{
    "uniprot_canonical_ac": "Q7TMV1-1",
    "uniprot_ac": "Q7TMV1",
    "uniprot_id": "RN139_MOUSE",
    "mass": {
        "chemical_mass": 76185.0,
        "monoisotopic_mass": 76185.0
    },
    "refseq": {
        "ac": "NP_780435",
        "name": "E3 ubiquitin-protein ligase RNF139",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780435"
    },
    "gene_names": [
        {
            "name": "Rnf139",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q7TMV1",
            "id": "Q7TMV1"
        },
        {
            "name": "4930555P18Rik",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780435",
            "id": "NP_780435"
        },
        {
            "name": "Rnf139",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780435",
            "id": "NP_780435"
        }
    ],
    "protein_names": [
        {
            "name": "E3 ubiquitin-protein ligase RNF139",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q7TMV1"
        },
        {
            "name": "2.3.2.27",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q7TMV1"
        },
        {
            "name": "E3 ubiquitin-protein ligase RNF139",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780435",
            "id": "NP_780435"
        },
        {
            "name": "RING finger protein 139",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q7TMV1"
        },
        {
            "name": "RING-type E3 ubiquitin transferase RNF139",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q7TMV1"
        },
        {
            "name": "Translocation in renal carcinoma on chromosome 8 protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q7TMV1"
        },
        {
            "name": "translocation in renal carcinoma on chromosome 8 protein; RING-type E3 ubiquitin transferase RNF139",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780435",
            "id": "NP_780435"
        }
    ],
    "function": [
        {
            "annotation": "E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Involved in the sterol-accelerated degradation of HMGCR. This is achieved through binding to INSIG1 and/or INSIG2 at the ER membrane. In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q7TMV1",
                    "url": "https://www.uniprot.org/uniprot/Q7TMV1#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q8WU17",
                    "url": "https://www.uniprot.org/uniprot/Q8WU17#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:4450",
            "recommended_name": {
                "id": "DOID:4450",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:4450",
                "name": "renal cell carcinoma",
                "description": "A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney."
            },
            "synonyms": [
                {
                    "id": "DOID:4450",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4450",
                    "name": "RCC",
                    "description": ""
                },
                {
                    "id": "DOID:4450",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4450",
                    "name": "adenocarcinoma of kidney",
                    "description": ""
                },
                {
                    "id": "DOID:4450",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4450",
                    "name": "hypernephroma",
                    "description": ""
                },
                {
                    "id": "MONDO:0010456",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010456",
                    "name": "renal cell carcinoma, Xp11-associated",
                    "description": ""
                },
                {
                    "id": "MONDO:0010456",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010456",
                    "name": "renal cell carcinoma, Xp11-associated",
                    "description": ""
                },
                {
                    "id": "MONDO:0010456",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010456",
                    "name": "renal cell carcinoma, papillary, 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010456",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010456",
                    "name": "RCCX1",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "4450",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:4450"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q7TMV1",
                    "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Rnf139",
            "url": "https://www.uniprot.org/uniprot/Q7TMV1",
            "locus": {
                "chromosome": "15",
                "start_pos": 58778906,
                "end_pos": 58761078,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000037075",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000037075"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000037075",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037075",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd16683",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16683",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "75841",
            "url": "https://www.ncbi.nlm.nih.gov/gene/75841",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001841",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011016",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011016",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013083",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR025754",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR025754",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:75841",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:75841",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1923091",
            "url": "http://www.informatics.jax.org/marker/MGI:1923091",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "NGAYTMV",
            "url": "https://omabrowser.org/oma/group/NGAYTMV/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2912447at2759",
            "url": "http://www.orthodb.org/?query=2912447at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR22763",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22763",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR22763:SF163",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22763:SF163",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13639",
            "url": "http://pfam.xfam.org/family/PF13639",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13705",
            "url": "http://pfam.xfam.org/family/PF13705",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q7TMV1",
            "url": "http://purl.obolibrary.org/obo/PR_Q7TMV1",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_780435",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_780435",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0R4J0K8",
            "url": "https://www.uniprot.org/uniprot/A0A0R4J0K8",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0R4J0K8-1",
            "url": "https://www.uniprot.org/uniprot/A0A0R4J0K8-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q7TMV1",
            "url": "https://www.uniprot.org/uniprot/Q7TMV1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q7TMV1-1",
            "url": "https://www.uniprot.org/uniprot/Q7TMV1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAAVGPPQQQVRMAQQQVWAALEVALRVPCLYIIDAIFNSYYDSSQSRFCIGLQIFLRLLGIVVSSIVLILSQRSLFKFYMYSSAFLLAATSVLVNYYAALHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYVTLLQIQSIYSQLMILNILVPIIGLITELPLHIRETVVLMSSLILIFNTVLVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRITTQATVLMYILRMANETESFFISWDDFWDVICNLIISGCDSTLTVLGMSAVISSIAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFHRHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYFVRSTGNIIEFIFGVVMFGNGAYTMMFESGSKIRACMMCLHAYFNIYLQVKNGWKTFMNRRTAVKKINSLPEIKGSHLQEIDDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDEIKDNSNASNNNGFIAPNENPNPEEALREDAAGSDRELNEDDSTDCDDDAQRERNGGIQHTGAAAAAAEFNDDTD",
        "length": 668,
        "header": "sp|Q7TMV1-1|RN139_MOUSE Isoform 1 of E3 ubiquitin-protein ligase RNF139  OS=Mus musculus OX=10090 GN=Rnf139 PE=1 SV=1 CANONICAL=Q7TMV1-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0R4J0K8-1",
            "url": "",
            "sequence": {
                "sequence": "MAAVGPPQQQVRMAQQQVWAALEVALRVPCLYIIDAIFNSYYDSSQSRFCIGLQIFLRLLGIVVSSIVLILSQRSLFKFYMYSSAFLLAATSVLVNYYAALHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYVTLLQIQSIYSQLMILNILVPIIGLITELPLHIRETVVLMSSLILIFNTVLVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRITAQATVLMYILRMANETESFFISWDDFWDVICNLIISGCDSTLTVLGMSAVISSIAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFHRHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYFVRSTGNIIEFIFGVVMFGNGAYTMMFESGSKIRACMMCLHAYFNIYLQVKNGWKTFMNRRTAVKKINSLPEIKGSHLQEIDDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDEIKDNSNASNNNGFIAPNENPNPEEALREDAAGSDRELNEDDSTDCDDDAQRERNGGIQHTGAAAAAAEFNDDTD",
                "length": 668,
                "header": "tr|A0A0R4J0K8-1|RN139_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase RNF139  OS=Mus musculus OX=10090 GN=Rnf139 PE=1 SV=1 CANONICAL=Q7TMV1-1"
            },
            "locus": {
                "chromosome": "15",
                "start_pos": 58771980,
                "end_pos": 58761163,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000036904.7",
                        "url": "https://www.ensembl.org/id/ENSMUST00000036904.7"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000046467.7",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000046467.7"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q7TMV1-1",
            "url": "",
            "sequence": {
                "sequence": "MAAVGPPQQQVRMAQQQVWAALEVALRVPCLYIIDAIFNSYYDSSQSRFCIGLQIFLRLLGIVVSSIVLILSQRSLFKFYMYSSAFLLAATSVLVNYYAALHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYVTLLQIQSIYSQLMILNILVPIIGLITELPLHIRETVVLMSSLILIFNTVLVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRITTQATVLMYILRMANETESFFISWDDFWDVICNLIISGCDSTLTVLGMSAVISSIAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFHRHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYFVRSTGNIIEFIFGVVMFGNGAYTMMFESGSKIRACMMCLHAYFNIYLQVKNGWKTFMNRRTAVKKINSLPEIKGSHLQEIDDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDEIKDNSNASNNNGFIAPNENPNPEEALREDAAGSDRELNEDDSTDCDDDAQRERNGGIQHTGAAAAAAEFNDDTD",
                "length": 668,
                "header": "sp|Q7TMV1-1|RN139_MOUSE Isoform 1 of E3 ubiquitin-protein ligase RNF139  OS=Mus musculus OX=10090 GN=Rnf139 PE=1 SV=1 CANONICAL=Q7TMV1-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 636,
            "end_pos": 636,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q7TMV1",
                    "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                }
            ],
            "site_lbl": "Ser636"
        },
        {
            "start_pos": 637,
            "end_pos": 637,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q7TMV1",
                    "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                }
            ],
            "site_lbl": "Thr637"
        },
        {
            "start_pos": 667,
            "end_pos": 667,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Thr",
            "comment": "Phosphothreonine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q7TMV1",
                    "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "PubMed",
                    "id": "17242355",
                    "url": "https://glygen.org/publication/PubMed/17242355"
                },
                {
                    "database": "phospho.ELM",
                    "id": "Q7TMV1",
                    "url": "http://phospho.elm.eu.org/byAccession/Q7TMV1.html"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q7TMV1",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q7TMV1"
                },
                {
                    "database": "PubMed",
                    "id": "17203969",
                    "url": "https://glygen.org/publication/PubMed/17203969"
                }
            ],
            "site_lbl": "Thr667"
        }
    ],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.",
            "journal": "Journal of proteome research",
            "date": "2007",
            "authors": "Dai J, Jin WH, Sheng QH, Shieh CH, Wu JR, Zeng R",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q7TMV1",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q7TMV1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17203969",
                    "url": "https://glygen.org/publication/PubMed/17203969"
                }
            ]
        },
        {
            "title": "Large-scale phosphorylation analysis of mouse liver.",
            "journal": "Proceedings of the National Academy of Sciences of the United States of America",
            "date": "2007",
            "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q7TMV1",
                    "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A0R4J0K8",
                    "url": "https://www.uniprot.org/uniprot/A0A0R4J0K8"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q7TMV1",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q7TMV1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17242355",
                    "url": "https://glygen.org/publication/PubMed/17242355"
                }
            ]
        },
        {
            "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.",
            "journal": "Cell",
            "date": "2010",
            "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q7TMV1",
                    "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q7TMV1",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q7TMV1"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:75841",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:75841",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "M0RCM9-1",
            "protein_name": "Ring finger protein 139",
            "gene_name": "Rnf139",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MAQQQVWAALEVALRVPCLYIIDAIFNSYYDSSQSRFCIGLQIFLRLLGIVVSSIVLILSQRSLFKFYMYSSAFLLAATSVLVNYYAALHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYVTLLHIQSIYSQLIILNILVPVIGLITELPLHIRETLVFMSSLILIFNTMLVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRITAQATVLMYILRMANETESFLISWDDFWDIICNLIISGCDSTLTVLGMSAVISSIAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFHRHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYFVRSTGNIIEFIFGVVMFGNGAYTMMFESGSKIRACMMCLHAYFNIYLQVKNGWKTFMNRRTAVKKINSLPEIKGSHLQEIDDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDDIKDNSNVSNNNGFIAPNENQNPEEALREDAAGSDREMNEDDSTDCDDDIQRERNGGIQHTGAAAAAAEFNDDTD",
                "length": 656
            },
            "evidence": [
                {
                    "id": "45234673",
                    "url": "http://www.informatics.jax.org/homology/45234673",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q8WU17-1",
            "protein_name": "E3 ubiquitin-protein ligase RNF139",
            "gene_name": "RNF139",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAAVGPPQQQVRMAHQQVWAALEVALRVPCLYIIDAIFNSYPDSSQSRFCIVLQIFLRLFGVFASSIVLILSQRSLFKFYTYSSAFLLAATSVLVNYYASLHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYVTLLQIHSIYSQLIILDLLVPVIGLITELPLHIRETLLFTSSLILTLNTVFVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRVTAQATVLMYILRMANETDSFFISWDDFWDLICNLIISGCDSTLTVLGMSAVISSVAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFRRHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYYVRSTGSIIEFIFGVVMFGNGAYTMMFESGSKIRAFMMCLHAYFNIYLQAKNGWKTFMNRRTAVKKINSLPEIKGSRLQEINDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDDIKDNSNVSNNNGFIPPNETPEEAVREAAAESDRELNEDDSTDCDDDVQRERNGVIQHTGAAAEEFNDDTD",
                "length": 664
            },
            "evidence": [
                {
                    "id": "45234673",
                    "url": "http://www.informatics.jax.org/homology/45234673",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 8,
                "go_terms": [
                    {
                        "name": "regulation of ER to Golgi vesicle-mediated transport",
                        "id": "GO:0060628",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060628",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7TMV1",
                                "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of cell population proliferation",
                        "id": "GO:0008285",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7TMV1",
                                "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein ubiquitination",
                        "id": "GO:0016567",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7TMV1",
                                "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of translation",
                        "id": "GO:0017148",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017148",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7TMV1",
                                "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ERAD pathway",
                        "id": "GO:0036503",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036503",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7TMV1",
                                "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein destabilization",
                        "id": "GO:0031648",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031648",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7TMV1",
                                "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of ubiquitin-dependent protein catabolic process",
                        "id": "GO:2000060",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000060",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7TMV1",
                                "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of protein processing",
                        "id": "GO:0070613",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070613",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7TMV1",
                                "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 5,
                "go_terms": [
                    {
                        "name": "protease binding",
                        "id": "GO:0002020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7TMV1",
                                "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "zinc ion binding",
                        "id": "GO:0008270",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7TMV1",
                                "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin protein ligase activity",
                        "id": "GO:0061630",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7TMV1",
                                "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin-like protein transferase activity",
                        "id": "GO:0019787",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019787",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7TMV1",
                                "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin-protein transferase activity",
                        "id": "GO:0004842",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7TMV1",
                                "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "Derlin-1 retrotranslocation complex",
                        "id": "GO:0036513",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036513",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7TMV1",
                                "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum",
                        "id": "GO:0005783",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7TMV1",
                                "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endomembrane system",
                        "id": "GO:0012505",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7TMV1",
                                "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 110,
            "end_pos": 112,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 261,
            "end_pos": 263,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 600,
            "end_pos": 602,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [
        {
            "annotation": "Autoubiquitinated. Ubiquitination is induced by sterol and leads to ist degradation via the ubiquitin-proteasome pathway.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q7TMV1",
                    "url": "https://www.uniprot.org/uniprot/Q7TMV1"
                },
                {
                    "database": "PubMed",
                    "id": "Q8WU17",
                    "url": "https://glygen.org/publication/PubMed/Q8WU17"
                }
            ]
        }
    ],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
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}