{ "uniprot_canonical_ac": "Q7TNC9-1", "uniprot_ac": "Q7TNC9", "uniprot_id": "I5P1_MOUSE", "mass": { "chemical_mass": 47622.0, "monoisotopic_mass": 47622.0 }, "refseq": { "ac": "NP_898967", "name": "inositol polyphosphate-5-phosphatase A isoform b", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898967" }, "gene_names": [ { "name": "Inpp5a", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q7TNC9", "id": "Q7TNC9" }, { "name": "Inpp5a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898967", "id": "NP_898967" } ], "protein_names": [ { "name": "Inositol polyphosphate-5-phosphatase A", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q7TNC9" }, { "name": "3.1.3.56", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q7TNC9" }, { "name": "5PTase; type I inositol 1,4,5-trisphosphate 5-phosphatase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898967", "id": "NP_898967" }, { "name": "5PTase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q7TNC9" }, { "name": "Type I inositol 1,4,5-trisphosphate 5-phosphatase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q7TNC9" }, { "name": "inositol polyphosphate-5-phosphatase A isoform b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898967", "id": "NP_898967" } ], "function": [ { "annotation": "A novel microduplication in INPP5A segregates with schizophrenia spectrum disorder in the family of a patient with both childhood onset schizophrenia and autism spectrum disorder.", "evidence": [ { "database": "RefSeq", "id": "NP_898967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898967" }, { "database": "PubMed", "id": "33720513", "url": "https://glygen.org/publication/PubMed/33720513" } ] }, { "annotation": "Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:26051944). Plays a crucial role in the survival of cerebellar Purkinje cells (PubMed:26051944).", "evidence": [ { "database": "UniProtKB", "id": "Q7TNC9", "url": "https://www.uniprot.org/uniprot/Q7TNC9#function" }, { "database": "PubMed", "id": "26051944", "url": "https://glygen.org/publication/PubMed/26051944" } ] }, { "annotation": "Using SCA17 knock-in mice that endogenously express mutant TATA box-binding protein (TBP), study found that Inpp5a, a protein that is highly abundant in the cerebellum and functions as a terminator of the inositol 1,4,5-trisphosphate (IP3) second messenger, is downregulated. This was caused by the abnormal binding of mutant TBP to the transcription factor SP1, leading to reduced Inpp5a transcription. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_898967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898967" }, { "database": "PubMed", "id": "32107387", "url": "https://glygen.org/publication/PubMed/32107387" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q7TNC9", "url": "https://www.uniprot.org/uniprot/Q7TNC9" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Inpp5a", "url": "https://www.uniprot.org/uniprot/Q7TNC9", "locus": { "chromosome": "7", "start_pos": 139159568, "end_pos": 138969025, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000025477", "url": "https://www.ensembl.org/id/ENSMUSG00000025477" } ] } } ], "crossref": [ { "id": "ENSMUSG00000025477", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000025477", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09092", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09092", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "212111", "url": "https://www.ncbi.nlm.nih.gov/gene/212111", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000300", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000300", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036691", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036691", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039737", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039737", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:212111", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:212111", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2686961", "url": "http://www.informatics.jax.org/marker/MGI:2686961", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "GDHKPVM", "url": "https://omabrowser.org/oma/group/GDHKPVM/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2898734at2759", "url": "http://www.orthodb.org/?query=2898734at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12997", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12997", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12997:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12997:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03372", "url": "http://pfam.xfam.org/family/PF03372", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q7TNC9", "url": "http://purl.obolibrary.org/obo/PR_Q7TNC9", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-1855183", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855183", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_898967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898967", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11392", "url": "https://www.rhea-db.org/rhea/11392", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "19797", "url": "https://www.rhea-db.org/rhea/19797", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q3TZT4", "url": "https://www.uniprot.org/uniprot/Q3TZT4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q3TZT4-1", "url": "https://www.uniprot.org/uniprot/Q3TZT4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7TNC9", "url": "https://www.uniprot.org/uniprot/Q7TNC9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7TNC9-1", "url": "https://www.uniprot.org/uniprot/Q7TNC9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7TNC9-2", "url": "https://www.uniprot.org/uniprot/Q7TNC9-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVLHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYKKVTGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGVRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVVLQLEKKLFDYFNQDVFRDNNGTALLEFDKELSVFKDRLYELDISFPPSYPYSEDSSQGEQYMNTRCPAWCDRILMSLSAKELVLKSESEEKVATYDHIGPNVCMGDHKPVFLAFRIAPGAGKPHAHVHKCCVVQ", "length": 412, "header": "sp|Q7TNC9-1|I5P1_MOUSE Isoform 1 of Inositol polyphosphate-5-phosphatase A OS=Mus musculus OX=10090 GN=Inpp5a PE=1 SV=1 CANONICAL=Q7TNC9-1" }, "isoforms": [ { "isoform_ac": "Q3TZT4-1", "url": "", "sequence": { "sequence": "MQGLWGLPDQLGVTFHVLLLCLSRKTWPGESMLPENLQKNWLREFYQVLHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYKKVTGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGVRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVVLQLEKKLFDYFNQDVFRDNNGTALLEFDKELSVFKDRLYELDISFPPSYPYSEDSSQGEQYMNTRCPAWCDRILMSLSAKELVLKSESEEKVATYDHIGPNVCMGDHKPVFLAFRIAPGAGKPHAHVHKCCVVQ", "length": 420, "header": "tr|Q3TZT4-1|I5P1_MOUSE Computationally mapped isoform of Inositol polyphosphate-5-phosphatase A OS=Mus musculus OX=10090 GN=Inpp5a PE=1 SV=1 CANONICAL=Q7TNC9-1" }, "locus": { "chromosome": "7", "start_pos": 139158175, "end_pos": 138980564, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000097975.3", "url": "https://www.ensembl.org/id/ENSMUST00000097975.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000095589.3", "url": "https://www.ensembl.org/id/ENSMUSP00000095589.3" } ] } }, { "isoform_ac": "Q7TNC9-1", "url": "", "sequence": { "sequence": "MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVLHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYKKVTGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGVRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVVLQLEKKLFDYFNQDVFRDNNGTALLEFDKELSVFKDRLYELDISFPPSYPYSEDSSQGEQYMNTRCPAWCDRILMSLSAKELVLKSESEEKVATYDHIGPNVCMGDHKPVFLAFRIAPGAGKPHAHVHKCCVVQ", "length": 412, "header": "sp|Q7TNC9-1|I5P1_MOUSE Isoform 1 of Inositol polyphosphate-5-phosphatase A OS=Mus musculus OX=10090 GN=Inpp5a PE=1 SV=1 CANONICAL=Q7TNC9-1" }, "locus": { "chromosome": "7", "start_pos": 139158175, "end_pos": 138969306, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000106098", "url": "https://www.ensembl.org/id/ENSMUST00000106098" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000101704", "url": "https://www.ensembl.org/id/ENSMUSP00000101704" } ] } }, { "isoform_ac": "Q7TNC9-2", "url": "", "sequence": { "sequence": "MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVLHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYKKVTGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGVRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVVLQLEKKLFDYFNQDVFRDNNGTALLEFDKELSVFKDRLYELDISFPPSYPYSEDSSQGEQYMNTRCPAWCDRILMSLSAKELVLKSESEEKVATYDHIGPNVCMGDHKPVFLAFRIAPGAGKRCQRRERILERPPCSSVSNSSS", "length": 422, "header": "sp|Q7TNC9-2|I5P1_MOUSE Isoform 2 of Inositol polyphosphate-5-phosphatase A OS=Mus musculus OX=10090 GN=Inpp5a PE=1 SV=1 CANONICAL=Q7TNC9-1" }, "locus": { "chromosome": "7", "start_pos": 139158340, "end_pos": 138969306, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000026550", "url": "https://www.ensembl.org/id/ENSMUST00000026550" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000026550", "url": "https://www.ensembl.org/id/ENSMUSP00000026550" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Deletion of Inpp5a causes ataxia and cerebellar degeneration in mice.", "journal": "Neurogenetics", "date": "2015", "authors": "Yang AW, Sachs AJ, Nystuen AM", "evidence": [ { "database": "UniProtKB", "id": "Q7TNC9", "url": "https://www.uniprot.org/uniprot/Q7TNC9" } ], "reference": [ { "type": "PubMed", "id": "26051944", "url": "https://glygen.org/publication/PubMed/26051944" } ] }, { "title": "Fam208a orchestrates interaction protein network essential for early embryonic development and cell division.", "journal": "Exp. Cell Res.", "date": "2019", "authors": "Gresakova V, Novosadova V, Prochazkova M, Bhargava S, Jenickova I, Prochazka J, Sedlacek R", "evidence": [ { "database": "UniProtKB", "id": "Q7TNC9", "url": "https://www.uniprot.org/uniprot/Q7TNC9" } ], "reference": [ { "type": "PubMed", "id": "31112734", "url": "https://glygen.org/publication/PubMed/31112734" } ] }, { "title": "Cerebellum-enriched protein INPP5A contributes to selective neuropathology in mouse model of spinocerebellar ataxias type 17.", "journal": "Nature communications", "date": "2020", "authors": "Liu Q, Huang S, Yin P, Yang S, Zhang J, Jing L, Cheng S, Tang B, Li XJ, Pan Y, Li S", "evidence": [ { "database": "RefSeq", "id": "NP_898967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898967" } ], "reference": [ { "type": "PubMed", "id": "32107387", "url": "https://glygen.org/publication/PubMed/32107387" } ] }, { "title": "A novel microduplication in INPP5A segregates with schizophrenia spectrum disorder in the family of a patient with both childhood onset schizophrenia and autism spectrum disorder.", "journal": "American journal of medical genetics. Part A", "date": "2021", "authors": "Fernandez A, Drozd M, Thummler S, Bardoni B, Askenazy F, Capovilla M", "evidence": [ { "database": "RefSeq", "id": "NP_898967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898967" } ], "reference": [ { "type": "PubMed", "id": "33720513", "url": "https://glygen.org/publication/PubMed/33720513" } ] } ], "pathway": [ { "id": "mmu:212111", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:212111", "resource": "KEGG Pathway" }, { "id": "R-MMU-1855183", "name": "Synthesis of IP2, IP, and Ins in the cytosol", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855183", "resource": "Reactome", "description": "Synthesis of IP2, IP, and Ins in the cytosol" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZZX1-1", "protein_name": "Inositol polyphosphate-5-phosphatase A", "gene_name": "Inpp5a", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVLHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYKKVTGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGVRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVVLQLEKKLFDYFNQDVFRDNNGTALLEFDKELSVFKDRLYELDISFPPSYPYSEDSSQGEQYMNTRCPAWCDRILMSLSAKELVLKSESEEKVATYDHIGPNVCMGDHKPVFLAFRIAPGAGKPHAHVHKCCVVQ", "length": 412 }, "evidence": [ { "id": "Q7TNC9", "url": "https://omabrowser.org/oma/group/Q7TNC9/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q14642-1", "protein_name": "Inositol polyphosphate-5-phosphatase A", "gene_name": "INPP5A", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGTALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKELVLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ", "length": 412 }, "evidence": [ { "id": "45241626", "url": "http://www.informatics.jax.org/homology/45241626", "database": "MGI" }, { "id": "Q7TNC9", "url": "https://omabrowser.org/oma/group/Q7TNC9/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q7TNC9", "url": "https://www.uniprot.org/uniprot/Q7TNC9" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q7TNC9", "url": "https://www.uniprot.org/uniprot/Q7TNC9" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "Q7TNC9", "url": "https://www.uniprot.org/uniprot/Q7TNC9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "phosphatidylinositol-mediated signaling", "id": "GO:0048015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048015", "evidence": [ { "database": "UniProtKB", "id": "Q7TNC9", "url": "https://www.uniprot.org/uniprot/Q7TNC9" } ], "pmid": "" }, { "name": "phosphatidylinositol dephosphorylation", "id": "GO:0046856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046856", "evidence": [ { "database": "UniProtKB", "id": "Q7TNC9", "url": "https://www.uniprot.org/uniprot/Q7TNC9" } ], "pmid": "" }, { "name": "inositol phosphate-mediated signaling", "id": "GO:0048016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048016", "evidence": [ { "database": "UniProtKB", "id": "Q7TNC9", "url": "https://www.uniprot.org/uniprot/Q7TNC9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "PH domain binding", "id": "GO:0042731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042731", "evidence": [ { "database": "UniProtKB", "id": "Q7TNC9", "url": "https://www.uniprot.org/uniprot/Q7TNC9" } ], "pmid": "" }, { "name": "inositol-polyphosphate 5-phosphatase activity", "id": "GO:0004445", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004445", "evidence": [ { "database": "UniProtKB", "id": "Q7TNC9", "url": "https://www.uniprot.org/uniprot/Q7TNC9" } ], "pmid": "" }, { "name": "inositol-1,4,5-trisphosphate 5-phosphatase activity", "id": "GO:0052658", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052658", "evidence": [ { "database": "UniProtKB", "id": "Q7TNC9", "url": "https://www.uniprot.org/uniprot/Q7TNC9" } ], "pmid": "" }, { "name": "inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity", "id": "GO:0052659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052659", "evidence": [ { "database": "UniProtKB", "id": "Q7TNC9", "url": "https://www.uniprot.org/uniprot/Q7TNC9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Isoprenylation at Cys-409 is required for localization at the membrane.", "evidence": [ { "database": "UniProtKB", "id": "Q7TNC9", "url": "https://www.uniprot.org/uniprot/Q7TNC9" }, { "database": "PubMed", "id": "Q14642", "url": "https://glygen.org/publication/PubMed/Q14642" } ] } ], "interactions": [], "reactions": [ { "id": "11392", "name": "", "equation": "1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZGS3-1", "Q9JMC1-1", "P97573-1", "D3ZZX1-1", "Q9BT40-1", "Q14642-1", "Q01968-1", "Q92835-1", "Q15735-1", "Q8C5L6-1", "Q6NVF0-1", "P59644-1", "Q9ES52-1", "Q7TNC9-1" ], "evidence": [ { "id": "11392", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11392" } ] }, { "id": "19797", "name": "", "equation": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZGS3-1", "Q9JMC1-1", "D3ZZX1-1", "Q9BT40-1", "Q14642-1", "Q01968-1", "Q15735-1", "Q8C5L6-1", "Q6NVF0-1", "P59644-1", "Q7TNC9-1" ], "evidence": [ { "id": "19797", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19797" } ] }, { "id": "R-MMU-1855222", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K337-1", "Q7TNC9-1" ], "evidence": [ { "id": "R-MMU-1855222", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855222" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "D3ZGS3", "gene_name": "Ocrl", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] }, { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] } ] }, { "uniprot_ac": "D3ZZX1", "gene_name": "Inpp5a", "activity": [ { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "D3ZZX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZX1" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "D3ZZX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZX1" } ] } ] }, { "uniprot_ac": "P59644", "gene_name": "Inpp5j", "activity": [ { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "P59644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59644" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "P59644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59644" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "P59644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59644" } ] } ] }, { "uniprot_ac": "P97573", "gene_name": "Inpp5d", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] } ] }, { "uniprot_ac": "Q01968", "gene_name": "OCRL", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "Q01968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01968" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q01968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01968" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q01968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01968" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "Q01968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01968" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q01968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01968" } ] } ] }, { "uniprot_ac": "Q14642", "gene_name": "INPP5A", "activity": [ { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q14642", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14642" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "Q14642", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14642" } ] } ] }, { "uniprot_ac": "Q15735", "gene_name": "INPP5J", "activity": [ { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q15735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15735" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q15735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15735" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q15735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15735" } ] } ] }, { "uniprot_ac": "Q6NVF0", "gene_name": "Ocrl", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "Q6NVF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NVF0" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q6NVF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NVF0" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q6NVF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NVF0" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q6NVF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NVF0" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "Q6NVF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NVF0" } ] } ] }, { "uniprot_ac": "Q7TNC9", "gene_name": "Inpp5a", "activity": [ { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q7TNC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TNC9" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "Q7TNC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TNC9" } ] } ] }, { "uniprot_ac": "Q8C5L6", "gene_name": "Inpp5k", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "Q8C5L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C5L6" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q8C5L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C5L6" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q8C5L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C5L6" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "Q8C5L6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C5L6" } ] } ] }, { "uniprot_ac": "Q8K337", "gene_name": "Inpp5b", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q8K337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K337" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q8K337", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K337" } ] } ] }, { "uniprot_ac": "Q92835", "gene_name": "INPP5D", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "Q92835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92835" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q92835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92835" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q92835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92835" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "Q92835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92835" } ] } ] }, { "uniprot_ac": 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"activity": "", "evidence": [ { "id": "Q9JMC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JMC1" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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