{
    "uniprot_canonical_ac": "Q792Y9-1",
    "uniprot_ac": "Q792Y9",
    "uniprot_id": "Q792Y9_MOUSE",
    "mass": {
        "chemical_mass": 25993.0,
        "monoisotopic_mass": 25993.0
    },
    "refseq": {
        "ac": "NP_001034086",
        "name": "trypsinogen 12 precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034086"
    },
    "gene_names": [
        {
            "name": "Gm5771",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q792Y9",
            "id": "Q792Y9"
        },
        {
            "name": "EG436523; Gm5771",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034086",
            "id": "NP_001034086"
        },
        {
            "name": "EG436523",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q792Y9",
            "id": "Q792Y9"
        },
        {
            "name": "Prss1l",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034086",
            "id": "NP_001034086"
        },
        {
            "name": "trypsinogen",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q792Y9",
            "id": "Q792Y9"
        }
    ],
    "protein_names": [
        {
            "name": "Predicted gene 5771",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q792Y9"
        },
        {
            "name": "Predicted gene, EG436523",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q792Y9"
        },
        {
            "name": "Trypsinogen 12",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q792Y9"
        },
        {
            "name": "trypsinogen 12 precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034086",
            "id": "NP_001034086"
        },
        {
            "name": "trypsinogen 12",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034086",
            "id": "NP_001034086"
        }
    ],
    "function": [],
    "disease": [
        {
            "disease_id": "DOID:4947",
            "recommended_name": {
                "id": "DOID:4947",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:4947",
                "name": "cholangiocarcinoma",
                "description": "A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells."
            },
            "synonyms": [
                {
                    "id": "DOID:4947",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4947",
                    "name": "adult primary Cholangiocarcinoma",
                    "description": ""
                },
                {
                    "id": "DOID:4947",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4947",
                    "name": "adult primary cholangiocellular carcinoma",
                    "description": ""
                },
                {
                    "id": "DOID:4947",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:4947",
                    "name": "cholangiosarcoma",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "4947",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:4947"
                }
            ]
        },
        {
            "disease_id": "DOID:4989",
            "recommended_name": {
                "id": "DOID:4989",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:4989",
                "name": "pancreatitis",
                "description": "A pancreas disease that is characterized by inflammation of the pancreas."
            },
            "synonyms": [
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "hereditary chronic pancreatitis",
                    "description": "Hereditary chronic pancreatitis (HCP), a rare inherited form of pancreatitis is defined as recurrent acute pancreatitis and/or chronic pancreatitis in two first-degree relatives or 3 or more second-degree relatives in 2 or more generations, for which no predisposing factors are identified. HCP is characterized by irreversible damage to both exocrine and endocrine components of the pancreas."
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "hereditary chronic pancreatitis",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "hereditary pancreatitis",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "HPC",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "Hp",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "PCTT",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "autosomal dominant hereditary pancreatitis",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "familial pancreatitis",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "pancreatitis, calcific",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "pancreatitis, calcific, included",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "pancreatitis, chronic",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "pancreatitis, chronic pancreatitis, chronic, susceptibility to, included",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "pancreatitis, chronic, protection against",
                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
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                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
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                    "description": ""
                },
                {
                    "id": "MONDO:0008185",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0008185",
                    "name": "pancreatitis, hereditary",
                    "description": ""
                },
                {
                    "id": "MIM:167800",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/167800",
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                    "description": "Pancreatitis, hereditary"
                }
            ],
            "evidence": [
                {
                    "id": "4989",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:4989"
                }
            ]
        }
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    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
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        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
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                    "database": "UniProtKB",
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                    "url": "https://www.uniprot.org/uniprot/Q792Y9"
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            ],
            "common_name": "Mouse"
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    ],
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            "name": "Gm5771",
            "url": "https://www.uniprot.org/uniprot/Q792Y9",
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                "end_pos": 41369290,
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            "id": "ENSMUSG00000058119",
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        },
        {
            "id": "cd00190",
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            "id": "436523",
            "url": "https://www.ncbi.nlm.nih.gov/gene/436523",
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        },
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            "id": "IPR001254",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254",
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            "categories": [
                "Protein Classification"
            ]
        },
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            "id": "IPR001314",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314",
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        },
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            "id": "IPR009003",
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            "categories": [
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        },
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            "id": "IPR018114",
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            "categories": [
                "Protein Classification"
            ]
        },
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            "id": "IPR033116",
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            "categories": [
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            ]
        },
        {
            "id": "IPR043504",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:436523",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:436523",
            "database": "KEGG Pathway",
            "categories": [
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            ]
        },
        {
            "id": "3646222",
            "url": "http://www.informatics.jax.org/marker/MGI:3646222",
            "database": "MGI",
            "categories": [
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            ]
        },
        {
            "id": "FTSWING",
            "url": "https://omabrowser.org/oma/group/FTSWING/",
            "database": "OMA",
            "categories": [
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            ]
        },
        {
            "id": "4629979at2759",
            "url": "http://www.orthodb.org/?query=4629979at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
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        },
        {
            "id": "PTHR24264",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24264",
            "database": "PANTHER",
            "categories": [
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        },
        {
            "id": "PTHR24264:SF10",
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            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00089",
            "url": "http://pfam.xfam.org/family/PF00089",
            "database": "Pfam",
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                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-1442490",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1442490",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
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        },
        {
            "id": "R-MMU-1462054",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1462054",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
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        },
        {
            "id": "R-MMU-1592389",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1592389",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
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        },
        {
            "id": "R-MMU-6798695",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6798695",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-6803157",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6803157",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001034086",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034086",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q792Y9",
            "url": "https://www.uniprot.org/uniprot/Q792Y9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q792Y9-1",
            "url": "https://www.uniprot.org/uniprot/Q792Y9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSALLFLALVGAAVAFPVDDDKIVGGYTCRENSVPYQVSLNSGYHFCGGSLINDQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFVNAAKIIKHPNFNRKTLNNDIMLIKLSSPVTLNARVATVALPSSCAPAGTQCLISGWGNTLSFGVSEPDLLQCLDAPLLPQADCEASYPGKITGNMVCAGFLEGGKDSCQGDSGGPVVCNGELQGIVSWGYGCALADNPGVYTKVCNYVDWIQDTIAAN",
        "length": 245,
        "header": "tr|Q792Y9-1|Q792Y9_MOUSE Isoform 1 of Trypsinogen 12  OS=Mus musculus OX=10090 GN=Gm5771 PE=1 SV=1 CANONICAL=Q792Y9-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q792Y9-1",
            "url": "",
            "sequence": {
                "sequence": "MSALLFLALVGAAVAFPVDDDKIVGGYTCRENSVPYQVSLNSGYHFCGGSLINDQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFVNAAKIIKHPNFNRKTLNNDIMLIKLSSPVTLNARVATVALPSSCAPAGTQCLISGWGNTLSFGVSEPDLLQCLDAPLLPQADCEASYPGKITGNMVCAGFLEGGKDSCQGDSGGPVVCNGELQGIVSWGYGCALADNPGVYTKVCNYVDWIQDTIAAN",
                "length": 245,
                "header": "tr|Q792Y9-1|Q792Y9_MOUSE Isoform 1 of Trypsinogen 12  OS=Mus musculus OX=10090 GN=Gm5771 PE=1 SV=1 CANONICAL=Q792Y9-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 41374134,
                "end_pos": 41369323,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000049079.9",
                        "url": "https://www.ensembl.org/id/ENSMUST00000049079.9"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000039684.8",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000039684.8"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Differential transcriptional regulation of individual TCR V beta segments before gene rearrangement.",
            "journal": "J. Immunol.",
            "date": "2001",
            "authors": "Chen F, Rowen L, Hood L, Rothenberg EV",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q792Y9",
                    "url": "https://www.uniprot.org/uniprot/Q792Y9"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11160223",
                    "url": "https://glygen.org/publication/PubMed/11160223"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:436523",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:436523",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-1442490",
            "name": "Collagen degradation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1442490",
            "resource": "Reactome",
            "description": "Collagen degradation"
        },
        {
            "id": "R-MMU-1462054",
            "name": "Alpha-defensins",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1462054",
            "resource": "Reactome",
            "description": "Alpha-defensins"
        },
        {
            "id": "R-MMU-1592389",
            "name": "Activation of Matrix Metalloproteinases",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1592389",
            "resource": "Reactome",
            "description": "Activation of Matrix Metalloproteinases"
        },
        {
            "id": "R-MMU-6798695",
            "name": "Neutrophil degranulation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6798695",
            "resource": "Reactome",
            "description": "Neutrophil degranulation"
        },
        {
            "id": "R-MMU-6803157",
            "name": "Antimicrobial peptides",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6803157",
            "resource": "Reactome",
            "description": "Antimicrobial peptides"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "P07477-1",
            "protein_name": "Serine protease 1",
            "gene_name": "PRSS1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS",
                "length": 247
            },
            "evidence": [
                {
                    "id": "45225307",
                    "url": "http://www.informatics.jax.org/homology/45225307",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "P07478-1",
            "protein_name": "Trypsin-2",
            "gene_name": "PRSS2",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNSGYHFCGGSLISEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVINSRVSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKITNNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNYVDWIKDTIAANS",
                "length": 247
            },
            "evidence": [
                {
                    "id": "45225307",
                    "url": "http://www.informatics.jax.org/homology/45225307",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "serine-type endopeptidase activity",
                        "id": "GO:0004252",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q792Y9",
                                "url": "https://www.uniprot.org/uniprot/Q792Y9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "extracellular space",
                        "id": "GO:0005615",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q792Y9",
                                "url": "https://www.uniprot.org/uniprot/Q792Y9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "collagen-containing extracellular matrix",
                        "id": "GO:0062023",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062023",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q792Y9",
                                "url": "https://www.uniprot.org/uniprot/Q792Y9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 1,
                "go_terms": [
                    {
                        "name": "proteolysis",
                        "id": "GO:0006508",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q792Y9",
                                "url": "https://www.uniprot.org/uniprot/Q792Y9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
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