{
    "uniprot_canonical_ac": "Q8BIG4-1",
    "uniprot_ac": "Q8BIG4",
    "uniprot_id": "FBX28_MOUSE",
    "mass": {
        "chemical_mass": 40978.0,
        "monoisotopic_mass": 40978.0
    },
    "refseq": {
        "ac": "NP_780336",
        "name": "F-box only protein 28",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780336"
    },
    "gene_names": [
        {
            "name": "Fbxo28",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q8BIG4",
            "id": "Q8BIG4"
        },
        {
            "name": "4833428J17Rik; 5730505P19Rik; D1Ertd578e; Fbx28; mKIAA0483",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780336",
            "id": "NP_780336"
        },
        {
            "name": "D1Ertd578e",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8BIG4",
            "id": "Q8BIG4"
        },
        {
            "name": "Fbxo28",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780336",
            "id": "NP_780336"
        },
        {
            "name": "Kiaa0483",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q8BIG4",
            "id": "Q8BIG4"
        }
    ],
    "protein_names": [
        {
            "name": "F-box only protein 28",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q8BIG4"
        },
        {
            "name": "F-box only protein 28",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780336",
            "id": "NP_780336"
        }
    ],
    "function": [
        {
            "annotation": "Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8BIG4",
                    "url": "https://www.uniprot.org/uniprot/Q8BIG4#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0070386",
            "recommended_name": {
                "id": "DOID:0070386",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0070386",
                "name": "developmental and epileptic encephalopathy 100",
                "description": "A developmental and epileptic encephalopathy characterized by onset of variable types of seizures in the first months or years of life preceded by global developmental delay that has_material_basis_in heterozygous mutation in the FBXO28 gene on chromosome 1q42."
            },
            "synonyms": [
                {
                    "id": "DOID:0070386",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070386",
                    "name": "DEE100",
                    "description": ""
                },
                {
                    "id": "DOID:0070386",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070386",
                    "name": "early infantile epileptic encephalopathy 100",
                    "description": ""
                },
                {
                    "id": "MONDO:0030695",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0030695",
                    "name": "developmental and epileptic encephalopathy 100",
                    "description": ""
                },
                {
                    "id": "MONDO:0030695",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0030695",
                    "name": "DEE100",
                    "description": ""
                },
                {
                    "id": "MONDO:0030695",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0030695",
                    "name": "developmental and epileptic encephalopathy 100",
                    "description": ""
                },
                {
                    "id": "MIM:619777",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/619777",
                    "name": "Developmental and epileptic encephalopathy 100",
                    "description": "Developmental and epileptic encephalopathy 100"
                }
            ],
            "evidence": [
                {
                    "id": "0070386",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070386"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8BIG4",
                    "url": "https://www.uniprot.org/uniprot/Q8BIG4"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Fbxo28",
            "url": "https://www.uniprot.org/uniprot/Q8BIG4",
            "locus": {
                "chromosome": "1",
                "start_pos": 182140667,
                "end_pos": 182169194,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000047539",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000047539"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000047539",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000047539",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd22100",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22100",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "67948",
            "url": "https://www.ncbi.nlm.nih.gov/gene/67948",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001810",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001810",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036047",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036047",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR039719",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039719",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:67948",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:67948",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1261890",
            "url": "http://www.informatics.jax.org/marker/MGI:1261890",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "KAPQRAH",
            "url": "https://omabrowser.org/oma/group/KAPQRAH/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5395010at2759",
            "url": "http://www.orthodb.org/?query=5395010at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13252",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13252",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13252:SF9",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13252:SF9",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00646",
            "url": "http://pfam.xfam.org/family/PF00646",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q8BIG4",
            "url": "http://purl.obolibrary.org/obo/PR_Q8BIG4",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_780336",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780336",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0A6YVQ6",
            "url": "https://www.uniprot.org/uniprot/A0A0A6YVQ6",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0A6YVQ6-1",
            "url": "https://www.uniprot.org/uniprot/A0A0A6YVQ6-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0A6YX00",
            "url": "https://www.uniprot.org/uniprot/A0A0A6YX00",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0A6YX00-1",
            "url": "https://www.uniprot.org/uniprot/A0A0A6YX00-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0A6YX52",
            "url": "https://www.uniprot.org/uniprot/A0A0A6YX52",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0A6YX52-1",
            "url": "https://www.uniprot.org/uniprot/A0A0A6YX52-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8BIG4",
            "url": "https://www.uniprot.org/uniprot/Q8BIG4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q8BIG4-1",
            "url": "https://www.uniprot.org/uniprot/Q8BIG4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAAASEERMAEEGGGGHGDGGSCSAAGSAQRQPPAPPSQAPPPGSQAPAAPALAPDHLPQNNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERFHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRVLRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLMGSPPVPGPSAALTTMQLFSKQNPSRQEVTKLQQQVRTNGAGVTVLRREISELRTKVQEQQKQLQDQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGTSSGSGQSEESPRKRRKATEAIDSLRKSKRLRNRK",
        "length": 368,
        "header": "sp|Q8BIG4-1|FBX28_MOUSE Isoform 1 of F-box only protein 28  OS=Mus musculus OX=10090 GN=Fbxo28 PE=1 SV=1 CANONICAL=Q8BIG4-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0A6YVQ6-1",
            "url": "",
            "sequence": {
                "sequence": "MAAASEERMAEEGGGGHGDGGSCSAAGSAQRQPPAPPSQAPPPGSQAPAAPALAPDHLPQNNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERFHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKSPSASSRGAAGVTGYLLHGDGVL",
                "length": 195,
                "header": "tr|A0A0A6YVQ6-1|A0A0A6YVQ6_MOUSE Computationally mapped isoform of F-box protein 28  OS=Mus musculus OX=10090 GN=Fbxo28 PE=1 SV=1 CANONICAL=Q8BIG4-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 182169154,
                "end_pos": 182145455,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000194213.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000194213.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000141219.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000141219.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A0A6YX00-1",
            "url": "",
            "sequence": {
                "sequence": "ERMAEEGGGGHGDGGSCSAAGSAQRQPPAPPSQAPPPGSQAPAAPALAPDHLPQNNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERFHNLCQKQVKAQLPRCCRSYGISPPWRWSTLMRRLFQF",
                "length": 143,
                "header": "tr|A0A0A6YX00-1|FBX28_MOUSE Computationally mapped isoform of F-box only protein 28  OS=Mus musculus OX=10090 GN=Fbxo28 PE=1 SV=1 CANONICAL=Q8BIG4-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 182169136,
                "end_pos": 182145432,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000195061.6",
                        "url": "https://www.ensembl.org/id/ENSMUST00000195061.6"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000141772.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000141772.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A0A6YX52-1",
            "url": "",
            "sequence": {
                "sequence": "MAAASEERMAEEGGGGHGDGGSCSAAGSAQRQPPAPPSQAPPPGSQAPAAPALAPDHLPQNNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERFHNLCQKQVKAQLPR",
                "length": 126,
                "header": "tr|A0A0A6YX52-1|FBX28_MOUSE Computationally mapped isoform of F-box only protein 28  OS=Mus musculus OX=10090 GN=Fbxo28 PE=1 SV=1 CANONICAL=Q8BIG4-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 182169154,
                "end_pos": 182145570,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000192544.6",
                        "url": "https://www.ensembl.org/id/ENSMUST00000192544.6"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000141838.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000141838.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q8BIG4-1",
            "url": "",
            "sequence": {
                "sequence": "MAAASEERMAEEGGGGHGDGGSCSAAGSAQRQPPAPPSQAPPPGSQAPAAPALAPDHLPQNNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERFHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRVLRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLMGSPPVPGPSAALTTMQLFSKQNPSRQEVTKLQQQVRTNGAGVTVLRREISELRTKVQEQQKQLQDQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGTSSGSGQSEESPRKRRKATEAIDSLRKSKRLRNRK",
                "length": 368,
                "header": "sp|Q8BIG4-1|FBX28_MOUSE Isoform 1 of F-box only protein 28  OS=Mus musculus OX=10090 GN=Fbxo28 PE=1 SV=1 CANONICAL=Q8BIG4-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 182169154,
                "end_pos": 182144459,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000051431",
                        "url": "https://www.ensembl.org/id/ENSMUST00000051431"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000054718",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000054718"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 235,
            "end_pos": 235,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8BIG4",
                    "url": "https://www.uniprot.org/uniprot/Q8BIG4"
                }
            ],
            "site_lbl": "Ser235"
        },
        {
            "start_pos": 242,
            "end_pos": 242,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8BIG4",
                    "url": "https://www.uniprot.org/uniprot/Q8BIG4"
                }
            ],
            "site_lbl": "Ser242"
        },
        {
            "start_pos": 270,
            "end_pos": 270,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8BIG4",
                    "url": "https://www.uniprot.org/uniprot/Q8BIG4"
                }
            ],
            "site_lbl": "Thr270"
        },
        {
            "start_pos": 344,
            "end_pos": 344,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8BIG4",
                    "url": "https://www.uniprot.org/uniprot/Q8BIG4"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8BIG4",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BIG4"
                }
            ],
            "site_lbl": "Ser344"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.",
            "journal": "Cell",
            "date": "2010",
            "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q8BIG4",
                    "url": "https://www.uniprot.org/uniprot/Q8BIG4"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q8BIG4",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BIG4"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:67948",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:67948",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "B2RZ28-1",
            "protein_name": "F-box protein 28",
            "gene_name": "Fbxo28",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MAAASEERMAEEGGGGHGDGGSCSAASSAQRQPPTPPSQALQPGSQAPAAPALAPDHLPQNNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERYHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRVLRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLMGSPPVPGPSAALTTMQLFSKQNPSRQEVTKLQQQVKTNGAGVTVLRREISELRTKVQEQQKQLQDQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGTSSGSGQSEESPRKRRKATEAIDSLRKSKRLRNRK",
                "length": 368
            },
            "evidence": [
                {
                    "id": "45238119",
                    "url": "http://www.informatics.jax.org/homology/45238119",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q9NVF7-1",
            "protein_name": "F-box only protein 28",
            "gene_name": "FBXO28",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAAAAEERMAEEGGGGQGDGGSSLASGSTQRQPPPPAPQHPQPGSQALPAPALAPDQLPQNNTLVALPIVAIENILSFMSYDEISQLRLVCKRMDLVCQRMLNQGFLKVERYHNLCQKQVKAQLPRRESERRNHSLARHADILAAVETRLSLLNMTFMKYVDSNLCCFIPGKVIDEIYRVLRYVNSTRAPQRAHEVLQELRDISSMAMEYFDEKIVPILKRKLPGSDVSGRLMGSPPVPGPSAALTTMQLFSKQNPSRQEVTKLQQQVKTNGAGVTVLRREISELRTKVQEQQKQLQDQDQKLLEQTQIIGEQNARLAELERKLREVMESAVGNSSGSGQNEESPRKRKKATEAIDSLRKSKRLRNRK",
                "length": 368
            },
            "evidence": [
                {
                    "id": "45238119",
                    "url": "http://www.informatics.jax.org/homology/45238119",
                    "database": "MGI"
                },
                {
                    "id": "Q8BIG4",
                    "url": "https://omabrowser.org/oma/group/Q8BIG4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "identical protein binding",
                        "id": "GO:0042802",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802",
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