{ "uniprot_canonical_ac": "Q7K1Y4-1", "uniprot_ac": "Q7K1Y4", "uniprot_id": "CIAO1_DROME", "mass": { "chemical_mass": 37044.0, "monoisotopic_mass": 37044.0 }, "refseq": { "ac": "NP_610996", "name": "Ciao1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610996" }, "gene_names": [ { "name": "Ciao1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q7K1Y4", "id": "Q7K1Y4" }, { "name": "CG12797; CiaO1; CIAO1; Dmel\\CG12797", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610996", "id": "NP_610996" }, { "name": "CG12797", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q7K1Y4", "id": "Q7K1Y4" }, { "name": "Ciao1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610996", "id": "NP_610996" } ], "protein_names": [ { "name": "Probable cytosolic iron-sulfur protein assembly protein Ciao1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q7K1Y4" }, { "name": "CG12797-PA; Ciao1-PA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610996", "id": "NP_610996" }, { "name": "Ciao1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610996", "id": "NP_610996" } ], "function": [ { "annotation": "Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.", "evidence": [ { "database": "UniProtKB", "id": "Q7K1Y4", "url": "https://www.uniprot.org/uniprot/Q7K1Y4#function" }, { "database": "UniProtKB", "id": "MF_03037", "url": "https://www.uniprot.org/uniprot/MF_03037#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q7K1Y4", "url": "https://www.uniprot.org/uniprot/Q7K1Y4" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "Ciao1", "url": "https://www.uniprot.org/uniprot/Q7K1Y4", "locus": { "chromosome": "2R", "start_pos": 14853863, "end_pos": 14855048, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0033972", "url": "https://www.ensembl.org/id/FBgn0033972" } ] } } ], "crossref": [ { "id": "FBgn0033972", "url": "https://bgee.org/?page=gene&gene_id=FBgn0033972", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "FBgn0033972", "url": "https://flybase.org/reports/FBgn0033972", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "36655", "url": "https://www.ncbi.nlm.nih.gov/gene/36655", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q7K1Y4", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q7K1Y4*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028608", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028608", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG12797", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG12797", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "IREIRWS", "url": "https://omabrowser.org/oma/group/IREIRWS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5486866at2759", "url": "http://www.orthodb.org/?query=5486866at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19920", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19920", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19920:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19920:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "6TBL", "url": "https://www.rcsb.org/structure/6TBL", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6TBN", "url": "https://www.rcsb.org/structure/6TBN", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6TC0", "url": "https://www.rcsb.org/structure/6TC0", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00400", "url": "http://pfam.xfam.org/family/PF00400", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q7K1Y4", "url": "http://purl.obolibrary.org/obo/PR_Q7K1Y4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_610996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610996", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q7K1Y4", "url": "https://www.uniprot.org/uniprot/Q7K1Y4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q7K1Y4-1", "url": "https://www.uniprot.org/uniprot/Q7K1Y4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRLILEHTLQGHKGRIWGVAWHPKGNVFASCGEDKAIRIWSLTGNTWSTKTILSDGHKRTIREIRWSPCGQYLASASFDATTAIWSKSSGEFECNATLEGHENEVKSVSWSRSGGLLATCSRDKSVWIWEVAGDDEFECAAVLNPHTQDVKRVVWHPTKDILASASYDNTIKMFAEEPIDNDWDCTATLTSHTSTVWGIDFDADGERLVSCSDDTTIKIWRAYHPGNTAGVATPDQQTVWKCVCTVSGQHSRAIYDVSWCKLTGLIATACGDDGIRIFKESSDSKPDEPTFEQITAEEGAHDQDVNSVQWNPVVAGQLISCSDDGTIKIWKVTE", "length": 335, "header": "sp|Q7K1Y4-1|CIAO1_DROME Isoform 1 of Probable cytosolic iron-sulfur protein assembly protein Ciao1 OS=Drosophila melanogaster OX=7227 GN=Ciao1 PE=1 SV=1 CANONICAL=Q7K1Y4-1" }, "isoforms": [ { "isoform_ac": "Q7K1Y4-1", "url": "", "sequence": { "sequence": "MGRLILEHTLQGHKGRIWGVAWHPKGNVFASCGEDKAIRIWSLTGNTWSTKTILSDGHKRTIREIRWSPCGQYLASASFDATTAIWSKSSGEFECNATLEGHENEVKSVSWSRSGGLLATCSRDKSVWIWEVAGDDEFECAAVLNPHTQDVKRVVWHPTKDILASASYDNTIKMFAEEPIDNDWDCTATLTSHTSTVWGIDFDADGERLVSCSDDTTIKIWRAYHPGNTAGVATPDQQTVWKCVCTVSGQHSRAIYDVSWCKLTGLIATACGDDGIRIFKESSDSKPDEPTFEQITAEEGAHDQDVNSVQWNPVVAGQLISCSDDGTIKIWKVTE", "length": 335, "header": "sp|Q7K1Y4-1|CIAO1_DROME Isoform 1 of Probable cytosolic iron-sulfur protein assembly protein Ciao1 OS=Drosophila melanogaster OX=7227 GN=Ciao1 PE=1 SV=1 CANONICAL=Q7K1Y4-1" }, "locus": { "chromosome": "2R", "start_pos": 14854959, "end_pos": 14853955, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0087460", "url": "https://www.ensembl.org/id/FBtr0087460" }, { "database": "Ensembl Peptide", "id": "FBpp0086590", "url": "https://www.ensembl.org/id/FBpp0086590" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "Q7K1Y4", "url": "https://www.uniprot.org/uniprot/Q7K1Y4" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "A Drosophila full-length cDNA resource.", "journal": "Genome Biol.", "date": "2002", "authors": "Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, George R, Guarin H, Kronmiller B, Pacleb J, Park S, Wan K, Rubin GM, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "Q7K1Y4", "url": "https://www.uniprot.org/uniprot/Q7K1Y4" } ], "reference": [ { "type": "PubMed", "id": "12537569", "url": "https://glygen.org/publication/PubMed/12537569" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "Q7K1Y4", "url": "https://www.uniprot.org/uniprot/Q7K1Y4" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "A proteomics approach to identify targets of the ubiquitin-like molecule Urm1 in Drosophila melanogaster.", "journal": "PLoS ONE", "date": "2017", "authors": "Khoshnood B, Dacklin I, Grabbe C", "evidence": [ { "database": "UniProtKB", "id": "Q7K1Y4", "url": "https://www.uniprot.org/uniprot/Q7K1Y4" } ], "reference": [ { "type": "PubMed", "id": "28953965", "url": "https://glygen.org/publication/PubMed/28953965" } ] } ], "pathway": [ { "id": "dme:Dmel_CG12797", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG12797", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O76071-1", "protein_name": "Probable cytosolic iron-sulfur protein assembly protein CIAO1", "gene_name": "CIAO1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKDSLVLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQRPEGL", "length": 339 }, "evidence": [ { "id": "Q7K1Y4", "url": "https://omabrowser.org/oma/group/Q7K1Y4/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q05583-1", "protein_name": "Cytosolic iron-sulfur protein assembly protein 1", "gene_name": "CIA1", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MASINLIKSLKLYKEKIWSFDFSQGILATGSTDRKIKLVSVKYDDFTLIDVLDETAHKKAIRSVAWRPHTSLLAAGSFDSTVSIWAKEESADRTFEMDLLAIIEGHENEVKGVAWSNDGYYLATCSRDKSVWIWETDESGEEYECISVLQEHSQDVKHVIWHPSEALLASSSYDDTVRIWKDYDDDWECVAVLNGHEGTVWSSDFDKTEGVFRLCSGSDDSTVRVWKYMGDDEDDQQEWVCEAILPDVHKRQVYNVAWGFNGLIASVGADGVLAVYEEVDGEWKVFAKRALCHGVYEINVVKWLELNGKTILATGGDDGIVNFWSLEKAA", "length": 330 }, "evidence": [ { "id": "Q7K1Y4", "url": "https://omabrowser.org/oma/group/Q7K1Y4/", "database": "OMA" } ], "common_name": "Yeast" }, { "uniprot_canonical_ac": "Q99KN2-1", "protein_name": "Probable cytosolic iron-sulfur protein assembly protein CIAO1", "gene_name": "Ciao1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKDSLVLQSRVPAHPDSRCWFLAWNPSGTLLASCGGDRKIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLSSHTQDVKHVVWHPSQELLASASYDDTVKLYQEEGDDWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHTRTIYDVAWCQLTGALATACGDDAIRVFEEDPGSDPQQPTFSLTAHLRQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWEYHQPAGL", "length": 339 }, "evidence": [ { "id": "Q7K1Y4", "url": "https://omabrowser.org/oma/group/Q7K1Y4/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "iron-sulfur cluster assembly", "id": "GO:0016226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016226", "evidence": [ { "database": "UniProtKB", "id": "Q7K1Y4", "url": "https://www.uniprot.org/uniprot/Q7K1Y4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "CIA complex", "id": "GO:0097361", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097361", "evidence": [ { "database": "UniProtKB", "id": "Q7K1Y4", "url": "https://www.uniprot.org/uniprot/Q7K1Y4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Conjugated to URM1, a ubiquitin-like protein.", "evidence": [ { "database": "UniProtKB", "id": "Q7K1Y4", "url": "https://www.uniprot.org/uniprot/Q7K1Y4" }, { "database": "PubMed", "id": "28953965", "url": "https://glygen.org/publication/PubMed/28953965" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }