{ "uniprot_canonical_ac": "Q811B1-1", "uniprot_ac": "Q811B1", "uniprot_id": "XYLT1_MOUSE", "mass": { "chemical_mass": 107298.0, "monoisotopic_mass": 107298.0 }, "refseq": { "ac": "NP_783576", "name": "xylosyltransferase 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783576" }, "gene_names": [ { "name": "Xylt1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q811B1", "id": "Q811B1" }, { "name": "8030490L12", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783576", "id": "NP_783576" }, { "name": "Xylt1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783576", "id": "NP_783576" } ], "protein_names": [ { "name": "Xylosyltransferase 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q811B1" }, { "name": "2.4.2.26", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q811B1" }, { "name": "Peptide O-xylosyltransferase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q811B1" }, { "name": "Xylosyltransferase I", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q811B1" }, { "name": "xylosyltransferase 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783576", "id": "NP_783576" }, { "name": "xylosyltransferase I; peptide O-xylosyltransferase 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783576", "id": "NP_783576" } ], "function": [ { "annotation": "Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Required for normal maturation of chondrocytes during bone development, normal onset of ossification and normal embryonic and postnatal skeleton development, especially of the long bones.", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1#function" }, { "database": "PubMed", "id": "24161523", "url": "https://glygen.org/publication/PubMed/24161523" } ] }, { "annotation": "Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism.", "evidence": [ { "database": "RefSeq", "id": "NP_783576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783576" }, { "database": "PubMed", "id": "26414444", "url": "https://glygen.org/publication/PubMed/26414444" } ] }, { "annotation": "Xylosyltransferase 2 deficiency and organ homeostasis.", "evidence": [ { "database": "RefSeq", "id": "NP_783576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783576" }, { "database": "PubMed", "id": "32965647", "url": "https://glygen.org/publication/PubMed/32965647" } ] } ], "disease": [ { "disease_id": "DOID:0060462", "recommended_name": { "id": "DOID:0060462", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060462", "name": "Desbuquois dysplasia", "description": "An osteochondrodysplasia characterized by short stature, joint laxity, scoliosis, and advanced carpal ossification with a delta phalanx." }, "synonyms": [ { "id": "DOID:0060462", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060462", "name": "Desbuquois syndrome", "description": "" }, { "id": "DOID:0060462", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060462", "name": "micromelic dwarfism with vertebral and metaphyseal abnormalities and advanced carpotarsal ossification", "description": "" }, { "id": "MONDO:0009629", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009629", "name": "Desbuquois dysplasia 1", "description": "Any Desbuquois dysplasia in which the cause of the disease is a mutation in the CANT1 gene." }, { "id": "MONDO:0009629", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009629", "name": "CANT1 Desbuquois dysplasia", "description": "" }, { "id": "MONDO:0009629", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009629", "name": "Desbuquois dysplasia 1", "description": "" }, { "id": "MONDO:0009629", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009629", "name": "Desbuquois dysplasia caused by mutation in CANT1", "description": "" }, { "id": "MONDO:0009629", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009629", "name": "Desbuquois dysplasia type 1", "description": "" }, { "id": "MONDO:0009629", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009629", "name": "DBQD1", "description": "" }, { "id": "MONDO:0009629", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009629", "name": "Desbuquois dysplasia, Kim variant", "description": "" }, { "id": "MONDO:0009629", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009629", "name": "desbuquois syndrome", "description": "" }, { "id": "MONDO:0009629", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009629", "name": "micromelic dwarfism with vertebral and metaphyseal abnormalities and advanced carpotarsal ossification", "description": "" }, { "id": "MONDO:0014343", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014343", "name": "Desbuquois dysplasia 2", "description": "Any Desbuquois dysplasia in which the cause of the disease is a mutation in the XYLT1 gene." }, { "id": "MONDO:0014343", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014343", "name": "Baratela-Scott syndrome", "description": "" }, { "id": "MONDO:0014343", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014343", "name": "Desbuquois dysplasia 2", "description": "" }, { "id": "MONDO:0014343", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014343", "name": "Desbuquois dysplasia caused by mutation in XYLT1", "description": "" }, { "id": "MONDO:0014343", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014343", "name": "Desbuquois dysplasia type 2", "description": "" }, { "id": "MONDO:0014343", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014343", "name": "XYLT1 Desbuquois dysplasia", "description": "" }, { "id": "MONDO:0014343", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014343", "name": "DBQD2", "description": "" }, { "id": "MIM:251450", "resource": "MIM", "url": "https://www.omim.org/entry/251450", "name": "Desbuquois dysplasia 1", "description": "Desbuquois dysplasia 1" }, { "id": "MIM:615777", "resource": "MIM", "url": "https://www.omim.org/entry/615777", "name": "Desbuquois dysplasia 2", "description": "Desbuquois dysplasia 2" } ], "evidence": [ { "id": "0060462", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060462" } ] }, { "disease_id": "DOID:2738", "recommended_name": { "id": "DOID:2738", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2738", "name": "pseudoxanthoma elasticum", "description": "A connective tissue disease that is characterized by the accumulation of deposits of calcium and other minerals in elastic fibers, which are a component of connective tissue, this can result in changes in the skin, eyes, cardiovascular system and gastrointestinal system." }, "synonyms": [ { "id": "DOID:2738", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2738", "name": "Gronblad-Strandberg syndrome", "description": "" }, { "id": "MONDO:0008333", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008333", "name": "pseudoxanthoma elasticum, forme fruste", "description": "An autosomal dominant form of PXE." }, { "id": "MONDO:0008333", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008333", "name": "pseudoxanthoma elasticum, forme fruste", "description": "" }, { "id": "MONDO:0008333", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008333", "name": "pseudoxanthoma elasticum, heterozygous", "description": "" }, { "id": "MONDO:0009925", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009925", "name": "autosomal recessive inherited pseudoxanthoma elasticum", "description": "An autosomal recessive form of PXE." }, { "id": "MONDO:0009925", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009925", "name": "AR inherited pseudoxanthoma elasticum", "description": "" }, { "id": "MONDO:0009925", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009925", "name": "Gronblad-Strandberg syndrome", "description": "" }, { "id": "MONDO:0009925", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009925", "name": "Gronblad-Strandberg-Touraine syndrome", "description": "" }, { "id": "MONDO:0009925", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009925", "name": "PXE", "description": "" }, { "id": "MONDO:0009925", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009925", "name": "Gronblad Strandberg syndrome", "description": "" }, { "id": "MONDO:0009925", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009925", "name": "PXE, modifier of severity of", "description": "" }, { "id": "MONDO:0009925", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009925", "name": "pseudoxanthoma elasticum", "description": "" }, { "id": "MONDO:0009925", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009925", "name": "pseudoxanthoma elasticum, modifier of severity of", "description": "" }, { "id": "MIM:264800", "resource": "MIM", "url": "https://www.omim.org/entry/264800", "name": "Pseudoxanthoma elasticum", "description": "Pseudoxanthoma elasticum" } ], "evidence": [ { "id": "2738", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2738" } ] }, { "disease_id": "DOID:557", "recommended_name": { "id": "DOID:557", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:557", "name": "kidney disease", "description": "A urinary system disease that is located_in the kidney." }, "synonyms": [ { "id": "DOID:557", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:557", "name": "impaired renal function disease", "description": "" }, { "id": "DOID:557", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:557", "name": "nephropathy", "description": "" } ], "evidence": [ { "id": "557", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:557" } ] }, { "disease_id": "DOID:9744", "recommended_name": { "id": "DOID:9744", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9744", "name": "type 1 diabetes mellitus", "description": "A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production." }, "synonyms": [ { "id": "DOID:9744", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9744", "name": "IDDM", "description": "" }, { "id": "DOID:9744", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9744", "name": "insulin-dependent diabetes mellitus", "description": "" }, { "id": "DOID:9744", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9744", "name": "type I diabetes mellitus", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "type 1 diabetes mellitus", "description": "A chronic condition characterized by minimal or absent production of insulin by the pancreas." }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "IDDM", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "diabetes mellitis type 1", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "diabetes mellitis type I", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "immune mediated diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "insulin dependent diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "insulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "juvenile diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "type 1 diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "type I diabetes", "description": "" }, { "id": "MONDO:0005147", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005147", "name": "type I diabetes mellitus", "description": "" }, { "id": "MIM:222100", "resource": "MIM", "url": "https://www.omim.org/entry/222100", "name": "Type 1 diabetes mellitus", "description": "Type 1 diabetes mellitus" } ], "evidence": [ { "id": "9744", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9744" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 932, "end_pos": 932, "sequence_org": "W", "sequence_mut": "R", "comment": "In pug; strongly reduced enzyme activity leads to defects in proteoglycan synthesis, abnormal chondrocyte maturation, premature ossification and dwarfism with short limbs and a compressed ribcage, which may be the cause for the increased mortality before weaning.", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" }, { "database": "PubMed", "id": "24161523", "url": "https://glygen.org/publication/PubMed/24161523" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Xylt1", "url": "https://www.uniprot.org/uniprot/Q811B1", "locus": { "chromosome": "7", "start_pos": 117272803, "end_pos": 116980214, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000030657", "url": "https://www.ensembl.org/id/ENSMUSG00000030657" } ] } } ], "crossref": [ { "id": "ENSMUSG00000030657", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000030657", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "GT14", "url": "http://www.cazy.org/GT14.html", "database": "CAZy", "categories": [ "Protein Classification" ] }, { "id": "233781", "url": "https://www.ncbi.nlm.nih.gov/gene/233781", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003406", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003406", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024448", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024448", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043538", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043538", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:233781", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:233781", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2451073", "url": "http://www.informatics.jax.org/marker/MGI:2451073", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q811B1", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q811B1", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "QYKGFLV", "url": "https://omabrowser.org/oma/group/QYKGFLV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4166917at2759", "url": "http://www.orthodb.org/?query=4166917at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46025", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46025", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46025:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46025:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02485", "url": "http://pfam.xfam.org/family/PF02485", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12529", "url": "http://pfam.xfam.org/family/PF12529", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q811B1", "url": "http://purl.obolibrary.org/obo/PR_Q811B1", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-1971475", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1971475", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_783576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783576", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "50192", "url": "https://www.rhea-db.org/rhea/50192", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "F8VPK6", "url": "https://www.uniprot.org/uniprot/F8VPK6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F8VPK6-1", "url": "https://www.uniprot.org/uniprot/F8VPK6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q811B1-1", "url": "https://www.uniprot.org/uniprot/Q811B1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVAAPCARRLARRSHSALLAALMVLLLHTLVVWNFSSLDSGAGEQRRAGAAAGAAEQQQPAAPRRERRDLAAHLPAARGGPGGRAGGGGARGGGPGGARAQQPASRGALASRARDPQPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDFENVDNSNFAPRTQKQKHQPELAKKPPSRQKEHLQRKLDALDKRQGQSVLGKGPKEVLPPREKATGNSSQGKDLSRHSHARKSGGGGSPETKSDQAPKCDISGKEAISALTRAKSKHCRQEIAETYCRHKLGLLMPEKVARFCPLKGKAHKNVQWDEDAVEYMPANPVRIAFVLVVHGRAFRQFQRMSKAIYHKDHFYYIHVDKRSNYLHRQGLQFSRQYENVRVTSWKMATIWGGASFLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDTHMWRLGDRRIPEGIAVDGGSDWFLLNRKFVEYVAFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAIVNQEIIGQLDSYLSGNFPAGTPGLRSYWEKLYDQSAPLRSLSDVALTMYHSFIRLGLRRAESSLHTDGENSCRYYPMGHPVSVHFYFLADRFQGFLIKHHVTNLAVSKLETLETWMMPKEVFKVASPPSDFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVITATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNKQPIKPEEALKLHNGPPRSAYMEQSFQSLNPVLSLHINPAQVEQARKNAAFTGTALEAWLDSLVGGTWTAMDICTTGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR", "length": 953, "header": "sp|Q811B1-1|XYLT1_MOUSE Isoform 1 of Xylosyltransferase 1 OS=Mus musculus OX=10090 GN=Xylt1 PE=1 SV=1 CANONICAL=Q811B1-1" }, "isoforms": [ { "isoform_ac": "F8VPK6-1", "url": "", "sequence": { "sequence": "MVAAPCARRLARRSHSALLAALMVLLLQTLVVWNFSSLDSGAGEQRRAGAAAGAAEQQQPAAPRRERRDLAAHLPAARGGPGGRAGGGGARGGGPGGARAQQPASRGALASRARDPQPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDFENVDNSNFAPRTQKQKHQPELAKKPPSRQKEHLQRKLDAQDKRQGQSVLGKGPKEVLPPREKATGNSSQGKDLSRHSHARKSGGGGSPETKSDQAPKCDISGKEAISALTRAKSKHCRQEIAETYCRHKLGLLMPEKVARFCPLEGKANKNVQWDEDAVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQFSRQYDNVRVTSWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDTHMWRLGDRRIPEGIAVDGGSDWFLLNRKFVEYVAFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAIVNQEIIGQLDSYLYGNYPAGTPGLRSYWENVYDEPDGIHTLSDVALTLYHSFIRLGLRRAESSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHVTNLAVSKLETLETWMMPKKVFKVASPPSDFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNKQPIKPEEALKLHNGPPRSAYMEQSFQSLNPVLSLHINPAQVEQARKNAAFTGTALEAWLDSLVGGTWTAMDICTTGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR", "length": 953, "header": "tr|F8VPK6-1|XYLT1_MOUSE Computationally mapped isoform of Xylosyltransferase 1 OS=Mus musculus OX=10090 GN=Xylt1 PE=1 SV=1 CANONICAL=Q811B1-1" }, "locus": { "chromosome": "7", "start_pos": 117266842, "end_pos": 116980414, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000032892.7", "url": "https://www.ensembl.org/id/ENSMUST00000032892.7" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000032892.6", "url": "https://www.ensembl.org/id/ENSMUSP00000032892.6" } ] } }, { "isoform_ac": "Q811B1-1", "url": "", "sequence": { "sequence": "MVAAPCARRLARRSHSALLAALMVLLLHTLVVWNFSSLDSGAGEQRRAGAAAGAAEQQQPAAPRRERRDLAAHLPAARGGPGGRAGGGGARGGGPGGARAQQPASRGALASRARDPQPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDFENVDNSNFAPRTQKQKHQPELAKKPPSRQKEHLQRKLDALDKRQGQSVLGKGPKEVLPPREKATGNSSQGKDLSRHSHARKSGGGGSPETKSDQAPKCDISGKEAISALTRAKSKHCRQEIAETYCRHKLGLLMPEKVARFCPLKGKAHKNVQWDEDAVEYMPANPVRIAFVLVVHGRAFRQFQRMSKAIYHKDHFYYIHVDKRSNYLHRQGLQFSRQYENVRVTSWKMATIWGGASFLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDTHMWRLGDRRIPEGIAVDGGSDWFLLNRKFVEYVAFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAIVNQEIIGQLDSYLSGNFPAGTPGLRSYWEKLYDQSAPLRSLSDVALTMYHSFIRLGLRRAESSLHTDGENSCRYYPMGHPVSVHFYFLADRFQGFLIKHHVTNLAVSKLETLETWMMPKEVFKVASPPSDFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVITATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNKQPIKPEEALKLHNGPPRSAYMEQSFQSLNPVLSLHINPAQVEQARKNAAFTGTALEAWLDSLVGGTWTAMDICTTGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR", "length": 953, "header": "sp|Q811B1-1|XYLT1_MOUSE Isoform 1 of Xylosyltransferase 1 OS=Mus musculus OX=10090 GN=Xylt1 PE=1 SV=1 CANONICAL=Q811B1-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 219, "start_aa": "Asn", "end_pos": 219, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn219", "evidence": [ { "id": "Q811B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q811B1#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 415, "start_aa": "Asn", "end_pos": 415, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn415", "evidence": [ { "id": "Q811B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q811B1#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 771, "start_aa": "Asn", "end_pos": 771, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn771", "evidence": [ { "id": "Q811B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q811B1#ptm_processing" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q811B1", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q811B1" }, { "id": "29187734", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29187734" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycosyltransferase-activity", "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Molecular cloning and expression of human UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase and its first isoform XT-II.", "journal": "J. Mol. Biol.", "date": "2000", "authors": "Gotting C, Kuhn J, Zahn R, Brinkmann T, Kleesiek K", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "reference": [ { "type": "PubMed", "id": "11099377", "url": "https://glygen.org/publication/PubMed/11099377" } ] }, { "title": "Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity.", "journal": "Biochem. J.", "date": "2005", "authors": "Muller S, Schottler M, Schon S, Prante C, Brinkmann T, Kuhn J, Gotting C, Kleesiek K", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "reference": [ { "type": "PubMed", "id": "15461586", "url": "https://glygen.org/publication/PubMed/15461586" } ] }, { "title": "Human xylosyltransferase II is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulfate and heparan sulfate proteoglycans.", "journal": "J. Biol. Chem.", "date": "2007", "authors": "Esko J.D., Kuhn J., Casanova J.C., Goetting C., Kleesiek K., Prante C., Ambrosius M., Poenighaus C.", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "reference": [ { "type": "PubMed", "id": "17189265", "url": "https://glygen.org/publication/PubMed/17189265" } ] }, { "title": "Polycystic disease caused by deficiency in xylosyltransferase 2, an initiating enzyme of glycosaminoglycan biosynthesis.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2007", "authors": "Condac E, Silasi-Mansat R, Kosanke S, Schoeb T, Towner R, Lupu F, Cummings RD, Hinsdale ME", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "reference": [ { "type": "PubMed", "id": "17517600", "url": "https://glygen.org/publication/PubMed/17517600" } ] }, { "title": "Forward genetics defines Xylt1 as a key, conserved regulator of early chondrocyte maturation and skeletal length.", "journal": "Dev. Biol.", "date": "2014", "authors": "Mis EK, Liem KF Jr, Kong Y, Schwartz NB, Domowicz M, Weatherbee SD", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "reference": [ { "type": "PubMed", "id": "24161523", "url": "https://glygen.org/publication/PubMed/24161523" } ] }, { "title": "Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism.", "journal": "Nature chemical biology", "date": "2015", "authors": "Yu H, Takeuchi M, LeBarron J, Kantharia J, London E, Bakker H, Haltiwanger RS, Li H, Takeuchi H", "evidence": [ { "database": "RefSeq", "id": "NP_783576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783576" } ], "reference": [ { "type": "PubMed", "id": "26414444", "url": "https://glygen.org/publication/PubMed/26414444" } ] }, { "title": "O-GlcNAcylation is required for B cell homeostasis and antibody responses.", "journal": "Nature communications", "date": "2017", "authors": "Wu JL, Chiang MF, Hsu PH, Tsai DY, Hung KH, Wang YH, Angata T, Lin KI", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q811B1", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q811B1" } ], "reference": [ { "type": "PubMed", "id": "29187734", "url": "https://glygen.org/publication/PubMed/29187734" } ] }, { "title": "Xylosyltransferase 2 deficiency and organ homeostasis.", "journal": "Glycoconjugate journal", "date": "2020", "authors": "Ferencz B, Condac E, Poudel N, Munteanu MC, Sivasami P, Choudhury B, Naidu NN, Zhang F, Breshears M, Linhardt RJ, Hinsdale ME", "evidence": [ { "database": "RefSeq", "id": "NP_783576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783576" } ], "reference": [ { "type": "PubMed", "id": "32965647", "url": "https://glygen.org/publication/PubMed/32965647" } ] } ], "pathway": [ { "id": "mmu:233781", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:233781", "resource": "KEGG Pathway" }, { "id": "R-MMU-1971475", "name": "A tetrasaccharide linker sequence is required for GAG synthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1971475", "resource": "Reactome", "description": "A tetrasaccharide linker sequence is required for GAG synthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "Q86Y38-1", "protein_name": "Xylosyltransferase 1", "gene_name": "XYLT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MVAAPCARRLARRSHSALLAALTVLLLQTLVVWNFSSLDSGAGERRGGAAVGGGEQPPPAPAPRRERRDLPAEPAAARGGGGGGGGGGGGRGPQARARGGGPGEPRGQQPASRGALPARALDPHPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDFENVDNSNFAPRTQKQKHQPELAKKPPSRQKELLKRKLEQQEKGKGHTFPGKGPGEVLPPGDRAAANSSHGKDVSRPPHARKTGGSSPETKYDQPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNVQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIASPPSDFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR", "length": 959 }, "evidence": [ { "id": "45230771", "url": "http://www.informatics.jax.org/homology/45230771", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "pmid": "" }, { "name": "Golgi cis cisterna", "id": "GO:0000137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000137", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "pmid": "" }, { "name": "protein xylosyltransferase activity", "id": "GO:0030158", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030158", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "heparan sulfate proteoglycan biosynthetic process", "id": "GO:0015012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015012", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "pmid": "" }, { "name": "chondroitin sulfate biosynthetic process", "id": "GO:0030206", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030206", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "pmid": "" }, { "name": "ossification involved in bone maturation", "id": "GO:0043931", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043931", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "pmid": "" }, { "name": "cellular response to heat", "id": "GO:0034605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034605", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "pmid": "" }, { "name": "glycosaminoglycan biosynthetic process", "id": "GO:0006024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006024", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "pmid": "" }, { "name": "chondroitin sulfate proteoglycan biosynthetic process", "id": "GO:0050650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050650", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "pmid": "" }, { "name": "proteoglycan biosynthetic process", "id": "GO:0030166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030166", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "pmid": "" }, { "name": "embryonic skeletal system development", "id": "GO:0048706", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048706", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "pmid": "" }, { "name": "negative regulation of axon regeneration", "id": "GO:0048681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048681", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 219, "end_pos": 221, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 415, "end_pos": 417, "annotation": "n_glycosylation_sequon" }, { "start_pos": 771, "end_pos": 773, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Contains 7 disulfide bonds.", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" }, { "database": "PubMed", "id": "Q86Y38", "url": "https://glygen.org/publication/PubMed/Q86Y38" } ] }, { "annotation": "N-glycosylated.", "evidence": [ { "database": "UniProtKB", "id": "Q811B1", "url": "https://www.uniprot.org/uniprot/Q811B1" }, { "database": "PubMed", "id": "Q86Y38", "url": "https://glygen.org/publication/PubMed/Q86Y38" } ] } ], "interactions": [], "reactions": [ { "id": "50192", "name": "", "equation": "L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9EPI0-1", "Q9EPI1-1", "Q9H1B5-1", "Q86Y38-1", "Q811B1-1", "Q9EPL0-1", "Q55CU3-1", "Q55DR5-1", "Q55F91-1", "Q7KVA1-1" ], "evidence": [ { "id": "50192", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50192" } ] }, { "id": "R-MMU-1878002", "name": "XYLTs transfer Xyl to core protein", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q811B1-1", "Q9EPL0-1" ], "evidence": [ { "id": "R-MMU-1878002", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1878002" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q55CU3", "gene_name": "gnt10", "activity": [ { "ec_number": "2.4.2.26", "activity": "L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP.", "evidence": [ { "id": "Q55CU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CU3" } ] }, { "ec_number": "2.4.2.26", "activity": "", "evidence": [ { "id": "Q55CU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CU3" } ] } ] }, { "uniprot_ac": "Q55DR5", "gene_name": "gnt11", "activity": [ { "ec_number": "2.4.2.26", "activity": "L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP.", "evidence": [ { "id": "Q55DR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DR5" } ] }, { "ec_number": "2.4.2.26", "activity": "", "evidence": [ { "id": "Q55DR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55DR5" } ] } ] }, { "uniprot_ac": "Q55F91", "gene_name": "gnt9", "activity": [ { "ec_number": "2.4.2.26", "activity": "L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP.", "evidence": [ { "id": "Q55F91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55F91" } ] }, { "ec_number": "2.4.2.26", "activity": "", "evidence": [ { "id": "Q55F91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55F91" } ] } ] }, { "uniprot_ac": "Q7KVA1", "gene_name": "oxt", "activity": [ { "ec_number": "2.4.2.26", "activity": "L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP.", "evidence": [ { "id": "Q7KVA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KVA1" } ] }, { "ec_number": "2.4.2.26", "activity": "", "evidence": [ { "id": "Q7KVA1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KVA1" } ] } ] }, { "uniprot_ac": "Q811B1", "gene_name": "Xylt1", "activity": [ { "ec_number": "2.4.2.26", "activity": "L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP.", "evidence": [ { "id": "Q811B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q811B1" } ] }, { "ec_number": "2.4.2.26", "activity": "", "evidence": [ { "id": "Q811B1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q811B1" } ] } ] }, { "uniprot_ac": "Q86Y38", "gene_name": "XYLT1", "activity": [ { "ec_number": "2.4.2.26", "activity": "L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP.", "evidence": [ { "id": "Q86Y38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y38" } ] }, { "ec_number": "2.4.2.26", "activity": "", "evidence": [ { "id": "Q86Y38", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y38" } ] } ] }, { "uniprot_ac": "Q9EPI0", "gene_name": "Xylt2", "activity": [ { "ec_number": "2.4.2.26", "activity": "L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP.", "evidence": [ { "id": "Q9EPI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EPI0" } ] }, { "ec_number": "2.4.2.26", "activity": "", "evidence": [ { "id": "Q9EPI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EPI0" } ] } ] }, { "uniprot_ac": "Q9EPI1", "gene_name": "Xylt1", "activity": [ { "ec_number": "2.4.2.26", "activity": "L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP.", "evidence": [ { "id": "Q9EPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EPI1" } ] }, { "ec_number": "2.4.2.26", "activity": "", "evidence": [ { "id": "Q9EPI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EPI1" } ] } ] }, { "uniprot_ac": "Q9EPL0", "gene_name": "Xylt2", "activity": [ { "ec_number": "2.4.2.26", "activity": "L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP.", "evidence": [ { "id": "Q9EPL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EPL0" } ] }, { "ec_number": "2.4.2.26", "activity": "", "evidence": [ { "id": "Q9EPL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EPL0" } ] } ] }, { "uniprot_ac": "Q9H1B5", "gene_name": "XYLT2", "activity": [ { "ec_number": "2.4.2.26", "activity": "L-seryl-[protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[protein] + H(+) + UDP.", "evidence": [ { "id": "Q9H1B5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H1B5" } ] }, { 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