMQDKSSYLLAADSEAEMEEWVTVLNKILQLNFEAAMQEKRNGDPHEDDEQSKLEGSGSGLDSYLPELAKSTREAEIKLKSESRVKLFYLDPDTQKLDFSSAEPEVKPFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLAPTSPALMNGGQSPPAFQDALHTAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMRSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAARTLFKDTSGNLDKNARFSAIYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDSVSCDFPNYLNSSYIPMRQFETCSKSPITFEVEEFVPCIPKHTQPYTVYSNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSALAAVLHHQQNPEFYDEIKIELPAQLHERHHLLFTFFHVSCDNSTKGSTKKKDAVETQVGFSWLPLLKDGRVLTSEQHIPVSANLPSGYLGYQELGMGRHYGPEVKWVEGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQASGSELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKFAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENNKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRVIAISMLKNLLIKHSFDDRYNSRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNPGSIVKDEALAVPAGNPLMTPQKGNTLDHSLHKDLLGAISGIASPYTASTPNINSVRNADSRGSLISTDSGNSLPDRNPEKSNSLDKQQQSGMLGNSVVRCDKLDQSEIKSLLMCFLYVLKSMSDDALFTYWNKASTAELMDFFTISEVCLHQFQYMGKRYIARNQEGLGPIGHDRKSQTLPVSRNRTGMMHARLQQLGSLDNSVTFNHSYGHSEADVVHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMALKNVFTALRSLIYKFPSAFYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRIIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKEADLALQREPPAFPYSHSTCQRKSWGGMFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKFAYIQVTHVTPFFDEKELQERRTEFERCHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSDIMREQICPLEEKTSVLPNSLHIFNAISGTPTSTVVQGLTSSSSVV", "length": 2128, "header": "sp|Q8BIK4-2|DOCK9_MOUSE Isoform 2 of Dedicator of cytokinesis protein 9 OS=Mus musculus OX=10090 GN=Dock9 PE=1 SV=2 CANONICAL=Q8BIK4-1" }, "locus": {} }, { "isoform_ac": "Q8BIK4-3", "url": "", "sequence": { "sequence": "MMHARLQQLGSLDNSVTFNHSYGHSEADVVHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSEMALKNVFTALRSLIYKFPSAFYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRIIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKGMFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQAAQYQFTDSETDVEGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKFAYIQVTHVTPFFDEKELQERRTEFERCHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSDIMREQMG", "length": 689, "header": "sp|Q8BIK4-3|DOCK9_MOUSE Isoform 3 of Dedicator of cytokinesis protein 9 OS=Mus musculus OX=10090 GN=Dock9 PE=1 SV=2 CANONICAL=Q8BIK4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 1244, "end_pos": 1244, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" } ], "site_lbl": "Ser1244" }, { "start_pos": 1250, "end_pos": 1250, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" } ], "site_lbl": "Thr1250" }, { "start_pos": 1264, "end_pos": 1264, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" } ], "site_lbl": "Ser1264" }, { "start_pos": 1270, "end_pos": 1270, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q8BIK4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BIK4" } ], "site_lbl": "Ser1270" }, { "start_pos": 1273, "end_pos": 1273, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q8BIK4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BIK4" } ], "site_lbl": "Ser1273" }, { "start_pos": 178, "end_pos": 178, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q8BIK4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BIK4" } ], "site_lbl": "Ser178" }, { "start_pos": 181, "end_pos": 181, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q8BIK4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BIK4" } ], "site_lbl": "Ser181" }, { "start_pos": 444, "end_pos": 444, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q8BIK4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BIK4" } ], "site_lbl": "Ser444" }, { "start_pos": 453, "end_pos": 453, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q8BIK4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BIK4" } ], "site_lbl": "Ser453" }, { "start_pos": 936, "end_pos": 936, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" }, { "database": "phospho.ELM", "id": "Q8BIK4", "url": "http://phospho.elm.eu.org/byAccession/Q8BIK4.html" }, { "database": "iPTMnet", "id": "Q8BIK4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BIK4" }, { "database": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" }, { "database": "PRO", "id": "Q8BIK4", "url": "http://purl.obolibrary.org/obo/Q8BIK4" } ], "site_lbl": "Ser936" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.", "journal": "Molecular & cellular proteomics : MCP", "date": "2007", "authors": "Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM", "evidence": [ { "database": "iPTMnet", "id": "Q8BIK4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BIK4" } ], "reference": [ { "type": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ] }, { "title": "Regulation of dendrite growth by the Cdc42 activator Zizimin1/Dock9 in hippocampal neurons.", "journal": "Journal of neuroscience research", "date": "2009", "authors": "Kuramoto K, Negishi M, Katoh H", "evidence": [ { "database": "RefSeq", "id": "NP_001334525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334525" }, { "database": "RefSeq", "id": "NP_598835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598835" }, { "database": "RefSeq", "id": "NP_001074508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074508" }, { "database": "RefSeq", "id": "NP_001121779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121779" }, { "database": "RefSeq", "id": "NP_001121780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121780" } ], "reference": [ { "type": "PubMed", "id": "19156867", "url": "https://glygen.org/publication/PubMed/19156867" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" }, { "database": "iPTMnet", "id": "Q8BIK4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BIK4" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells.", "journal": "Immun. Ageing", "date": "2012", "authors": "Sakabe I, Asai A, Iijima J, Maruyama M", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" } ], "reference": [ { "type": "PubMed", "id": "22494997", "url": "https://glygen.org/publication/PubMed/22494997" } ] }, { "title": "The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation.", "journal": "Immun. Ageing", "date": "2015", "authors": "Maruyama M., Matsuda T., Takaoka A., Yanase S.", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" } ], "reference": [ { "type": "PubMed", "id": "25729399", "url": "https://glygen.org/publication/PubMed/25729399" } ] }, { "title": "The RhoGEF DOCK10 is essential for dendritic spine morphogenesis.", "journal": "Mol. Biol. Cell", "date": "2015", "authors": "Jaudon F, Raynaud F, Wehrle R, Bellanger JM, Doulazmi M, Vodjdani G, Gasman S, Fagni L, Dusart I, Debant A, Schmidt S", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" } ], "reference": [ { "type": "PubMed", "id": "25851601", "url": "https://glygen.org/publication/PubMed/25851601" } ] }, { "title": "Exosomal lncRNA DOCK9-AS2 derived from cancer stem cell-like cells activated Wnt/beta-catenin pathway to aggravate stemness, proliferation, migration, and invasion in papillary thyroid carcinoma.", "journal": "Cell death & disease", "date": "2020", "authors": "Dai W, Jin X, Han L, Huang H, Ji Z, Xu X, Tang M, Jiang B, Chen W", "evidence": [ { "database": "RefSeq", "id": "NP_001334525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334525" }, { "database": "RefSeq", "id": "NP_001121780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121780" }, { "database": "RefSeq", "id": "NP_598835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598835" }, { "database": "RefSeq", "id": "NP_001074508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074508" }, { "database": "RefSeq", "id": "NP_001121779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121779" } ], "reference": [ { "type": "PubMed", "id": "32917852", "url": "https://glygen.org/publication/PubMed/32917852" } ] } ], "pathway": [ { "id": "mmu:105445", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:105445", "resource": "KEGG Pathway" }, { "id": "R-MMU-9013148", "name": "CDC42 GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" }, { "id": "R-MMU-9013149", "name": "RAC1 GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013149", "resource": "Reactome", "description": "RAC1 GTPase cycle" }, { "id": "R-MMU-983231", "name": "Factors involved in megakaryocyte development and platelet production", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983231", "resource": "Reactome", "description": "Factors involved in megakaryocyte development and platelet production" } ], "orthologs": [ { "uniprot_canonical_ac": "Q63603-1", "protein_name": "Dedicator of cytokinesis protein 9", "gene_name": "Dock9", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "KLSRGHSPLMKKVFDVYLCFLQKHQSEMALKNVFTALRSLIYKFPSTFYEGRADMCASLCYEVLKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISLSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKEADLALQREPPVFPYSHTSCQRKSRGGMFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERLRAGLLTSINSSSPSMKSGGTLETTHLYDTLHRPYSKVTEVITRAAGSWDLLPGGLFGQGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKFAYIQVTHVTPFFDEKELQERKTEFERCHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELHQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREIRKELSDIIVPRICPGEDKRATKFPAHLQRHQRDTNKHSGSRVDQFILSCVTLPHEPHVGTCFVMCKLRTTFRANHWFCQAQEEAMGNGREKEPGL", "length": 720 }, "evidence": [ { "id": "45234870", "url": "http://www.informatics.jax.org/homology/45234870", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9BZ29-1", "protein_name": "Dedicator of cytokinesis protein 9", "gene_name": "DOCK9", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSQPPLLPASAETRKFTRALSKPGTAAELRQSVSEVVRGSVLLAKPKLIEPLDYENVIVQKKTQILNDCLREMLLFPYDDFQTAILRRQGRYICSTVPAKAEEEAQSLFVTECIKTYNSDWHLVNYKYEDYSGEFRQLPNKVVKLDKLPVHVYEVDEEVDKDEDAASLGSQKGGITKHGWLYKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVVQNNKVRRFAFELKMQDKSSYLLAADSEVEMEEWITILNKILQLNFEAAMQEKRNGDSHEDDEQSKLEGSGSGLDSYLPELAKSAREAEIKLKSESRVKLFYLDPDAQKLDFSSAEPEVKSFEEKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLNHFSVRQMLATTSPALMNGSGQSPSVLKGILHEAAMQYPKQGIFSVTCPHPDIFLVARIEKVLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAARTLFKDASGNLDKNARFSAIYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDNVSSDFPNYVNSSYIPTKQFETCSKTPITFEVEEFVPCIPKHTQPYTIYTNHLYVYPKYLKYDSQKSFAKARNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSAFAAVLHHHQNPEFYDEIKIELPTQLHEKHHLLLTFFHVSCDNSSKGSTKKRDVVETQVGYSWLPLLKDGRVVTSEQHIPVSANLPSGYLGYQELGMGRHYGPEIKWVDGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESGAQALGNELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQCHEEGLESHLRSYVKYAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSWFFFDVLIKSMAQHLIENSKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKNANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPLNLPMPFGKGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRLIAISVLKNLLIKHSFDDRYASRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNAGMTVKDESLALPAVNPLVTPQKGSTLDNSLHKDLLGAISGIASPYTTSTPNINSVRNADSRGSLISTDSGNSLPERNSEKSNSLDKHQQSSTLGNSVVRCDKLDQSEIKSLLMCFLYILKSMSDDALFTYWNKASTSELMDFFTISEVCLHQFQYMGKRYIARTGMMHARLQQLGSLDNSLTFNHSYGHSDADVLHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQKHQSETALKNVFTALRSLIYKFPSTFYEGRADMCAALCYEILKCCNSKLSSIRTEASQLLYFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIKHTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSMARIHVKNGDLSEAAMCYVHVTALVAEYLTRKEAVQWEPPLLPHSHSACLRRSRGGVFRQGCTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLIIPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQAAQYQFTDSETDVEGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDSKYAYIQVTHVIPFFDEKELQERKTEFERSHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTILTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQGSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKEDQLEYQEEMKANYREMAKELSEIMHEQLG", "length": 2069 }, "evidence": [ { "id": "45234870", "url": "http://www.informatics.jax.org/homology/45234870", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "small GTPase mediated signal transduction", "id": "GO:0007264", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" } ], "pmid": "" }, { "name": "positive regulation of GTPase activity", "id": "GO:0043547", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043547", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" } ], "pmid": "" }, { "name": "endomembrane system", "id": "GO:0012505", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505", "evidence": [ { "database": "UniProtKB", "id": "Q8BIK4", "url": "https://www.uniprot.org/uniprot/Q8BIK4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1032, "end_pos": 1034, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1385, "end_pos": 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}, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": 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