{
    "uniprot_canonical_ac": "Q811S7-1",
    "uniprot_ac": "Q811S7",
    "uniprot_id": "UBIP1_MOUSE",
    "mass": {
        "chemical_mass": 60212.0,
        "monoisotopic_mass": 60212.0
    },
    "refseq": {
        "ac": "NP_001076788",
        "name": "upstream-binding protein 1 isoform a",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076788"
    },
    "gene_names": [
        {
            "name": "Ubp1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q811S7",
            "id": "Q811S7"
        },
        {
            "name": "Cp2b; LBP-1a; LBP-1b; NF2d9",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076788",
            "id": "NP_001076788"
        },
        {
            "name": "Cp2b",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q811S7",
            "id": "Q811S7"
        },
        {
            "name": "Nf2d9",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q811S7",
            "id": "Q811S7"
        },
        {
            "name": "Ubp1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076788",
            "id": "NP_001076788"
        }
    ],
    "protein_names": [
        {
            "name": "Upstream-binding protein 1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q811S7"
        },
        {
            "name": "NF2d9",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q811S7"
        },
        {
            "name": "Nuclear factor 2d9",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q811S7"
        },
        {
            "name": "nuclear factor 2d9",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076788",
            "id": "NP_001076788"
        },
        {
            "name": "upstream-binding protein 1 isoform a",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076788",
            "id": "NP_001076788"
        }
    ],
    "function": [
        {
            "annotation": "Functions as a transcriptional activator in a promoter context-dependent manner. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2. Functions as a trans-acting factor that regulates the domestic strain CYP2D9 gene through specific association with the regulatory element SDI-A1. Binding to SDI-A1 depends on the type of nucleotide at position 299; binding is abolished by a nucleotide substitution at this position. Modulates the placental expression of CYP11A1 (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q811S7",
                    "url": "https://www.uniprot.org/uniprot/Q811S7#function"
                },
                {
                    "database": "PubMed",
                    "id": "7623810",
                    "url": "https://glygen.org/publication/PubMed/7623810"
                },
                {
                    "database": "PubMed",
                    "id": "15988015",
                    "url": "https://glygen.org/publication/PubMed/15988015"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q811S7",
                    "url": "https://www.uniprot.org/uniprot/Q811S7"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Ubp1",
            "url": "https://www.uniprot.org/uniprot/Q811S7",
            "locus": {
                "chromosome": "9",
                "start_pos": 113806270,
                "end_pos": 113760002,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000009741",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000009741"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000009741",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000009741",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd09588",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09588",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "22221",
            "url": "https://www.ncbi.nlm.nih.gov/gene/22221",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q811S7",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q811S7*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR007604",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007604",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013761",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR037600",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037600",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR040167",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR040167",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR041418",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041418",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:22221",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:22221",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "104889",
            "url": "http://www.informatics.jax.org/marker/MGI:104889",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "INHVYRQ",
            "url": "https://omabrowser.org/oma/group/INHVYRQ/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1363858at2759",
            "url": "http://www.orthodb.org/?query=1363858at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11037",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11037",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11037:SF13",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11037:SF13",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF04516",
            "url": "http://pfam.xfam.org/family/PF04516",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF18016",
            "url": "http://pfam.xfam.org/family/PF18016",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q811S7",
            "url": "http://purl.obolibrary.org/obo/PR_Q811S7",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001076788",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076788",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q811S7",
            "url": "https://www.uniprot.org/uniprot/Q811S7",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q811S7-1",
            "url": "https://www.uniprot.org/uniprot/Q811S7-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q811S7-2",
            "url": "https://www.uniprot.org/uniprot/Q811S7-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAWVLSMDEVIESGLVHDFDSSLSGIGQELGAGAYSMSDVLALPIFKQEDSSLSLEDEAKHPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPELSGKLVKSIIRVVFHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRTSAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGADRKQKNDREKMEKRTAHEKEKYQPSYDTTILTEMRLEPIIEDAVEHEQKKSSKRTLPADYGDSLAKRGSCSPWPDTPTAYVNNSPSPAPTFTSSQPSTCSVPDSNSSSPNHQGDGAAQASGEQIQPSATTQETQQWLLKNRFSSYTRLFSNFSGADLLKLTKEDLVQICGAADGIRLYNSLKSRSVRPRLTIYVCQEQPSSTALQGQPQAAGSGGESGGGTPSVYHAIYLEEMVASEVARKLASVFNIPFHQINQVYRQGPTGIHILVSDQMVQNFQDETCFLFSTVKAENNDGIHIILK",
        "length": 540,
        "header": "sp|Q811S7-1|UBIP1_MOUSE Isoform 1 of Upstream-binding protein 1  OS=Mus musculus OX=10090 GN=Ubp1 PE=1 SV=1 CANONICAL=Q811S7-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q811S7-1",
            "url": "",
            "sequence": {
                "sequence": "MAWVLSMDEVIESGLVHDFDSSLSGIGQELGAGAYSMSDVLALPIFKQEDSSLSLEDEAKHPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPELSGKLVKSIIRVVFHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRTSAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGADRKQKNDREKMEKRTAHEKEKYQPSYDTTILTEMRLEPIIEDAVEHEQKKSSKRTLPADYGDSLAKRGSCSPWPDTPTAYVNNSPSPAPTFTSSQPSTCSVPDSNSSSPNHQGDGAAQASGEQIQPSATTQETQQWLLKNRFSSYTRLFSNFSGADLLKLTKEDLVQICGAADGIRLYNSLKSRSVRPRLTIYVCQEQPSSTALQGQPQAAGSGGESGGGTPSVYHAIYLEEMVASEVARKLASVFNIPFHQINQVYRQGPTGIHILVSDQMVQNFQDETCFLFSTVKAENNDGIHIILK",
                "length": 540,
                "header": "sp|Q811S7-1|UBIP1_MOUSE Isoform 1 of Upstream-binding protein 1  OS=Mus musculus OX=10090 GN=Ubp1 PE=1 SV=1 CANONICAL=Q811S7-1"
            },
            "locus": {
                "chromosome": "9",
                "start_pos": 113804448,
                "end_pos": 113760722,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000084885",
                        "url": "https://www.ensembl.org/id/ENSMUST00000084885"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000081946",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000081946"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q811S7-2",
            "url": "",
            "sequence": {
                "sequence": "MAWVLSMDEVIESGLVHDFDSSLSGIGQELGAGAYSMSDVLALPIFKQEDSSLSLEDEAKHPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPELSGKLVKSIIRVVFHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRTSAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGADRKQKNDREKMEKRTAHEKEKYQPSYDTTILTECSPWPDTPTAYVNNSPSPAPTFTSSQPSTCSVPDSNSSSPNHQGDGAAQASGEQIQPSATTQETQQWLLKNRFSSYTRLFSNFSGADLLKLTKEDLVQICGAADGIRLYNSLKSRSVRPRLTIYVCQEQPSSTALQGQPQAAGSGGESGGGTPSVYHAIYLEEMVASEVARKLASVFNIPFHQINQVYRQGPTGIHILVSDQMVQNFQDETCFLFSTVKAENNDGIHIILK",
                "length": 504,
                "header": "sp|Q811S7-2|UBIP1_MOUSE Isoform 2 of Upstream-binding protein 1  OS=Mus musculus OX=10090 GN=Ubp1 PE=1 SV=1 CANONICAL=Q811S7-1"
            },
            "locus": {
                "chromosome": "9",
                "start_pos": 113804448,
                "end_pos": 113760722,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000009885",
                        "url": "https://www.ensembl.org/id/ENSMUST00000009885"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000009885",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000009885"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 22,
            "end_pos": 22,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q811S7",
                    "url": "https://www.uniprot.org/uniprot/Q811S7"
                }
            ],
            "site_lbl": "Ser22"
        },
        {
            "start_pos": 390,
            "end_pos": 390,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q811S7",
                    "url": "https://www.uniprot.org/uniprot/Q811S7"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q811S7",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q811S7"
                }
            ],
            "site_lbl": "Ser390"
        },
        {
            "start_pos": 393,
            "end_pos": 393,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q811S7",
                    "url": "https://www.uniprot.org/uniprot/Q811S7"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q811S7",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q811S7"
                }
            ],
            "site_lbl": "Ser393"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Erythroid cell-specific alpha-globin gene regulation by the CP2 transcription factor family.",
            "journal": "Mol. Cell. Biol.",
            "date": "2005",
            "authors": "Cho Y.S., Kim S.-H., Lee Y.H., Kang H.C., Kim C.G., Shin J.H., Chae J.H., Fiering S., Park M.-A., Ye S.-K.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q811S7",
                    "url": "https://www.uniprot.org/uniprot/Q811S7"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15988015",
                    "url": "https://glygen.org/publication/PubMed/15988015"
                }
            ]
        },
        {
            "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.",
            "journal": "Cell",
            "date": "2010",
            "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q811S7",
                    "url": "https://www.uniprot.org/uniprot/Q811S7"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q811S7",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q811S7"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "title": "A nuclear factor (NF2d9) that binds to the male-specific P450 (Cyp 2d-9) gene in mouse liver.",
            "journal": "Mol. Cell. Biol.",
            "date": "1995",
            "authors": "Sueyoshi T, Kobayashi R, Nishio K, Aida K, Moore R, Wada T, Handa H, Negishi M",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q811S7",
                    "url": "https://www.uniprot.org/uniprot/Q811S7"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "7623810",
                    "url": "https://glygen.org/publication/PubMed/7623810"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:22221",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:22221",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A8I6GFC7-1",
            "protein_name": "Upstream binding protein 1",
            "gene_name": "Ubp1",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MRRGAGGRGRAARLAARSLPLQLLAGTLCPDSWASAALVSAASRAAAGDHSPRRRRLHPRPPSGRARGARAPSPRTRRPRCAGRRRGRKMAWVLSMDEVIESGLVHDFDSSLSGIGQELGAGAYSMSDVLALPIFKQEDSSLSLEAEAKHPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDVPEISGKLVKSIIRVVFHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRTSAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGADRKQKNDREKMEKRTAHEKEKYQPSYDTTILTEMRLEPIIEDAVEHEQKKSSKRTLPADYGDSLAKRGSCSPWPDTPTAYVNNSPSPAPTFTSSQQSTCSVPDSNSSSPNHQGDGVAQASGEQIQPSATTQETQQWLLKNRFSSYTRLFSNFSGADLLKLTKEDLVQICGAADGIRLYNSLKSRSVRPRLTIYVCQEQPSSAVPQGQPQAAGSGGEGGAGTPCVYHAIYLEEMVASEVARKLASVFNIPFHQINQVYRQGPTGIHILVSDQMVQNFQDESCFLFSTVKAENNDGIHIILK",
                "length": 629
            },
            "evidence": [
                {
                    "id": "45234016",
                    "url": "http://www.informatics.jax.org/homology/45234016",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q9NZI7-1",
            "protein_name": "Upstream-binding protein 1",
            "gene_name": "UBP1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAWVLKMDEVIESGLVHDFDASLSGIGQELGAGAYSMSDVLALPIFKQEDSSLPLDGETEHPPFQYVMCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPEINGKLVKSIIRVVFHDRRLQYTEHQQLEGWKWNRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRTSAFIQVHCISTEFTPRKHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGADRKQKTDREKMEKRTAHEKEKYQPSYDTTILTEMRLEPIIEDAVEHEQKKSSKRTLPADYGDSLAKRGSCSPWPDAPTAYVNNSPSPAPTFTSPQQSTCSVPDSNSSSPNHQGDGASQTSGEQIQPSATIQETQQWLLKNRFSSYTRLFSNFSGADLLKLTKEDLVQICGAADGIRLYNSLKSRSVRPRLTIYVCREQPSSTVLQGQQQAASSASENGSGAPYVYHAIYLEEMIASEVARKLALVFNIPLHQINQVYRQGPTGIHILVSDQMVQNFQDESCFLFSTVKAESSDGIHIILK",
                "length": 540
            },
            "evidence": [
                {
                    "id": "45234016",
                    "url": "http://www.informatics.jax.org/homology/45234016",
                    "database": "MGI"
                },
                {
                    "id": "Q811S7",
                    "url": "https://omabrowser.org/oma/group/Q811S7/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 4,
                "go_terms": [
                    {
                        "name": "negative regulation of viral transcription",
                        "id": "GO:0032897",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032897",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q811S7",
                                "url": "https://www.uniprot.org/uniprot/Q811S7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "angiogenesis",
                        "id": "GO:0001525",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001525",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q811S7",
                                "url": "https://www.uniprot.org/uniprot/Q811S7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
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