{ "uniprot_canonical_ac": "Q8BFR2-1", "uniprot_ac": "Q8BFR2", "uniprot_id": "FSTL5_MOUSE", "mass": { "chemical_mass": 95816.0, "monoisotopic_mass": 95816.0 }, "refseq": { "ac": "NP_001240648", "name": "follistatin-related protein 5 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240648" }, "gene_names": [ { "name": "Fstl5", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q8BFR2", "id": "Q8BFR2" }, { "name": "9130207J01Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240648", "id": "NP_001240648" }, { "name": "Fstl5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240648", "id": "NP_001240648" }, { "name": "Kiaa1263", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q8BFR2", "id": "Q8BFR2" } ], "protein_names": [ { "name": "Follistatin-related protein 5", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q8BFR2" }, { "name": "Follistatin-like protein 5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8BFR2" }, { "name": "follistatin-related protein 5 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240648", "id": "NP_001240648" }, { "name": "m-D/Bsp120I 1-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q8BFR2" }, { "name": "ollistatin-like 5; follistatin-related protein 5; m-D/Bsp120I 1-2; follistatin-like protein 5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240648", "id": "NP_001240648" } ], "function": [ { "annotation": "Restricted expression in the olfactory system suggests a possible role for Fstl5 in maintaining odor perception", "evidence": [ { "database": "RefSeq", "id": "NP_001240648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240648" }, { "database": "PubMed", "id": "24588779", "url": "https://glygen.org/publication/PubMed/24588779" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs3393265025", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3393265025" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 112, "end_pos": 112, "sequence_org": "C", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NHC->NHS).", "chr_id": "3", "chr_pos": "76229534", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "C112", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs3388634110", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3388634110" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 425, "end_pos": 425, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (ISS->NSS).", "chr_id": "3", "chr_pos": "76500846", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I425", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q8BFR2", "url": "https://www.uniprot.org/uniprot/Q8BFR2" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Fstl5", "url": "https://www.uniprot.org/uniprot/Q8BFR2", "locus": { "chromosome": "3", "start_pos": 76617326, "end_pos": 75981577, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000034098", "url": "https://www.ensembl.org/id/ENSMUSG00000034098" } ] } } ], "crossref": [ { "id": "ENSMUSG00000034098", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000034098", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00096", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00096", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00104", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00104", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd05736", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05736", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "213262", "url": "https://www.ncbi.nlm.nih.gov/gene/213262", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018247", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:213262", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:213262", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2442179", "url": "http://www.informatics.jax.org/marker/MGI:2442179", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "IMFSHYD", "url": "https://omabrowser.org/oma/group/IMFSHYD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3043918at2759", "url": "http://www.orthodb.org/?query=3043918at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10913", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10913", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10913:SF44", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10913:SF44", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07648", "url": "http://pfam.xfam.org/family/PF07648", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13927", "url": "http://pfam.xfam.org/family/PF13927", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q8BFR2", "url": "http://purl.obolibrary.org/obo/PR_Q8BFR2", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001240648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240648", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F7B641", "url": "https://www.uniprot.org/uniprot/F7B641", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7B641-1", "url": "https://www.uniprot.org/uniprot/F7B641-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8BFR2", "url": "https://www.uniprot.org/uniprot/Q8BFR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q8BFR2-1", "url": "https://www.uniprot.org/uniprot/Q8BFR2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFRCWSAILILGFIFLASEGRPTKESGYGLKSYQPLTRLRHKQEKSQESSRIKEFLIHDGPFGSCENKYCGLGRHCVINRETRHAECACMDLCKQHYKPVCGSDGEFYENHCEVHRAACLKKQKITIVHNEDCFFEGDNCMAIEYSKMKSMLLDLQNQKYITQENENPNSDDISRKKPLVDQMFKYFDADSNGLVDINELTQVIKQEELNKDLSDCTLYDLLKYDDFNADKHLALEEFYRAFQVIQLSLPEDQRVSITAATVGQSAVLSCAIVGTLRPPIIWKRNNIVLNNLDLEDINDFGDDGSLYITKVTTVHMGNYTCYADGYENVRQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPDPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIARNEAGVDEDISSLFVEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPTECEFQRHIKPSEKLLGYQDEVCPKAEEDEVQRCVWASAVNVKDKFIYVAQPTLDRILIVDVQSQKVVQAVSTDPVPVKLHYDKSHDQVWVLSWGSMEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDDFFIPTPTLIITHMRFGFILHKDESALHKIDLETMSYIKTINLKDSRCIPLSLAYTHLGGYYFISCKADITGATPPQLVVDSVTDSIIGFNSDVTGTPYVSPDGHYLVSVNDVKGLVRVQYITIRGEILDAFDIHTNLHISDLAFQPSFTEAHQYNIYGSSSQQTDVLFVELSSGKVKMIKSLKEPLKTEDWPWSQKNRHIQGSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVQKGNTVVWVGDA", "length": 847, "header": "sp|Q8BFR2-1|FSTL5_MOUSE Isoform 1 of Follistatin-related protein 5 OS=Mus musculus OX=10090 GN=Fstl5 PE=2 SV=1 CANONICAL=Q8BFR2-1" }, "isoforms": [ { "isoform_ac": "F7B641-1", "url": "", "sequence": { "sequence": "FVEDSARKTRLGIGNMFYVFYEDGIKVIQPTECEFQRHIKPSEKLLGYQDEVCPKAEEDEVQRCVWASAVNVKDKFIYVAQPTLDRILIVDVQSQKVVQAVSTDPVPVKLHYDKSHDQVWVLSWGSMEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDDFFIPTPTLIITHMRFGFILHKDESALHKIDLETMSYIK", "length": 201, "header": "tr|F7B641-1|F7B641_MOUSE Computationally mapped isoform of Follistatin-like 5 OS=Mus musculus OX=10090 GN=Fstl5 PE=1 SV=8 CANONICAL=Q8BFR2-1" }, "locus": { "chromosome": "3", "start_pos": 76614854, "end_pos": 76500857, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000162471.2", "url": "https://www.ensembl.org/id/ENSMUST00000162471.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000125688.2", "url": "https://www.ensembl.org/id/ENSMUSP00000125688.2" } ] } }, { "isoform_ac": "Q8BFR2-1", "url": "", "sequence": { "sequence": "MFRCWSAILILGFIFLASEGRPTKESGYGLKSYQPLTRLRHKQEKSQESSRIKEFLIHDGPFGSCENKYCGLGRHCVINRETRHAECACMDLCKQHYKPVCGSDGEFYENHCEVHRAACLKKQKITIVHNEDCFFEGDNCMAIEYSKMKSMLLDLQNQKYITQENENPNSDDISRKKPLVDQMFKYFDADSNGLVDINELTQVIKQEELNKDLSDCTLYDLLKYDDFNADKHLALEEFYRAFQVIQLSLPEDQRVSITAATVGQSAVLSCAIVGTLRPPIIWKRNNIVLNNLDLEDINDFGDDGSLYITKVTTVHMGNYTCYADGYENVRQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPDPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIARNEAGVDEDISSLFVEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPTECEFQRHIKPSEKLLGYQDEVCPKAEEDEVQRCVWASAVNVKDKFIYVAQPTLDRILIVDVQSQKVVQAVSTDPVPVKLHYDKSHDQVWVLSWGSMEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDDFFIPTPTLIITHMRFGFILHKDESALHKIDLETMSYIKTINLKDSRCIPLSLAYTHLGGYYFISCKADITGATPPQLVVDSVTDSIIGFNSDVTGTPYVSPDGHYLVSVNDVKGLVRVQYITIRGEILDAFDIHTNLHISDLAFQPSFTEAHQYNIYGSSSQQTDVLFVELSSGKVKMIKSLKEPLKTEDWPWSQKNRHIQGSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVQKGNTVVWVGDA", "length": 847, "header": "sp|Q8BFR2-1|FSTL5_MOUSE Isoform 1 of Follistatin-related protein 5 OS=Mus musculus OX=10090 GN=Fstl5 PE=2 SV=1 CANONICAL=Q8BFR2-1" }, "locus": { "chromosome": "3", "start_pos": 76615481, "end_pos": 76052272, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000160261", "url": "https://www.ensembl.org/id/ENSMUST00000160261" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000125393", "url": "https://www.ensembl.org/id/ENSMUSP00000125393" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 318, "start_aa": "Asn", "end_pos": 318, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn318", "evidence": [ { "id": "Q8BFR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BFR2#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 394, "start_aa": "Asn", "end_pos": 394, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn394", "evidence": [ { "id": "Q8BFR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BFR2#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Follistatin-like 5 is expressed in restricted areas of the adult mouse brain: Implications for its function in the olfactory system.", "journal": "Congenital anomalies", "date": "2014", "authors": "Masuda T, Sakuma C, Nagaoka A, Yamagishi T, Ueda S, Nagase T, Yaginuma H", "evidence": [ { "database": "RefSeq", "id": "NP_001240648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240648" } ], "reference": [ { "type": "PubMed", "id": "24588779", "url": "https://glygen.org/publication/PubMed/24588779" } ] } ], "pathway": [ { "id": "mmu:213262", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:213262", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A096MK67-1", "protein_name": "Follistatin-like 5", "gene_name": "Fstl5", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MFKCWSAVLILGFIFLASEGRPTKESGYGLKYYQPLTRLRHKEKSQESSRIKEFLIHDGPFGSCENKYCGLGRHCVISRETRHAECTCMDLCKQHYKPVCGSDGEFYENHCEVHRAACLKKQKITIVHNEDCFFKGDNCMTTEYSKMKSMLLDLQNQKYITQENENPNSDDISRKKTLVDQMFKYFDADSNGLVDINELTQVIKQEELNKDLSDCTLYDLLKYDDFNADKHLALEEFYRAFQVIQLSLPEDQRVSITAATVGQSAVLSCAVVGTLRPPIIWKRNNIVLNNLDLEDINDFGDDGSLYITKVTTVHMGNYTCYADGYEDVHQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPDPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIARNEAGVDEDISSLFVEDSARKTLANILWREEGLGIGNMFYVFYDDGVKVIQPTECEFQRHIKPSEKLLGFQDEVCPKDEEDEVQRCVWASAVNVKDKFIYVAQPTLDRILIVDVQSQKVVQAVSTDPVPVKLHYDKSHDQVWVLSWGSMEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDDFFIPTPTLIITHMRFGFILHKDESALHKIDLETMSYIKTISLKDSKCIPLSLAYSHLGGYYFISCKPDITGAIPPQLVVDSVTDSIIGSNSDVTGTPYVSPDGHYLVSVNDVKGLVRVQYITIRGEILDAFDIHTNLHISDLAFQPSFTEAHQYNIYGSSSQQTDVLFVELSTGKVKMIKSLKEPLKTEDWPWSPKNRHIQGSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVQKGNTVVWVGDA", "length": 846 }, "evidence": [ { "id": "45228978", "url": "http://www.informatics.jax.org/homology/45228978", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8N475-1", "protein_name": "Follistatin-related protein 5", "gene_name": "FSTL5", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHKQEKNQESSRVKGFMIQDGPFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACLKKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLVDQMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYRAFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVSTDPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDDFFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGYYFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQYITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIKSLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNTVIWVGDA", "length": 847 }, "evidence": [ { "id": "45228978", "url": "http://www.informatics.jax.org/homology/45228978", "database": "MGI" }, { "id": "Q8BFR2", "url": "https://omabrowser.org/oma/group/Q8BFR2/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q8BFR2", "url": "https://www.uniprot.org/uniprot/Q8BFR2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q8BFR2", "url": "https://www.uniprot.org/uniprot/Q8BFR2" } ], "pmid": "" }, { "name": "regulation of BMP signaling pathway", "id": "GO:0030510", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030510", "evidence": [ { "database": "UniProtKB", "id": "Q8BFR2", "url": "https://www.uniprot.org/uniprot/Q8BFR2" } ], "pmid": "" } ] }, { "name": "Molecular 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