{ "uniprot_canonical_ac": "Q80VX4-1", "uniprot_ac": "Q80VX4", "uniprot_id": "ZHX2_RAT", "mass": { "chemical_mass": 92107.0, "monoisotopic_mass": 92107.0 }, "refseq": { "ac": "NP_001257985", "name": "zinc fingers and homeoboxes protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257985" }, "gene_names": [ { "name": "Zhx2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q80VX4", "id": "Q80VX4" }, { "name": "Afr1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q80VX4", "id": "Q80VX4" }, { "name": "Raf", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q80VX4", "id": "Q80VX4" }, { "name": "Zhx2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257985", "id": "NP_001257985" } ], "protein_names": [ { "name": "Zinc fingers and homeoboxes protein 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q80VX4" }, { "name": "AFP regulator 1; regulator of AFP; alpha-fetoprotein regulator 1; zinc finger and homeodomain protein 2; transcription factor ZHX2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257985", "id": "NP_001257985" }, { "name": "AFP regulator 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q80VX4" }, { "name": "Alpha-fetoprotein regulator 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q80VX4" }, { "name": "Regulator of AFP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q80VX4" }, { "name": "Zinc finger and homeodomain protein 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q80VX4" }, { "name": "zinc fingers and homeoboxes protein 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257985", "id": "NP_001257985" } ], "function": [ { "annotation": "Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex.", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4#function" }, { "database": "UniProtKB", "id": "Q9Y6X8", "url": "https://www.uniprot.org/uniprot/Q9Y6X8#function" }, { "database": "UniProtKB", "id": "Q8C0C0", "url": "https://www.uniprot.org/uniprot/Q8C0C0#function" } ] }, { "annotation": "Upregulation of B7.1 with the downregulation of GLEPP1, Wilms' tumor gene (WT1), megalin, and vascular endothelial growth factor started early and persisted through the course of primary glomerular disease.", "evidence": [ { "database": "RefSeq", "id": "NP_001257985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257985" }, { "database": "PubMed", "id": "17457373", "url": "https://glygen.org/publication/PubMed/17457373" } ] }, { "annotation": "ZHX proteins 1, 2 and 3 are major transcriptional mediators of podocyte disease Erratum:[J Biol Chem. 2007 Apr 27;282(17):13140]", "evidence": [ { "database": "RefSeq", "id": "NP_001257985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257985" }, { "database": "PubMed", "id": "17056598", "url": "https://glygen.org/publication/PubMed/17056598" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "common_name": "Rat" } ], "gene": [ { "name": "Zhx2", "url": "https://www.uniprot.org/uniprot/Q80VX4", "locus": { "chromosome": "7", "start_pos": 89374378, "end_pos": 89226463, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000005417", "url": "https://www.ensembl.org/id/ENSRNOG00000005417" } ] } } ], "crossref": [ { "id": "ENSRNOG00000005417", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000005417", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "314988", "url": "https://www.ncbi.nlm.nih.gov/gene/314988", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q80VX4", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q80VX4*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:314988", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314988", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ENHMEGT", "url": "https://omabrowser.org/oma/group/ENHMEGT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5350395at2759", "url": "http://www.orthodb.org/?query=5350395at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15467", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15467", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15467:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15467:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "http://pfam.xfam.org/family/PF00046", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF18387", "url": "http://pfam.xfam.org/family/PF18387", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q80VX4", "url": "http://purl.obolibrary.org/obo/PR_Q80VX4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001257985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257985", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "727926", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=727926", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q80VX4-1", "url": "https://www.uniprot.org/uniprot/Q80VX4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASKRKSTTPCMVRTSQVVEQDVLEEADRAKDKGLGVPPSDVSKERWAAEPEPSSKESEVVEVRSVGESQSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHPNVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGETNFKLKLIKRNNQTVLEQSIEATNHVVSITASAPGSSDNDPGVSVGKTATVKTGKQKADAKKVPKKPDEAAPDNHMEGTARLVTDTAEILSRLGSVELLHDSLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMFNGTIQSVPPTITVLPAQLTPTKVSQPILQTALPCQILGQPSLVLTQVTSGSTAVSCSPITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANTPLTPASDRKKTKLQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAKDQMAITGTRHGRTYHVYPDFAAQKFKEKSQGQLKTLEDSFLKSSFPTQAEVERLRVETKLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGSDVVAPNGALSRLDQLSGAQLAGPLPSPSSAVVQNQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLKTGTLSWLEQYQRHHLSDDHGHDVASRRATKHVAESPKNGSEVAHQYAKDPKALGEEESEKLVPRVKLVGDPSKDCLAGKPSEATSDRSEGSRDGQGSEENEESGIVDFVEVTVGEEDAISEKWGSWSQRVAEGTVERADSDSDSTPAEAGQA", "length": 836, "header": "sp|Q80VX4-1|ZHX2_RAT Isoform 1 of Zinc fingers and homeoboxes protein 2 OS=Rattus norvegicus OX=10116 GN=Zhx2 PE=2 SV=2 CANONICAL=Q80VX4-1" }, "isoforms": [ { "isoform_ac": "Q80VX4-1", "url": "", "sequence": { "sequence": "MASKRKSTTPCMVRTSQVVEQDVLEEADRAKDKGLGVPPSDVSKERWAAEPEPSSKESEVVEVRSVGESQSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHPNVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGETNFKLKLIKRNNQTVLEQSIEATNHVVSITASAPGSSDNDPGVSVGKTATVKTGKQKADAKKVPKKPDEAAPDNHMEGTARLVTDTAEILSRLGSVELLHDSLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMFNGTIQSVPPTITVLPAQLTPTKVSQPILQTALPCQILGQPSLVLTQVTSGSTAVSCSPITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANTPLTPASDRKKTKLQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAKDQMAITGTRHGRTYHVYPDFAAQKFKEKSQGQLKTLEDSFLKSSFPTQAEVERLRVETKLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGSDVVAPNGALSRLDQLSGAQLAGPLPSPSSAVVQNQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLKTGTLSWLEQYQRHHLSDDHGHDVASRRATKHVAESPKNGSEVAHQYAKDPKALGEEESEKLVPRVKLVGDPSKDCLAGKPSEATSDRSEGSRDGQGSEENEESGIVDFVEVTVGEEDAISEKWGSWSQRVAEGTVERADSDSDSTPAEAGQA", "length": 836, "header": "sp|Q80VX4-1|ZHX2_RAT Isoform 1 of Zinc fingers and homeoboxes protein 2 OS=Rattus norvegicus OX=10116 GN=Zhx2 PE=2 SV=2 CANONICAL=Q80VX4-1" }, "locus": { "chromosome": "7", "start_pos": 89374378, "end_pos": 89373208, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000107215", "url": "https://www.ensembl.org/id/ENSRNOT00000107215" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000092484", "url": "https://www.ensembl.org/id/ENSRNOP00000092484" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 824, "end_pos": 824, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "site_lbl": "Ser824" }, { "start_pos": 826, "end_pos": 826, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "site_lbl": "Ser826" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor.", "journal": "Biochem. J.", "date": "2003", "authors": "Kawata H, Yamada K, Shou Z, Mizutani T, Yazawa T, Yoshino M, Sekiguchi T, Kajitani T, Miyamoto K", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "reference": [ { "type": "PubMed", "id": "12741956", "url": "https://glygen.org/publication/PubMed/12741956" } ] }, { "title": "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Liu G, Clement LC, Kanwar YS, Avila-Casado C, Chugh SS", "evidence": [ { "database": "RefSeq", "id": "NP_001257985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257985" } ], "reference": [ { "type": "PubMed", "id": "17056598", "url": "https://glygen.org/publication/PubMed/17056598" } ] }, { "title": "Early changes in gene expression that influence the course of primary glomerular disease.", "journal": "Kidney international", "date": "2007", "authors": "Clement LC, Liu G, Perez-Torres I, Kanwar YS, Avila-Casado C, Chugh SS", "evidence": [ { "database": "RefSeq", "id": "NP_001257985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257985" } ], "reference": [ { "type": "PubMed", "id": "17457373", "url": "https://glygen.org/publication/PubMed/17457373" } ] } ], "pathway": [ { "id": "rno:314988", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:314988", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8C0C0-1", "protein_name": "Zinc fingers and homeoboxes protein 2", "gene_name": "Zhx2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASKRKSTTPCMVRTSQVLEQDMLEEADRAKDKGAGMPQSDVTKDSWAAEPEHSSKETEVVEVKSMGENLSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHPNVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGETNFKLKLIKRNNQTVLEQSIEATNHVVPITASGPGSSDNDPGVSVGKTPMTKTGKLKADAKKVPKKPDEAAPENHMEGTARLVTDTAEILARLGSVELLQDSLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMFNGTIQSVPPTITVLPAQLTPTKVSQPILQTALPCQILGQPSLVLTQVTSGSTTVSCSPITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANTPLTPASDRKKTKLQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAKDQMAITGTRHGRTYHVYPDFAPQKFKEKSQGQLKTLEDSFLKSSFPTQAEVERLRVETKLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGSDAVAPNGALSRLDQLSGAQLAGSLPSPSSAIVQNQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLKTGTLSWLEQYQRHHMSDDRGRDAVSRKVAKQVAESPKNGSEAAHQYAKDPKALSEEDSEKLVPRMKVGGDPTKDCLAGKPSEATSDRSEGSRDGQGSEENEESGIVDFVEVTVGEEDAISEKWGSWSRRVAEGTVERADSDSDSTPAEAGQA", "length": 836 }, "evidence": [ { "id": "45226057", "url": "http://www.informatics.jax.org/homology/45226057", "database": "MGI" }, { "id": "Q80VX4", "url": "https://omabrowser.org/oma/group/Q80VX4/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y6X8-1", "protein_name": "Zinc fingers and homeoboxes protein 2", "gene_name": "ZHX2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASKRKSTTPCMVRTSQVVEQDVPEEVDRAKEKGIGTPQPDVAKDSWAAELENSSKENEVIEVKSMGESQSKKLQGGYECKYCPYSTQNLNEFTEHVDMQHPNVILNPLYVCAECNFTTKKYDSLSDHNSKFHPGEANFKLKLIKRNNQTVLEQSIETTNHVVSITTSGPGTGDSDSGISVSKTPIMKPGKPKADAKKVPKKPEEITPENHVEGTARLVTDTAEILSRLGGVELLQDTLGHVMPSVQLPPNINLVPKVPVPLNTTKYNSALDTNATMINSFNKFPYPTQAELSWLTAASKHPEEHIRIWFATQRLKHGISWSPEEVEEARKKMFNGTIQSVPPTITVLPAQLAPTKVTQPILQTALPCQILGQTSLVLTQVTSGSTTVSCSPITLAVAGVTNHGQKRPLVTPQAAPEPKRPHIAQVPEPPPKVANPPLTPASDRKKTKEQIAHLKASFLQSQFPDDAEVYRLIEVTGLARSEIKKWFSDHRYRCQRGIVHITSESLAKDQLAIAASRHGRTYHAYPDFAPQKFKEKTQGQVKILEDSFLKSSFPTQAELDRLRVETKLSRREIDSWFSERRKLRDSMEQAVLDSMGSGKKGQDVGAPNGALSRLDQLSGAQLTSSLPSPSPAIAKSQEQVHLLRSTFARTQWPTPQEYDQLAAKTGLVRTEIVRWFKENRCLLKTGTVKWMEQYQHQPMADDHGYDAVARKATKPMAESPKNGGDVVPQYYKDPKKLCEEDLEKLVTRVKVGSEPAKDCLPAKPSEATSDRSEGSSRDGQGSDENEESSVVDYVEVTVGEEDAISDRSDSWSQAAAEGVSELAESDSDCVPAEAGQA", "length": 837 }, "evidence": [ { "id": "45226057", "url": "http://www.informatics.jax.org/homology/45226057", "database": "MGI" }, { "id": "Q80VX4", "url": "https://omabrowser.org/oma/group/Q80VX4/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "pmid": "" }, { "name": "negative regulation of neuron differentiation", "id": "GO:0045665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045665", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "pmid": "" }, { "name": "neuron differentiation", "id": "GO:0030182", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030182", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "pmid": "" }, { "name": "mRNA catabolic process", "id": "GO:0006402", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006402", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "pmid": "" }, { "name": "somatic stem cell population maintenance", "id": "GO:0035019", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035019", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "pmid": "" }, { "name": "retinal bipolar neuron differentiation", "id": "GO:0060040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060040", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "pmid": "" }, { "name": "protein homodimerization activity", "id": "GO:0042803", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "pmid": "" }, { "name": "protein heterodimerization activity", "id": "GO:0046982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q80VX4", "url": "https://www.uniprot.org/uniprot/Q80VX4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 116, "end_pos": 118, "annotation": "n_glycosylation_sequon" }, { "start_pos": 148, "end_pos": 150, "annotation": "n_glycosylation_sequon" }, { "start_pos": 263, "end_pos": 265, "annotation": "n_glycosylation_sequon" }, { "start_pos": 274, "end_pos": 276, "annotation": "n_glycosylation_sequon" }, { "start_pos": 335, "end_pos": 337, "annotation": "n_glycosylation_sequon" }, { "start_pos": 722, "end_pos": 724, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }