{
    "uniprot_canonical_ac": "Q7JY33-1",
    "uniprot_ac": "Q7JY33",
    "uniprot_id": "Q7JY33_DROME",
    "mass": {
        "chemical_mass": 37148.0,
        "monoisotopic_mass": 37148.0
    },
    "refseq": {
        "ac": "NP_477315",
        "name": "ribonuclease H1, isoform A",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477315"
    },
    "gene_names": [
        {
            "name": "rnh1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q7JY33",
            "id": "Q7JY33"
        },
        {
            "name": "74/9; CG8729; Dmel\\CG8729; l(2)43F1-5; l(2)43Fa; l(2)k07409; l(2)k07624; RNase H1; RnH1; rnhl",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_995777",
            "id": "NP_995777"
        },
        {
            "name": "9",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q7JY33",
            "id": "Q7JY33"
        },
        {
            "name": "CG8729",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q7JY33",
            "id": "Q7JY33"
        },
        {
            "name": "Dmel\\CG8729",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q7JY33",
            "id": "Q7JY33"
        },
        {
            "name": "Dmel_CG8729",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q7JY33",
            "id": "Q7JY33"
        },
        {
            "name": "RNase H1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q7JY33",
            "id": "Q7JY33"
        },
        {
            "name": "RnH1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q7JY33",
            "id": "Q7JY33"
        },
        {
            "name": "l(2)43F1-5",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q7JY33",
            "id": "Q7JY33"
        },
        {
            "name": "l(2)43Fa",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q7JY33",
            "id": "Q7JY33"
        },
        {
            "name": "l(2)k07409",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q7JY33",
            "id": "Q7JY33"
        },
        {
            "name": "l(2)k07624",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q7JY33",
            "id": "Q7JY33"
        },
        {
            "name": "rnh1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_995777",
            "id": "NP_995777"
        },
        {
            "name": "rnhl",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q7JY33",
            "id": "Q7JY33"
        }
    ],
    "protein_names": [
        {
            "name": "Ribonuclease H1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q7JY33"
        },
        {
            "name": "3.1.26.4",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q7JY33"
        },
        {
            "name": "CG8729-PA; rnh1-PA; RNaseH1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477315",
            "id": "NP_477315"
        },
        {
            "name": "CG8729-PB; rnh1-PB; RNaseH1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_995777",
            "id": "NP_995777"
        },
        {
            "name": "RNase H1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q7JY33"
        },
        {
            "name": "ribonuclease H1, isoform A",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477315",
            "id": "NP_477315"
        },
        {
            "name": "ribonuclease H1, isoform B",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_995777",
            "id": "NP_995777"
        }
    ],
    "function": [
        {
            "annotation": "Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A1Z768",
                    "url": "https://www.uniprot.org/uniprot/A1Z768#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "PIRNR036852",
                    "url": "https://www.uniprot.org/uniprot/PIRNR036852#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q7JY33",
                    "url": "https://www.uniprot.org/uniprot/Q7JY33#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0111515",
            "recommended_name": {
                "id": "DOID:0111515",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111515",
                "name": "autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 2",
                "description": "A chronic progressive external ophthalmoplegia characterized by adult onset of progressive external ophthalmoplegia, exercise intolerance, muscle weakness, and signs and symptoms of spinocerebellar ataxia that has_material_basis_in homozygous or compound heterozygous mutation in the RNASEH1 gene on chromosome 2p25.3."
            },
            "synonyms": [
                {
                    "id": "DOID:0111515",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111515",
                    "name": "PEOB2",
                    "description": ""
                },
                {
                    "id": "DOID:0111515",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111515",
                    "name": "adult-onset CPEO with mitochondrial myopathy",
                    "description": ""
                },
                {
                    "id": "DOID:0111515",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111515",
                    "name": "adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy",
                    "description": ""
                },
                {
                    "id": "DOID:0111515",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111515",
                    "name": "autosomal recessive progressive external ophthalmoplegia 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0014656",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014656",
                    "name": "progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2",
                    "description": "Any progressive external ophthalmoplegia with mitochondrial DNA deletions in which the cause of the disease is a mutation in the RNASEH1 gene."
                },
                {
                    "id": "MONDO:0014656",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014656",
                    "name": "RNASEH1 progressive external ophthalmoplegia with mitochondrial DNA deletions",
                    "description": ""
                },
                {
                    "id": "MONDO:0014656",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014656",
                    "name": "progressive external ophthalmoplegia with mitochondrial DNA deletions caused by mutation in RNASEH1",
                    "description": ""
                },
                {
                    "id": "MONDO:0014656",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014656",
                    "name": "progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0014656",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014656",
                    "name": "progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive type 2",
                    "description": ""
                },
                {
                    "id": "MONDO:0014656",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014656",
                    "name": "PEOB2",
                    "description": ""
                },
                {
                    "id": "MONDO:0014656",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014656",
                    "name": "progressive external ophthalmoplegia, autosomal recessive 2",
                    "description": ""
                },
                {
                    "id": "MIM:616479",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/616479",
                    "name": "Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2",
                    "description": "Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2"
                }
            ],
            "evidence": [
                {
                    "id": "0111515",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111515"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Drosophila melanogaster",
            "taxid": 7227,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q7JY33",
                    "url": "https://www.uniprot.org/uniprot/Q7JY33"
                }
            ],
            "common_name": "Fruit fly"
        }
    ],
    "gene": [
        {
            "name": "rnh1",
            "url": "https://www.uniprot.org/uniprot/Q7JY33",
            "locus": {
                "chromosome": "2R",
                "start_pos": 7931054,
                "end_pos": 7932380,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "FBgn0023171",
                        "url": "https://www.ensembl.org/id/FBgn0023171"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "FBgn0023171",
            "url": "https://bgee.org/?page=gene&gene_id=FBgn0023171",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd09280",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09280",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "FBgn0023171",
            "url": "https://flybase.org/reports/FBgn0023171",
            "database": "FlyBase",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "35746",
            "url": "https://www.ncbi.nlm.nih.gov/gene/35746",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR002156",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002156",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR009027",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009027",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011320",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011320",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR012337",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR012337",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR017067",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017067",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036397",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036397",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR037056",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR037056",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "dme:Dmel_CG8729",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG8729",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "ELWYGLY",
            "url": "https://omabrowser.org/oma/group/ELWYGLY/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3280806at2759",
            "url": "http://www.orthodb.org/?query=3280806at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10642",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10642",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10642:SF26",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10642:SF26",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00075",
            "url": "http://pfam.xfam.org/family/PF00075",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01693",
            "url": "http://pfam.xfam.org/family/PF01693",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_477315",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477315",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A1Z768",
            "url": "https://www.uniprot.org/uniprot/A1Z768",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A1Z768-1",
            "url": "https://www.uniprot.org/uniprot/A1Z768-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q7JY33",
            "url": "https://www.uniprot.org/uniprot/Q7JY33",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q7JY33-1",
            "url": "https://www.uniprot.org/uniprot/Q7JY33-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MLLPRYFCWNLQRCTMAFYAVASGRRSGVYGSWAECEEQVKGFKNAKYKKFKTRQEADQFVNGCKSYAPQDVAVPLGKEKASLASWKNSIEVNKNPKYTDEWPEEDHDLAEDDLNAAMNEVEGDPKPSNSSNLPDILNRKRKGTTSGDKRNKIPRHASQVSEATGLKQVGAFQFEIDAEGYVIVYTDGSCIGNGRAGACAGYGVYFGKNHQLNAAKPVEGRVTNNVGEIQAAIHAIKTALDLGIQKLCISTDSQFLINSITLWVAGWKKRDWKLKNNQPVKNVVDFKELDKLLQENNITVKWNYVEAHKGIEGNEMADKLARQGSALYKQKNG",
        "length": 333,
        "header": "tr|Q7JY33-1|Q7JY33_DROME Isoform 1 of Ribonuclease H1  OS=Drosophila melanogaster OX=7227 GN=rnh1 PE=1 SV=1 CANONICAL=Q7JY33-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A1Z768-1",
            "url": "",
            "sequence": {
                "sequence": "MLLPRYFCWNLQRCTMAFYAVASGRRSGVYGSWAECEEQVKGFKNAKYKKFKTRQEADQFVNGCKSYAPQDVAVPLGKEKASLASWKNSIEVNKNPKYTDEWPEEDHDLAEDDLPDILNRKRKGTTSGDKRNKIPRHASQVSEATGLKQVGAFQFEIDAEGYVIVYTDGSCIGNGRAGACAGYGVYFGKNHQLNAAKPVEGRVTNNVGEIQAAIHAIKTALDLGIQKLCISTDSQFLINSITLWVAGWKKRDWKLKNNQPVKNVVDFKELDKLLQENNITVKWNYVEAHKGIEGNEMADKLARQGSALYKQKNG",
                "length": 314,
                "header": "tr|A1Z768-1|Q7JY33_DROME Computationally mapped isoform of Ribonuclease H1  OS=Drosophila melanogaster OX=7227 GN=rnh1 PE=1 SV=1 CANONICAL=Q7JY33-1"
            },
            "locus": {
                "chromosome": "2R",
                "start_pos": 7932349,
                "end_pos": 7931132,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0088884",
                        "url": "https://www.ensembl.org/id/FBtr0088884"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0089188",
                        "url": "https://www.ensembl.org/id/FBpp0089188"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q7JY33-1",
            "url": "",
            "sequence": {
                "sequence": "MLLPRYFCWNLQRCTMAFYAVASGRRSGVYGSWAECEEQVKGFKNAKYKKFKTRQEADQFVNGCKSYAPQDVAVPLGKEKASLASWKNSIEVNKNPKYTDEWPEEDHDLAEDDLNAAMNEVEGDPKPSNSSNLPDILNRKRKGTTSGDKRNKIPRHASQVSEATGLKQVGAFQFEIDAEGYVIVYTDGSCIGNGRAGACAGYGVYFGKNHQLNAAKPVEGRVTNNVGEIQAAIHAIKTALDLGIQKLCISTDSQFLINSITLWVAGWKKRDWKLKNNQPVKNVVDFKELDKLLQENNITVKWNYVEAHKGIEGNEMADKLARQGSALYKQKNG",
                "length": 333,
                "header": "tr|Q7JY33-1|Q7JY33_DROME Isoform 1 of Ribonuclease H1  OS=Drosophila melanogaster OX=7227 GN=rnh1 PE=1 SV=1 CANONICAL=Q7JY33-1"
            },
            "locus": {
                "chromosome": "2R",
                "start_pos": 7932349,
                "end_pos": 7931132,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "FBtr0088883",
                        "url": "https://www.ensembl.org/id/FBtr0088883"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "FBpp0087959",
                        "url": "https://www.ensembl.org/id/FBpp0087959"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "The genome sequence of Drosophila melanogaster.",
            "journal": "Science",
            "date": "2000",
            "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A1Z768",
                    "url": "https://www.uniprot.org/uniprot/A1Z768"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q7JY33",
                    "url": "https://www.uniprot.org/uniprot/Q7JY33"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10731132",
                    "url": "https://glygen.org/publication/PubMed/10731132"
                }
            ]
        },
        {
            "title": "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.",
            "journal": "Genome Biol.",
            "date": "2002",
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