{ "uniprot_canonical_ac": "Q7K4B6-1", "uniprot_ac": "Q7K4B6", "uniprot_id": "TMTC3_DROME", "mass": { "chemical_mass": 105361.0, "monoisotopic_mass": 105361.0 }, "refseq": { "ac": "NP_477246", "name": "transmembrane O-mannosyltransferase targeting cadherins 3, isoform A", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477246" }, "gene_names": [ { "name": "Tmtc3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q7K4B6", "id": "Q7K4B6" }, { "name": "CG4050", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q7K4B6", "id": "Q7K4B6" }, { "name": "Dmel\\CG4050", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q7K4B6", "id": "Q7K4B6" }, { "name": "Dmel_CG4050", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q7K4B6", "id": "Q7K4B6" }, { "name": "Tmtc3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477246", "id": "NP_477246" }, { "name": "anon-DM192; anon-j; CG4050; Dmel\\CG4050", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477246", "id": "NP_477246" }, { "name": "anon-DM192", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q7K4B6", "id": "Q7K4B6" }, { "name": "anon-j", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q7K4B6", "id": "Q7K4B6" } ], "protein_names": [ { "name": "Protein O-mannosyl-transferase Tmtc3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q7K4B6" }, { "name": "2.4.1.109", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q7K4B6" }, { "name": "CG4050-PA; Tmtc3-PA; transmembrane and tetratricopeptide repeat containing 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477246", "id": "NP_477246" }, { "name": "Transmembrane and TPR repeat-containing protein 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q7K4B6" }, { "name": "transmembrane O-mannosyltransferase targeting cadherins 3, isoform A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477246", "id": "NP_477246" } ], "function": [ { "annotation": "Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.", "evidence": [ { "database": "UniProtKB", "id": "E2QCJ5", "url": "https://www.uniprot.org/uniprot/E2QCJ5#function" }, { "database": "UniProtKB", "id": "ARBA00003582", "url": "https://www.uniprot.org/uniprot/ARBA00003582#function" }, { "database": "UniProtKB", "id": "Q7K4B6", "url": "https://www.uniprot.org/uniprot/Q7K4B6#function" }, { "database": "UniProtKB", "id": "Q6ZXV5", "url": "https://www.uniprot.org/uniprot/Q6ZXV5#function" } ] } ], "disease": [ { "disease_id": "DOID:0112233", "recommended_name": { "id": "DOID:0112233", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112233", "name": "lissencephaly 8", "description": "A lissencephaly characterized by delayed psychomotor development, intellectual disability with poor or absent speech, early-onset refractory seizures, and hypotonia that has_material_basis_in homozygous or compound heterozygous mutation in the TMTC3 gene on chromosome 12q21.32." }, "synonyms": [ { "id": "DOID:0112233", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112233", "name": "LIS8", "description": "" }, { "id": "MONDO:0014992", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014992", "name": "lissencephaly 8", "description": "Any lissencephaly (disease) in which the cause of the disease is a mutation in the TMTC3 gene." }, { "id": "MONDO:0014992", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014992", "name": "LIS8", "description": "" }, { "id": "MONDO:0014992", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014992", "name": "TMTC3 lissencephaly (disease)", "description": "" }, { "id": "MONDO:0014992", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014992", "name": "lissencephaly (disease) caused by mutation in TMTC3", "description": "" }, { "id": "MONDO:0014992", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014992", "name": "lissencephaly 8", "description": "" }, { "id": "MONDO:0014992", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014992", "name": "lissencephaly 8; LIS8", "description": "" }, { "id": "MONDO:0014992", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014992", "name": "lissencephaly type 8", "description": "" }, { "id": "MIM:617255", "resource": "MIM", "url": "https://www.omim.org/entry/617255", "name": "Lissencephaly 8", "description": "Lissencephaly 8" } ], "evidence": [ { "id": "0112233", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0112233" } ] }, { "disease_id": "DOID:1826", "recommended_name": { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epilepsy", "description": "A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions." }, "synonyms": [ { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epilepsy syndrome", "description": "" }, { "id": "DOID:1826", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1826", "name": "epileptic syndrome", "description": "" } ], "evidence": [ { "id": "1826", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1826" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q7K4B6", "url": "https://www.uniprot.org/uniprot/Q7K4B6" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "Tmtc3", "url": "https://www.uniprot.org/uniprot/Q7K4B6", "locus": { "chromosome": "2R", "start_pos": 21123735, "end_pos": 21128510, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0020312", "url": "https://www.ensembl.org/id/FBgn0020312" } ] } } ], "crossref": [ { "id": "FBgn0020312", "url": "https://bgee.org/?page=gene&gene_id=FBgn0020312", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FBgn0020312", "url": "https://flybase.org/reports/FBgn0020312", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "37401", "url": "https://www.ncbi.nlm.nih.gov/gene/37401", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013618", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013618", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG4050", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG4050", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "AKACFTR", "url": "https://omabrowser.org/oma/group/AKACFTR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "155869at2759", "url": "http://www.orthodb.org/?query=155869at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44395:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44395:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF08409", "url": "http://pfam.xfam.org/family/PF08409", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13181", "url": "http://pfam.xfam.org/family/PF13181", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13414", "url": "http://pfam.xfam.org/family/PF13414", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13432", "url": "http://pfam.xfam.org/family/PF13432", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q7K4B6", "url": "http://purl.obolibrary.org/obo/PR_Q7K4B6", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_477246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477246", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17377", "url": "https://www.rhea-db.org/rhea/17377", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53396", "url": "https://www.rhea-db.org/rhea/53396", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E2QCJ5", "url": "https://www.uniprot.org/uniprot/E2QCJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E2QCJ5-1", "url": "https://www.uniprot.org/uniprot/E2QCJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7K4B6", "url": "https://www.uniprot.org/uniprot/Q7K4B6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7K4B6-1", "url": "https://www.uniprot.org/uniprot/Q7K4B6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTNPNPGIHQYAPSTLPREREREGATNSPQRNLLEFLCICVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKSYRPLTVLTFRFNYLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSSVSQLNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGCPRRTNWLTLFGCFGSCLLASMLCKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKLANPSGIRRWSSSTLWKRLSFLVGITLTLLVGRVYVMGSQLPIFTRFDNPASAADTPERQLTYGYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLALGAMVAKTCFTRNLALSRTLIMCLGWMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQLQRRGSLSWQRFSQAALAILLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNENADIYYNLGVVFLEQGKSQQAQVYFNKAIELYPEHEQALLNSAILLQELGGEEARRVSRSRLYKVLENDDQNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLKADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIYINHMKDLDEAEKCYRSILHYDPHNTQGLHNLCVVFVERKRLAKAAACLQYAQRLAPAEDYIGRHLQIVLARLQKINKLPESAPERKLAYEDYDPLEFKLPQDRPTHKSRKRS", "length": 926, "header": "sp|Q7K4B6-1|TMTC3_DROME Isoform 1 of Protein O-mannosyl-transferase Tmtc3 OS=Drosophila melanogaster OX=7227 GN=Tmtc3 PE=2 SV=1 CANONICAL=Q7K4B6-1" }, "isoforms": [ { "isoform_ac": "E2QCJ5-1", "url": "", "sequence": { "sequence": "MSTNPNPGIHQYAPSTLPREREREGATNSPQRNLLEFLCICVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKSYRPLTVLTFRFNYLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSSVSQLNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGCPRRTNWLTLFGCFGSCLLASMLCKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKLANPSGIRRWSSSTLWKRLSFLVGITLTLLVGRVYVMGSQLPIFTRFDNPASAADTPERQLTYGYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLALGAMVAKTCFTRNLALSRTLIMCLGWMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQLQRRGSLSWQRFSQAALAILLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNENADIYYNLGVVFLEQGKSQQAQVYFNKAIELYPEHEQALLNSAILLQELGGEEARRVSRSRLYKVLENDDQNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLKADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIYINHMKDLDEAEKCYRSILHYDPHNTQGLHNLCVVFVERKRLAKAAACLQYAQRLAPAEDYIGRHLQIVLARLQKINKLPESAPERKLAYEDYDPLEFKLPQDRPTHKSRKRS", "length": 926, "header": "tr|E2QCJ5-1|TMTC3_DROME Computationally mapped isoform of Protein O-mannosyl-transferase Tmtc3 OS=Drosophila melanogaster OX=7227 GN=Tmtc3 PE=2 SV=1 CANONICAL=Q7K4B6-1" }, "locus": { "chromosome": "2R", "start_pos": 21127019, "end_pos": 21124121, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0071637", "url": "https://www.ensembl.org/id/FBtr0071637" }, { "database": "Ensembl Peptide", "id": "FBpp0071560", "url": "https://www.ensembl.org/id/FBpp0071560" } ] } }, { "isoform_ac": "Q7K4B6-1", "url": "", "sequence": { "sequence": "MSTNPNPGIHQYAPSTLPREREREGATNSPQRNLLEFLCICVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKSYRPLTVLTFRFNYLLHALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSSVSQLNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSVGDSGCPRRTNWLTLFGCFGSCLLASMLCKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKLANPSGIRRWSSSTLWKRLSFLVGITLTLLVGRVYVMGSQLPIFTRFDNPASAADTPERQLTYGYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRNITTLLTFLALGAMVAKTCFTRNLALSRTLIMCLGWMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQLQRRGSLSWQRFSQAALAILLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALENEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHARIAPNHLNVFINLANLIAKNQTRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYEQALLYDNENADIYYNLGVVFLEQGKSQQAQVYFNKAIELYPEHEQALLNSAILLQELGGEEARRVSRSRLYKVLENDDQNEKVYFNLGMLAMDESSFDEAEQFFKRAIHLKADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPSHVKGLILLGDIYINHMKDLDEAEKCYRSILHYDPHNTQGLHNLCVVFVERKRLAKAAACLQYAQRLAPAEDYIGRHLQIVLARLQKINKLPESAPERKLAYEDYDPLEFKLPQDRPTHKSRKRS", "length": 926, "header": "sp|Q7K4B6-1|TMTC3_DROME Isoform 1 of Protein O-mannosyl-transferase Tmtc3 OS=Drosophila melanogaster OX=7227 GN=Tmtc3 PE=2 SV=1 CANONICAL=Q7K4B6-1" }, "locus": { "chromosome": "2R", "start_pos": 21127019, "end_pos": 21124121, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0071637", "url": "https://www.ensembl.org/id/FBtr0071637" }, { "database": "Ensembl Peptide", "id": "FBpp0071560", "url": "https://www.ensembl.org/id/FBpp0071560" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 609, "start_aa": "Asn", "end_pos": 609, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn609", "evidence": [ { "id": "Q7K4B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7K4B6#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 645, "start_aa": "Asn", "end_pos": 645, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn645", "evidence": [ { "id": "Q7K4B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7K4B6#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "E2QCJ5", "url": "https://www.uniprot.org/uniprot/E2QCJ5" }, { "database": "UniProtKB", "id": "Q7K4B6", "url": "https://www.uniprot.org/uniprot/Q7K4B6" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.", "journal": "Genome Biol.", "date": "2002", "authors": "Celniker SE, Wheeler DA, Kronmiller B, Carlson JW, Halpern A, Patel S, Adams M, Champe M, Dugan SP, Frise E, Hodgson A, George RA, Hoskins RA, Laverty T, Muzny DM, Nelson CR, Pacleb JM, Park S, Pfeiffer BD, Richards S, Sodergren EJ, Svirskas R, Tabor PE, Wan K, Stapleton M, Sutton GG, Venter C, Weinstock G, Scherer SE, Myers EW, Gibbs RA, Rubin GM", "evidence": [ { "database": "UniProtKB", "id": "E2QCJ5", "url": "https://www.uniprot.org/uniprot/E2QCJ5" } ], "reference": [ { "type": "PubMed", "id": "12537568", "url": "https://glygen.org/publication/PubMed/12537568" } ] }, { "title": "A Drosophila full-length cDNA resource.", "journal": "Genome Biol.", "date": "2002", "authors": "Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, George R, Guarin H, Kronmiller B, Pacleb J, Park S, Wan K, Rubin GM, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "Q7K4B6", "url": "https://www.uniprot.org/uniprot/Q7K4B6" } ], "reference": [ { "type": "PubMed", "id": "12537569", "url": "https://glygen.org/publication/PubMed/12537569" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "E2QCJ5", "url": "https://www.uniprot.org/uniprot/E2QCJ5" }, { "database": "UniProtKB", "id": "Q7K4B6", "url": "https://www.uniprot.org/uniprot/Q7K4B6" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.", "journal": "Genome Biol.", "date": "2002", "authors": "Kaminker JS, Bergman CM, Kronmiller B, Carlson J, Svirskas R, Patel S, Frise E, Wheeler DA, Lewis SE, Rubin GM, Ashburner M, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "E2QCJ5", "url": "https://www.uniprot.org/uniprot/E2QCJ5" } ], "reference": [ { "type": "PubMed", "id": "12537573", "url": "https://glygen.org/publication/PubMed/12537573" } ] }, { "title": "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.", "journal": "Genome Biol.", "date": "2002", "authors": "Hoskins RA, Smith CD, Carlson JW, Carvalho AB, Halpern A, Kaminker JS, Kennedy C, Mungall CJ, Sullivan BA, Sutton GG, Yasuhara JC, Wakimoto BT, Myers EW, Celniker SE, Rubin GM, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "E2QCJ5", "url": "https://www.uniprot.org/uniprot/E2QCJ5" } ], "reference": [ { "type": "PubMed", "id": "12537574", "url": "https://glygen.org/publication/PubMed/12537574" } ] }, { "title": "Combined evidence annotation of transposable elements in genome sequences.", "journal": "PLoS Comput. Biol.", "date": "2005", "authors": "Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D", "evidence": [ { "database": "UniProtKB", "id": "E2QCJ5", "url": "https://www.uniprot.org/uniprot/E2QCJ5" } ], "reference": [ { "type": "PubMed", "id": "16110336", "url": "https://glygen.org/publication/PubMed/16110336" } ] }, { "title": "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Smith CD, Shu S, Mungall CJ, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "E2QCJ5", "url": "https://www.uniprot.org/uniprot/E2QCJ5" } ], "reference": [ { "type": "PubMed", "id": "17569856", "url": "https://glygen.org/publication/PubMed/17569856" } ] }, { "title": "Sequence finishing and mapping of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "E2QCJ5", "url": "https://www.uniprot.org/uniprot/E2QCJ5" } ], "reference": [ { "type": "PubMed", "id": "17569867", "url": "https://glygen.org/publication/PubMed/17569867" } ] } ], "pathway": [ { "id": "dme:Dmel_CG4050", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG4050", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "dolichyl-phosphate-mannose-protein mannosyltransferase activity", "id": "GO:0004169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004169", "evidence": [ { "database": "UniProtKB", "id": "Q7K4B6", "url": "https://www.uniprot.org/uniprot/Q7K4B6" } ], "pmid": "" }, { "name": "mannosyltransferase activity", "id": "GO:0000030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000030", "evidence": [ { "database": "UniProtKB", "id": "Q7K4B6", "url": "https://www.uniprot.org/uniprot/Q7K4B6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q7K4B6", "url": "https://www.uniprot.org/uniprot/Q7K4B6" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q7K4B6", "url": "https://www.uniprot.org/uniprot/Q7K4B6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein O-linked mannosylation", "id": "GO:0035269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035269", "evidence": [ { "database": "UniProtKB", "id": "Q7K4B6", "url": "https://www.uniprot.org/uniprot/Q7K4B6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 385, "end_pos": 387, "annotation": "n_glycosylation_sequon" }, { "start_pos": 50, "end_pos": 52, "annotation": "n_glycosylation_sequon" }, { "start_pos": 609, "end_pos": 611, "annotation": "n_glycosylation_sequon" }, { "start_pos": 645, "end_pos": 647, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17377", "name": "", "equation": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99PR0-1", "Q14U74-1", "Q9UKY4-1", "Q9Y6A1-1", "Q5T4D3-1", "Q8IUR5-5", "Q8N394-1", "Q6ZXV5-1", "Q9NX78-1", "Q8R2R1-1", "Q8BGQ4-1", "Q8BG19-1", "Q8BRH0-1", "Q56A06-1", "Q3UV71-1", "Q8BMD6-1", "P31382-1", "P46971-1", "P33775-1", "P47190-1", "P52867-1", "P42934-1", "Q06644-1", "Q8MXQ3-1", "Q9W5D4-1", "Q7K4B6-1", "Q9V3X5-1", "Q9VF81-1", "Q9VQE9-1", "Q9VTK2-1" ], "evidence": [ { "id": "17377", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17377" } ] }, { "id": "53396", "name": "", "equation": "a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99PR0-1", "Q14U74-1", "Q9UKY4-1", "Q9Y6A1-1", "Q5T4D3-1", "Q8IUR5-5", "Q8N394-1", "Q6ZXV5-1", "Q9NX78-1", "Q8R2R1-1", "Q8BGQ4-1", "Q8BG19-1", "Q8BRH0-1", "Q56A06-1", "Q3UV71-1", "Q8BMD6-1", "P31382-1", "P46971-1", "P33775-1", "P47190-1", "P52867-1", "P42934-1", "Q06644-1", "Q8MXQ3-1", "Q9W5D4-1", "Q7K4B6-1", "Q9V3X5-1", "Q9VF81-1", "Q9VQE9-1", "Q9VTK2-1" ], "evidence": [ { "id": "53396", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53396" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "P31382", "gene_name": "PMT2", "activity": [ { "ec_number": "2.4.1.109", "activity": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+).", "evidence": [ { "id": "P31382", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31382" } ] }, { "ec_number": "2.4.1.109", "activity": "", "evidence": [ { "id": "P31382", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31382" } ] } ] }, { "uniprot_ac": "P33775", "gene_name": "PMT1", "activity": [ { "ec_number": "2.4.1.109", "activity": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+).", "evidence": [ { "id": "P33775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33775" } ] }, { "ec_number": "2.4.1.109", "activity": "", "evidence": [ { "id": "P33775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33775" } ] } ] }, { "uniprot_ac": "P42934", "gene_name": "PMT6", "activity": [ { "ec_number": "2.4.1.109", "activity": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+).", "evidence": [ { "id": "P42934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42934" } ] }, { "ec_number": "2.4.1.109", "activity": "", "evidence": [ { "id": "P42934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42934" } ] } ] }, { "uniprot_ac": "P46971", "gene_name": "PMT4", "activity": [ { "ec_number": "2.4.1.109", "activity": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+).", "evidence": [ { "id": "P46971", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46971" } ] }, { "ec_number": "2.4.1.109", "activity": "", "evidence": [ { "id": "P46971", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46971" } ] } ] }, { "uniprot_ac": "P47190", "gene_name": "PMT3", "activity": [ { 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"activity": [ { "ec_number": "2.4.1.109", "activity": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+).", "evidence": [ { "id": "Q06644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06644" } ] }, { "ec_number": "2.4.1.109", "activity": "", "evidence": [ { "id": "Q06644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06644" } ] } ] }, { "uniprot_ac": "Q14U74", "gene_name": "Pomt2", "activity": [ { "ec_number": "2.4.1.109", "activity": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+).", "evidence": [ { "id": "Q14U74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14U74" } ] }, { "ec_number": "2.4.1.109", "activity": "", "evidence": [ { "id": "Q14U74", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14U74" } ] } ] }, { "uniprot_ac": "Q3UV71", "gene_name": "Tmtc1", "activity": [ { "ec_number": "2.4.1.109", "activity": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+).", "evidence": [ { "id": "Q3UV71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UV71" } ] }, { "ec_number": "2.4.1.109", "activity": "", "evidence": [ { "id": "Q3UV71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UV71" } ] } ] }, { "uniprot_ac": "Q56A06", "gene_name": "Tmtc2", "activity": [ { "ec_number": "2.4.1.109", "activity": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+).", "evidence": [ { "id": "Q56A06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q56A06" } ] }, { "ec_number": "2.4.1.109", "activity": "", "evidence": [ { "id": "Q56A06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q56A06" } ] } ] }, { 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"https://www.uniprot.org/uniprot/Q6ZXV5" } ] } ] }, { "uniprot_ac": "Q7K4B6", "gene_name": "Tmtc3", "activity": [ { "ec_number": "2.4.1.109", "activity": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+).", "evidence": [ { "id": "Q7K4B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7K4B6" } ] }, { "ec_number": "2.4.1.109", "activity": "", "evidence": [ { "id": "Q7K4B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7K4B6" } ] } ] }, { "uniprot_ac": "Q8BG19", "gene_name": "Tmtc4", "activity": [ { "ec_number": "2.4.1.109", "activity": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+).", "evidence": [ { "id": "Q8BG19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BG19" } ] }, { "ec_number": "2.4.1.109", "activity": "", "evidence": [ { "id": "Q8BG19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BG19" } ] } ] }, { "uniprot_ac": "Q8BGQ4", "gene_name": "Pomt2", "activity": [ { "ec_number": "2.4.1.109", "activity": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+).", "evidence": [ { "id": "Q8BGQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGQ4" } ] }, { "ec_number": "2.4.1.109", "activity": "", "evidence": [ { "id": "Q8BGQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGQ4" } ] } ] }, { "uniprot_ac": "Q8BMD6", "gene_name": "Tmem260", "activity": [ { "ec_number": "2.4.1.109", "activity": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+).", "evidence": [ { "id": "Q8BMD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BMD6" } ] }, { "ec_number": "2.4.1.109", "activity": "", "evidence": [ { "id": "Q8BMD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BMD6" } ] } ] }, { "uniprot_ac": "Q8BRH0", "gene_name": "Tmtc3", "activity": [ { "ec_number": "2.4.1.109", "activity": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+).", "evidence": [ { "id": "Q8BRH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BRH0" } ] }, { "ec_number": "2.4.1.109", "activity": "", "evidence": [ { "id": "Q8BRH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BRH0" } ] } ] }, { "uniprot_ac": "Q8IUR5", "gene_name": "TMTC1", "activity": [ { "ec_number": "2.4.1.109", "activity": "a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+).", "evidence": [ { "id": "Q8IUR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IUR5" } ] }, { "ec_number": "2.4.1.109", "activity": "", 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