{ "uniprot_canonical_ac": "Q78EH2-1", "uniprot_ac": "Q78EH2", "uniprot_id": "PCSK4_RAT", "mass": { "chemical_mass": 75740.0, "monoisotopic_mass": 75740.0 }, "refseq": { "ac": "NP_598243", "name": "proprotein convertase subtilisin/kexin type 4 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598243" }, "gene_names": [ { "name": "Pcsk4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q78EH2", "id": "Q78EH2" }, { "name": "Nec-3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q78EH2", "id": "Q78EH2" }, { "name": "Nec3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q78EH2", "id": "Q78EH2" }, { "name": "Pcsk4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598243", "id": "NP_598243" } ], "protein_names": [ { "name": "Proprotein convertase subtilisin/kexin type 4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q78EH2" }, { "name": "3.4.21.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q78EH2" }, { "name": "KEX2-like endoprotease 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q78EH2" }, { "name": "NEC 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q78EH2" }, { "name": "Neuroendocrine convertase 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q78EH2" }, { "name": "PC4; NEC 3; prohormone convertase 3; KEX2-like endoprotease 3; neuroendocrine convertase 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598243", "id": "NP_598243" }, { "name": "PC4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q78EH2" }, { "name": "Prohormone convertase 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q78EH2" }, { "name": "proprotein convertase subtilisin/kexin type 4 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598243", "id": "NP_598243" } ], "function": [ { "annotation": "Maturation by propeptide removal occurs very inefficiently when rat or human proPCSK4 is overexpressed in HEK293 cells.", "evidence": [ { "database": "RefSeq", "id": "NP_598243", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598243" }, { "database": "PubMed", "id": "21080038", "url": "https://glygen.org/publication/PubMed/21080038" } ] }, { "annotation": "Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (By similarity). May also participate in folliculogenesis in the ovaries (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2#function" }, { "database": "UniProtKB", "id": "P29121", "url": "https://www.uniprot.org/uniprot/P29121#function" }, { "database": "UniProtKB", "id": "Q6UW60", "url": "https://www.uniprot.org/uniprot/Q6UW60#function" } ] } ], "disease": [ { "disease_id": "DOID:0050861", "recommended_name": { "id": "DOID:0050861", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050861", "name": "colorectal adenocarcinoma", "description": "A colorectal carcinoma that derives_from epithelial cells of glandular origin." }, "synonyms": [], "evidence": [ { "id": "0050861", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050861" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2" } ], "common_name": "Rat" } ], "gene": [ { "name": "Pcsk4", "url": "https://www.uniprot.org/uniprot/Q78EH2", "locus": { "chromosome": "7", "start_pos": 9389585, "end_pos": 9381361, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000016405", "url": "https://www.ensembl.org/id/ENSRNOG00000016405" } ] } } ], "crossref": [ { "id": "ENSRNOG00000016405", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000016405", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3.4.21.B24", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.21.B24&UniProtAcc=Q78EH2", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "3.4.21.B25", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.4.21.B25&UniProtAcc=Q78EH2", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd04059", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04059", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "171085", "url": "https://www.ncbi.nlm.nih.gov/gene/171085", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR000209", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000209", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002884", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002884", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015500", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015500", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022398", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022398", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023827", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023827", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023828", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023828", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032815", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032815", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR034182", "url": "https://www.ebi.ac.uk/interpro/entry/IPR034182", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036852", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036852", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038466", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038466", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:171085", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:171085", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HRGTRQK", "url": "https://omabrowser.org/oma/group/HRGTRQK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5474719at2759", "url": "http://www.orthodb.org/?query=5474719at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42884", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42884", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42884:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42884:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00082", "url": "http://pfam.xfam.org/family/PF00082", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01483", "url": "http://pfam.xfam.org/family/PF01483", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16470", "url": "http://pfam.xfam.org/family/PF16470", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q78EH2", "url": "http://purl.obolibrary.org/obo/PR_Q78EH2", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_598243", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598243", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "620325", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=620325", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "D3ZKU8", "url": "https://www.uniprot.org/uniprot/D3ZKU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3ZKU8-1", "url": "https://www.uniprot.org/uniprot/D3ZKU8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q78EH2-1", "url": "https://www.uniprot.org/uniprot/Q78EH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q78EH2-2", "url": "https://www.uniprot.org/uniprot/Q78EH2-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q78EH2-3", "url": "https://www.uniprot.org/uniprot/Q78EH2-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q78EH2-4", "url": "https://www.uniprot.org/uniprot/Q78EH2-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q78EH2-5", "url": "https://www.uniprot.org/uniprot/Q78EH2-5", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRPSQTALWLGLVLSLALLAVGWASARPPIYVSSWAVRVTKGYQEAERLARKFGFVNLGQIFPDDQYFHLRHRGVAQQSLTPHWGHRLRLKKEPKVRWFEQQTLRRRVKRSLVVPTDPWFSKQWYMNKEIEQDLNILKVWNQGLTGRGVVVSILDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPNDENRHGTRCAGEVSATANNGFCGAGVAFNARIGGVRMLDGAITDIVEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGLLTQEAFRRGVTKGRQGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTRQGRVPWYSEACASTFTTTFSSGVVTDPQIVTTDLHHQCTDKHTGTSASAPLAAGMIALALEANPLLTWRDLQHLVVRASRPAQLQAEDWRINGVGRQVSHHYGYGLLDAGLLVDLARVWLPTKPQKKCTIRVVHTPTPILPRMLVPKNVTVCCDGSRRRLIRSLEHVQVQLSLSYSRRGDLEIFLTSPMGTRSTLVAIRPLDISGQGYNNWIFMSTHYWDEDPQGLWTLGLENKGYYYNTGTLYYCTLLLYGTAEDMTARPQTPQESHCPLSIVAELCLISSKQWWWLYSHTQQPVTKGQDSCHPPTTPARQLDQRLHCLFPAPHAGSASEPLQGLSPLAAILAISLGPWCCPC", "length": 678, "header": "sp|Q78EH2-1|PCSK4_RAT Isoform 1 of Proprotein convertase subtilisin/kexin type 4 OS=Rattus norvegicus OX=10116 GN=Pcsk4 PE=2 SV=1 CANONICAL=Q78EH2-1" }, "isoforms": [ { "isoform_ac": "D3ZKU8-1", "url": "", "sequence": { "sequence": "MRPSQTALWLGLVLSLALLAVGWASARPPIYVSSWAVRVTKGYQEAERLARKFGFVNLGQIFPDDQYFHLRHRGVAQQSLTPHWGHRLRLKKEPKVRWFEQQTLRRRVKRSLVVPTDPWFSKQWYMNKEIEQDLNILKVWNQGLTGRGVVVSILDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPNDENRHGTRCAGEVSATANNGFCGAGVAFNARIGGVRMLDGAITDIVEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGLLTQEAFRRGVTKGRQGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTRQGRVPWYSEACASTFTTTFSSGVVTDPQIVTTDLHHQCTDKHTGTSASAPLAAGMIALALEANPLLTWRDLQHLVVRASRPAQLQAEDWRINGVGRQVSHHYGYGLLDAGLLVDLARVWLPTKPQKKCTIRVVHTPTPILPRMLVPKNVTVCCDGSRRRLIRSLEHVQVQLSLSYSRRGDLEIFLTSPMGTRSTLVAIRPLDISGQGYNNWIFMSTHYWDEDPQGLWTLGLENKGYYYNTGTLYYCTLLLYGTAEDMTARPQTPQVTSCAHACAEGHRGAVPGKSLSPLHRGRTLPHLQQAVVVALQPHTAASDQGTGQLSPSYHTCSAA", "length": 654, "header": "tr|D3ZKU8-1|PCSK4_RAT Computationally mapped isoform of Proprotein convertase subtilisin/kexin type 4 OS=Rattus norvegicus OX=10116 GN=Pcsk4 PE=2 SV=1 CANONICAL=Q78EH2-1" }, "locus": { "chromosome": "7", "start_pos": 9389106, "end_pos": 9381366, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000022358.8", "url": "https://www.ensembl.org/id/ENSRNOT00000022358.8" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000022358.5", "url": "https://www.ensembl.org/id/ENSRNOP00000022358.5" } ] } }, { "isoform_ac": "Q78EH2-1", "url": "", "sequence": { "sequence": "MRPSQTALWLGLVLSLALLAVGWASARPPIYVSSWAVRVTKGYQEAERLARKFGFVNLGQIFPDDQYFHLRHRGVAQQSLTPHWGHRLRLKKEPKVRWFEQQTLRRRVKRSLVVPTDPWFSKQWYMNKEIEQDLNILKVWNQGLTGRGVVVSILDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPNDENRHGTRCAGEVSATANNGFCGAGVAFNARIGGVRMLDGAITDIVEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGLLTQEAFRRGVTKGRQGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTRQGRVPWYSEACASTFTTTFSSGVVTDPQIVTTDLHHQCTDKHTGTSASAPLAAGMIALALEANPLLTWRDLQHLVVRASRPAQLQAEDWRINGVGRQVSHHYGYGLLDAGLLVDLARVWLPTKPQKKCTIRVVHTPTPILPRMLVPKNVTVCCDGSRRRLIRSLEHVQVQLSLSYSRRGDLEIFLTSPMGTRSTLVAIRPLDISGQGYNNWIFMSTHYWDEDPQGLWTLGLENKGYYYNTGTLYYCTLLLYGTAEDMTARPQTPQESHCPLSIVAELCLISSKQWWWLYSHTQQPVTKGQDSCHPPTTPARQLDQRLHCLFPAPHAGSASEPLQGLSPLAAILAISLGPWCCPC", "length": 678, "header": "sp|Q78EH2-1|PCSK4_RAT Isoform 1 of Proprotein convertase subtilisin/kexin type 4 OS=Rattus norvegicus OX=10116 GN=Pcsk4 PE=2 SV=1 CANONICAL=Q78EH2-1" }, "locus": {} }, { "isoform_ac": "Q78EH2-2", "url": "", "sequence": { "sequence": "MRPSQTALWLGLVLSLALLAVGWASARPPIYVSSWAVRVTKGYQEAERLARKFGFVNLGQIFPDDQYFHLRHRGVAQQSLTPHWGHRLRLKKEPKVRWFEQQTLRRRVKRSLVVPTDPWFSKQWYMNKEIEQDLNILKVWNQGLTGRGVVVSILDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPNDENRHGTRCAGEVSATANNGFCGAGVAFNARIGGVRMLDGAITDIVEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGLLTQEAFRRGVTKGRQGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTRQGRVPWYSEACASTFTTTFSSGVVTDPQIVTTDLHHQCTDKHTGTSASAPLAAGMIALALEANPLLTWRDLQHLVVRASRPAQLQAEDWRINGVGRQVSHHYGYGLLDAGLLVDLARVWLPTKPQKKCTIRVVHTPTPILPRMLVPKNVTVCCDGSRRRLIRSLEHVQVQLSLSYSRRGDLEIFLTSPMGTRSTLVAIRPLDISGQGYNNWIFMSTHYWDEDPQGLWTLGLENKGYYYNTGTLYYCTLLLYGTAEDMTARPQTPQELCLISSKQWWWLYSHTQQPVTKGQDSCHPPTTPARQLDQRLHCLFPAPHAGSASEPLQGLSPLAAILAISLGPWCCPC", "length": 668, "header": "sp|Q78EH2-2|PCSK4_RAT Isoform 2 of Proprotein convertase subtilisin/kexin type 4 OS=Rattus norvegicus OX=10116 GN=Pcsk4 PE=2 SV=1 CANONICAL=Q78EH2-1" }, "locus": {} }, { "isoform_ac": "Q78EH2-3", "url": "", "sequence": { "sequence": "MRPSQTALWLGLVLSLALLAVGWASARPPIYVSSWAVRVTKGYQEAERLARKFGFVNLGQIFPDDQYFHLRHRGVAQQSLTPHWGHRLRLKKEPKVRWFEQQTLRRRVKRSLVVPTDPWFSKQWYMNKEIEQDLNILKVWNQGLTGRGVVVSILDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPNDENRHGTRCAGEVSATANNGFCGAGVAFNARIGGVRMLDGAITDIVEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGLLTQEAFRRGVTKGRQGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTRQGRVPWYSEACASTFTTTFSSGVVTDPQIVTTDLHHQCTDKHTGTSASAPLAAGMIALALEANPLLTWRDLQHLVVRASRPAQLQAEDWRINGVGRQVSHHYGYGLLDAGLLVDLARVWLPTKPQKKCTIRVVHTPTPILPRMLVPKNVTVCCDGSRRRLIRSLEHVQVQLSLSYSRRGDLEIFLTSPMGTRSTLVAIRPLDISGQGYNNWIFMSTHYWDEDPQGLWTLGLENKGYYYNTGTLYYCTLLLYGTAEDMTARPQTPQVTSCAHACAEGHRGAVPGKSLSPLHCGRTLPHLQQAVVVALQPHTAASDQGTGQLSPSYHTCSAA", "length": 654, "header": "sp|Q78EH2-3|PCSK4_RAT Isoform 3 of Proprotein convertase subtilisin/kexin type 4 OS=Rattus norvegicus OX=10116 GN=Pcsk4 PE=2 SV=1 CANONICAL=Q78EH2-1" }, "locus": {} }, { "isoform_ac": "Q78EH2-4", "url": "", "sequence": { "sequence": "MRPSQTALWLGLVLSLALLAVGWASARPPIYVSSWAVRVTKGYQEAERLARKFGFVNLGQIFPDDQYFHLRHRGVAQQSLTPHWGHRLRLKKEPKVRWFEQQTLRRRVKRSLVVPTDPWFSKQWYMNKEIEQDLNILKVWNQGLTGRGVVVSILDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPNDENRHGTRCAGEVSATANNGFCGAGVAFNARIGGVRMLDGAITDIVEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGLLTQEAFRRGVTKGRQGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTRQGRVPWYSEACASTFTTTFSSGVVTDPQIVTTDLHHQCTDKHTGTSASAPLAAGMIALALEANPLLTWRDLQHLVVRASRPAQLQAEDWRINGVGRQVSHHYGYGLLDAGLLVDLARVWLPTKPQKKCTIRVVHTPTPILPRMLVPKNVTVCCDGSRRRLIRSLEHVQVQLSLSYSRRGDLEIFLTSPMGTRSTLVAIRPLDISGQGYNNWIFMSTHYWDEDPQGLWTLGLENKGYYYNTGTLYYCTLLLYGTAEDMTARPQTPQKVIVPSPLWQNSASSPASSGGGSTATHSSQ", "length": 619, "header": "sp|Q78EH2-4|PCSK4_RAT Isoform 4 of Proprotein convertase subtilisin/kexin type 4 OS=Rattus norvegicus OX=10116 GN=Pcsk4 PE=2 SV=1 CANONICAL=Q78EH2-1" }, "locus": {} }, { "isoform_ac": "Q78EH2-5", "url": "", "sequence": { "sequence": "MRPSQTALWLGLVLSLALLAVGWASARPPIYVSSWAVRVTKGYQEAERLARKFGFVNLGQIFPDDQYFHLRHRGVAQQSLTPHWGHRLRLKKEPKVRWFEQQTLRRRVKRSLVVPTDPWFSKQWYMNKEIEQDLNILKVWNQGLTGRGVVVSILDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPNDENRHGTRCAGEVSATANNGFCGAGVAFNARIGGVRMLDGAITDIVEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGLLTQEAFRRGVTKGRQGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTRQGRVPWYSEACASTFTTTFSSGVVTDPQIVTTDLHHQCTDKHTGTSASAPLAAGMIALALEANPLLTWRDLQHLVVRASRPAQLQAEDWRINGVGRQVSHHYGYGLLDAGLLVDLARVWLPTKPQKKCTIRVVHTPTPILPRMLVPKNVTVCCDGSRRRLIRSLEHVQVQLSLSYSRRGDLEIFLTSPMGTRSTLVAIRPLDISGQGYNNWIFMSTHYWDEDPQGLWTLGLENKGYYYNTGTLYYCTLLLYGTAEDMTARPQTPQNSASSPASSGGGSTATHSSQ", "length": 609, "header": "sp|Q78EH2-5|PCSK4_RAT Isoform 5 of Proprotein convertase subtilisin/kexin type 4 OS=Rattus norvegicus OX=10116 GN=Pcsk4 PE=2 SV=1 CANONICAL=Q78EH2-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 472, "start_aa": "Asn", "end_pos": 472, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn472", "evidence": [ { "id": "Q78EH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q78EH2#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase.", "journal": "Mol. Endocrinol.", "date": "1992", "authors": "Seidah NG, Day R, Hamelin J, Gaspar A, Collard MW, Chretien M", "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2" } ], "reference": [ { "type": "PubMed", "id": "1448111", "url": "https://glygen.org/publication/PubMed/1448111" } ] }, { "title": "The precursor to the germ cell-specific PCSK4 proteinase is inefficiently activated in transfected somatic cells: evidence of interaction with the BiP chaperone.", "journal": "Mol. Cell. Biochem.", "date": "2011", "authors": "Gyamera-Acheampong C, Sirois F, Denis NJ, Mishra P, Figeys D, Basak A, Mbikay M", "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2" }, { "database": "RefSeq", "id": "NP_598243", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598243" } ], "reference": [ { "type": "PubMed", "id": "21080038", "url": "https://glygen.org/publication/PubMed/21080038" } ] } ], "pathway": [ { "id": "rno:171085", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:171085", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P29121-1", "protein_name": "Proprotein convertase subtilisin/kexin type 4", "gene_name": "Pcsk4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRPSQTELWLGLTLTLALLAVRWASAQAPIYVSSWAVRVTKGYQEAERLARKFGFVNLGQIFPDDQYFHLRHRGVAQQSLTPHWGHRLRLKKDPKVRWFEQQTLRRRVKRSLVVPTDPWFSKQWYMNKEIQQDLNILKAWNQGLTGRGVVISILDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPNDENRHGTRCAGEVSATANNGFCGAGVAFNARIGGVRMLDGAITDIVEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGLLTQEAFRRGVTKGRQGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTRQGRVPWYSEACASTFTTTFSSGVVTDPQIVTTDLHHQCTDKHTGTSASAPLAAGMIALALEANPLLTWRDLQHLVVRASRPAQLQAEDWRINGVGRQVSHHYGYGLLDAGLLVDLARVWLPTKPQKKCAIRVVHTPTPILPRMLVPKNVTACSDGSRRRLIRSLEHVQVQLSLSYSRRGDLEIFLTSPMGTRSTLVAIRPLDISGQGYNNWIFMSTHYWDEDPQGLWTLGLENKGYYFNTGTLYYYTLLLYGTAEDMTARPQAPQVTSRARACVQRDTEGLCQESHSPLSILAGLCLISSQQWWWLYSHPQQPVTEGQASCHPPVTPAAAA", "length": 655 }, "evidence": [ { "id": "45243164", "url": "http://www.informatics.jax.org/homology/45243164", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6UW60-1", "protein_name": "Proprotein convertase subtilisin/kexin type 4", "gene_name": "PCSK4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRPAPIALWLRLVLALALVRPRAVGWAPVRAPIYVSSWAVQVSQGNREVERLARKFGFVNLGPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNPKVQWFQQQTLQRRVKRSVVVPTDPWFSKQWYMNSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVRMLDGTITDVIEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGVATDPQIVTTDLHHGCTDQHTGTSASAPLAAGMIALALEANPFLTWRDMQHLVVRASKPAHLQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDTARTWLPTQPQRKCAVRVQSRPTPILPLIYIRENVSACAGLHNSIRSLEHVQAQLTLSYSRRGDLEISLTSPMGTRSTLVAIRPLDVSTEGYNNWVFMSTHFWDENPQGVWTLGLENKGYYFNTGTLYRYTLLLYGTAEDMTARPTGPQVTSSACVQRDTEGLCQACDGPAYILGQLCLAYCPPRFFNHTRLVTAGPGHTAAPALRVCSSCHASCYTCRGGSPRDCTSCPPSSTLDQQQGSCMGPTTPDSRPRLRAAACPHHRCPASAMVLSLLAVTLGGPVLCGMSMDLPLYAWLSRARATPTKPQVWLPAGT", "length": 755 }, "evidence": [ { "id": "45243164", "url": "http://www.informatics.jax.org/homology/45243164", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "binding of sperm to zona pellucida", "id": "GO:0007339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007339", "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2" } ], "pmid": "" }, { "name": "protein processing", "id": "GO:0016485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016485", "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2" } ], "pmid": "" }, { "name": "acrosome reaction", "id": "GO:0007340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007340", "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2" } ], "pmid": "" }, { "name": "sperm capacitation", "id": "GO:0048240", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048240", "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2" } ], "pmid": "" }, { "name": "fertilization", "id": "GO:0009566", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009566", "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2" } ], "pmid": "" }, { "name": "peptide hormone processing", "id": "GO:0016486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016486", "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2" } ], "pmid": "" }, { "name": "reproductive process", "id": "GO:0022414", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022414", "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "acrosomal membrane", "id": "GO:0002080", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002080", "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2" } ], "pmid": "" }, { "name": "acrosomal vesicle", "id": "GO:0001669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 472, "end_pos": 474, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "N-glycosylated.", "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2" }, { "database": "PubMed", "id": "Q6UW60", "url": "https://glygen.org/publication/PubMed/Q6UW60" } ] }, { "annotation": "Synthesized in the endoplasmic reticulum as a zymogen, is matured by autocatalytic cleavage between the prodomain and the catalytic domain.", "evidence": [ { "database": "UniProtKB", "id": "Q78EH2", "url": "https://www.uniprot.org/uniprot/Q78EH2" }, { "database": "PubMed", "id": "Q6UW60", "url": "https://glygen.org/publication/PubMed/Q6UW60" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }