{
    "uniprot_canonical_ac": "Q7JZB4-1",
    "uniprot_ac": "Q7JZB4",
    "uniprot_id": "GMPPB_DROME",
    "mass": {
        "chemical_mass": 40448.0,
        "monoisotopic_mass": 40448.0
    },
    "refseq": {
        "ac": "NP_001189177",
        "name": "uncharacterized protein, isoform D",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189177"
    },
    "gene_names": [
        {
            "name": "Gmppb",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q7JZB4",
            "id": "Q7JZB4"
        },
        {
            "name": "CG1129",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189177",
            "id": "NP_001189177"
        },
        {
            "name": "CG1129",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q7JZB4",
            "id": "Q7JZB4"
        },
        {
            "name": "Dmel\\CG1129; Gmppb",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189177",
            "id": "NP_001189177"
        },
        {
            "name": "Dmel\\CG1129",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q7JZB4",
            "id": "Q7JZB4"
        },
        {
            "name": "Dmel_CG1129",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q7JZB4",
            "id": "Q7JZB4"
        }
    ],
    "protein_names": [
        {
            "name": "Mannose-1-phosphate guanyltransferase beta",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q7JZB4"
        },
        {
            "name": "2.7.7.13",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q7JZB4"
        },
        {
            "name": "CG1129-PD",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189177",
            "id": "NP_001189177"
        },
        {
            "name": "GDP-mannose pyrophosphorylase B",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q7JZB4"
        },
        {
            "name": "GTP-mannose-1-phosphate guanylyltransferase beta",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q7JZB4"
        },
        {
            "name": "uncharacterized protein, isoform D",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189177",
            "id": "NP_001189177"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:0110294",
            "recommended_name": {
                "id": "DOID:0110294",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0110294",
                "name": "autosomal recessive limb-girdle muscular dystrophy type 2T",
                "description": "An autosomal recessive limb-girdle muscular dystrophy that has_material_basis_in homozygous or compound heterozygous mutation in the GMPPB gene encoding the beta subunit of GDP-mannose pyrophosphorylase on chromosome 3p21."
            },
            "synonyms": [
                {
                    "id": "DOID:0110294",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110294",
                    "name": "LGMD2T",
                    "description": ""
                },
                {
                    "id": "DOID:0110294",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110294",
                    "name": "MDDGC14",
                    "description": ""
                },
                {
                    "id": "DOID:0110294",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110294",
                    "name": "muscular dystrophy limb-girdle type 2T",
                    "description": ""
                },
                {
                    "id": "DOID:0110294",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110294",
                    "name": "muscular dystrophy-dystroglycanopathy (limb-girdle) type C14",
                    "description": ""
                },
                {
                    "id": "DOID:0110294",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110294",
                    "name": "muscular dystrophy-dystroglycanopathy limb-girdle GMPPB-related",
                    "description": ""
                },
                {
                    "id": "MONDO:0014142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014142",
                    "name": "autosomal recessive limb-girdle muscular dystrophy type 2T",
                    "description": "Autosomal recessive limb-girdle muscular dystrophy type 2T (LGMD2T) is a form of limb-girdle muscular dystrophy, that can present from birth to early childhood, characterized by hypotonia, microcephaly, mild proximal muscle weakness (leading to delayed walking and difficulty climbing stairs), mild intellectual disability and epilepsy. Additional manifestations reported in some patients include cataracts, nystagmus, cardiomyopathy, and respiratory insufficiency."
                },
                {
                    "id": "MONDO:0014142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014142",
                    "name": "GMPPB autosomal recessive limb-girdle muscular dystrophy",
                    "description": ""
                },
                {
                    "id": "MONDO:0014142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014142",
                    "name": "LGMD-GMPPB related",
                    "description": ""
                },
                {
                    "id": "MONDO:0014142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014142",
                    "name": "LGMD2T",
                    "description": ""
                },
                {
                    "id": "MONDO:0014142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014142",
                    "name": "MDDGC14",
                    "description": ""
                },
                {
                    "id": "MONDO:0014142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014142",
                    "name": "autosomal recessive limb-girdle muscular dystrophy caused by mutation in GMPPB",
                    "description": ""
                },
                {
                    "id": "MONDO:0014142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014142",
                    "name": "muscular dystrophy limb-girdle type 2T",
                    "description": ""
                },
                {
                    "id": "MONDO:0014142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014142",
                    "name": "muscular dystrophy-dystroglycanopathy (limb-girdle) type C14",
                    "description": ""
                },
                {
                    "id": "MONDO:0014142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014142",
                    "name": "muscular dystrophy-dystroglycanopathy limb-girdle GMPPB-related",
                    "description": ""
                },
                {
                    "id": "MONDO:0014142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014142",
                    "name": "limb-girdle muscular dystrophy type 2T",
                    "description": ""
                },
                {
                    "id": "MONDO:0014142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014142",
                    "name": "muscular dystrophy, limb-girdle, type 2T",
                    "description": ""
                },
                {
                    "id": "MONDO:0014142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014142",
                    "name": "muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 14",
                    "description": ""
                },
                {
                    "id": "MONDO:0014142",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014142",
                    "name": "muscular dystrophy-dystroglycanopathy, limb-girdle, GMPPB-related",
                    "description": ""
                },
                {
                    "id": "MIM:615352",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/615352",
                    "name": "Muscular dystrophy-dystroglycanopathy limb-girdle C14",
                    "description": "Muscular dystrophy-dystroglycanopathy limb-girdle C14"
                }
            ],
            "evidence": [
                {
                    "id": "0110294",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110294"
                }
            ]
        },
        {
            "disease_id": "DOID:0111233",
            "recommended_name": {
                "id": "DOID:0111233",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111233",
                "name": "congenital muscular dystrophy-dystroglycanopathy A14",
                "description": "A congenital muscular dystrophy-dystroglycanopathy type A that has_material_basis_in homozygous or compound heterozygous mutation in in GMPPB on 3p21.31."
            },
            "synonyms": [
                {
                    "id": "DOID:0111233",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111233",
                    "name": "Walker-Warburg syndrome or muscle-eye-brain disease GMPPB-related",
                    "description": ""
                },
                {
                    "id": "DOID:0111233",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111233",
                    "name": "MDDGA14",
                    "description": ""
                },
                {
                    "id": "DOID:0111233",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111233",
                    "name": "congenital muscular dystrophy-dystroglycanopathy with brain and eye anomalies type A14",
                    "description": ""
                },
                {
                    "id": "MONDO:0014140",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014140",
                    "name": "muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A14",
                    "description": ""
                },
                {
                    "id": "MONDO:0014140",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014140",
                    "name": "muscle-eye-brain-GMPPB related",
                    "description": ""
                },
                {
                    "id": "MONDO:0014140",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014140",
                    "name": "MDDGA14",
                    "description": ""
                },
                {
                    "id": "MONDO:0014140",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014140",
                    "name": "Walker-Warburg syndrome or muscle-eye-brain disease, GMPPB-related",
                    "description": ""
                },
                {
                    "id": "MONDO:0014140",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014140",
                    "name": "muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 14",
                    "description": ""
                },
                {
                    "id": "MIM:615350",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/615350",
                    "name": "Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A14",
                    "description": "Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A14"
                }
            ],
            "evidence": [
                {
                    "id": "0111233",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111233"
                }
            ]
        },
        {
            "disease_id": "DOID:0112374",
            "recommended_name": {
                "id": "DOID:0112374",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0112374",
                "name": "muscular dystrophy-dystroglycanopathy",
                "description": "A congenital muscular dystrophy characterized by muscular dystrophy resulting from defective glycosylation of dystroglycan."
            },
            "synonyms": [
                {
                    "id": "DOID:0112374",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112374",
                    "name": "CMD due to dystroglycanopathy",
                    "description": ""
                },
                {
                    "id": "DOID:0112374",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112374",
                    "name": "congenital muscular dystrophy due to dystroglycanopathy",
                    "description": ""
                },
                {
                    "id": "DOID:0112374",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112374",
                    "name": "MDDG",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "0112374",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0112374"
                }
            ]
        },
        {
            "disease_id": "DOID:0112377",
            "recommended_name": {
                "id": "DOID:0112377",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0112377",
                "name": "muscular dystrophy-dystroglycanopathy type B14",
                "description": "A muscular dystrophy-dystroglycanopathy type B that has_material_basis_in homozygous or compound heterozygous mutation in the GMPPB gene on chromosome 3p21.31."
            },
            "synonyms": [
                {
                    "id": "DOID:0112377",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112377",
                    "name": "MDDGB14",
                    "description": ""
                },
                {
                    "id": "DOID:0112377",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0112377",
                    "name": "congenital muscular dystrophy GMPPB-related",
                    "description": ""
                },
                {
                    "id": "MONDO:0014141",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014141",
                    "name": "muscular dystrophy-dystroglycanopathy (congenital with intellectual disability), type B14",
                    "description": ""
                },
                {
                    "id": "MONDO:0014141",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014141",
                    "name": "congenital muscular dystrophy-GMPPB related",
                    "description": ""
                },
                {
                    "id": "MONDO:0014141",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014141",
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                    "description": ""
                },
                {
                    "id": "MONDO:0014141",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014141",
                    "name": "muscular dystrophy, congenital, GMPPB-related",
                    "description": ""
                },
                {
                    "id": "MONDO:0014141",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014141",
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                    "description": ""
                },
                {
                    "id": "MONDO:0014141",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014141",
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                    "description": ""
                },
                {
                    "id": "MIM:615351",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/615351",
                    "name": "Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B14",
                    "description": "Muscular dystrophy-dystroglycanopathy congenital with impaired intellectual development B14"
                }
            ],
            "evidence": [
                {
                    "id": "0112377",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0112377"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Drosophila melanogaster",
            "taxid": 7227,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q7JZB4",
                    "url": "https://www.uniprot.org/uniprot/Q7JZB4"
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            ],
            "common_name": "Fruit fly"
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            "url": "https://www.uniprot.org/uniprot/Q7JZB4",
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        }
    ],
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            "categories": [
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        },
        {
            "id": "cd06425",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06425",
            "database": "CDD",
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        },
        {
            "id": "FBgn0037279",
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        },
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            "id": "40599",
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        },
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        },
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            "id": "IPR001451",
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        },
        {
            "id": "IPR005835",
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            "categories": [
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            ]
        },
        {
            "id": "IPR018357",
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            "categories": [
                "Protein Classification"
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        },
        {
            "id": "IPR029044",
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        },
        {
            "id": "IPR045233",
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            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "dme:Dmel_CG1129",
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        {
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        {
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        },
        {
            "id": "5486038at2759",
            "url": "http://www.orthodb.org/?query=5486038at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR22572",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22572",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
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        },
        {
            "id": "PTHR22572:SF15",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22572:SF15",
            "database": "PANTHER",
            "categories": [
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        },
        {
            "id": "PF00132",
            "url": "http://pfam.xfam.org/family/PF00132",
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        {
            "id": "PF00483",
            "url": "http://pfam.xfam.org/family/PF00483",
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        {
            "id": "15229",
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        {
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    ],
    "sequence": {
        "sequence": "MCGNPAVGNGTRALILVGGYGTRLRPLTLSTPKPLVEFANKPILLHQLEALVDAGCRQVILAVSYRAEQMEKELKVEAKKLGVELIFSHETEPLGTAGPLALAKTILAASSEPFFVLNSDVICDFPFKQLVQFHCNHGKEGTIVVTKVEEPSKYGVVLYDENGCIKNFIEKPQEFVSNKINAGIYIFNPSVLDRIEVKPTSIEKEVFPEMTQQQELYAMDLTGFWMDIGQPKDFLTGMCLYLSSLRQKQSPKLYTGPGVVGNVLVDPTAKIGEGCRIGPNVTIGPDVVIEDGVCIKRSTILKGAIVRSHSWLDSCIVGWRSTVGRWVRIEGITVLGEDVIVKDELYINGGQVLPHKSIAASVPEPQIIM",
        "length": 369,
        "header": "sp|Q7JZB4-1|GMPPB_DROME Isoform 1 of Mannose-1-phosphate guanyltransferase beta  OS=Drosophila melanogaster OX=7227 GN=Gmppb PE=1 SV=1 CANONICAL=Q7JZB4-1"
    },
    "isoforms": [
        {
            "isoform_ac": "E2QCZ9-1",
            "url": "",
            "sequence": {
                "sequence": "MCGNPAVGNGTRALILVGGYGTRLRPLTLSTPKPLVEFANKPILLHQLEALVDAGCRQVILAVSYRAEQMEKELKVEAKKLGVELIFSHETEPLGTAGPLALAKTILAASSEPFFVLNSDVICDFPFKQLVQFHCNHGKEGTIVVTKVEEPSKYGVVLYDENGCIKNFIEKPQEFVSNKINAGIYIFNPSVLDRIEVKPTSIEKEVFPEMTQQQELYAMDLTGFWMDIGQPKDFLTGMCLYLSSLRQKQSPKLYTGPGVVGNVLVDPTAKIGEGCRIGPNVTIGPDVVIEDGVCIKRSTILKGAIVRSHSWLDSCIVGWRSTVGRWVRIEGITVLGEDVIVKDELYINGGQVLPHKSIAASVPEPQIIM",
                "length": 369,
                "header": "tr|E2QCZ9-1|E2QCZ9_DROME Computationally mapped isoform of mannose-1-phosphate guanylyltransferase  OS=Drosophila melanogaster OX=7227 GN=Gmppb PE=1 SV=1 CANONICAL=Q7JZB4-1"
            },
            "locus": {
                "chromosome": "3R",
                "start_pos": 4815684,
                "end_pos": 4813803,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0078870",
                        "url": "https://www.ensembl.org/id/FBtr0078870"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0078510",
                        "url": "https://www.ensembl.org/id/FBpp0078510"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q7JZB4-1",
            "url": "",
            "sequence": {
                "sequence": "MCGNPAVGNGTRALILVGGYGTRLRPLTLSTPKPLVEFANKPILLHQLEALVDAGCRQVILAVSYRAEQMEKELKVEAKKLGVELIFSHETEPLGTAGPLALAKTILAASSEPFFVLNSDVICDFPFKQLVQFHCNHGKEGTIVVTKVEEPSKYGVVLYDENGCIKNFIEKPQEFVSNKINAGIYIFNPSVLDRIEVKPTSIEKEVFPEMTQQQELYAMDLTGFWMDIGQPKDFLTGMCLYLSSLRQKQSPKLYTGPGVVGNVLVDPTAKIGEGCRIGPNVTIGPDVVIEDGVCIKRSTILKGAIVRSHSWLDSCIVGWRSTVGRWVRIEGITVLGEDVIVKDELYINGGQVLPHKSIAASVPEPQIIM",
                "length": 369,
                "header": "sp|Q7JZB4-1|GMPPB_DROME Isoform 1 of Mannose-1-phosphate guanyltransferase beta  OS=Drosophila melanogaster OX=7227 GN=Gmppb PE=1 SV=1 CANONICAL=Q7JZB4-1"
            },
            "locus": {
                "chromosome": "3R",
                "start_pos": 4815684,
                "end_pos": 4813803,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0078870",
                        "url": "https://www.ensembl.org/id/FBtr0078870"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0078510",
                        "url": "https://www.ensembl.org/id/FBpp0078510"
                    }
                ]
            }
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "G49108TO",
            "type": "O-linked",
            "subtype": "O-GlcNAcylation",
            "site_category": "reported_with_glycan",
            "site_seq": "",
            "relation": "attached",
            "comment": "O-GlcNAcylation",
            "evidence": [
                {
                    "id": "Q7JZB4",
                    "database": "O-GlcNAc Database",
                    "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q7JZB4"
                },
                {
                    "id": "15952742",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/15952742"
                }
            ]
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme",
        "glycoprotein",
        "glycoprotein_reported_with_glycan"
    ],
    "publication": [
        {
            "title": "The genome sequence of Drosophila melanogaster.",
            "journal": "Science",
            "date": "2000",
            "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q7JZB4",
                    "url": "https://www.uniprot.org/uniprot/Q7JZB4"
                },
                {
                    "database": "UniProtKB",
                    "id": "E2QCZ9",
                    "url": "https://www.uniprot.org/uniprot/E2QCZ9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10731132",
                    "url": "https://glygen.org/publication/PubMed/10731132"
                }
            ]
        },
        {
            "title": "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.",
            "journal": "Genome Biol.",
            "date": "2002",
            "authors": "Celniker SE, Wheeler DA, Kronmiller B, Carlson JW, Halpern A, Patel S, Adams M, Champe M, Dugan SP, Frise E, Hodgson A, George RA, Hoskins RA, Laverty T, Muzny DM, Nelson CR, Pacleb JM, Park S, Pfeiffer BD, Richards S, Sodergren EJ, Svirskas R, Tabor PE, Wan K, Stapleton M, Sutton GG, Venter C, Weinstock G, Scherer SE, Myers EW, Gibbs RA, Rubin GM",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "E2QCZ9",
                    "url": "https://www.uniprot.org/uniprot/E2QCZ9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12537568",
                    "url": "https://glygen.org/publication/PubMed/12537568"
                }
            ]
        },
        {
            "title": "A Drosophila full-length cDNA resource.",
            "journal": "Genome Biol.",
            "date": "2002",
            "authors": "Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, George R, Guarin H, Kronmiller B, Pacleb J, Park S, Wan K, Rubin GM, Celniker SE",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q7JZB4",
                    "url": "https://www.uniprot.org/uniprot/Q7JZB4"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12537569",
                    "url": "https://glygen.org/publication/PubMed/12537569"
                }
            ]
        },
        {
            "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.",
            "journal": "Genome Biol.",
            "date": "2002",
            "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q7JZB4",
                    "url": "https://www.uniprot.org/uniprot/Q7JZB4"
                },
                {
                    "database": "UniProtKB",
                    "id": "E2QCZ9",
                    "url": "https://www.uniprot.org/uniprot/E2QCZ9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12537572",
                    "url": "https://glygen.org/publication/PubMed/12537572"
                }
            ]
        },
        {
            "title": "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.",
            "journal": "Genome Biol.",
            "date": "2002",
            "authors": "Kaminker JS, Bergman CM, Kronmiller B, Carlson J, Svirskas R, Patel S, Frise E, Wheeler DA, Lewis SE, Rubin GM, Ashburner M, Celniker SE",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "E2QCZ9",
                    "url": "https://www.uniprot.org/uniprot/E2QCZ9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12537573",
                    "url": "https://glygen.org/publication/PubMed/12537573"
                }
            ]
        },
        {
            "title": "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.",
            "journal": "Genome Biol.",
            "date": "2002",
            "authors": "Hoskins RA, Smith CD, Carlson JW, Carvalho AB, Halpern A, Kaminker JS, Kennedy C, Mungall CJ, Sullivan BA, Sutton GG, Yasuhara JC, Wakimoto BT, Myers EW, Celniker SE, Rubin GM, Karpen GH",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "E2QCZ9",
                    "url": "https://www.uniprot.org/uniprot/E2QCZ9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12537574",
                    "url": "https://glygen.org/publication/PubMed/12537574"
                }
            ]
        },
        {
            "title": "Tagging-via-substrate strategy for probing O-GlcNAc modified proteins.",
            "journal": "Journal of proteome research",
            "date": "2005",
            "authors": "Sprung R, Nandi A, Chen Y, Kim SC, Barma D, Falck JR, Zhao Y",
            "evidence": [
                {
                    "database": "O-GlcNAc Database",
                    "id": "Q7JZB4",
                    "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q7JZB4"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15952742",
                    "url": "https://glygen.org/publication/PubMed/15952742"
                }
            ]
        },
        {
            "title": "Combined evidence annotation of transposable elements in genome sequences.",
            "journal": "PLoS Comput. Biol.",
            "date": "2005",
            "authors": "Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "E2QCZ9",
                    "url": "https://www.uniprot.org/uniprot/E2QCZ9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "16110336",
                    "url": "https://glygen.org/publication/PubMed/16110336"
                }
            ]
        },
        {
            "title": "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.",
            "journal": "Science",
            "date": "2007",
            "authors": "Smith CD, Shu S, Mungall CJ, Karpen GH",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "E2QCZ9",
                    "url": "https://www.uniprot.org/uniprot/E2QCZ9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17569856",
                    "url": "https://glygen.org/publication/PubMed/17569856"
                }
            ]
        },
        {
            "title": "Sequence finishing and mapping of Drosophila melanogaster heterochromatin.",
            "journal": "Science",
            "date": "2007",
            "authors": "Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "E2QCZ9",
                    "url": "https://www.uniprot.org/uniprot/E2QCZ9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17569867",
                    "url": "https://glygen.org/publication/PubMed/17569867"
                }
            ]
        },
        {
            "title": "The Release 6 reference sequence of the Drosophila melanogaster genome.",
            "journal": "Genome Res.",
            "date": "2015",
            "authors": "Hoskins RA, Carlson JW, Wan KH, Park S, Mendez I, Galle SE, Booth BW, Pfeiffer BD, George RA, Svirskas R, Krzywinski M, Schein J, Accardo MC, Damia E, Messina G, Mendez-Lago M, de Pablos B, Demakova OV, Andreyeva EN, Boldyreva LV, Marra M, Carvalho AB, Dimitri P, Villasante A, Zhimulev IF, Rubin GM, Karpen GH, Celniker SE",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "E2QCZ9",
                    "url": "https://www.uniprot.org/uniprot/E2QCZ9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "25589440",
                    "url": "https://glygen.org/publication/PubMed/25589440"
                }
            ]
        },
        {
            "title": "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.",
            "journal": "G3 (Bethesda)",
            "date": "2015",
            "authors": "Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "E2QCZ9",
                    "url": "https://www.uniprot.org/uniprot/E2QCZ9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26109356",
                    "url": "https://glygen.org/publication/PubMed/26109356"
                }
            ]
        },
        {
            "title": "Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.",
            "journal": "G3 (Bethesda)",
            "date": "2015",
            "authors": "Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "E2QCZ9",
                    "url": "https://www.uniprot.org/uniprot/E2QCZ9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "26109357",
                    "url": "https://glygen.org/publication/PubMed/26109357"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "dme:Dmel_CG1129",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG1129",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P41940-1",
            "protein_name": "Mannose-1-phosphate guanyltransferase",
            "gene_name": "PSA1",
            "tax_id": 559292,
            "organism": "Saccharomyces cerevisiae S288C",
            "sequence": {
                "sequence": "MKGLILVGGYGTRLRPLTLTVPKPLVEFGNRPMILHQIEALANAGVTDIVLAVNYRPEVMVETLKKYEKEYGVNITFSVETEPLGTAGPLKLAEDVLKKDNSPFFVLNSDVICEYPFKELADFHKAHGGKGTIVATKVDEPSKYGVIVHDIATPNLIDRFVEKPKEFVGNRINAGLYILNPEVIDLIEMKPTSIEKETFPILVEEKQLYSFDLEGFWMDVGQPKDFLSGTVLYLNSLAKRQPKKLATGANIVGNALIDPTAKISSTAKIGPDVVIGPNVTIGDGVRITRSVVLCNSTIKNHSLVKSTIVGWNSTVGQWCRLEGVTVLGDDVEVKDEIYINGGKVLPHKSISDNVPKEAIIM",
                "length": 361
            },
            "evidence": [
                {
                    "id": "Q7JZB4",
                    "url": "https://omabrowser.org/oma/group/Q7JZB4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Yeast"
        },
        {
            "uniprot_canonical_ac": "Q8BTZ7-1",
            "protein_name": "Mannose-1-phosphate guanyltransferase beta",
            "gene_name": "Gmppb",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQMLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSPAVLQRIQLKPTSIEKEIFPVMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKHPERLYSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDAHIRSHSWLESCIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPRIIM",
                "length": 360
            },
            "evidence": [
                {
                    "id": "Q7JZB4",
                    "url": "https://omabrowser.org/oma/group/Q7JZB4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9Y5P6-1",
            "protein_name": "Mannose-1-phosphate guanyltransferase beta",
            "gene_name": "GMPPB",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSPAVLQRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQPERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSHSWLESCIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPRIIM",
                "length": 360
            },
            "evidence": [
                {
                    "id": "Q7JZB4",
                    "url": "https://omabrowser.org/oma/group/Q7JZB4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "mannose-1-phosphate guanylyltransferase (GTP) activity",
                        "id": "GO:0004475",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004475",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7JZB4",
                                "url": "https://www.uniprot.org/uniprot/Q7JZB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "GTP binding",
                        "id": "GO:0005525",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7JZB4",
                                "url": "https://www.uniprot.org/uniprot/Q7JZB4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7JZB4",
                                "url": "https://www.uniprot.org/uniprot/Q7JZB4"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "protein glycosylation",
                        "id": "GO:0006486",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006486",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7JZB4",
                                "url": "https://www.uniprot.org/uniprot/Q7JZB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "GDP-mannose biosynthetic process",
                        "id": "GO:0009298",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009298",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q7JZB4",
                                "url": "https://www.uniprot.org/uniprot/Q7JZB4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "larval lymph gland hemopoiesis",
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