{ "uniprot_canonical_ac": "Q7KWX2-1", "uniprot_ac": "Q7KWX2", "uniprot_id": "PGPS1_DICDI", "mass": { "chemical_mass": 65509.0, "monoisotopic_mass": 65509.0 }, "refseq": { "ac": "XP_642872", "name": "phosphatidylglycerophosphate synthase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_642872" }, "gene_names": [ { "name": "pgs1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q7KWX2", "id": "Q7KWX2" }, { "name": "DDB_G0277037", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q7KWX2", "id": "Q7KWX2" }, { "name": "pgs1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_642872", "id": "XP_642872" } ], "protein_names": [ { "name": "Probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q7KWX2" }, { "name": "2.7.8.5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q7KWX2" }, { "name": "PGP synthase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q7KWX2" }, { "name": "Phosphatidylglycerophosphate synthase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q7KWX2" }, { "name": "phosphatidylglycerophosphate synthase 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_642872", "id": "XP_642872" } ], "function": [ { "annotation": "Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.", "evidence": [ { "database": "UniProtKB", "id": "Q7KWX2", "url": "https://www.uniprot.org/uniprot/Q7KWX2#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "Q7KWX2", "url": "https://www.uniprot.org/uniprot/Q7KWX2" } ], "common_name": "Dictyostelium discoideum" } ], "gene": 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"https://www.ebi.ac.uk/interpro/entry/IPR025202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0277037", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0277037", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "ADFYAQF", "url": "https://omabrowser.org/oma/group/ADFYAQF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR12586", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12586", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12586:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12586:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13091", "url": "http://pfam.xfam.org/family/PF13091", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q7KWX2", "url": "http://purl.obolibrary.org/obo/PR_Q7KWX2", "database": "PRO", "categories": [ "Protein" ] }, { "id": "XP_642872", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_642872", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "12593", "url": "https://www.rhea-db.org/rhea/12593", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q7KWX2", "url": "https://www.uniprot.org/uniprot/Q7KWX2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7KWX2-1", "url": "https://www.uniprot.org/uniprot/Q7KWX2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIKRALAPIVQPQRLFAALMVIGGGGRSATTTTTTTTKACGNGSSQSPPSTPLLSSKSSTITSNKKSAIPSSHLYIPKKSTLDSRQIGNYSREYSTSSSSSSKKSIFNDTYLNDLFWQLSSQGPAFEVNPNNIDFIQEPIDFYNHLIDGVKRSKKRITMASLYLGTSKQEIELVKEMKLAMERNKELKIHILLDGLRGTRIGLDKESSATILGELLSLYSDRVTISMYHTPDLNGILKKVLPPRINETIGVQHIKTYIFDDDLLLSGANLSKDYFTNRQDRYVLIRSTSTVSNYFNEIVEIIGSLSLHVDKDNRNQLLLSSGSIDPVTQSNEFKNLAYTKLSTLLKSHSYYPSNSNSNSSVDSPFDCNNINNGETTWIFPTIQMGPFNIRQDEVVTSHIFESVPNDSKFFITSPYFNLTENYLNLILTGKPKLDIITCSPQANGFYGSKGLSSAVPDCYAIIEKRFLQRVQDTDNGDRISVQEYIRDKWTYHAKGLWIQVKNQQHPSITLIGSPNFGSRSVEKDLEAQIILITQNKQLQQKMENEKNYLWTDTQNANLELFEKRKVSLMVRFLVYIFGNYL", "length": 581, "header": "sp|Q7KWX2-1|PGPS1_DICDI Isoform 1 of Probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase OS=Dictyostelium discoideum OX=44689 GN=pgs1 PE=3 SV=1 CANONICAL=Q7KWX2-1" }, "isoforms": [ { "isoform_ac": "Q7KWX2-1", "url": "", "sequence": { "sequence": "MIKRALAPIVQPQRLFAALMVIGGGGRSATTTTTTTTKACGNGSSQSPPSTPLLSSKSSTITSNKKSAIPSSHLYIPKKSTLDSRQIGNYSREYSTSSSSSSKKSIFNDTYLNDLFWQLSSQGPAFEVNPNNIDFIQEPIDFYNHLIDGVKRSKKRITMASLYLGTSKQEIELVKEMKLAMERNKELKIHILLDGLRGTRIGLDKESSATILGELLSLYSDRVTISMYHTPDLNGILKKVLPPRINETIGVQHIKTYIFDDDLLLSGANLSKDYFTNRQDRYVLIRSTSTVSNYFNEIVEIIGSLSLHVDKDNRNQLLLSSGSIDPVTQSNEFKNLAYTKLSTLLKSHSYYPSNSNSNSSVDSPFDCNNINNGETTWIFPTIQMGPFNIRQDEVVTSHIFESVPNDSKFFITSPYFNLTENYLNLILTGKPKLDIITCSPQANGFYGSKGLSSAVPDCYAIIEKRFLQRVQDTDNGDRISVQEYIRDKWTYHAKGLWIQVKNQQHPSITLIGSPNFGSRSVEKDLEAQIILITQNKQLQQKMENEKNYLWTDTQNANLELFEKRKVSLMVRFLVYIFGNYL", "length": 581, "header": "sp|Q7KWX2-1|PGPS1_DICDI Isoform 1 of Probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase OS=Dictyostelium discoideum OX=44689 GN=pgs1 PE=3 SV=1 CANONICAL=Q7KWX2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.", "journal": "Nature", "date": "2002", "authors": "Gloeckner G., Kumpf K., Lehmann R., Platzer M., Rosenthal A., Bankier A.T., Dear P.H., Szafranski K., Guigo R., Parra G., Noegel A.A., Glockner G., Tunggal B., Abril J.F., Cox E., Eichinger L., Quail M.A., Cox E.C., Baumgart C., Pachebat J.A.", "evidence": [ { "database": "UniProtKB", "id": "Q7KWX2", "url": "https://www.uniprot.org/uniprot/Q7KWX2" } ], "reference": [ { "type": "PubMed", "id": "12097910", "url": "https://glygen.org/publication/PubMed/12097910" } ] }, { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Chen G., Gibbs R.A., Gloeckner G., Hernandez J., Johnson D., Knights A., Lehmann R., Loulseged H., Ma J., Muzny D.M., Oliver K., Platzer M., Rosenthal A., Saito T., Sodergren E., Steffen D., Sugano S., Walker D., Weinstock G., Lu M., Muzny D., Tanaka Y., Song J., Sodergren E.J., Xu Q., Bankier A.T., Barrell B.G., Williams J., Fey P., Nie X., Gibbs R., Dear P.H., Szafranski K., Davies R., Price C., James K., Noegel A.A., Glockner G., Cooper J., Morio T., Davis P., Williams J.G., Kay R.R., Cronin A., Schleicher M., Olsen R., Kummerfeld S., Sharp S., Hauser H., Weinstock G.M., White B., Quiles M., Rost R., Tunggal B., Pain A., Madan Babu M., Madera M., Rivero F., Saunders D., Eichinger L., Sanders M., Kohara Y., Chisholm R.L., Barrell B., Churcher C.M., Hamlin N., Rajandream M.A., Thangavelu M., Quail M.A., Anjard C., Cox E.C., Haydock S., Kuspa A., Loomis W.F., Shaulsky G., Sucgang R., Urushihara H., Bason N., Berriman M., Buchrieser C., Churcher C., Desany B., Farbrother P., Felder M., Gaudet P., Goodhead I., Hall N., Harper D., Hemphill L., James K.D., Just E., Kerhornou A., Konfortov B.A., Lindsay R., Mourier T., Mungall K., Mungall K.L., Pachebat J.A., Pilcher K., Rabbinowitsch E., Simmonds M., Simmonds M.N., Spiegler S., Tivey A., Wardroper A., Winckler T., Woodward J., Woodward J.R., van Driessche N.", "evidence": [ { "database": "UniProtKB", "id": "Q7KWX2", "url": "https://www.uniprot.org/uniprot/Q7KWX2" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] } ], "pathway": [ { "id": "ddi:DDB_G0277037", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0277037", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q7KWX2", "url": "https://www.uniprot.org/uniprot/Q7KWX2" } ], "pmid": "" }, { "name": "CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity", "id": "GO:0008444", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008444", "evidence": [ { "database": "UniProtKB", "id": "Q7KWX2", "url": "https://www.uniprot.org/uniprot/Q7KWX2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q7KWX2", "url": "https://www.uniprot.org/uniprot/Q7KWX2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "phospholipid biosynthetic process", "id": "GO:0008654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008654", "evidence": [ { "database": "UniProtKB", "id": "Q7KWX2", "url": "https://www.uniprot.org/uniprot/Q7KWX2" } ], "pmid": "" }, { "name": "cardiolipin biosynthetic process", "id": "GO:0032049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032049", "evidence": [ { "database": "UniProtKB", "id": "Q7KWX2", "url": "https://www.uniprot.org/uniprot/Q7KWX2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 108, "end_pos": 110, "annotation": "n_glycosylation_sequon" }, { "start_pos": 246, 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