{ "uniprot_canonical_ac": "Q810I2-1", "uniprot_ac": "Q810I2", "uniprot_id": "TRI50_MOUSE", "mass": { "chemical_mass": 54607.0, "monoisotopic_mass": 54607.0 }, "refseq": { "ac": "NP_001333674", "name": "E3 ubiquitin-protein ligase TRIM50 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333674" }, "gene_names": [ { "name": "Trim50", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q810I2", "id": "Q810I2" }, { "name": "Trim50", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333674", "id": "NP_001333674" } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase TRIM50", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q810I2" }, { "name": "2.3.2.27", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q810I2" }, { "name": "E3 ubiquitin-protein ligase TRIM50 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_839971", "id": "NP_839971" }, { "name": "E3 ubiquitin-protein ligase TRIM50 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333674", "id": "NP_001333674" }, { "name": "E3 ubiquitin-protein ligase TRIM50; tripartite motif-containing protein 50; RING-type E3 ubiquitin transferase TRIM50", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_839971", "id": "NP_839971" }, { "name": "RING-type E3 ubiquitin transferase TRIM50", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q810I2" }, { "name": "Tripartite motif-containing protein 50", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q810I2" } ], "function": [ { "annotation": "E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1 (PubMed:29604308). In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction (PubMed:22792322). Promotes also NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (PubMed:36178239).", "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2#function" }, { "database": "PubMed", "id": "22792322", "url": "https://glygen.org/publication/PubMed/22792322" }, { "database": "PubMed", "id": "29604308", "url": "https://glygen.org/publication/PubMed/29604308" }, { "database": "PubMed", "id": "36178239", "url": "https://glygen.org/publication/PubMed/36178239" } ] }, { "annotation": "TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization.", "evidence": [ { "database": "RefSeq", "id": "NP_839971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_839971" }, { "database": "PubMed", "id": "36178239", "url": "https://glygen.org/publication/PubMed/36178239" }, { "database": "RefSeq", "id": "NP_001333674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333674" } ] }, { "annotation": "TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells", "evidence": [ { "database": "RefSeq", "id": "NP_839971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_839971" }, { "database": "PubMed", "id": "22872646", "url": "https://glygen.org/publication/PubMed/22872646" }, { "database": "RefSeq", "id": "NP_001333674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333674" } ] }, { "annotation": "TRIM50, via the RING domain, ubiquitinates Beclin 1 in a K63-dependent manner enhancing its binding with ULK1 and autophagy activity.", "evidence": [ { "database": "RefSeq", "id": "NP_839971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_839971" }, { "database": "PubMed", "id": "29604308", "url": "https://glygen.org/publication/PubMed/29604308" }, { "database": "RefSeq", "id": "NP_001333674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333674" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 372, "end_pos": 372, "sequence_org": "K", "sequence_mut": "R", "comment": "Complete loss of acetylation.", "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2" }, { "database": "PubMed", "id": "24308962", "url": "https://glygen.org/publication/PubMed/24308962" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Trim50", "url": "https://www.uniprot.org/uniprot/Q810I2", "locus": { "chromosome": "5", "start_pos": 135396859, "end_pos": 135382149, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000053388", "url": "https://www.ensembl.org/id/ENSMUSG00000053388" } ] } } ], "crossref": [ { "id": "ENSMUSG00000053388", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000053388", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13743", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13743", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16605", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16605", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "215061", "url": "https://www.ncbi.nlm.nih.gov/gene/215061", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001870", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001870", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003877", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003877", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003879", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003879", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006574", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006574", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043136", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043136", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:215061", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:215061", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2664992", "url": "http://www.informatics.jax.org/marker/MGI:2664992", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "DVCWHER", "url": "https://omabrowser.org/oma/group/DVCWHER/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3453019at2759", "url": "http://www.orthodb.org/?query=3453019at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24103", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24103", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24103:SF326", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24103:SF326", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00622", "url": "http://pfam.xfam.org/family/PF00622", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00643", "url": "http://pfam.xfam.org/family/PF00643", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13445", "url": "http://pfam.xfam.org/family/PF13445", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13765", "url": "http://pfam.xfam.org/family/PF13765", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q810I2", "url": "http://purl.obolibrary.org/obo/PR_Q810I2", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_839971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_839971", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E9PVV5", "url": "https://www.uniprot.org/uniprot/E9PVV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PVV5-1", "url": "https://www.uniprot.org/uniprot/E9PVV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q810I2-1", "url": "https://www.uniprot.org/uniprot/Q810I2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAWRLTVPELQDQLQCPICLEVFKEPLMLQCGHSYCKDCLDNLSQHLDSELCCPVCRQSVDCSSSPPNVSLARVIDALRLPGDIEPTVCVHHRNPLSLFCEKDQEFICGLCGLLGSHQHHRVTPVSTVYSRMKEELAGRISELKEEHRNVEEHIGKLVNNRTRIINESDVFSWVIRREFQELHHLVDEEKARCLEGLEGHTRGLVASLDMQLEQAQGTQERLAQAEQVLEQFGNESHHEFIRFHSVASRAEVQQARPLEGVFSPISFKPALHQADIKLTVWKRLFRKVLPAPASLKLDPATAHPLLELSKGNTVVHCGLLAQRRASQPERFDYSTCVLASKGFSWGRHYWEVVVGSKSDWRLGVIKGTASRKGKLNKSPEHGVWLIGLKEGRVYEAFGCPRLPLPVAGHPHRIGVYLHYEQGELTFFDADRPDDLRTLYTFQADFQGKLYPILDTCWHERGSNSLPMVLPPPSGPGHFTLGQV", "length": 483, "header": "sp|Q810I2-1|TRI50_MOUSE Isoform 1 of E3 ubiquitin-protein ligase TRIM50 OS=Mus musculus OX=10090 GN=Trim50 PE=1 SV=1 CANONICAL=Q810I2-1" }, "isoforms": [ { "isoform_ac": "E9PVV5-1", "url": "", "sequence": { "sequence": "MAWRLTVPELQDQLQCPICLEVFKEPLMLQCGHSYCKDCLDNLSQHLDSELCCPVCRQSVDCSSSPPNVSLARVIDALRLPGDIEPTVCVHHRNPLSLFCEKDQEFICGLCGLLGSHQHHRVTPVSTVYSRMKEELAGRISELKEEHRNVEEHIGKLVNNRTRIINESDVFSWVIRREFQELHHLVDEEKARCLEGLEGHTRGLVASLDMQLEQAQGTQERLAQAEQVLEQFGNESHHEFIRKFHSVASRAEVQQARPLEGVFSPISFKPALHQADIKLTVWKRLFRKVLPAPASLKLDPATAHPLLELSKGNTVVHCGLLAQRRASQPERFDYSTCVLASKGFSWGRHYWEVVVGSKSDWRLGVIKGTASRKGKLNKSPEHGVWLIGLKEGRVYEAFGCPRLPLPVAGHPHRIGVYLHYEQGELTFFDADRPDDLRTLYTFQADFQGKLYPILDTCWHERGSNSLPMVLPPPSGPGHFTLGQV", "length": 484, "header": "tr|E9PVV5-1|TRI50_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase TRIM50 OS=Mus musculus OX=10090 GN=Trim50 PE=1 SV=1 CANONICAL=Q810I2-1" }, "locus": { "chromosome": "5", "start_pos": 135396505, "end_pos": 135382150, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000111180.9", "url": "https://www.ensembl.org/id/ENSMUST00000111180.9" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000106811.3", "url": "https://www.ensembl.org/id/ENSMUSP00000106811.3" } ] } }, { "isoform_ac": "Q810I2-1", "url": "", "sequence": { "sequence": "MAWRLTVPELQDQLQCPICLEVFKEPLMLQCGHSYCKDCLDNLSQHLDSELCCPVCRQSVDCSSSPPNVSLARVIDALRLPGDIEPTVCVHHRNPLSLFCEKDQEFICGLCGLLGSHQHHRVTPVSTVYSRMKEELAGRISELKEEHRNVEEHIGKLVNNRTRIINESDVFSWVIRREFQELHHLVDEEKARCLEGLEGHTRGLVASLDMQLEQAQGTQERLAQAEQVLEQFGNESHHEFIRFHSVASRAEVQQARPLEGVFSPISFKPALHQADIKLTVWKRLFRKVLPAPASLKLDPATAHPLLELSKGNTVVHCGLLAQRRASQPERFDYSTCVLASKGFSWGRHYWEVVVGSKSDWRLGVIKGTASRKGKLNKSPEHGVWLIGLKEGRVYEAFGCPRLPLPVAGHPHRIGVYLHYEQGELTFFDADRPDDLRTLYTFQADFQGKLYPILDTCWHERGSNSLPMVLPPPSGPGHFTLGQV", "length": 483, "header": "sp|Q810I2-1|TRI50_MOUSE Isoform 1 of E3 ubiquitin-protein ligase TRIM50 OS=Mus musculus OX=10090 GN=Trim50 PE=1 SV=1 CANONICAL=Q810I2-1" }, "locus": { "chromosome": "5", "start_pos": 135396505, "end_pos": 135382150, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000065785", "url": "https://www.ensembl.org/id/ENSMUST00000065785" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000066662", "url": "https://www.ensembl.org/id/ENSMUSP00000066662" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase.", "journal": "Eur. J. Hum. Genet.", "date": "2008", "authors": "Micale L, Fusco C, Augello B, Napolitano LM, Dermitzakis ET, Meroni G, Merla G, Reymond A", "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2" } ], "reference": [ { "type": "PubMed", "id": "18398435", "url": "https://glygen.org/publication/PubMed/18398435" } ] }, { "title": "The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.", "journal": "PLoS ONE", "date": "2012", "authors": "Fusco C, Micale L, Egorov M, Monti M, D'Addetta EV, Augello B, Cozzolino F, Calcagni A, Fontana A, Polishchuk RS, Didelot G, Reymond A, Pucci P, Merla G", "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2" } ], "reference": [ { "type": "PubMed", "id": "22792322", "url": "https://glygen.org/publication/PubMed/22792322" } ] }, { "title": "TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Nishi M, Aoyama F, Kisa F, Zhu H, Sun M, Lin P, Ohta H, Van B, Yamamoto S, Kakizawa S, Sakai H, Ma J, Sawaguchi A, Takeshima H", "evidence": [ { "database": "RefSeq", "id": "NP_839971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_839971" }, { "database": "RefSeq", "id": "NP_001333674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333674" } ], "reference": [ { "type": "PubMed", "id": "22872646", "url": "https://glygen.org/publication/PubMed/22872646" } ] }, { "title": "HDAC6 mediates the acetylation of TRIM50.", "journal": "Cell. Signal.", "date": "2014", "authors": "Fusco C, Micale L, Augello B, Mandriani B, Pellico MT, De Nittis P, Calcagni A, Monti M, Cozzolino F, Pucci P, Merla G", "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2" } ], "reference": [ { "type": "PubMed", "id": "24308962", "url": "https://glygen.org/publication/PubMed/24308962" } ] }, { "title": "TRIM50 regulates Beclin 1 proautophagic activity.", "journal": "Biochim. Biophys. Acta", "date": "2018", "authors": "Fusco C, Mandriani B, Di Rienzo M, Micale L, Malerba N, Cocciadiferro D, Sjottem E, Augello B, Squeo GM, Pellico MT, Jain A, Johansen T, Fimia GM, Merla G", "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2" }, { "database": "RefSeq", "id": "NP_839971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_839971" }, { "database": "RefSeq", "id": "NP_001333674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333674" } ], "reference": [ { "type": "PubMed", "id": "29604308", "url": "https://glygen.org/publication/PubMed/29604308" } ] }, { "title": "TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization.", "journal": "EMBO Rep.", "date": "2022", "authors": "Lin Yueke, Lv Xiaoting, Sun Caiyu, Sun Yanlin, Yang Min, Ma Dapeng, Jing Weiqiang, Zhao Yunxue, Cheng Yeping, Xuan Haocheng, Han Lihui", "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2" }, { "database": "RefSeq", "id": "NP_001333674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333674" }, { "database": "RefSeq", "id": "NP_839971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_839971" } ], "reference": [ { "type": "PubMed", "id": "36178239", "url": "https://glygen.org/publication/PubMed/36178239" } ] } ], "pathway": [ { "id": "mmu:215061", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:215061", "resource": "KEGG Pathway" }, { "id": "R-MMU-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q810I1-1", "protein_name": "E3 ubiquitin-protein ligase TRIM50", "gene_name": "Trim50", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAWQLTVPELQDQLQCPICLEVFKEPLMLQCGHSYCKNCLDSLSEHLDSELRCPVCRQSVDCSSSPPNVSLARVIDALRLPGDTEPTVCVHHRNPLSLFCEKDQEFICGLCGLLGSHQHHRVTPVSTVYSRMKEELAGRLSELKEQHRDVEEHIGKLVNNRTRIINESDVFSWVIRREFQELHHLVDEEKARCLEGVESHTRGLVASLDMQLEQAQGTQERLAQAERVLEQFGNESHHEFIRFHSITSRGEVQQARPLEGVFSPISFKPALHQADIKLTVWKRLFRKVLPAPESLKLDPATAHPLLELSKGNTVVHCGLLAQRRASQPERFDYSTCVLASKGFSWGRHYWEVVVGSKSDWRLGVIKGTASRKGKLSKSPEHGVWLIGLKEGRLYEAFGCPRLPLPVAGHPHRIGVYLHYEQGELTFFDADRPDDLRALYTFQADFQGKLYPILDTCWHERGSNSLPMVLPPPSAPGHLTRAQV", "length": 483 }, "evidence": [ { "id": "45232027", "url": "http://www.informatics.jax.org/homology/45232027", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q86UV6-1", "protein_name": "Tripartite motif-containing protein 74", "gene_name": "TRIM74", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAWQVSLLELEDWLQCPICLEVFKESLMLQCGHSYCKGCLVSLSYHLDTKVRCPMCWQVVDGSSSLPNVSLAWVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVTPVSTVCSRMKEELAALFSELKQEQKKVDELIAKLVKNRTRIVNESDVFSWVIRREFQELRHPVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHEFIWKFHSMASR", "length": 250 }, "evidence": [ { "id": "45232027", "url": "http://www.informatics.jax.org/homology/45232027", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q86UV7-1", "protein_name": "Tripartite motif-containing protein 73", "gene_name": "TRIM73", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAWQVSLLELEDRLQCPICLEVFKESLMLQCGHSYCKGCLVSLSYHLDTKVRCPMCWQVVDGSSSLPNVSLAWVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVTPVSTVCSRMKEELAALFSELKQEQKKVDELIAKLVKNRTRIVNESDVFSWVIRREFQELRHPVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHEFIWKFHSMASR", "length": 250 }, "evidence": [ { "id": "45232027", "url": "http://www.informatics.jax.org/homology/45232027", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q86XT4-1", "protein_name": "E3 ubiquitin-protein ligase TRIM50", "gene_name": "TRIM50", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAWQVSLPELEDRLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVCRQAVDGSSSLPNVSLARVIEALRLPGDPEPKVCVHHRNPLSLFCEKDQELICGLCGLLGSHQHHPVTPVSTVYSRMKEELAALISELKQEQKKVDELIAKLVNNRTRIVNESDVFSWVIRREFQELHHLVDEEKARCLEGIGGHTRGLVASLDMQLEQAQGTRERLAQAECVLEQFGNEDHHKFIRKFHSMASRAEMPQARPLEGAFSPISFKPGLHQADIKLTVWKRLFRKVLPAPEPLKLDPATAHPLLELSKGNTVVQCGLLAQRRASQPERFDYSTCVLASRGFSCGRHYWEVVVGSKSDWRLGVIKGTASRKGKLNRSPEHGVWLIGLKEGRVYEAFACPRVPLPVAGHPHRIGLYLHYEQGELTFFDADRPDDLRPLYTFQADFQGKLYPILDTCWHERGSNSLPMVLPPPSGPGPLSPEQPTKL", "length": 487 }, "evidence": [ { "id": "45232027", "url": "http://www.informatics.jax.org/homology/45232027", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2" } ], "pmid": "" }, { "name": "aggresome", "id": "GO:0016235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016235", "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2" } ], "pmid": "" }, { "name": "regulation of establishment of protein localization", "id": "GO:0070201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070201", "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 160, "end_pos": 162, "annotation": "n_glycosylation_sequon" }, { "start_pos": 166, "end_pos": 168, "annotation": "n_glycosylation_sequon" }, { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 376, "end_pos": 378, "annotation": "n_glycosylation_sequon" }, { "start_pos": 42, "end_pos": 44, "annotation": "n_glycosylation_sequon" }, { "start_pos": 68, "end_pos": 70, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Acetylated by EP300 and KAT2B. HDAC6 drives TRIM50 deacetylation. Acetylation antagonizes with TRIM50 ubiquitination.", "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2" }, { "database": "PubMed", "id": "24308962", "url": "https://glygen.org/publication/PubMed/24308962" } ] }, { "annotation": "Auto-ubiquitinated.", "evidence": [ { "database": "UniProtKB", "id": "Q810I2", "url": "https://www.uniprot.org/uniprot/Q810I2" }, { "database": "PubMed", "id": "Q86XT4", "url": "https://glygen.org/publication/PubMed/Q86XT4" } ] } ], "interactions": [], "reactions": [ { "id": "R-MMU-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CFI0-1", "Q6P073-1", "Q8CFI2-1", "Q91W82-1", "Q921J4-1", "Q922B6-1", "Q99PQ2-1", "Q9WUD1-1", "Q9WUB0-1", "Q8BM54-1", "Q8C432-1", "Q9DBU5-1", "Q9ET26-1", "Q9JI90-1", "Q7TMY8-1", "Q1PSW8-1", "Q8R516-1", "Q9D074-1", "O55176-3", "Q8BH75-1", "Q99KR6-1", "Q9D0C1-1", "Q9WTV7-1", "G5E870-1", "Q80WG7-1", "Q80X56-1", "Q8CH72-1", "Q3UE37-1", "Q8CCJ3-3", "Q8VDW4-1", "Q06986-1", "P60605-1", "Q3U487-1", "P97868-1", "Q5XPI3-1", "Q6PDX6-1", "Q91YL2-1", "A2A5Z6-1", "Q925F4-1", "Q99ML9-1", "Q9JIY2-1", "Q69ZI1-1", "O08759-1", "P62257-1", "Q6WKZ8-1", "Q6ZPJ3-1", "A2AN08-1", "Q71FD5-1", "Q8CHG5-1", "P61092-1", "Q3UIR3-1", "Q6I6G8-1", "Q05A36-1", "Q9QXP6-1", "A2A7Q9-1", "E9Q555-1", "P50636-1", "Q9QZR0-1", "Q9QZS2-1", "P61089-1", "Q38HM4-1", "Q9ESN2-1", "Q5FWH2-3", "Q8BX13-1", "O70481-1", "P52482-1", "P61080-1", "P61087-1", "P62254-1", "P62838-1", "P63147-1", "P68037-1", "Q6ZWZ2-1", "Q80U95-1", "Q8K2Z8-1", "Q9CY34-1", "Q9D1C1-1", "Q9ES34-1", "Q9JJZ4-1", "Q9QZU9-1", "Q9Z255-1", "Q91V17-1", "Q9CR50-1", "Q3TTA7-1", "Q80TR8-1", "O70263-1", "Q80U04-1", "Q80ZI6-1", "D3YYI7-1", "Q9CQE0-1", "Q8C863-1", "Q9WVS6-1", "Q62191-1", "Q7TPV2-1", "Q3U0D9-1", "Q4U2R1-1", "P46935-1", "F2Z461-1", "P62878-1", "Q8BKD6-1", "Q9CUN6-1", "Q8BZZ3-1", "Q69ZR2-1", "Q6PAV2-1", "Q8CDU6-1", "Q8C7M3-1", "Q8VIG6-1", "E9Q735-1", "P52483-1", "P61079-1", "P61082-1", "Q7TSS2-1", "Q9Z1K6-1", "Q8VEM1-1", "Q6A009-1", "Q5NCC3-1", "Q6PCX9-1", "Q810I2-1", "Q9DBK7-1" ], "evidence": [ { "id": "R-MMU-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983140" } ] }, { "id": "R-MMU-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CFI0-1", "Q922B6-1", "Q99PQ2-1", "Q9WUD1-1", "Q9WUB0-1", "Q8BM54-1", "Q8C432-1", "Q9DBU5-1", "Q9ET26-1", "Q9JI90-1", "Q7TMY8-1", "Q1PSW8-1", "Q8R516-1", "Q9D074-1", "O55176-3", "Q8BH75-1", "Q99KR6-1", "Q9D0C1-1", "Q9WTV7-1", "G5E870-1", "Q80WG7-1", "Q80X56-1", "Q8CH72-1", "Q8CCJ3-3", "Q06986-1", "Q3U487-1", "P97868-1", "Q5XPI3-1", "Q6PDX6-1", "Q91YL2-1", "A2A5Z6-1", "Q925F4-1", "Q99ML9-1", "Q9JIY2-1", "Q69ZI1-1", "O08759-1", "Q6WKZ8-1", "A2AN08-1", "Q71FD5-1", "Q8CHG5-1", "P61092-1", "Q3UIR3-1", "Q6I6G8-1", "Q05A36-1", "Q9QXP6-1", "A2A7Q9-1", "E9Q555-1", "P50636-1", "Q9QZR0-1", "Q9QZS2-1", "Q38HM4-1", "Q9ESN2-1", "Q5FWH2-3", "Q8BX13-1", "O70481-1", "Q80U95-1", "Q9ES34-1", "Q91V17-1", "Q9CR50-1", "Q3TTA7-1", "Q80TR8-1", "O70263-1", "Q80U04-1", "Q80ZI6-1", "D3YYI7-1", "Q9CQE0-1", "Q8C863-1", "Q9WVS6-1", "Q62191-1", "Q7TPV2-1", "Q3U0D9-1", "Q4U2R1-1", "P46935-1", "F2Z461-1", "P62878-1", "Q8BKD6-1", "Q9CUN6-1", "Q8BZZ3-1", "Q69ZR2-1", "Q6PAV2-1", "Q8CDU6-1", "Q8C7M3-1", "Q8VIG6-1", "E9Q735-1", "Q9Z1K6-1", "Q8VEM1-1", "Q6A009-1", "Q5NCC3-1", "Q6PCX9-1", "Q810I2-1" ], "evidence": [ { "id": "R-MMU-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983147" } ] }, { "id": "R-MMU-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CFI0-1", "Q6P073-1", "Q8CFI2-1", "Q91W82-1", "Q921J4-1", "Q922B6-1", "Q99PQ2-1", "Q9WUD1-1", "Q9WUB0-1", "Q8BM54-1", "Q8C432-1", "Q9DBU5-1", "Q9ET26-1", "Q9JI90-1", "Q7TMY8-1", "Q1PSW8-1", "Q8R516-1", "Q9D074-1", "O55176-3", "Q8BH75-1", "Q99KR6-1", "Q9D0C1-1", "Q9WTV7-1", "G5E870-1", "Q80WG7-1", "Q80X56-1", "Q8CH72-1", "Q3UE37-1", "Q8CCJ3-3", "Q8VDW4-1", "Q06986-1", "P60605-1", "Q3U487-1", "P97868-1", "Q5XPI3-1", "Q6PDX6-1", "Q91YL2-1", "A2A5Z6-1", "Q925F4-1", "Q99ML9-1", "Q9JIY2-1", "Q69ZI1-1", "O08759-1", "P62257-1", "Q6WKZ8-1", "Q6ZPJ3-1", "A2AN08-1", "Q71FD5-1", "Q8CHG5-1", "P61092-1", "Q3UIR3-1", "Q6I6G8-1", "Q05A36-1", "Q9QXP6-1", "A2A7Q9-1", "E9Q555-1", "P50636-1", "Q9QZR0-1", "Q9QZS2-1", "P61089-1", "Q38HM4-1", "Q9ESN2-1", "Q5FWH2-3", "Q8BX13-1", "O70481-1", "P52482-1", "P61080-1", "P61087-1", "P62254-1", "P62838-1", "P63147-1", "P68037-1", "Q6ZWZ2-1", "Q80U95-1", "Q8K2Z8-1", "Q9CY34-1", "Q9D1C1-1", "Q9ES34-1", "Q9JJZ4-1", "Q9QZU9-1", "Q9Z255-1", "Q91V17-1", "Q9CR50-1", "Q3TTA7-1", "Q80TR8-1", "O70263-1", "Q80U04-1", "Q80ZI6-1", "D3YYI7-1", "Q9CQE0-1", "Q8C863-1", "Q9WVS6-1", "Q62191-1", "Q7TPV2-1", "Q3U0D9-1", "Q4U2R1-1", "P46935-1", "F2Z461-1", "P62878-1", "Q8BKD6-1", "Q9CUN6-1", "Q8BZZ3-1", "Q69ZR2-1", "Q6PAV2-1", "Q8CDU6-1", "Q8C7M3-1", "Q8VIG6-1", "E9Q735-1", "P52483-1", "P61079-1", "P61082-1", "Q7TSS2-1", "Q9Z1K6-1", "Q8VEM1-1", "Q6A009-1", "Q5NCC3-1", "Q6PCX9-1", "Q810I2-1", "Q9DBK7-1" ], "evidence": [ { "id": "R-MMU-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983156" } ] }, { "id": "R-MMU-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CFI0-1", "Q6P073-1", "Q8CFI2-1", "Q91W82-1", "Q921J4-1", "Q922B6-1", "Q99PQ2-1", "Q9WUD1-1", "Q9WUB0-1", "Q8BM54-1", "Q8C432-1", "Q9DBU5-1", "Q9ET26-1", "Q9JI90-1", "Q7TMY8-1", "Q1PSW8-1", "Q8R516-1", "Q9D074-1", "O55176-3", "Q8BH75-1", "Q99KR6-1", "Q9D0C1-1", "Q9WTV7-1", "G5E870-1", "Q80WG7-1", "Q80X56-1", "Q8CH72-1", "Q3UE37-1", "Q8CCJ3-3", "Q8VDW4-1", "Q06986-1", "P60605-1", "Q3U487-1", "P97868-1", "Q5XPI3-1", "Q6PDX6-1", "Q91YL2-1", "A2A5Z6-1", "Q925F4-1", "Q99ML9-1", "Q9JIY2-1", "Q69ZI1-1", "O08759-1", "P62257-1", "Q6WKZ8-1", "Q6ZPJ3-1", "A2AN08-1", "Q71FD5-1", "Q8CHG5-1", "P61092-1", "Q3UIR3-1", "Q6I6G8-1", "Q05A36-1", "Q9QXP6-1", "A2A7Q9-1", "E9Q555-1", "P50636-1", "Q9QZR0-1", "Q9QZS2-1", "P61089-1", "Q38HM4-1", "Q9ESN2-1", "Q5FWH2-3", "Q8BX13-1", "O70481-1", "P52482-1", "P61080-1", "P61087-1", "P62254-1", "P62838-1", "P63147-1", "P68037-1", "Q6ZWZ2-1", "Q80U95-1", "Q8K2Z8-1", "Q9CY34-1", "Q9D1C1-1", "Q9ES34-1", "Q9JJZ4-1", "Q9QZU9-1", "Q9Z255-1", "Q91V17-1", "Q9CR50-1", "Q3TTA7-1", "Q80TR8-1", "O70263-1", "Q80U04-1", "Q80ZI6-1", "D3YYI7-1", "Q9CQE0-1", "Q8C863-1", "Q9WVS6-1", "Q62191-1", "Q7TPV2-1", "Q3U0D9-1", "Q4U2R1-1", "P46935-1", "F2Z461-1", "P62878-1", "Q8BKD6-1", "Q9CUN6-1", "Q8BZZ3-1", "Q69ZR2-1", "Q6PAV2-1", "Q8CDU6-1", "Q8C7M3-1", "Q8VIG6-1", "E9Q735-1", "P52483-1", "P61079-1", "P61082-1", "Q7TSS2-1", "Q9Z1K6-1", "Q8VEM1-1", "Q6A009-1", "Q5NCC3-1", "Q6PCX9-1", "Q810I2-1", "Q9DBK7-1" ], "evidence": [ { "id": "R-MMU-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A2A5Z6", "gene_name": "Smurf2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A2A5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A5Z6" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A2A5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A5Z6" } ] } ] }, { "uniprot_ac": "A2A7Q9", "gene_name": "Rnf19b", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A2A7Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A7Q9" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A2A7Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A7Q9" } ] } ] }, { "uniprot_ac": "A2AN08", "gene_name": "Ubr4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A2AN08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AN08" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A2AN08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AN08" } ] } ] }, { "uniprot_ac": "D3YYI7", "gene_name": "Rnf217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "D3YYI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YYI7" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "D3YYI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YYI7" } ] } ] }, { "uniprot_ac": "E9Q555", "gene_name": "Rnf213", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] } ] }, { "uniprot_ac": "E9Q735", "gene_name": "Ube4a", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E9Q735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q735" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E9Q735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q735" } ] } ] }, { "uniprot_ac": "F2Z461", "gene_name": "Herc6", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "F2Z461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F2Z461" } ] } ] }, { "uniprot_ac": "G5E870", "gene_name": "Trip12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "G5E870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G5E870" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "G5E870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G5E870" } ] } ] }, { "uniprot_ac": "O08759", "gene_name": "Ube3a", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O08759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08759" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "O08759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08759" } ] } ] }, { "uniprot_ac": "O55176", "gene_name": "Pja1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O55176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55176" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O55176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55176" } ] } ] }, { "uniprot_ac": "O70263", "gene_name": "Lnx1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O70263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70263" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O70263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70263" } ] } ] }, { "uniprot_ac": "O70481", "gene_name": "Ubr1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O70481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70481" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O70481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70481" } ] } ] }, { "uniprot_ac": "P46935", "gene_name": "Nedd4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P46935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46935" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "P46935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46935" } ] } ] }, { "uniprot_ac": "P50636", "gene_name": "Rnf19a", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "P50636", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50636" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "P50636", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50636" } ] } ] }, { "uniprot_ac": "P52482", "gene_name": "Ube2e1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P52482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52482" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P52482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52482" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P52482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52482" } ] } ] }, { "uniprot_ac": "P52483", "gene_name": "Ube2e3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P52483", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52483" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P52483", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52483" } ] } ] }, { "uniprot_ac": "P60605", "gene_name": "Ube2g2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P60605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60605" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P60605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60605" } ] } ] }, { "uniprot_ac": "P61079", "gene_name": "Ube2d3", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61079" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61079" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61079" } ] } ] }, { "uniprot_ac": "P61080", "gene_name": "Ube2d1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61080" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61080" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61080" } ] } ] }, { "uniprot_ac": "P61082", "gene_name": "Ube2m", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "P61082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61082" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "P61082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61082" } ] } ] }, { "uniprot_ac": "P61087", "gene_name": "Ube2k", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61087", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61087" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61087", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61087" } ] } ] }, { "uniprot_ac": "P61089", "gene_name": "Ube2n", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61089" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61089" } ] } ] }, { "uniprot_ac": "P61092", "gene_name": "Siah1a", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61092" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P61092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61092" } ] } ] }, { "uniprot_ac": "P62254", "gene_name": "Ube2g1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62254", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62254" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62254", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62254" } ] } ] }, { "uniprot_ac": "P62257", "gene_name": "Ube2h", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62257" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62257" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62257" } ] } ] }, { "uniprot_ac": "P62838", "gene_name": "Ube2d2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62838" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62838" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62838" } ] } ] }, { "uniprot_ac": "P62878", "gene_name": "Rbx1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62878" } ] }, { "ec_number": "2.3.2.32", "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.", "evidence": [ { "id": "P62878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62878" } ] }, { "ec_number": "2.3.2.32", "activity": "", "evidence": [ { "id": "P62878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62878" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P62878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62878" } ] } ] }, { "uniprot_ac": "P63147", "gene_name": "Ube2b", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P63147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63147" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P63147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63147" } ] } ] }, { "uniprot_ac": "P68037", "gene_name": "Ube2l3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P68037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68037" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P68037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68037" } ] } ] }, { "uniprot_ac": "P97868", "gene_name": "Rbbp6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P97868", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97868" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P97868", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97868" } ] } ] }, { "uniprot_ac": "Q05A36", "gene_name": "Mex3c", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q05A36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05A36" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q05A36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05A36" } ] } ] }, { "uniprot_ac": "Q06986", "gene_name": "Siah2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q06986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06986" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q06986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06986" } ] } ] }, { "uniprot_ac": "Q1PSW8", "gene_name": "Trim71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1PSW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1PSW8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q1PSW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1PSW8" } ] } ] }, { "uniprot_ac": "Q38HM4", "gene_name": "Trim63", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q38HM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q38HM4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q38HM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q38HM4" } ] } ] }, { "uniprot_ac": "Q3TTA7", "gene_name": "Cblb", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3TTA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTA7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q3TTA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTA7" } ] } ] }, { "uniprot_ac": "Q3U0D9", "gene_name": "Hace1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3U0D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U0D9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q3U0D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U0D9" } ] } ] }, { "uniprot_ac": "Q3U487", "gene_name": "Hectd3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3U487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U487" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q3U487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U487" } ] } ] }, { "uniprot_ac": "Q3UE37", "gene_name": "Ube2z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3UE37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UE37" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3UE37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UE37" } ] } ] }, { "uniprot_ac": "Q3UIR3", "gene_name": "Dtx3l", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3UIR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UIR3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q3UIR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UIR3" } ] } ] }, { "uniprot_ac": "Q4U2R1", "gene_name": "Herc2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q4U2R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4U2R1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q4U2R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4U2R1" } ] } ] }, { "uniprot_ac": "Q5FWH2", "gene_name": "Unkl", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q5FWH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FWH2" } ] } ] }, { "uniprot_ac": "Q5NCC3", "gene_name": "Trim41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5NCC3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5NCC3" } ] } ] }, { "uniprot_ac": "Q5XPI3", "gene_name": "Rnf123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5XPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XPI3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5XPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XPI3" } ] } ] }, { "uniprot_ac": "Q62191", "gene_name": "Trim21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q62191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62191" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q62191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62191" } ] } ] }, { "uniprot_ac": "Q69ZI1", "gene_name": "Sh3rf1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q69ZI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZI1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q69ZI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZI1" } ] } ] }, { "uniprot_ac": "Q69ZR2", "gene_name": "Hectd1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q69ZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZR2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q69ZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZR2" } ] } ] }, { "uniprot_ac": "Q6A009", "gene_name": "Ltn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6A009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6A009" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6A009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6A009" } ] } ] }, { "uniprot_ac": "Q6I6G8", "gene_name": "Hecw2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6I6G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6I6G8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q6I6G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6I6G8" } ] } ] }, { "uniprot_ac": "Q6P073", "gene_name": "Ube2j2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q6P073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P073" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q6P073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P073" } ] } ] }, { "uniprot_ac": "Q6PAV2", "gene_name": "Herc4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6PAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PAV2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q6PAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PAV2" } ] } ] }, { "uniprot_ac": "Q6PCX9", "gene_name": "Trim37", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6PCX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCX9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6PCX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCX9" } ] } ] }, { "uniprot_ac": "Q6PDX6", "gene_name": "Rnf220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6PDX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PDX6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6PDX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PDX6" } ] } ] }, { "uniprot_ac": "Q6WKZ8", "gene_name": "Ubr2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6WKZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6WKZ8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6WKZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6WKZ8" } ] } ] }, { "uniprot_ac": "Q6ZPJ3", "gene_name": "Ube2o", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6ZPJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZPJ3" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q6ZPJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZPJ3" } ] } ] }, { "uniprot_ac": "Q6ZWZ2", "gene_name": "Ube2r2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q6ZWZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZWZ2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q6ZWZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZWZ2" } ] } ] }, { "uniprot_ac": "Q71FD5", "gene_name": "Znrf2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q71FD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q71FD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ] } ] }, { "uniprot_ac": "Q7TMY8", "gene_name": "Huwe1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7TMY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TMY8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q7TMY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TMY8" } ] } ] }, { "uniprot_ac": "Q7TPV2", "gene_name": "Dzip3", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7TPV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TPV2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7TPV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TPV2" } ] } ] }, { "uniprot_ac": "Q7TSS2", "gene_name": "Ube2q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q7TSS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TSS2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q7TSS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TSS2" } ] } ] }, { "uniprot_ac": "Q80TR8", "gene_name": "Dcaf1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80TR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80TR8" } ] } ] }, { "uniprot_ac": "Q80U04", "gene_name": "Pja2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80U04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80U04" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q80U04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80U04" } ] } ] }, { "uniprot_ac": "Q80U95", "gene_name": "Ube3c", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80U95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80U95" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q80U95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80U95" } ] } ] }, { "uniprot_ac": "Q80WG7", "gene_name": "Trim36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80WG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80WG7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q80WG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80WG7" } ] } ] }, { "uniprot_ac": "Q80X56", "gene_name": "Trim69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80X56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80X56" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q80X56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80X56" } ] } ] }, { "uniprot_ac": "Q80ZI6", "gene_name": "Lrsam1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80ZI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80ZI6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q80ZI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80ZI6" } ] } ] }, { "uniprot_ac": "Q810I2", "gene_name": "Trim50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q810I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810I2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q810I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810I2" } ] } ] }, { "uniprot_ac": "Q8BH75", "gene_name": "Rnf41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8BH75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BH75" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8BH75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BH75" } ] } ] }, { "uniprot_ac": "Q8BKD6", "gene_name": "Rnf144b", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q8BKD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BKD6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q8BKD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BKD6" } ] } ] }, { "uniprot_ac": "Q8BM54", "gene_name": "Mylip", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8BM54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BM54" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8BM54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BM54" } ] } ] }, { "uniprot_ac": "Q8BX13", "gene_name": "Ube3d", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8BX13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BX13" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8BX13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BX13" } ] } ] }, { "uniprot_ac": "Q8BZZ3", "gene_name": "Wwp1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8BZZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZZ3" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8BZZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZZ3" } ] } ] }, { "uniprot_ac": "Q8C432", "gene_name": "Rnf182", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8C432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C432" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8C432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C432" } ] } ] }, { "uniprot_ac": "Q8C7M3", "gene_name": "Trim9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8C7M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C7M3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8C7M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C7M3" } ] } ] }, { "uniprot_ac": "Q8C863", "gene_name": "Itch", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8C863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C863" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8C863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C863" } ] } ] }, { "uniprot_ac": "Q8CCJ3", "gene_name": "Ufl1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q8CCJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CCJ3" } ] } ] }, { "uniprot_ac": "Q8CDU6", "gene_name": "Hectd2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CDU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CDU6" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8CDU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CDU6" } ] } ] }, { "uniprot_ac": "Q8CFI0", "gene_name": "Nedd4l", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CFI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8CFI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI0" } ] }, { "ec_number": "2.3.2.36", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.", "evidence": [ { "id": "Q8CFI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI0" } ] }, { "ec_number": "2.3.2.36", "activity": "", "evidence": [ { "id": "Q8CFI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI0" } ] } ] }, { "uniprot_ac": "Q8CFI2", "gene_name": "Cdc34", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CFI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8CFI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8CFI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI2" } ] } ] }, { "uniprot_ac": "Q8CH72", "gene_name": "Trim32", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CH72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CH72" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8CH72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CH72" } ] } ] }, { "uniprot_ac": "Q8CHG5", "gene_name": "Arel1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CHG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHG5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8CHG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHG5" } ] } ] }, { "uniprot_ac": "Q8K2Z8", "gene_name": "Ube2q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8K2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K2Z8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8K2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K2Z8" } ] } ] }, { "uniprot_ac": "Q8R516", "gene_name": "Mib2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8R516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R516" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8R516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R516" } ] } ] }, { "uniprot_ac": "Q8VDW4", "gene_name": "Ube2w", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "Q8VDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDW4" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8VDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDW4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8VDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDW4" } ] } ] }, { "uniprot_ac": "Q8VEM1", "gene_name": "Rnf130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8VEM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEM1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8VEM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEM1" } ] } ] }, { "uniprot_ac": "Q8VIG6", "gene_name": "Traip", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8VIG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VIG6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8VIG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VIG6" } ] } ] }, { "uniprot_ac": "Q91V17", "gene_name": "Znrf1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q91V17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91V17" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q91V17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91V17" } ] } ] }, { "uniprot_ac": "Q91W82", "gene_name": "Ube2e2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q91W82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91W82" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q91W82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91W82" } ] } ] }, { "uniprot_ac": "Q91YL2", "gene_name": "Rnf126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q91YL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91YL2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q91YL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91YL2" } ] } ] }, { "uniprot_ac": "Q921J4", "gene_name": "Ube2s", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q921J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q921J4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q921J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q921J4" } ] } ] }, { "uniprot_ac": "Q922B6", "gene_name": "Traf7", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q922B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922B6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q922B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922B6" } ] } ] }, { "uniprot_ac": "Q925F4", "gene_name": "Ubox5", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q925F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925F4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q925F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925F4" } ] } ] }, { "uniprot_ac": "Q99KR6", "gene_name": "Rnf34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q99KR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99KR6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q99KR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99KR6" } ] } ] }, { "uniprot_ac": "Q99ML9", "gene_name": "Rnf111", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q99ML9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q99ML9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML9" } ] } ] }, { "uniprot_ac": "Q99PQ2", "gene_name": "Trim11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q99PQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99PQ2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q99PQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99PQ2" } ] } ] }, { "uniprot_ac": "Q9CQE0", "gene_name": "Rnf138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9CQE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQE0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9CQE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQE0" } ] } ] }, { "uniprot_ac": "Q9CR50", "gene_name": "Rchy1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9CR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CR50" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9CR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CR50" } ] } ] }, { "uniprot_ac": "Q9CUN6", "gene_name": "Smurf1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9CUN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9CUN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ] } ] }, { "uniprot_ac": "Q9CY34", "gene_name": "Ube2f", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q9CY34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CY34" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q9CY34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CY34" } ] } ] }, { "uniprot_ac": "Q9D074", "gene_name": "Mgrn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9D074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D074" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9D074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D074" } ] } ] }, { "uniprot_ac": "Q9D0C1", "gene_name": "Rnf115", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9D0C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D0C1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9D0C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D0C1" } ] } ] }, { "uniprot_ac": "Q9D1C1", "gene_name": "Ube2c", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9D1C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D1C1" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9D1C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D1C1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9D1C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D1C1" } ] } ] }, { "uniprot_ac": "Q9DBK7", "gene_name": "Uba7", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9DBK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBK7" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "Q9DBK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBK7" } ] } ] }, { "uniprot_ac": "Q9DBU5", "gene_name": "Rnf6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9DBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBU5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9DBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBU5" } ] } ] }, { "uniprot_ac": "Q9ES34", "gene_name": "Ube3b", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9ES34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES34" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9ES34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES34" } ] } ] }, { "uniprot_ac": "Q9ESN2", "gene_name": "Trim39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9ESN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESN2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9ESN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESN2" } ] } ] }, { "uniprot_ac": "Q9ET26", "gene_name": "Rnf114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9ET26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ET26" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9ET26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ET26" } ] } ] }, { "uniprot_ac": "Q9JI90", "gene_name": "Rnf14", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9JI90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9JI90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ] } ] }, { "uniprot_ac": "Q9JIY2", "gene_name": "Cbll1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9JIY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JIY2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9JIY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JIY2" } ] } ] }, { "uniprot_ac": "Q9JJZ4", "gene_name": "Ube2j1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9JJZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JJZ4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9JJZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JJZ4" } ] } ] }, { "uniprot_ac": "Q9QXP6", "gene_name": "Mkrn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9QXP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXP6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9QXP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXP6" } ] } ] }, { "uniprot_ac": "Q9QZR0", "gene_name": "Rnf25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9QZR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZR0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9QZR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZR0" } ] } ] }, { "uniprot_ac": "Q9QZS2", "gene_name": "Rnf4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9QZS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZS2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9QZS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZS2" } ] } ] }, { "uniprot_ac": "Q9QZU9", "gene_name": "Ube2l6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9QZU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU9" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9QZU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU9" } ] } ] }, { "uniprot_ac": "Q9WTV7", "gene_name": "Rlim", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9WTV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTV7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9WTV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTV7" } ] } ] }, { "uniprot_ac": "Q9WUB0", "gene_name": "Rbck1", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9WUB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUB0" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9WUB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUB0" } ] } ] }, { "uniprot_ac": "Q9WUD1", "gene_name": "Stub1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9WUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUD1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9WUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUD1" } ] } ] }, { "uniprot_ac": "Q9WVS6", "gene_name": "Prkn", "activity": [ { "ec_number": "6.3.2.19", "activity": "", "evidence": [ { "id": "Q9WVS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVS6" } ] }, { "ec_number": 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0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 6 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }