{
    "uniprot_canonical_ac": "Q80UY1-1",
    "uniprot_ac": "Q80UY1",
    "uniprot_id": "CARME_MOUSE",
    "mass": {
        "chemical_mass": 46339.0,
        "monoisotopic_mass": 46339.0
    },
    "refseq": {
        "ac": "NP_080396",
        "name": "carnosine N-methyltransferase isoform 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080396"
    },
    "gene_names": [
        {
            "name": "Carnmt1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q80UY1",
            "id": "Q80UY1"
        },
        {
            "name": "2410127L17Rik",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080396",
            "id": "NP_080396"
        },
        {
            "name": "Carnmt1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080396",
            "id": "NP_080396"
        }
    ],
    "protein_names": [
        {
            "name": "Carnosine N-methyltransferase",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q80UY1"
        },
        {
            "name": "2.1.1.22",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q80UY1"
        },
        {
            "name": "UPF0586 protein C9orf41 homolog",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080396",
            "id": "NP_080396"
        },
        {
            "name": "carnosine N-methyltransferase isoform 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080396",
            "id": "NP_080396"
        }
    ],
    "function": [
        {
            "annotation": "Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080396",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080396"
                },
                {
                    "database": "PubMed",
                    "id": "37612136",
                    "url": "https://glygen.org/publication/PubMed/37612136"
                }
            ]
        },
        {
            "annotation": "N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q80UY1",
                    "url": "https://www.uniprot.org/uniprot/Q80UY1#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q5BJZ6",
                    "url": "https://www.uniprot.org/uniprot/Q5BJZ6#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q80UY1",
                    "url": "https://www.uniprot.org/uniprot/Q80UY1"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Carnmt1",
            "url": "https://www.uniprot.org/uniprot/Q80UY1",
            "locus": {
                "chromosome": "19",
                "start_pos": 18684564,
                "end_pos": 18648128,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000024726",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000024726"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000024726",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000024726",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "67383",
            "url": "https://www.ncbi.nlm.nih.gov/gene/67383",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q80UY1",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q80UY1*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR012901",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR012901",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR029063",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:67383",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:67383",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1914633",
            "url": "http://www.informatics.jax.org/marker/MGI:1914633",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "GSMSMCA",
            "url": "https://omabrowser.org/oma/group/GSMSMCA/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "167229at2759",
            "url": "http://www.orthodb.org/?query=167229at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12303",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12303",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12303:SF6",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12303:SF6",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF07942",
            "url": "http://pfam.xfam.org/family/PF07942",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q80UY1",
            "url": "http://purl.obolibrary.org/obo/PR_Q80UY1",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-70921",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-70921",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_080396",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080396",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "14205",
            "url": "https://www.rhea-db.org/rhea/14205",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "A0A494BA54",
            "url": "https://www.uniprot.org/uniprot/A0A494BA54",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A494BA54-1",
            "url": "https://www.uniprot.org/uniprot/A0A494BA54-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q80UY1",
            "url": "https://www.uniprot.org/uniprot/Q80UY1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q80UY1-1",
            "url": "https://www.uniprot.org/uniprot/Q80UY1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MQRRQRAPPASQPAQDGGRSEDVEVQFSAGRLGSAAPAGPPARGTAEDEERLEREHFWKVINAFRYYGTSMHERVNRTERQFRSLPENQQKLLPQFPLHLDKIRKCIDHNQEILLTIVNDCIHMFENKEYGEDANGKIMPASTFDMDKLKSTLKQFVRDWSETGKAERDACYKPIIKEIIKNFPKERWDPSKVNILVPGAGLGRLAWEVAMLGYACQGNEWSFFMLFSSNFVLNRCSEINKYKLYPWIHQFSNNRRSADQIRPILFPDVDPHSLPPGSNFSMTAGDFQEIYSECNAWDCIATCFFIDTAHNVIDYIDTIWRILKPGGIWINLGPLLYHFENLANELSIELSYEDIKNVVLQYGFQLEVEKESVLSTYTVNDLSMMKYYYECVLFVVRKPQ",
        "length": 400,
        "header": "sp|Q80UY1-1|CARME_MOUSE Isoform 1 of Carnosine N-methyltransferase  OS=Mus musculus OX=10090 GN=Carnmt1 PE=1 SV=1 CANONICAL=Q80UY1-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A494BA54-1",
            "url": "",
            "sequence": {
                "sequence": "MQRRQRAPPASQPAQDGGRSEDVEVQFSAGRLGSAAPAGPPARGTAEDEERLEREHFWKVINAFRYYG",
                "length": 68,
                "header": "tr|A0A494BA54-1|CARME_MOUSE Computationally mapped isoform of Carnosine N-methyltransferase  OS=Mus musculus OX=10090 GN=Carnmt1 PE=1 SV=1 CANONICAL=Q80UY1-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "Q80UY1-1",
            "url": "",
            "sequence": {
                "sequence": "MQRRQRAPPASQPAQDGGRSEDVEVQFSAGRLGSAAPAGPPARGTAEDEERLEREHFWKVINAFRYYGTSMHERVNRTERQFRSLPENQQKLLPQFPLHLDKIRKCIDHNQEILLTIVNDCIHMFENKEYGEDANGKIMPASTFDMDKLKSTLKQFVRDWSETGKAERDACYKPIIKEIIKNFPKERWDPSKVNILVPGAGLGRLAWEVAMLGYACQGNEWSFFMLFSSNFVLNRCSEINKYKLYPWIHQFSNNRRSADQIRPILFPDVDPHSLPPGSNFSMTAGDFQEIYSECNAWDCIATCFFIDTAHNVIDYIDTIWRILKPGGIWINLGPLLYHFENLANELSIELSYEDIKNVVLQYGFQLEVEKESVLSTYTVNDLSMMKYYYECVLFVVRKPQ",
                "length": 400,
                "header": "sp|Q80UY1-1|CARME_MOUSE Isoform 1 of Carnosine N-methyltransferase  OS=Mus musculus OX=10090 GN=Carnmt1 PE=1 SV=1 CANONICAL=Q80UY1-1"
            },
            "locus": {
                "chromosome": "19",
                "start_pos": 18681482,
                "end_pos": 18648364,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000025632",
                        "url": "https://www.ensembl.org/id/ENSMUST00000025632"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000025632",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000025632"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism.",
            "journal": "Genes & development",
            "date": "2023-08-01",
            "authors": "Shimazu Tadahiro, Yoshimoto Rei, Kotoshiba Kaoru, Suzuki Takehiro, Matoba Shogo, Hirose Michiko, Akakabe Mai, Sohtome Yoshihiro, Sodeoka Mikiko, Ogura Atsuo, Dohmae Naoshi, Shinkai Yoichi",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080396",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080396"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "37612136",
                    "url": "https://glygen.org/publication/PubMed/37612136"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:67383",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:67383",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-70921",
            "name": "Histidine catabolism",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-70921",
            "resource": "Reactome",
            "description": "Histidine catabolism"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q5BJZ6-1",
            "protein_name": "Carnosine N-methyltransferase",
            "gene_name": "Carnmt1",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MQRRRRAPPASQPAQDSGHSEEVEVQFSAGRLGSAAPAGPPVRGTAEDEERLEREHFWKVINAFRYYGTSMHERVNRTERQFRSLPDNQQKLLPQFPLHLDKIRKCVDHNQEILLTIVNDCIHMFENKEYGEDANGKIMPASTFDMDKLKSTLKQFVRDWSGTGKAERDACYKPIIKEIIKNFPKERWDPSKVNILVPGAGLGRLAWEIAMLGYACQGNEWSFFMLFSSNFVLNRCSEVDKYKLYPWIHQFSNNRRSADQIRPIFFPDVDPHSLPPGSNFSMTAGDFQEIYSECNTWDCIATCFFIDTAHNVIDYIDTIWRILKPGGIWINLGPLLYHFENLANELSIELSYEDIKNVVLQYGFQLEVEKESVLSTYTVNDLSMMKYYYECVLFVVRKPQ",
                "length": 400
            },
            "evidence": [
                {
                    "id": "45238993",
                    "url": "http://www.informatics.jax.org/homology/45238993",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q8N4J0-1",
            "protein_name": "Carnosine N-methyltransferase",
            "gene_name": "CARNMT1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MQRRRRPPPPTSRLPEGCGGGGGGSEEVEVQFSAGRWGSAAAVSAAAAAATRSTEEEEERLEREHFWKIINAFRYYGTSMHERVNRTERQFRSLPANQQKLLPQFLLHLDKIRKCIDHNQEILLTIVNDCIHMFENKEYGEDGNGKIMPASTFDMDKLKSTLKQFVRDWSETGKAERDACYQPIIKEILKNFPKERWDPSKVNILVPGAGLGRLAWEIAMLGYACQGNEWSFFMLFSSNFVLNRCSEINKYKLYPWIHQFSNNRRSADQIRPIFFPDVDPHSLPPGSNFSMTAGDFQEIYSECNTWDCIATCFFIDTAHNVIDYIDTIWKILKPGGIWINLGPLLYHFENLANELSIELSYEDIKNVVLQYGFKVEVEKESVLSTYTVNDLSMMKYYYECVLFVVRKPQ",
                "length": 409
            },
            "evidence": [
                {
                    "id": "45238993",
                    "url": "http://www.informatics.jax.org/homology/45238993",
                    "database": "MGI"
                },
                {
                    "id": "Q80UY1",
                    "url": "https://omabrowser.org/oma/group/Q80UY1/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9I7X6-1",
            "protein_name": "Carnosine N-methyltransferase",
            "gene_name": "",
            "tax_id": 7227,
            "organism": "Drosophila melanogaster",
            "sequence": {
                "sequence": "MSSMDCATFPMHPKMDEQLARTFVINEEEEEKHIQKVQNAFLYYGPYACQRLKRSMDYLNSLSGEDQIMLAKYRGHLECVRTCIDRNQAVIREILRGRVLYPTDEATGDPSEFDEPPPNVRHGDMDQAQSTLKLIARDWSTEGALEREQSYKPIIDSIVAYFKHSDFELKDIKILVPGAGLGRLTYELACLGYSCEGNEFSYFMLIASNFVLNLCDNENKYVLYPWVHQYVNNLRREDQVAPVRFPDVCPLKNPPKGHFEIAAGDFLEVYKTPNAYNCVATCFFIDCANNVIDFIRTIYKILVPGGIWVNLGPLLYHFSDVSGQNSIEPAFEDLCIIMESVGFVIEKSRTGIRTKYAQNPSSMKQSEYQSLFWVCRKPDLFEEQRGKRKASREPHDLIVREDSEEEGEQQPERNETEEKQQLKPLATANCETEIKEQPS",
                "length": 439
            },
            "evidence": [
                {
                    "id": "Q80UY1",
                    "url": "https://omabrowser.org/oma/group/Q80UY1/",
                    "database": "OMA"
                }
            ],
            "common_name": "Fruit fly"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q80UY1",
                                "url": "https://www.uniprot.org/uniprot/Q80UY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q80UY1",
                                "url": "https://www.uniprot.org/uniprot/Q80UY1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "protein homodimerization activity",
                        "id": "GO:0042803",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q80UY1",
                                "url": "https://www.uniprot.org/uniprot/Q80UY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "S-adenosylmethionine-dependent methyltransferase activity",
                        "id": "GO:0008757",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008757",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q80UY1",
                                "url": "https://www.uniprot.org/uniprot/Q80UY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "carnosine N-methyltransferase activity",
                        "id": "GO:0030735",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030735",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q80UY1",
                                "url": "https://www.uniprot.org/uniprot/Q80UY1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "methylation",
                        "id": "GO:0032259",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q80UY1",
                                "url": "https://www.uniprot.org/uniprot/Q80UY1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "carnosine metabolic process",
                        "id": "GO:0035498",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035498",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q80UY1",
                                "url": "https://www.uniprot.org/uniprot/Q80UY1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 279,
            "end_pos": 281,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 76,
            "end_pos": 78,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "14205",
            "name": "",
            "equation": "carnosine + S-adenosyl-L-methionine = anserine + H(+) + S-adenosyl-L-homocysteine",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q5BJZ6-1",
                "Q8N4J0-1",
                "Q80UY1-1",
                "P53934-1",
                "Q54ST2-1",
                "Q9I7X6-1"
            ],
            "evidence": [
                {
                    "id": "14205",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/14205"
                }
            ]
        },
        {
            "id": "R-MMU-8876789",
            "name": "CARNMT1 methylates CARN to Anserine",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol",
            "input_participant_list": [],
            "output_participant_list": [
                "R-ALL-8876775"
            ],
            "enzyme_list": [
                "Q80UY1-1"
            ],
            "evidence": [
                {
                    "id": "R-MMU-8876789",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8876789"
                }
            ]
        }
    ],
    "reaction_participants": [
        {
            "participant_id": "R-ALL-8876775",
            "participant_name": "Anserine [cytosol]",
            "crossref": [
                {
                    "id": "58445",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "000001532910",
                    "database": "ZINC",
                    "url": ""
                },
                {
                    "id": "58445",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "000001532910",
                    "database": "ZINC",
                    "url": ""
                },
                {
                    "id": "58445",
                    "database": "ChEBI",
                    "url": ""
                },
                {
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