{ "uniprot_canonical_ac": "Q8BG05-1", "uniprot_ac": "Q8BG05", "uniprot_id": "ROA3_MOUSE", "mass": { "chemical_mass": 39652.0, "monoisotopic_mass": 39652.0 }, "refseq": { "ac": "NP_444493", "name": "heterogeneous nuclear ribonucleoprotein A3 isoform c", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444493" }, "gene_names": [ { "name": "Hnrnpa3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8BG05", "id": "Q8BG05" }, { "name": "2410013L13Rik; 2610209F03Rik; 2610510D13Rik; Hnrpa3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444493", "id": "NP_444493" }, { "name": "Hnrnpa3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444493", "id": "NP_444493" }, { "name": "Hnrpa3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8BG05", "id": "Q8BG05" } ], "protein_names": [ { "name": "Heterogeneous nuclear ribonucleoprotein A3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8BG05" }, { "name": "heterogeneous nuclear ribonucleoprotein A3 isoform c", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444493", "id": "NP_444493" }, { "name": "hnRNP A3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444493", "id": "NP_444493" }, { "name": "hnRNP A3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8BG05" } ], "function": [ { "annotation": "Characterization of hnRNP A3 in human and mouse cell lines", "evidence": [ { "database": "RefSeq", "id": "NP_444493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444493" }, { "database": "PubMed", "id": "22546510", "url": "https://glygen.org/publication/PubMed/22546510" } ] }, { "annotation": "Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_444493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444493" }, { "database": "PubMed", "id": "32321712", "url": "https://glygen.org/publication/PubMed/32321712" } ] }, { "annotation": "HnRNP A3 is a major liver nuclear protein binding to age related increase element of the factor IX gene. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_444493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444493" }, { "database": "PubMed", "id": "20885981", "url": "https://glygen.org/publication/PubMed/20885981" } ] }, { "annotation": "Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05#function" } ] } ], "disease": [ { "disease_id": "DOID:0110306", "recommended_name": { "id": "DOID:0110306", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110306", "name": "autosomal dominant limb-girdle muscular dystrophy type 3", "description": "An autosomal dominant limb-girdle muscular dystrophy that has_material_basis_in heterozygous mutation in the HNRNPDL gene on chromosome 4q21." }, "synonyms": [ { "id": "DOID:0110306", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110306", "name": "LGMD1G", "description": "" }, { "id": "DOID:0110306", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110306", "name": "autosomal dominant limb-girdle muscular dystrophy type 1G", "description": "" }, { "id": "DOID:0110306", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110306", "name": "muscular dystrophy limb-girdle type 1G", "description": "" }, { "id": "MONDO:0012193", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012193", "name": "autosomal dominant limb-girdle muscular dystrophy type 1G", "description": "Autosomal dominant limb-girdle muscular dystrophy (LGMD1G) is a mild subtype of autosomal dominant limb-girdle muscular dystrophy characterized by a typically adult onset of mild, progressive, proximal weakness of pelvic and shoulder girdle muscles and progressive, permanent finger and toes flexion limitation without flexion contractures. Normal to highly elevated creatine kinase serum levels are observed." }, { "id": "MONDO:0012193", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012193", "name": "HNRNPDL autosomal dominant limb-girdle muscular dystrophy", "description": "" }, { "id": "MONDO:0012193", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012193", "name": "LGMD1G", "description": "" }, { "id": "MONDO:0012193", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012193", "name": "autosomal dominant limb-girdle muscular dystrophy caused by mutation in HNRNPDL", "description": "" }, { "id": "MONDO:0012193", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012193", "name": "muscular dystrophy limb-girdle type 1G", "description": "" }, { "id": "MONDO:0012193", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012193", "name": "muscular dystrophy, limb-girdle, autosomal dominant 3", "description": "" }, { "id": "MONDO:0012193", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012193", "name": "limb-girdle muscular dystrophy type 1G", "description": "" }, { "id": "MONDO:0012193", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012193", "name": "limb-girdle muscular dystrophy, type 1G", "description": "" }, { "id": "MIM:609115", "resource": "MIM", "url": "https://www.omim.org/entry/609115", "name": "Muscular dystrophy, limb-girdle, autosomal dominant 3", "description": "Muscular dystrophy, limb-girdle, autosomal dominant 3" } ], "evidence": [ { "id": "0110306", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110306" } ] }, { "disease_id": "DOID:10325", "recommended_name": { "id": "DOID:10325", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10325", "name": "silicosis", "description": "A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles." }, "synonyms": [ { "id": "DOID:10325", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10325", "name": "Pneumoconiosis due to silicates", "description": "" }, { "id": "DOID:10325", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10325", "name": "Silica pneumoconiosis", "description": "" }, { "id": "DOID:10325", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10325", "name": "Silicotic fibrosis of lung", "description": "" }, { "id": "DOID:10325", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10325", "name": "silicotuberculosis", "description": "" } ], "evidence": [ { "id": "10325", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10325" } ] }, { "disease_id": "DOID:1289", "recommended_name": { "id": "DOID:1289", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1289", "name": "neurodegenerative disease", "description": "A central nervous system disease that results in the progressive deterioration of function or structure of neurons." }, "synonyms": [ { "id": "DOID:1289", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1289", "name": "degenerative disease", "description": "" } ], "evidence": [ { "id": "1289", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1289" } ] }, { "disease_id": "DOID:423", "recommended_name": { "id": "DOID:423", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:423", "name": "myopathy", "description": "A muscular disease in which the muscle fibers do not function resulting in muscular weakness." }, "synonyms": [], "evidence": [ { "id": "423", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:423" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Hnrnpa3", "url": "https://www.uniprot.org/uniprot/Q8BG05", "locus": { "chromosome": "2", "start_pos": 75499751, "end_pos": 75489605, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000059005", "url": "https://www.ensembl.org/id/ENSMUSG00000059005" } ] } } ], "crossref": [ { "id": "ENSMUSG00000059005", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000059005", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd12578", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12578", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12582", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12582", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "229279", "url": "https://www.ncbi.nlm.nih.gov/gene/229279", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q8BG05", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q8BG05*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000504", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000504", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012677", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012677", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR021662", "url": "https://www.ebi.ac.uk/interpro/entry/IPR021662", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034516", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034516", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:229279", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:229279", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1917171", "url": "http://www.informatics.jax.org/marker/MGI:1917171", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q8BG05", "url": "https://oglcnac.org/atlas/detail/Q8BG05", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q8BG05", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8BG05", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "WGNNRQN", "url": "https://omabrowser.org/oma/group/WGNNRQN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3127428at2759", "url": "http://www.orthodb.org/?query=3127428at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR48026", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48026", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR48026:SF12", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48026:SF12", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00076", "url": "http://pfam.xfam.org/family/PF00076", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF11627", "url": "http://pfam.xfam.org/family/PF11627", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8BG05", "url": "http://purl.obolibrary.org/obo/PR_Q8BG05", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72163", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-72203", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72203", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_444493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444493", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A2AL12", "url": "https://www.uniprot.org/uniprot/A2AL12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AL12-1", "url": "https://www.uniprot.org/uniprot/A2AL12-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AL13", "url": "https://www.uniprot.org/uniprot/A2AL13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A2AL13-1", "url": "https://www.uniprot.org/uniprot/A2AL13-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8BG05-1", "url": "https://www.uniprot.org/uniprot/Q8BG05-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8BG05-2", "url": "https://www.uniprot.org/uniprot/Q8BG05-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVKPPPGRPQPDSGRRRRRRGEEGHDPKEPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEEVDAAMCARPHKVDGRVVEPKRAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIETIEVMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGRGGGSGNFMGRGGNFGGGGGNFGRGGNFGGRGGYGGGGGGSRGSYGGGDGGYNGFGGDGGNYGGGPGYSSRGGYGGGGPGYGNQGGGYGGGGGGYDGYNEGGNFGGGNYGGGGNYNDFGNYSGQQQSNYGPMKGGSFGGRSSGSPYGGGYGSGGGSGGYGSRRF", "length": 379, "header": "sp|Q8BG05-1|ROA3_MOUSE Isoform 1 of Heterogeneous nuclear ribonucleoprotein A3 OS=Mus musculus OX=10090 GN=Hnrnpa3 PE=1 SV=1 CANONICAL=Q8BG05-1" }, "isoforms": [ { "isoform_ac": "A2AL12-1", "url": "", "sequence": { "sequence": "MEVKPPPGRPQPDSGRRRRRRGEEGHDPKEPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEEVDAAMCARPHKVDGRVVEPKRAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIETIEVMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGRGGGSGNFMGRGGNFGGGGGNFGRGGNFGGRGGYDGYNEGGNFGGGNYGGGGNYNDFGNYSGQQQSNYGPMKGGSFGGRSSGSPYGGGYGSGGGSGGYGSRRF", "length": 318, "header": "tr|A2AL12-1|A2AL12_MOUSE Computationally mapped isoform of Heterogeneous nuclear ribonucleoprotein A3 OS=Mus musculus OX=10090 GN=Hnrnpa3 PE=1 SV=1 CANONICAL=Q8BG05-1" }, "locus": { "chromosome": "2", "start_pos": 75495627, "end_pos": 75489662, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000111961.8", "url": "https://www.ensembl.org/id/ENSMUST00000111961.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000107592.2", "url": "https://www.ensembl.org/id/ENSMUSP00000107592.2" } ] } }, { "isoform_ac": "A2AL13-1", "url": "", "sequence": { "sequence": "QKYHTINGHNCEVKKALSKQEMQSAGSQRGRGGGSGNFMGRGGNFGGGGGNFGRGGNFGGRGGYGGGGGGSRGSYGGGDGGYNGFGGDGGNYGGGPGYSSRGGYGGGGPGYGNQGGGYGGGGGGYDGYNEGGNFGGGNYGGGGNYNDFGNYSGQQQSNYGPMKGGSFGGRSSGSPYGGGYGSGGGSGGYGSRRF", "length": 194, "header": "tr|A2AL13-1|A2AL13_MOUSE Computationally mapped isoform of Heterogeneous nuclear ribonucleoprotein A3 OS=Mus musculus OX=10090 GN=Hnrnpa3 PE=1 SV=1 CANONICAL=Q8BG05-1" }, "locus": { "chromosome": "2", "start_pos": 75495627, "end_pos": 75492833, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000141974.2", "url": "https://www.ensembl.org/id/ENSMUST00000141974.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000116125.2", "url": "https://www.ensembl.org/id/ENSMUSP00000116125.2" } ] } }, { "isoform_ac": "Q8BG05-1", "url": "", "sequence": { "sequence": "MEVKPPPGRPQPDSGRRRRRRGEEGHDPKEPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEEVDAAMCARPHKVDGRVVEPKRAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIETIEVMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGRGGGSGNFMGRGGNFGGGGGNFGRGGNFGGRGGYGGGGGGSRGSYGGGDGGYNGFGGDGGNYGGGPGYSSRGGYGGGGPGYGNQGGGYGGGGGGYDGYNEGGNFGGGNYGGGGNYNDFGNYSGQQQSNYGPMKGGSFGGRSSGSPYGGGYGSGGGSGGYGSRRF", "length": 379, "header": "sp|Q8BG05-1|ROA3_MOUSE Isoform 1 of Heterogeneous nuclear ribonucleoprotein A3 OS=Mus musculus OX=10090 GN=Hnrnpa3 PE=1 SV=1 CANONICAL=Q8BG05-1" }, "locus": { "chromosome": "2", "start_pos": 75495627, "end_pos": 75489662, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000090792", "url": "https://www.ensembl.org/id/ENSMUST00000090792" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000088298", "url": "https://www.ensembl.org/id/ENSMUSP00000088298" } ] } }, { "isoform_ac": "Q8BG05-2", "url": "", "sequence": { "sequence": "MEGHDPKEPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEEVDAAMCARPHKVDGRVVEPKRAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIETIEVMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGRGGGSGNFMGRGGNFGGGGGNFGRGGNFGGRGGYGGGGGGSRGSYGGGDGGYNGFGGDGGNYGGGPGYSSRGGYGGGGPGYGNQGGGYGGGGGGYDGYNEGGNFGGGNYGGGGNYNDFGNYSGQQQSNYGPMKGGSFGGRSSGSPYGGGYGSGGGSGGYGSRRF", "length": 357, "header": "sp|Q8BG05-2|ROA3_MOUSE Isoform 2 of Heterogeneous nuclear ribonucleoprotein A3 OS=Mus musculus OX=10090 GN=Hnrnpa3 PE=1 SV=1 CANONICAL=Q8BG05-1" }, "locus": { "chromosome": "2", "start_pos": 75495627, "end_pos": 75489662, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000164947", "url": "https://www.ensembl.org/id/ENSMUST00000164947" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000126069", "url": "https://www.ensembl.org/id/ENSMUSP00000126069" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 367, "start_aa": "Ser", "end_pos": 367, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser367", "evidence": [ { "id": "Q8BG05", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q8BG05" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q8BG05", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8BG05" }, { "id": "28528544", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28528544" }, { "id": "25153642", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25153642" }, { "id": "28135057", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28135057" }, { "id": "21540332", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/21540332" }, { "id": "36288343", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36288343" }, { "id": "33300544", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33300544" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" } ] } ], "phosphorylation": [ { "start_pos": 112, "end_pos": 112, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" } ], "site_lbl": "Ser112" }, { "start_pos": 116, "end_pos": 116, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" } ], "site_lbl": "Ser116" }, { "start_pos": 124, "end_pos": 124, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" } ], "site_lbl": "Thr124" }, { "start_pos": 14, "end_pos": 14, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" } ], "site_lbl": "Ser14" }, { "start_pos": 351, "end_pos": 351, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" } ], "site_lbl": "Ser351" }, { "start_pos": 356, "end_pos": 356, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "Q8BG05", "url": "http://phospho.elm.eu.org/byAccession/Q8BG05.html" }, { "database": "iPTMnet", "id": "Q8BG05", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BG05" }, { "database": "PubMed", "id": "17203969", "url": "https://glygen.org/publication/PubMed/17203969" } ], "site_lbl": "Ser356" }, { "start_pos": 359, "end_pos": 359, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" }, { "database": "phospho.ELM", "id": "Q8BG05", "url": "http://phospho.elm.eu.org/byAccession/Q8BG05.html" }, { "database": "iPTMnet", "id": "Q8BG05", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BG05" }, { "database": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "PubMed", "id": "20885981", "url": "https://glygen.org/publication/PubMed/20885981" } ], "site_lbl": "Ser359" }, { "start_pos": 361, "end_pos": 361, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" }, { "database": "phospho.ELM", "id": "Q8BG05", "url": "http://phospho.elm.eu.org/byAccession/Q8BG05.html" }, { "database": "iPTMnet", "id": "Q8BG05", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BG05" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ], "site_lbl": "Tyr361" }, { "start_pos": 365, "end_pos": 365, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" } ], "site_lbl": "Tyr365" }, { "start_pos": 367, "end_pos": 367, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" } ], "site_lbl": "Ser367" }, { "start_pos": 371, "end_pos": 371, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" }, { "database": "phospho.ELM", "id": "Q8BG05", "url": "http://phospho.elm.eu.org/byAccession/Q8BG05.html" }, { "database": "iPTMnet", "id": "Q8BG05", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BG05" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ], "site_lbl": "Ser371" }, { "start_pos": 374, "end_pos": 374, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" } ], "site_lbl": "Tyr374" }, { "start_pos": 376, "end_pos": 376, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" } ], "site_lbl": "Ser376" }, { "start_pos": 43, "end_pos": 43, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" } ], "site_lbl": "Ser43" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.", "journal": "Molecular & cellular proteomics : MCP", "date": "2007", "authors": "Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM", "evidence": [ { "database": "iPTMnet", "id": "Q8BG05", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BG05" } ], "reference": [ { "type": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ] }, { "title": "Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.", "journal": "Journal of proteome research", "date": "2007", "authors": "Dai J, Jin WH, Sheng QH, Shieh CH, Wu JR, Zeng R", "evidence": [ { "database": "iPTMnet", "id": "Q8BG05", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BG05" } ], "reference": [ { "type": "PubMed", "id": "17203969", "url": "https://glygen.org/publication/PubMed/17203969" } ] }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "Q8BG05", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BG05" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] }, { "title": "Heterogeneous nuclear ribonucleoprotein A3 is the liver nuclear protein binding to age related increase element RNA of the factor IX gene.", "journal": "PloS one", "date": "2010", "authors": "Hamada T, Kurachi S, Kurachi K", "evidence": [ { "database": "RefSeq", "id": "NP_444493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444493" }, { "database": "iPTMnet", "id": "Q8BG05", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q8BG05" } ], "reference": [ { "type": "PubMed", "id": "20885981", "url": "https://glygen.org/publication/PubMed/20885981" } ] }, { "title": "Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2011", "authors": "Zaro BW, Yang YY, Hang HC, Pratt MR", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8BG05", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8BG05" } ], "reference": [ { "type": "PubMed", "id": "21540332", "url": "https://glygen.org/publication/PubMed/21540332" } ] }, { "title": "Expression profile and interactions of hnRNP A3 within hnRNP/mRNP complexes in mammals.", "journal": "Archives of biochemistry and biophysics", "date": "2012", "authors": "Papadopoulou C, Boukakis G, Ganou V, Patrinou-Georgoula M, Guialis A", "evidence": [ { "database": "RefSeq", "id": "NP_444493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444493" } ], "reference": [ { "type": "PubMed", "id": "22546510", "url": "https://glygen.org/publication/PubMed/22546510" } ] }, { "title": "Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse.", "journal": "Molecular & cellular proteomics : MCP", "date": "2012", "authors": "Trinidad JC, Barkan DT, Gulledge BF, Thalhammer A, Sali A, Schoepfer R, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8BG05", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8BG05" }, { "database": "O-GlcNAc Atlas", "id": "Q8BG05", "url": "https://oglcnac.org/atlas/detail/Q8BG05" } ], "reference": [ { "type": "PubMed", "id": "22645316", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "journal": "Mol. Cell. Proteomics", "date": "2014", "authors": "Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee KA, Yang V, Aguiar M, Kornhauser J, Jia X, Ren J, Beausoleil SA, Silva JC, Vemulapalli V, Bedford MT, Comb MJ", "evidence": [ { "database": "UniProtKB", "id": "A2AL13", "url": "https://www.uniprot.org/uniprot/A2AL13" }, { "database": "UniProtKB", "id": "A2AL12", "url": "https://www.uniprot.org/uniprot/A2AL12" }, { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" } ], "reference": [ { "type": "PubMed", "id": "24129315", "url": "https://glygen.org/publication/PubMed/24129315" } ] }, { "title": "Changes in metabolic chemical reporter structure yield a selective probe of O-GlcNAc modification.", "journal": "Journal of the American Chemical Society", "date": "2014", "authors": "Chuh KN, Zaro BW, Piller F, Piller V, Pratt MR", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8BG05", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8BG05" } ], "reference": [ { "type": "PubMed", "id": "25153642", "url": "https://glygen.org/publication/PubMed/25153642" } ] }, { "title": "The Small Molecule 2-Azido-2-deoxy-glucose Is a Metabolic Chemical Reporter of O-GlcNAc Modifications in Mammalian Cells, Revealing an Unexpected Promiscuity of O-GlcNAc Transferase.", "journal": "ACS chemical biology", "date": "2017", "authors": "Zaro BW, Batt AR, Chuh KN, Navarro MX, Pratt MR", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8BG05", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8BG05" } ], "reference": [ { "type": "PubMed", "id": "28135057", "url": "https://glygen.org/publication/PubMed/28135057" } ] }, { "title": "The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8.", "journal": "Journal of the American Chemical Society", "date": "2017", "authors": "Chuh KN, Batt AR, Zaro BW, Darabedian N, Marotta NP, Brennan CK, Amirhekmat A, Pratt MR", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8BG05", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8BG05" } ], "reference": [ { "type": "PubMed", "id": "28528544", "url": "https://glygen.org/publication/PubMed/28528544" } ] }, { "title": "Heterogeneous nuclear ribonucleoprotein A3 controls mitotic progression of neural progenitors via interaction with cohesin.", "journal": "Development (Cambridge, England)", "date": "2020", "authors": "Ou MY, Ju XC, Cai YJ, Sun XY, Wang JF, Fu XQ, Sun Q, Luo ZG", "evidence": [ { "database": "RefSeq", "id": "NP_444493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_444493" } ], "reference": [ { "type": "PubMed", "id": "32321712", "url": "https://glygen.org/publication/PubMed/32321712" } ] }, { "title": "O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease.", "journal": "Brain : a journal of neurology", "date": "2020", "authors": "Lee BE, Kim HY, Kim HJ, Jeong H, Kim BG, Lee HE, Lee J, Kim HB, Lee SE, Yang YR, Yi EC, Hanover JA, Myung K, Suh PG, Kwon T, Kim JI", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8BG05", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8BG05" } ], "reference": [ { "type": "PubMed", "id": "33300544", "url": "https://glygen.org/publication/PubMed/33300544" } ] }, { "title": "First comprehensive identification of cardiac proteins with putative increased O-GlcNAc levels during pressure overload hypertrophy.", "journal": "PloS one", "date": "2022", "authors": "Zhu Wei Zhong, Palazzo Teresa, Zhou Mowei, Ledee Dolena, Olson Heather M, Pa\u0161a-Toli\u0107 Ljiljana, Olson Aaron K", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q8BG05", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q8BG05" } ], "reference": [ { "type": "PubMed", "id": "36288343", "url": "https://glygen.org/publication/PubMed/36288343" } ] } ], "pathway": [ { "id": "mmu:229279", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:229279", "resource": "KEGG Pathway" }, { "id": "R-MMU-72163", "name": "mRNA Splicing - Major Pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72163", "resource": "Reactome", "description": "mRNA Splicing - Major Pathway" }, { "id": "R-MMU-72203", "name": "Processing of Capped Intron-Containing Pre-mRNA", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72203", "resource": "Reactome", "description": "Processing of Capped Intron-Containing Pre-mRNA" } ], "orthologs": [ { "uniprot_canonical_ac": "P48810-1", "protein_name": "Heterogeneous nuclear ribonucleoprotein 87F", "gene_name": "Hrb87F", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0035770", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" } ], "pmid": "" }, { "name": "messenger ribonucleoprotein complex", "id": "GO:1990124", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990124", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "mRNA processing", "id": "GO:0006397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" } ], "pmid": "" }, { "name": "RNA splicing", "id": "GO:0008380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "evidence": [ { "database": "UniProtKB", "id": "Q8BG05", "url": "https://www.uniprot.org/uniprot/Q8BG05" } ], "pmid": "" }, { "name": "mRNA splicing, via spliceosome", "id": 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