{
    "uniprot_canonical_ac": "Q80UU1-1",
    "uniprot_ac": "Q80UU1",
    "uniprot_id": "ANKZ1_MOUSE",
    "mass": {
        "chemical_mass": 82976.0,
        "monoisotopic_mass": 82976.0
    },
    "refseq": {
        "ac": "NP_001254549",
        "name": "tRNA endonuclease ANKZF1 isoform 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254549"
    },
    "gene_names": [
        {
            "name": "Ankzf1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q80UU1",
            "id": "Q80UU1"
        },
        {
            "name": "1300008P06Rik; 2810025E10Rik; D1Ertd161e",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254549",
            "id": "NP_001254549"
        },
        {
            "name": "Ankzf1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254549",
            "id": "NP_001254549"
        },
        {
            "name": "D1Ertd161e",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q80UU1",
            "id": "Q80UU1"
        }
    ],
    "protein_names": [
        {
            "name": "tRNA endonuclease ANKZF1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q80UU1"
        },
        {
            "name": "3.1.-.-",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q80UU1"
        },
        {
            "name": "Ankyrin repeat and zinc finger domain-containing protein 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q80UU1"
        },
        {
            "name": "ankyrin repeat and zinc finger domain-containing protein 1; tRNA endonuclease ANKZF1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080463",
            "id": "NP_080463"
        },
        {
            "name": "tRNA endonuclease ANKZF1 isoform 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080463",
            "id": "NP_080463"
        },
        {
            "name": "tRNA endonuclease ANKZF1 isoform 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254549",
            "id": "NP_001254549"
        }
    ],
    "function": [
        {
            "annotation": "Endonuclease that cleaves polypeptidyl-tRNAs downstream of the ribosome-associated quality control (RQC) pathway to release incompletely synthesized polypeptides for degradation. The RQC pathway disassembles aberrantly stalled translation complexes to recycle or degrade the constituent parts. ANKZF1 acts downstream disassembly of stalled ribosomes and specifically cleaves off the terminal 3'-CCA nucleotides universal to all tRNAs from polypeptidyl-tRNAs, releasing (1) ubiquitinated polypeptides from 60S ribosomal subunit for degradation and (2) cleaved tRNAs. ANKZF1-cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1. Also plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q80UU1",
                    "url": "https://www.uniprot.org/uniprot/Q80UU1#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9H8Y5",
                    "url": "https://www.uniprot.org/uniprot/Q9H8Y5#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0050589",
            "recommended_name": {
                "id": "DOID:0050589",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050589",
                "name": "inflammatory bowel disease",
                "description": "An intestinal disease characterized by inflammation located in all parts of digestive tract."
            },
            "synonyms": [
                {
                    "id": "MONDO:0009960",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960",
                    "name": "inflammatory bowel disease 1",
                    "description": "Any inflammatory bowel disease in which the cause of the disease is a mutation in the NOD2 gene."
                },
                {
                    "id": "MONDO:0009960",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960",
                    "name": "IBD1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009960",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960",
                    "name": "NOD2 inflammatory bowel disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0009960",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960",
                    "name": "crohn disease-associated growth failure",
                    "description": ""
                },
                {
                    "id": "MONDO:0009960",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960",
                    "name": "inflammatory bowel disease 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009960",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960",
                    "name": "inflammatory bowel disease 1, Crohn disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0009960",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960",
                    "name": "inflammatory bowel disease caused by mutation in NOD2",
                    "description": ""
                },
                {
                    "id": "MONDO:0009960",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960",
                    "name": "inflammatory bowel disease type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009960",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960",
                    "name": "Crohn disease",
                    "description": ""
                },
                {
                    "id": "MONDO:0009960",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960",
                    "name": "Crohn disease-associated Growth failure, susceptibility to",
                    "description": ""
                },
                {
                    "id": "MONDO:0009960",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960",
                    "name": "inflammatory bowel disease (Crohn disease) 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0009960",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960",
                    "name": "paediatric ulcerative colitis",
                    "description": ""
                },
                {
                    "id": "MONDO:0009960",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960",
                    "name": "pediatric ulcerative colitis",
                    "description": ""
                },
                {
                    "id": "MONDO:0009960",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960",
                    "name": "regional enteritis",
                    "description": ""
                },
                {
                    "id": "MONDO:0009960",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960",
                    "name": "ulcerative colitis",
                    "description": ""
                },
                {
                    "id": "MONDO:0009960",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960",
                    "name": "ulcerative colitis, paediatric",
                    "description": ""
                },
                {
                    "id": "MONDO:0009960",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0009960",
                    "name": "ulcerative colitis, pediatric",
                    "description": ""
                },
                {
                    "id": "MIM:266600",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/266600",
                    "name": "Inflammatory bowel disease 1",
                    "description": "Inflammatory bowel disease 1"
                }
            ],
            "evidence": [
                {
                    "id": "0050589",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050589"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q80UU1",
                    "url": "https://www.uniprot.org/uniprot/Q80UU1"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Ankzf1",
            "url": "https://www.uniprot.org/uniprot/Q80UU1",
            "locus": {
                "chromosome": "1",
                "start_pos": 75176031,
                "end_pos": 75168795,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000026199",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000026199"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000026199",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000026199",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "52231",
            "url": "https://www.ncbi.nlm.nih.gov/gene/52231",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q80UU1",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q80UU1*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR002110",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013087",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036770",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR041175",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041175",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR041540",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041540",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR047139",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR047139",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:52231",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:52231",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1098746",
            "url": "http://www.informatics.jax.org/marker/MGI:1098746",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "GPHIFMC",
            "url": "https://omabrowser.org/oma/group/GPHIFMC/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "8371at2759",
            "url": "http://www.orthodb.org/?query=8371at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR16036",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16036",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR16036:SF2",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16036:SF2",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00023",
            "url": "http://pfam.xfam.org/family/PF00023",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF18716",
            "url": "http://pfam.xfam.org/family/PF18716",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF18826",
            "url": "http://pfam.xfam.org/family/PF18826",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q80UU1",
            "url": "http://purl.obolibrary.org/obo/PR_Q80UU1",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001254549",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254549",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "J3KMQ5",
            "url": "https://www.uniprot.org/uniprot/J3KMQ5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "J3KMQ5-1",
            "url": "https://www.uniprot.org/uniprot/J3KMQ5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "J3QM81",
            "url": "https://www.uniprot.org/uniprot/J3QM81",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "J3QM81-1",
            "url": "https://www.uniprot.org/uniprot/J3QM81-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "J3QPB4",
            "url": "https://www.uniprot.org/uniprot/J3QPB4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "J3QPB4-1",
            "url": "https://www.uniprot.org/uniprot/J3QPB4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q80UU1",
            "url": "https://www.uniprot.org/uniprot/Q80UU1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q80UU1-1",
            "url": "https://www.uniprot.org/uniprot/Q80UU1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q80UU1-2",
            "url": "https://www.uniprot.org/uniprot/Q80UU1-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAKPAGDAAVGSRSGELFLPSVSSSATSPAPSAAPAPASVSLLSLNGEAPLIRGLSLVSQAPGEALAWAPRTSCPGENTSSGGKVSPYSLEISEKLFCSACDQIFQNHQEQREHYKLDWHRFNLKQRLKNKPLLSASDFEQQSSTGDLSSISGSDDTDSSSEEDLLPLDEGRAESEKPNRPPGFYPHRVLFKNAQGQFLYAYRCVLGPHQIPPEKAELLLQNLQNGGPRYYVVLMAAAGHFAGAIFQGREVVAHKTFHRYTVRAKRGTAQGLQDAHGRASRSAGANLRRYNEAMLYKDVRNLLAGPIWSKALGEAETVLFRAPRSGRSLFFGGQGAPLQRDDPRLWDIPLTTRRPTFGELQRVLHKLTTLQVYDEDPREMVRFHSPETHWKPVREERKKDTEKEKTKVPSDANKPLGQDEEPLKQGSESQEEDGSEVELELVELTLGTLDLREFEVLPKRRRRRKKKERSQEQQCGAHGPLPQQPQDEPFSQPTQEVETPLDTLVYEAKAPGQPELWDTLLAACRAGEVEVLKLQLATGLVDPGVKSLLNAPLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNLDAYDYNKARVPGPLTQEMEARQATRKKEQKAARRQREQQQRKQREQEEQEQEEQRRFAALSDREKRALAAERRLAAQLGAPSPPVPDSAVASAGRCWSCGVSLQGLIPFHYLDFSFCSTRCLRDHRSQAGRPSS",
        "length": 748,
        "header": "sp|Q80UU1-1|ANKZ1_MOUSE Isoform 1 of tRNA endonuclease ANKZF1  OS=Mus musculus OX=10090 GN=Ankzf1 PE=1 SV=2 CANONICAL=Q80UU1-1"
    },
    "isoforms": [
        {
            "isoform_ac": "J3KMQ5-1",
            "url": "",
            "sequence": {
                "sequence": "MAKPAGDAAVGSRSGELFLPSVSSSATSPAPSAASAPASVSLLSLNGEAPLIRGLSLVSQAPGEALAWAPRTSCPGENTSSGGKVSPYSLEISEKLFCSACDQIFQNHQEQREHYKLDWHRFNLKQRLKNKPLLSASDFEQQSSTGDLSSISGSDDTDSSSEEDLLPLDEGRAESEKPNRPPGFYPHRVLFKNAQGQFLYAYRCVLGPHQHVECLLMCHLDSPRKGRIATTKPTEWRSQILRGAHGCGWTFCWCHFSRKRSGGTQNLSPLHCAGQAGHSPGASGCPW",
                "length": 287,
                "header": "tr|J3KMQ5-1|ANKZ1_MOUSE Computationally mapped isoform of tRNA endonuclease ANKZF1  OS=Mus musculus OX=10090 GN=Ankzf1 PE=1 SV=1 CANONICAL=Q80UU1-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 75172531,
                "end_pos": 75169096,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000145459.9",
                        "url": "https://www.ensembl.org/id/ENSMUST00000145459.9"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000135971.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000135971.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "J3QM81-1",
            "url": "",
            "sequence": {
                "sequence": "MAKPAGDAAVGSRSGELFLPSVSSSATSPAPSAASAPASVSLLSLNGEAPLIRGLSLVSQAPGEALAWAPRTSCPGENTSSGGKVSPYSLEISEKLFCSACDQIFQNHQEQREHYKLDWHRFNLKQRLKNKPLLSASDFEQQSSTGDLSSISGSDDTDSSSEEDLLPLDEGRAESEKPNRPPGFYPHRVLFKNAQGQFLYAYRCVLGPHQIPPEKAELLLQNLQNGGPRYYVVLMAAAGHFAGAIFQGREVVAHKTFHRYTVRAKRGTAQGLQDAHGRASRSAGANLRRYNEAMLYKDVRNLLAGPIWSKALGEAETVLFRAPRSGRSLFFGGQGAPLQRDDPRLWDIPLTTRRPTFGELQRVLHKLTTLQVYDEDPREMVRFHSPETHWKPVREERKKDTEKEKTKVPSDANKPLGQDEEPLKQGSESQEEDGSEVELELVELTLGTLDLREFEVLPKRRRRRKKKERSQEQQCGAHGPLPQQPQDEPFSQPTQEVETPLDTLVYEAKAPGQPELWDTLLAACRAGEVEVLKLQLATGLVDPGVKSLLNAPLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNLDAYDYNKARVPGPLTQEMEARQATRKKEQKAARRQREQQQRKQREQEEQEQEEQRRFAALSDREKRALAAERRLAAQLGAPSPPVPDSAVASAGRCWSCGVSLQGLIPFHYLDFSFCSTRCLRDHRSQAGRPSS",
                "length": 748,
                "header": "tr|J3QM81-1|ANKZ1_MOUSE Computationally mapped isoform of tRNA endonuclease ANKZF1  OS=Mus musculus OX=10090 GN=Ankzf1 PE=1 SV=1 CANONICAL=Q80UU1-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 75175828,
                "end_pos": 75169096,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000152233.9",
                        "url": "https://www.ensembl.org/id/ENSMUST00000152233.9"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000136163.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000136163.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "J3QPB4-1",
            "url": "",
            "sequence": {
                "sequence": "MAKPAGDAAVGSRSGELFLPSVSSSATSPAPSAASAPASVSLLSLNGEAPLIRGLSLVSQAPGEALAWAPRTSCPGENTSSGGKVSPYSLEISEKLFCSACDQIFQNHQEQREHYKLDWHRFNLKQRLKNKPLLSASDFEQQSSTGDLSSISGSDDTDSSSEEDLLPLDEGRAESEKPNRPPGFYPHRVLFKNAQGQFLYAYRCVLGPHQASNSPDCVLTPNFVY",
                "length": 225,
                "header": "tr|J3QPB4-1|ANKZ1_MOUSE Computationally mapped isoform of tRNA endonuclease ANKZF1  OS=Mus musculus OX=10090 GN=Ankzf1 PE=1 SV=1 CANONICAL=Q80UU1-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 75171946,
                "end_pos": 75169096,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000127625.3",
                        "url": "https://www.ensembl.org/id/ENSMUST00000127625.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000137179.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000137179.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q80UU1-1",
            "url": "",
            "sequence": {
                "sequence": "MAKPAGDAAVGSRSGELFLPSVSSSATSPAPSAAPAPASVSLLSLNGEAPLIRGLSLVSQAPGEALAWAPRTSCPGENTSSGGKVSPYSLEISEKLFCSACDQIFQNHQEQREHYKLDWHRFNLKQRLKNKPLLSASDFEQQSSTGDLSSISGSDDTDSSSEEDLLPLDEGRAESEKPNRPPGFYPHRVLFKNAQGQFLYAYRCVLGPHQIPPEKAELLLQNLQNGGPRYYVVLMAAAGHFAGAIFQGREVVAHKTFHRYTVRAKRGTAQGLQDAHGRASRSAGANLRRYNEAMLYKDVRNLLAGPIWSKALGEAETVLFRAPRSGRSLFFGGQGAPLQRDDPRLWDIPLTTRRPTFGELQRVLHKLTTLQVYDEDPREMVRFHSPETHWKPVREERKKDTEKEKTKVPSDANKPLGQDEEPLKQGSESQEEDGSEVELELVELTLGTLDLREFEVLPKRRRRRKKKERSQEQQCGAHGPLPQQPQDEPFSQPTQEVETPLDTLVYEAKAPGQPELWDTLLAACRAGEVEVLKLQLATGLVDPGVKSLLNAPLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNLDAYDYNKARVPGPLTQEMEARQATRKKEQKAARRQREQQQRKQREQEEQEQEEQRRFAALSDREKRALAAERRLAAQLGAPSPPVPDSAVASAGRCWSCGVSLQGLIPFHYLDFSFCSTRCLRDHRSQAGRPSS",
                "length": 748,
                "header": "sp|Q80UU1-1|ANKZ1_MOUSE Isoform 1 of tRNA endonuclease ANKZF1  OS=Mus musculus OX=10090 GN=Ankzf1 PE=1 SV=2 CANONICAL=Q80UU1-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "Q80UU1-2",
            "url": "",
            "sequence": {
                "sequence": "MAKPAGDAAVGSRSGELFLPSVSSSATSPAPSAAPAPASVSLLSLNGEAPLIRGLSLVSQAPGEALAWAPRTSCPGENTSSGGKVSPYSLEISEKLFCSACDQIFQNHQEQREHYKLDWHRFNLKQRLKNKPLLSASDFEQQSSTGDLSSISGSDDTDSSSEEDLLPLDEGRAESEKPNRPPGFYPHRVLFKNAQGQFLYAYRCVLGPHQASNSPDCVLTPNF",
                "length": 223,
                "header": "sp|Q80UU1-2|ANKZ1_MOUSE Isoform 2 of tRNA endonuclease ANKZF1  OS=Mus musculus OX=10090 GN=Ankzf1 PE=1 SV=2 CANONICAL=Q80UU1-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 282,
            "end_pos": 282,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q80UU1",
                    "url": "https://www.uniprot.org/uniprot/Q80UU1"
                }
            ],
            "site_lbl": "Ser282"
        },
        {
            "start_pos": 385,
            "end_pos": 385,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q80UU1",
                    "url": "https://www.uniprot.org/uniprot/Q80UU1"
                }
            ],
            "site_lbl": "Ser385"
        },
        {
            "start_pos": 555,
            "end_pos": 555,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q80UU1",
                    "url": "https://www.uniprot.org/uniprot/Q80UU1"
                }
            ],
            "site_lbl": "Ser555"
        },
        {
            "start_pos": 629,
            "end_pos": 629,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q80UU1",
                    "url": "https://www.uniprot.org/uniprot/Q80UU1"
                }
            ],
            "site_lbl": "Thr629"
        },
        {
            "start_pos": 702,
            "end_pos": 702,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q80UU1",
                    "url": "https://www.uniprot.org/uniprot/Q80UU1"
                }
            ],
            "site_lbl": "Ser702"
        }
    ],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [],
    "pathway": [
        {
            "id": "mmu:52231",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:52231",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q66H85-1",
            "protein_name": "tRNA endonuclease ANKZF1",
            "gene_name": "Ankzf1",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MLPAPRAAPVPASVSLLTLNGEAPLVRGLSLVSQAPGEALAWAPRTSCPGENTSSGRKVSPCSLDISDKLFCSACDQVFQNHQEQREHYKLDWHRFNLKQRLKNKPLLSASDFERQSSRGDLSSISGSEDSDSASEEDLLTLDEERAESEKPNRPPGFYPHRVLFRNAQGQFLYAYRCVLGPHQIPPEKAELLLQNLQNGGPRHYVVLMAAAGHFAGAIFQGREVVAHKTFHRYTVRAKRGTAQGLQDAQGRASRSAGANLRRYNEAMLYKDVRDLLAGPTWSKALGEAETILLHAPRSGRSLFFGGQGAPLQRSDFRLWDIPLTTRRPTFGELQRVLHKLTTLQVYDEDPREMVRFHSPETHCKPVREERKRDTEKEKTKVPSDANKALGQDEEPLKQGSESQEEDGSEVELELVELTLGTLDLREFEVLPKRRKKRKKKERSQKQQCGAHGPLLQQPQDEPFSQPTQVVATPLDTLVDEAKAPGQPELWDMLLAACRAGEVEVLKLQLATGPVDPGVMSLLSAPLGSGGFTLLHAAAAAGRGLVVRLLLEAGADPTVHDSRARPPYTVAADRSTRNEFRRFMEKNLDAYDYSKARVPGPLTQEMEARQATRKKEQKAARRQREQQQRKQREQEEQEQEERRRFAALSDREKRALAAERRLAAQLGAPSPPVPDSAVVNAGRCWSCGVSLQGLIPFHYLDFSFCSTRCLRDHRSQAGRPSS",
                "length": 722
            },
            "evidence": [
                {
                    "id": "45229056",
                    "url": "http://www.informatics.jax.org/homology/45229056",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q9H8Y5-1",
            "protein_name": "tRNA endonuclease ANKZF1",
            "gene_name": "ANKZF1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSPAPDAAPAPASISLFDLSADAPVFQGLSLVSHAPGEALARAPRTSCSGSGERESPERKLLQGPMDISEKLFCSTCDQTFQNHQEQREHYKLDWHRFNLKQRLKDKPLLSALDFEKQSSTGDLSSISGSEDSDSASEEDLQTLDRERATFEKLSRPPGFYPHRVLFQNAQGQFLYAYRCVLGPHQDPPEEAELLLQNLQSRGPRDCVVLMAAAGHFAGAIFQGREVVTHKTFHRYTVRAKRGTAQGLRDARGGPSHSAGANLRRYNEATLYKDVRDLLAGPSWAKALEEAGTILLRAPRSGRSLFFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEEDPREAVRLHSPQTHWKTVREERKKPTEEEIRKICRDEKEALGQNEESPKQGSGSEGEDGFQVELELVELTVGTLDLCESEVLPKRRRRKRNKKEKSRDQEAGAHRTLLQQTQEEEPSTQSSQAVAAPLGPLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADPRVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGADPTVQDSRARPPYTVAADKSTRNEFRRFMEKNPDAYDYNKAQVPGPLTPEMEARQATRKREQKAARRQREEQQQRQQEQEEREREEQRRFAALSDREKRALAAERRLAAQLGAPTSPIPDSAIVNTRRCWSCGASLQGLTPFHYLDFSFCSTRCLQDHRRQAGRPSS",
                "length": 726
            },
            "evidence": [
                {
                    "id": "45229056",
                    "url": "http://www.informatics.jax.org/homology/45229056",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 4,
                "go_terms": [
                    {
                        "name": "rescue of stalled ribosome",
                        "id": "GO:0072344",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072344",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q80UU1",
                                "url": "https://www.uniprot.org/uniprot/Q80UU1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular response to hydrogen peroxide",
                        "id": "GO:0070301",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070301",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q80UU1",
                                "url": "https://www.uniprot.org/uniprot/Q80UU1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin-dependent ERAD pathway",
                        "id": "GO:0030433",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030433",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q80UU1",
                                "url": "https://www.uniprot.org/uniprot/Q80UU1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein quality control for misfolded or incompletely synthesized proteins",
                        "id": "GO:0006515",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006515",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q80UU1",
                                "url": "https://www.uniprot.org/uniprot/Q80UU1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q80UU1",
                                "url": "https://www.uniprot.org/uniprot/Q80UU1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q80UU1",
                                "url": "https://www.uniprot.org/uniprot/Q80UU1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA endonuclease activity",
                        "id": "GO:0004521",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004521",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q80UU1",
                                "url": "https://www.uniprot.org/uniprot/Q80UU1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "catalytic activity, acting on a tRNA",
                        "id": "GO:0140101",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140101",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q80UU1",
                                "url": "https://www.uniprot.org/uniprot/Q80UU1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 78,
            "end_pos": 80,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
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                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
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                },
                {
                    "field": "o_linked_glycans",
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                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 5
                },
                {
                    "field": "total_sites",
                    "count": 5
                }
            ],
            "sort_fields": [
                "start_pos",
                "end_pos",
                "kinase_uniprot_canonical_ac",
                "kinase_gene_name",
                "residue",
                "comment",
                "site_lbl"
            ]
        },
        {
            "table_id": "snv",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_non_disease",
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                    "field": "total",
                    "count": 0
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                {
                    "field": "total_sites",
                    "count": 0
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            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
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                {
                    "field": "total",
                    "count": 0
                }
            ],
            "sort_fields": []
        }
    ]
}