{ "uniprot_canonical_ac": "Q80TH2-3", "uniprot_ac": "Q80TH2", "uniprot_id": "ERBIN_MOUSE", "mass": { "chemical_mass": 157248.0, "monoisotopic_mass": 157248.0 }, "refseq": { "ac": "NP_001005868", "name": "erbin isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005868" }, "gene_names": [ { "name": "Erbin", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q80TH2", "id": "Q80TH2" }, { "name": "1700028E05Rik; Erbb2ip; mKIAA1225", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005868", "id": "NP_001005868" }, { "name": "Erbb2ip", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q80TH2", "id": "Q80TH2" }, { "name": "Erbin", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005868", "id": "NP_001005868" }, { "name": "Kiaa1225", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q80TH2", "id": "Q80TH2" }, { "name": "Lap2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q80TH2", "id": "Q80TH2" } ], "protein_names": [ { "name": "Erbin", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q80TH2" }, { "name": "Densin-180-like protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q80TH2" }, { "name": "Erbb2-interacting protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q80TH2" }, { "name": "Protein LAP2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q80TH2" }, { "name": "erbin isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005868", "id": "NP_001005868" }, { "name": "protein LAP2; densin-180-like protein; erbb2-interacting protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005868", "id": "NP_001005868" } ], "function": [ { "annotation": "Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state (By similarity). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728).", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2#function" }, { "database": "UniProtKB", "id": "Q96RT1", "url": "https://www.uniprot.org/uniprot/Q96RT1#function" }, { "database": "PubMed", "id": "16203728", "url": "https://glygen.org/publication/PubMed/16203728" } ] }, { "annotation": "By degrading Erbin and Nrf2, Sag activates the Ras-Raf pathway and causes ROS accumulation to trigger autophagy and senescence", "evidence": [ { "database": "RefSeq", "id": "NP_001005868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005868" }, { "database": "PubMed", "id": "26056141", "url": "https://glygen.org/publication/PubMed/26056141" } ] }, { "annotation": "Knockout of Erbin promotes pyroptosis via regulating NLRP3/caspase-1/Gasdermin D pathway in sepsis-induced acute kidney injury.", "evidence": [ { "database": "RefSeq", "id": "NP_001005868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005868" }, { "database": "PubMed", "id": "37310569", "url": "https://glygen.org/publication/PubMed/37310569" } ] }, { "annotation": "Tumor organoids derived from Erbin/Apc double knockout mice displayed increased tumor initiation potential and activation of Wnt signaling", "evidence": [ { "database": "RefSeq", "id": "NP_001005868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005868" }, { "database": "PubMed", "id": "29980571", "url": "https://glygen.org/publication/PubMed/29980571" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs3389312643", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389312643" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 808, "end_pos": 808, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGA->NGT).", "chr_id": "13", "chr_pos": "103971193", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A808", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs3389309772", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389309772" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 837, "end_pos": 837, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KAS->NAS).", "chr_id": "13", "chr_pos": "103971104", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K837", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 315, "end_pos": 315, "sequence_org": "P", "sequence_mut": "L", "comment": "Decreases interaction with NOD2.", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" }, { "database": "PubMed", "id": "16203728", "url": "https://glygen.org/publication/PubMed/16203728" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Erbin", "url": "https://www.uniprot.org/uniprot/Q80TH2", "locus": { "chromosome": "13", "start_pos": 103955295, "end_pos": 104057022, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000021709", "url": "https://www.ensembl.org/id/ENSMUSG00000021709" } ] } } ], "crossref": [ { "id": "ENSMUSG00000021709", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000021709", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00992", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00992", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "59079", "url": "https://www.ncbi.nlm.nih.gov/gene/59079", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q80TH2", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q80TH2*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001478", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036034", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:59079", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:59079", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1890169", "url": "http://www.informatics.jax.org/marker/MGI:1890169", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q80TH2", "url": "https://oglcnac.org/atlas/detail/Q80TH2", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q80TH2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q80TH2", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "VPPDWRE", "url": "https://omabrowser.org/oma/group/VPPDWRE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2909504at2759", "url": "http://www.orthodb.org/?query=2909504at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23119", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23119", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23119:SF46", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23119:SF46", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00595", "url": "http://pfam.xfam.org/family/PF00595", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "http://pfam.xfam.org/family/PF13855", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q80TH2", "url": "http://purl.obolibrary.org/obo/PR_Q80TH2", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-1227986", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1227986", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-8863795", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8863795", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8980692", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-9013026", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013026", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-9013106", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013106", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-9013149", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013149", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-9013404", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013404", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-9013408", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013408", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-9013423", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013423", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-9652282", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9652282", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001005868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005868", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q80TH2-1", "url": "https://www.uniprot.org/uniprot/Q80TH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q80TH2-2", "url": "https://www.uniprot.org/uniprot/Q80TH2-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q80TH2-3", "url": "https://www.uniprot.org/uniprot/Q80TH2-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLREFWMDGNRLTFIPGFIGSLRQLTYLDVSKNNIEMVEEGISTCENLQDFLLSSNSLQQLPETIGSLKNVTTLKIDENQLMYLPDSIGGLRSIEELDCSFNEIEALPSSIGQLTNMRTFAADHNYLQQLPPEIGNWKNITVLFLHCNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDTETQKMVLTNYMFPQQPRTEDVMFISDNESFNPALWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEESGRDLKQHEDQQVVNKDKCVKTSESTTTKSKLDEREKYMNSVQKMSEPEAETNGGNLPVTASMKLSGNLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIESSINQPKVVALSNNKKDDAKDADSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTPVDSNSKVRQEDENFNSLLQNGVNLNNSPEEKFKINDKKDFKLPEYDLNIEEQLVLIEKDIDSKATSDDSRQLDHINMNINKLVTNNIFQPEVMERSKMQDIVLGTGFLSIHPKNEAEHIENGAKFPNLESINKVNGLCEDTAPSPGRVEPQKASSSADVGISKSTEDLSPQRSGPTGAVVKSHSITNMETGGLKIYDILGDDGPQPPSAAVKIASAVDGKNIVRSKSATLLYDQPLQVFTAASSSSELLSGTKAVFKFDSNHNPEEPDIIRAATVSGPQSTPHLYGPPQYNVQYSGSATVKDTLWHPKQNPQIDPVSFPPQRLPRSESAENHSYAKHSANMNFSNHNNVRANTGYHLQQRLAPARHGEMWAISPNDRLVPAVTRTTIQRQSSVSSTASVNLGDPTRRTEGDYLSYRELHSMGRTPVMSGSQRPLSARAYSIDGPNTSRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNTRVGSEHSLLDPPGKSKVPHDWREQVLRHIEAKKLEKHPQTSSPGECCQDDRFMSEEQNHPSGALSHRGLPDSLMKMPLSNGQMGQPLRPQAHYSQTHHPPQASVARHPSREQLIDYLMLKVAHQPPYTHPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFHNAVDLIIVREVSS", "length": 1402, "header": "sp|Q80TH2-3|ERBIN_MOUSE Isoform 3 of Erbin OS=Mus musculus OX=10090 GN=Erbin PE=1 SV=3 CANONICAL=Q80TH2-3" }, "isoforms": [ { "isoform_ac": "Q80TH2-1", "url": "", "sequence": { "sequence": "MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLREFWMDGNRLTFIPGFIGSLRQLTYLDVSKNNIEMVEEGISTCENLQDFLLSSNSLQQLPETIGSLKNVTTLKIDENQLMYLPDSIGGLRSIEELDCSFNEIEALPSSIGQLTNMRTFAADHNYLQQLPPEIGNWKNITVLFLHCNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDTETQKMVLTNYMFPQQPRTEDVMFISDNESFNPALWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEESGRDLKQHEDQQVVNKDKCVKTSESTTTKSKLDEREKYMNSVQKMSEPEAETNGGNLPVTASMKLSGNLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIESSINQPKVVALSNNKKDDAKDADSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTPVDSNSKVRQEDENFNSLLQNGVNLNNSPEEKFKINDKKDFKLPEYDLNIEEQLVLIEKDIDSKATSDDSRQLDHINMNINKLVTNNIFQPEVMERSKMQDIVLGTGFLSIHPKNEAEHIENGAKFPNLESINKVNGLCEDTAPSPGRVEPQKASSSADVGISKSTEDLSPQRSGPTGAVVKSHSITNMETGGLKIYDILGDDGPQPPSAAVKIASAVDGKNIVRSKSATLLYDQPLQVFTAASSSSELLSGTKAVFKFDSNHNPEEPDIIRAATVSGPQSTPHLYGPPQYNVQYSGSATVKDTLWHPKQNPQIDPVSFPPQRLPRSESAENHSYAKHSANMNFSNHNNVRANTGYHLQQRLAPARHGEMWAISPNDRLVPAVTRTTIQRQSSVSSTASVNLGDPTRRTEGDYLSYRELHSMGRTPVMSGSQRPLSARAYSIDGPNTSRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNTRVGSEHSLLDPPGKSKVPHDWREQVLRHIEAKKLEKHPQTSSPGECCQDDRFMSEEQNHPSGALSHRGLPDSLMKASVARHPSREQLIDYLMLKVAHQPPYTHPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFHNAVDLIIVREVSS", "length": 1376, "header": "sp|Q80TH2-1|ERBIN_MOUSE Isoform 1 of Erbin OS=Mus musculus OX=10090 GN=Erbin PE=1 SV=3 CANONICAL=Q80TH2-3" }, "locus": { "chromosome": "13", "start_pos": 104022837, "end_pos": 103957210, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000022222", "url": "https://www.ensembl.org/id/ENSMUST00000022222" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000022222", "url": "https://www.ensembl.org/id/ENSMUSP00000022222" } ] } }, { "isoform_ac": "Q80TH2-2", "url": "", "sequence": { "sequence": "MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLREFWMDGNRLTFIPGFIGSLRQLTYLDVSKNNIEMVEEGISTCENLQDFLLSSNSLQQLPETIGSLKNVTTLKIDENQLMYLPDSIGGLRSIEELDCSFNEIEALPSSIGQLTNMRTFAADHNYLQQLPPEIGNWKNITVLFLHCNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDTETQKMVLTNYMFPQQPRTEDVMFISDNESFNPALWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEESGRDLKQHEDQQVVNKDKCVKTSESTTTKSKLDEREKYMNSVQKMSEPEAETNGGNLPVTASMKLSGNLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIESSINQPKVVALSNNKKDDAKDADSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTPVDSNSKVRQEDENFNSLLQNGVNLNNSPEEKFKINDKKDFKLPEYDLNIEEQLVLIEKDIDSKATSDDSRQLDHINMNINKLVTNNIFQPEVMERSKMQDIVLGTGFLSIHPKNEAEHIENGAKFPNLESINKVNGLCEDTAPSPGRVEPQKASSSADVGISKSTEDLSPQRSGPTGAVVKSHSITNMETGGLKIYDILGDDGPQPPSAAVKIASAVDGKNIVRSKSATLLYDQPLQVFTAASSSSELLSGTKAVFKFDSNHNPEEPDIIRAATVSGPQSTPHLYGPPQYNVQYSGSATVKDTLWHPKQNPQIDPVSFPPQRLPRSESAENHSYAKHSANMNFSNHNNVRANTGYHLQQRLAPARHGEMWAISPNDRLVPAVTRTTIQRQSSVSSTASVNLGDPTRRTEGDYLSYRELHSMGRTPVMSGSQRPLSARAYSIDGPNTSRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNTRVGSEHSLLDPPGKSKVPHDWREQVLRHIEAKKLEKSMLSRSFNSNLTAVSSSHYGSSRDLHGSQGSLALSVADGRGSGGHIFRHPQTSSPGECCQDDRFMSEEQNHPSGALSHRGLPDSLMKMPLSNGQMGQPLRPQAHYSQTHHPPQASVARHPSREQLIDYLMLKVAHQPPYTHPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFHNAVDLIIVREVSS", "length": 1450, "header": "sp|Q80TH2-2|ERBIN_MOUSE Isoform 2 of Erbin OS=Mus musculus OX=10090 GN=Erbin PE=1 SV=3 CANONICAL=Q80TH2-3" }, "locus": { "chromosome": "13", "start_pos": 104022837, "end_pos": 103957210, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000191275", "url": "https://www.ensembl.org/id/ENSMUST00000191275" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000140536", "url": "https://www.ensembl.org/id/ENSMUSP00000140536" } ] } }, { "isoform_ac": "Q80TH2-3", "url": "", "sequence": { "sequence": "MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLREFWMDGNRLTFIPGFIGSLRQLTYLDVSKNNIEMVEEGISTCENLQDFLLSSNSLQQLPETIGSLKNVTTLKIDENQLMYLPDSIGGLRSIEELDCSFNEIEALPSSIGQLTNMRTFAADHNYLQQLPPEIGNWKNITVLFLHCNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDTETQKMVLTNYMFPQQPRTEDVMFISDNESFNPALWEEQRKQRAQVAFECDEDKDEREAPPREGNLKRYPTPYPDELKNMVKTVQTIVHRLKDEETNEESGRDLKQHEDQQVVNKDKCVKTSESTTTKSKLDEREKYMNSVQKMSEPEAETNGGNLPVTASMKLSGNLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIESSINQPKVVALSNNKKDDAKDADSLSDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTPVDSNSKVRQEDENFNSLLQNGVNLNNSPEEKFKINDKKDFKLPEYDLNIEEQLVLIEKDIDSKATSDDSRQLDHINMNINKLVTNNIFQPEVMERSKMQDIVLGTGFLSIHPKNEAEHIENGAKFPNLESINKVNGLCEDTAPSPGRVEPQKASSSADVGISKSTEDLSPQRSGPTGAVVKSHSITNMETGGLKIYDILGDDGPQPPSAAVKIASAVDGKNIVRSKSATLLYDQPLQVFTAASSSSELLSGTKAVFKFDSNHNPEEPDIIRAATVSGPQSTPHLYGPPQYNVQYSGSATVKDTLWHPKQNPQIDPVSFPPQRLPRSESAENHSYAKHSANMNFSNHNNVRANTGYHLQQRLAPARHGEMWAISPNDRLVPAVTRTTIQRQSSVSSTASVNLGDPTRRTEGDYLSYRELHSMGRTPVMSGSQRPLSARAYSIDGPNTSRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNTRVGSEHSLLDPPGKSKVPHDWREQVLRHIEAKKLEKHPQTSSPGECCQDDRFMSEEQNHPSGALSHRGLPDSLMKMPLSNGQMGQPLRPQAHYSQTHHPPQASVARHPSREQLIDYLMLKVAHQPPYTHPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQPGDKIIQANGYSFINIEHGQAVSLLKTFHNAVDLIIVREVSS", "length": 1402, "header": "sp|Q80TH2-3|ERBIN_MOUSE Isoform 3 of Erbin OS=Mus musculus OX=10090 GN=Erbin PE=1 SV=3 CANONICAL=Q80TH2-3" }, "locus": { "chromosome": "13", "start_pos": 104022837, "end_pos": 103957210, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000091269", "url": "https://www.ensembl.org/id/ENSMUST00000091269" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000088813", "url": "https://www.ensembl.org/id/ENSMUSP00000088813" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1068, "start_aa": "Thr", "end_pos": 1068, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1068", "evidence": [ { "id": "Q80TH2", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q80TH2" }, { "id": "28528544", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28528544" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" }, { "id": "Q80TH2", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q80TH2" }, { "id": "32782141", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32782141" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1093, "start_aa": "Thr", "end_pos": 1093, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1093", "evidence": [ { "id": "Q80TH2", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q80TH2" }, { "id": "32848054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32848054" } ] } ], "phosphorylation": [ { "start_pos": 1097, "end_pos": 1097, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" }, { "database": "PubMed", "id": "17947660", "url": "https://glygen.org/publication/PubMed/17947660" }, { "database": "iPTMnet", "id": "Q80TH2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q80TH2" } ], "site_lbl": "Tyr1097" }, { "start_pos": 1150, "end_pos": 1150, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q80TH2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q80TH2" } ], "site_lbl": "Ser1150" }, { "start_pos": 1171, "end_pos": 1171, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" } ], "site_lbl": "Ser1171" }, { "start_pos": 1276, "end_pos": 1276, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" } ], "site_lbl": "Ser1276" }, { "start_pos": 440, "end_pos": 440, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q80TH2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q80TH2" } ], "site_lbl": "Ser440" }, { "start_pos": 444, "end_pos": 444, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q80TH2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q80TH2" } ], "site_lbl": "Ser444" }, { "start_pos": 483, "end_pos": 483, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q80TH2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q80TH2" } ], "site_lbl": "Tyr483" }, { "start_pos": 485, "end_pos": 485, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" } ], "site_lbl": "Thr485" }, { "start_pos": 595, "end_pos": 595, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q80TH2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q80TH2" } ], "site_lbl": "Ser595" }, { "start_pos": 599, "end_pos": 599, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" }, { "database": "phospho.ELM", "id": "Q80TH2", "url": "http://phospho.elm.eu.org/byAccession/Q80TH2.html" }, { "database": "iPTMnet", "id": "Q80TH2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q80TH2" } ], "site_lbl": "Ser599" }, { "start_pos": 600, "end_pos": 600, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" }, { "database": "phospho.ELM", "id": "Q80TH2", "url": "http://phospho.elm.eu.org/byAccession/Q80TH2.html" }, { "database": "iPTMnet", "id": "Q80TH2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q80TH2" } ], "site_lbl": "Ser600" }, { "start_pos": 617, "end_pos": 617, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" } ], "site_lbl": "Ser617" }, { "start_pos": 712, "end_pos": 712, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" }, { "database": "phospho.ELM", "id": "Q80TH2", "url": "http://phospho.elm.eu.org/byAccession/Q80TH2.html" }, { "database": "iPTMnet", "id": "Q80TH2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q80TH2" } ], "site_lbl": "Ser712" }, { "start_pos": 849, "end_pos": 849, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q80TH2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q80TH2" } ], "site_lbl": "Ser849" }, { "start_pos": 850, "end_pos": 850, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "Q80TH2", "url": "http://phospho.elm.eu.org/byAccession/Q80TH2.html" }, { "database": "iPTMnet", "id": "Q80TH2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q80TH2" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ], "site_lbl": "Thr850" }, { "start_pos": 854, "end_pos": 854, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" }, { "database": "phospho.ELM", "id": "Q80TH2", "url": "http://phospho.elm.eu.org/byAccession/Q80TH2.html" }, { "database": "iPTMnet", "id": "Q80TH2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q80TH2" } ], "site_lbl": "Ser854" }, { "start_pos": 869, "end_pos": 869, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "phospho.ELM", "id": "Q80TH2", "url": "http://phospho.elm.eu.org/byAccession/Q80TH2.html" }, { "database": "iPTMnet", "id": "Q80TH2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q80TH2" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ], "site_lbl": "Ser869" }, { "start_pos": 914, "end_pos": 914, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" } ], "site_lbl": "Thr914" }, { "start_pos": 917, "end_pos": 917, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" } ], "site_lbl": "Tyr917" }, { "start_pos": 928, "end_pos": 928, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" } ], "site_lbl": "Ser928" }, { "start_pos": 970, "end_pos": 970, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" } ], "site_lbl": "Tyr970" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor.", "journal": "Nat. Cell Biol.", "date": "2000", "authors": "Borg JP, Marchetto S, Le Bivic A, Ollendorff V, Jaulin-Bastard F, Saito H, Fournier E, Adelaide J, Margolis B, Birnbaum D", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" } ], "reference": [ { "type": "PubMed", "id": "10878805", "url": "https://glygen.org/publication/PubMed/10878805" } ] }, { "title": "A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling.", "journal": "J. Biol. Chem.", "date": "2005", "authors": "McDonald C, Chen FF, Ollendorff V, Ogura Y, Marchetto S, Lecine P, Borg JP, Nunez G", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" } ], "reference": [ { "type": "PubMed", "id": "16203728", "url": "https://glygen.org/publication/PubMed/16203728" } ] }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" }, { "database": "iPTMnet", "id": "Q80TH2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q80TH2" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] }, { "title": "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2007", "authors": "Cao L, Yu K, Banh C, Nguyen V, Ritz A, Raphael BJ, Kawakami Y, Kawakami T, Salomon AR", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" }, { "database": "iPTMnet", "id": "Q80TH2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q80TH2" } ], "reference": [ { "type": "PubMed", "id": "17947660", "url": "https://glygen.org/publication/PubMed/17947660" } ] }, { "title": "Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes.", "journal": "Circ. Res.", "date": "2008", "authors": "Chen Q., Huang Y., Baye N.L., Healy C.L., Kasinathan S., O'Connell T.D., Wright C.D.", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" } ], "reference": [ { "type": "PubMed", "id": "18802028", "url": "https://glygen.org/publication/PubMed/18802028" } ] }, { "title": "The phagosomal proteome in interferon-gamma-activated macrophages.", "journal": "Immunity", "date": "2009", "authors": "Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" }, { "database": "iPTMnet", "id": "Q80TH2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q80TH2" } ], "reference": [ { "type": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q80TH2", "url": "https://www.uniprot.org/uniprot/Q80TH2" }, { "database": "iPTMnet", "id": "Q80TH2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q80TH2" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse.", "journal": "Molecular & cellular proteomics : MCP", "date": "2012", "authors": "Trinidad JC, Barkan DT, Gulledge BF, Thalhammer A, Sali A, Schoepfer R, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q80TH2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q80TH2" } ], "reference": [ { "type": "PubMed", "id": "22645316", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "title": "Erbin is a novel substrate of the Sag-betaTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis.", "journal": "The Journal of cell biology", "date": "2015", "authors": "Xie CM, Wei D, Zhao L, Marchetto S, Mei L, Borg JP, Sun Y", "evidence": [ { "database": "RefSeq", "id": "NP_001005868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005868" } ], "reference": [ { "type": "PubMed", "id": "26056141", "url": "https://glygen.org/publication/PubMed/26056141" } ] }, { "title": "The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8.", "journal": "Journal of the American Chemical Society", "date": "2017", "authors": "Chuh KN, Batt AR, Zaro BW, Darabedian N, Marotta NP, Brennan CK, Amirhekmat A, Pratt MR", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q80TH2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q80TH2" } ], "reference": [ { "type": "PubMed", "id": "28528544", "url": "https://glygen.org/publication/PubMed/28528544" } ] }, { "title": "Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer.", "journal": "Cancer research", "date": "2018", "authors": "Stevens PD, Wen YA, Xiong X, Zaytseva YY, Li AT, Wang C, Stevens AT, Farmer TN, Gan T, Weiss HL, Inagaki M, Marchetto S, Borg JP, Gao T", "evidence": [ { "database": "RefSeq", "id": "NP_001005868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005868" } ], "reference": [ { "type": "PubMed", "id": "29980571", "url": "https://glygen.org/publication/PubMed/29980571" } ] }, { "title": "Cytosolic N-GlcNAc proteins are formed by the action of endo-beta-N-acetylglucosaminidase.", "journal": "Biochemical and biophysical research communications", "date": "2020", "authors": "Maynard JC, Fujihira H, Dolgonos GE, Suzuki T, Burlingame AL", "evidence": [ { 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"date": "2023-02-27", "authors": "Hao Yi, Li Xiang, Qin Ke, Shi Yujie, He Yanwen, Zhang Che, Cheng Bo, Zhang Xiwen, Hu Guangyu, Liang Shuyu, Tang Qi, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q80TH2", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q80TH2" } ], "reference": [ { "type": "PubMed", "id": "36852467", "url": "https://glygen.org/publication/PubMed/36852467" } ] }, { "title": "Knockout of Erbin promotes pyroptosis via regulating NLRP3/caspase-1/Gasdermin D pathway in sepsis-induced acute kidney injury.", "journal": "Clinical and experimental nephrology", "date": "2023-09", "authors": "Liu Yuping, Fang Qing, Ming Tingqian, Zuo Jing, Jing Guoqing, Song Xuemin", "evidence": [ { "database": "RefSeq", "id": "NP_001005868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005868" } ], "reference": [ { "type": "PubMed", "id": "37310569", "url": "https://glygen.org/publication/PubMed/37310569" } ] } ], "pathway": [ { "id": "mmu:59079", "name": 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