{
    "uniprot_canonical_ac": "Q76M68-1",
    "uniprot_ac": "Q76M68",
    "uniprot_id": "IQEC3_RAT",
    "mass": {
        "chemical_mass": 129018.0,
        "monoisotopic_mass": 129018.0
    },
    "refseq": {
        "ac": "NP_997500",
        "name": "IQ motif and SEC7 domain-containing protein 3",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997500"
    },
    "gene_names": [
        {
            "name": "Iqsec3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q76M68",
            "id": "Q76M68"
        },
        {
            "name": "Iqsec3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997500",
            "id": "NP_997500"
        },
        {
            "name": "Sag",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q76M68",
            "id": "Q76M68"
        },
        {
            "name": "sag",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997500",
            "id": "NP_997500"
        }
    ],
    "protein_names": [
        {
            "name": "IQ motif and SEC7 domain-containing protein 3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q76M68"
        },
        {
            "name": "IQ motif and SEC7 domain-containing protein 3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997500",
            "id": "NP_997500"
        },
        {
            "name": "Potential synaptic guanine nucleotide exchange factor for Arf",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q76M68"
        },
        {
            "name": "SynArfGEF-Po",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q76M68"
        },
        {
            "name": "synArfGEF; synArfGEF-Po; potential synaptic guanine nucleotide exchange factor for Arf; IQ motif and Sec7 domain 3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997500",
            "id": "NP_997500"
        }
    ],
    "function": [
        {
            "annotation": "Acts as a guanine nucleotide exchange factor (GEF) for ARF1.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q76M68",
                    "url": "https://www.uniprot.org/uniprot/Q76M68#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9UPP2",
                    "url": "https://www.uniprot.org/uniprot/Q9UPP2#function"
                }
            ]
        },
        {
            "annotation": "Cloned from a rat brain cDNA library; both the mRNA and the protein were localized in the postsynaptic compartments; results suggest a postsynaptic role of synArfGEF in the brain",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_997500",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997500"
                },
                {
                    "database": "PubMed",
                    "id": "15189337",
                    "url": "https://glygen.org/publication/PubMed/15189337"
                }
            ]
        },
        {
            "annotation": "These data reveal that IQSEC3 acts together with gephyrin to regulate inhibitory synapse development.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_997500",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997500"
                },
                {
                    "database": "PubMed",
                    "id": "27002143",
                    "url": "https://glygen.org/publication/PubMed/27002143"
                }
            ]
        },
        {
            "annotation": "We provide biochemical evidence to confirm gephyrin/IQSEC3 interaction near the IQSEC3 IQ motif, which in turn binds calmodulin at low Ca(2+) concentrations",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_997500",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997500"
                },
                {
                    "database": "PubMed",
                    "id": "30142695",
                    "url": "https://glygen.org/publication/PubMed/30142695"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q76M68",
                    "url": "https://www.uniprot.org/uniprot/Q76M68"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Iqsec3",
            "url": "https://www.uniprot.org/uniprot/Q76M68",
            "locus": {
                "chromosome": "4",
                "start_pos": 154610934,
                "end_pos": 154707310,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000014083",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000014083"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000014083",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000014083",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00171",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00171",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd13318",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13318",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd14686",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14686",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "404781",
            "url": "https://www.ncbi.nlm.nih.gov/gene/404781",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000048",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR000904",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000904",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011993",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR023394",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023394",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR033742",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR033742",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR035999",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035999",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:404781",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:404781",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "QPCLARM",
            "url": "https://omabrowser.org/oma/group/QPCLARM/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "204547at2759",
            "url": "http://www.orthodb.org/?query=204547at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10663",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10663",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10663:SF318",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10663:SF318",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01369",
            "url": "http://pfam.xfam.org/family/PF01369",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF16453",
            "url": "http://pfam.xfam.org/family/PF16453",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q76M68",
            "url": "http://purl.obolibrary.org/obo/PR_Q76M68",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_997500",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997500",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1593191",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1593191",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "F1LPA3",
            "url": "https://www.uniprot.org/uniprot/F1LPA3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F1LPA3-1",
            "url": "https://www.uniprot.org/uniprot/F1LPA3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q76M68",
            "url": "https://www.uniprot.org/uniprot/Q76M68",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q76M68-1",
            "url": "https://www.uniprot.org/uniprot/Q76M68-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRQRIDELERRLDELSAENRSLWEHQQLLQAQPPPGLVPPPSAPLPAPAATAPAATAAQEPLQDHGQLIPATPEPPLQHHGQLLAQPQPAPSSRVQTPQSPHQHPVAPGAVADKEKERPSSCCAAAGALLQHASPAALGKGVLSRRPKNETVLHQFCCPATDTEQKPACSDLASQSDGSCAQAGGGMEDSVVAAVAAGRPSAHAPKAQAPELQQEEERPGAVGSPRAGPLRAASPGQQQPALATALCSHTPAASEYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRAPTAESLVAEKALLESCGLLGLPLGRSPSLPPTFAGSLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLQESGAYQLHQALHPSAGQPGLETEAAREPDSGPGSGDEAGSLPQGHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTAQATAEPAAVQTEQGDAATQEVSEVPASELMDPPVEDSEAAESGAQSAHEPTVAEAVVEEAVATEAEEEEEGAGQAGKGAEAEVGDNSEQLSSSSASTKSAKSGSEVSAAASKEALQAVILSLPRYHCENPASCRSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSNMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSMPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSFTYTFCKAVGLLGMRFHLFENEYYSHGITLATPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELERQQGTKTLSARSAGAQGDPQSKQGSPTAKREAMAGEKATESSGEVSIHNRLQTFQHSPKLGVERGAPAPSPPTSPPPPLPPDPQPSPLREQPPPLPLPPPTPPGTLVQCQQIVKVIVLDKPCLARMEPLLSQALSCYASSSSDSCGSTPLRGPGSPVKVIHQPPLPPPPPPYNHPHQFCPPGSLLLRRRYSSGSRSLV",
        "length": 1194,
        "header": "sp|Q76M68-1|IQEC3_RAT Isoform 1 of IQ motif and SEC7 domain-containing protein 3  OS=Rattus norvegicus OX=10116 GN=Iqsec3 PE=1 SV=1 CANONICAL=Q76M68-1"
    },
    "isoforms": [
        {
            "isoform_ac": "F1LPA3-1",
            "url": "",
            "sequence": {
                "sequence": "MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRQRIDELERRLDELSAENRSLWEHQQLLQAQPPPGLVPPPSAPLPAPAATAPAATAAQEPLQDHGQLIPATPEPPLQHHGQLLAQPQPAPSSRVQTPQSPHQHPVAPGAVADKEKERPSSCCAAAGALLQHASPAALGKGVLSRRPKNETVLHQFCCPAADTEQKPACSDLASQSDGSCAQAGGGMEDSVVAAVAAGRPSAHAPKAQAPELQQEEERPGAVGSPRAGPLRAASPGQQQPALATALCSHTPAASEYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRAPTAESLVAEKALLESCGLLGLPLGRSPSLPPTFAGSLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLQESGAYQLHQALHPSAGQPGLETEAAREPDSGPGSGDEAGSLPQGHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTAQATAEPAAVQTEQGDAATQEVSEVPASELMDPPVEDSEAAESGAQSAHEPTVAEAVVEEAVATEAEEEEEGAGQAGKGAEAEVGDNSEQLSSSSASTKSAKSGSEVSAAASKEALQAVILSLPRYHCENPASCRSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSNMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSMPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSFTYTFCKAVGLLGMRFHLFENEYYSHGITLATPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELERQQGTKTLSARSAGAQGDPQSKQGSPTAKREAMAGEKATESSGEVSIHNRLQTFQHSPKLGVERGAPAPSPPTSPPPPLPPDPQPSPLRSSPATATATTHTPRHPGTVPANCQGHCPG",
                "length": 1114,
                "header": "tr|F1LPA3-1|F1LPA3_RAT Computationally mapped isoform of IQ motif and Sec7 domain ArfGEF 3  OS=Rattus norvegicus OX=10116 GN=Iqsec3 PE=1 SV=2 CANONICAL=Q76M68-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 154706667,
                "end_pos": 154614340,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000018902.6",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000018902.6"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000018902.5",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000018902.5"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q76M68-1",
            "url": "",
            "sequence": {
                "sequence": "MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRQRIDELERRLDELSAENRSLWEHQQLLQAQPPPGLVPPPSAPLPAPAATAPAATAAQEPLQDHGQLIPATPEPPLQHHGQLLAQPQPAPSSRVQTPQSPHQHPVAPGAVADKEKERPSSCCAAAGALLQHASPAALGKGVLSRRPKNETVLHQFCCPATDTEQKPACSDLASQSDGSCAQAGGGMEDSVVAAVAAGRPSAHAPKAQAPELQQEEERPGAVGSPRAGPLRAASPGQQQPALATALCSHTPAASEYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRAPTAESLVAEKALLESCGLLGLPLGRSPSLPPTFAGSLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLQESGAYQLHQALHPSAGQPGLETEAAREPDSGPGSGDEAGSLPQGHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTAQATAEPAAVQTEQGDAATQEVSEVPASELMDPPVEDSEAAESGAQSAHEPTVAEAVVEEAVATEAEEEEEGAGQAGKGAEAEVGDNSEQLSSSSASTKSAKSGSEVSAAASKEALQAVILSLPRYHCENPASCRSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSNMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSMPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSFTYTFCKAVGLLGMRFHLFENEYYSHGITLATPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELERQQGTKTLSARSAGAQGDPQSKQGSPTAKREAMAGEKATESSGEVSIHNRLQTFQHSPKLGVERGAPAPSPPTSPPPPLPPDPQPSPLREQPPPLPLPPPTPPGTLVQCQQIVKVIVLDKPCLARMEPLLSQALSCYASSSSDSCGSTPLRGPGSPVKVIHQPPLPPPPPPYNHPHQFCPPGSLLLRRRYSSGSRSLV",
                "length": 1194,
                "header": "sp|Q76M68-1|IQEC3_RAT Isoform 1 of IQ motif and SEC7 domain-containing protein 3  OS=Rattus norvegicus OX=10116 GN=Iqsec3 PE=1 SV=1 CANONICAL=Q76M68-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 255,
            "end_pos": 255,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q76M68",
                    "url": "https://www.uniprot.org/uniprot/Q76M68"
                },
                {
                    "database": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q76M68",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q76M68"
                }
            ],
            "site_lbl": "Ser255"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Brain-specific potential guanine nucleotide exchange factor for Arf, synArfGEF (Po), is localized to postsynaptic density.",
            "journal": "J. Neurochem.",
            "date": "2004",
            "authors": "Inaba Y, Tian QB, Okano A, Zhang JP, Sakagami H, Miyazawa S, Li W, Komiyama A, Inokuchi K, Kondo H, Suzuki T",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q76M68",
                    "url": "https://www.uniprot.org/uniprot/Q76M68"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_997500",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997500"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15189337",
                    "url": "https://glygen.org/publication/PubMed/15189337"
                }
            ]
        },
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.",
            "journal": "Nature communications",
            "date": "2012",
            "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q76M68",
                    "url": "https://www.uniprot.org/uniprot/Q76M68"
                },
                {
                    "database": "UniProtKB",
                    "id": "F1LPA3",
                    "url": "https://www.uniprot.org/uniprot/F1LPA3"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q76M68",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q76M68"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                }
            ]
        },
        {
            "title": "IQ Motif and SEC7 Domain-containing Protein 3 (IQSEC3) Interacts with Gephyrin to Promote Inhibitory Synapse Formation.",
            "journal": "The Journal of biological chemistry",
            "date": "2016",
            "authors": "Um JW, Choii G, Park D, Kim D, Jeon S, Kang H, Mori T, Papadopoulos T, Yoo T, Lee Y, Kim E, Tabuchi K, Ko J",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_997500",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997500"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "27002143",
                    "url": "https://glygen.org/publication/PubMed/27002143"
                }
            ]
        },
        {
            "title": "The catalytic function of the gephyrin-binding protein IQSEC3 regulates neurotransmitter-specific matching of pre- and post-synaptic structures in primary hippocampal cultures.",
            "journal": "Journal of neurochemistry",
            "date": "2018",
            "authors": "Fruh S, Tyagarajan SK, Campbell B, Bosshard G, Fritschy JM",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_997500",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997500"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30142695",
                    "url": "https://glygen.org/publication/PubMed/30142695"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:404781",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:404781",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q3TES0-1",
            "protein_name": "IQ motif and SEC7 domain-containing protein 3",
            "gene_name": "Iqsec3",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRQRIDELERRLDELSAENRSLWEHQQLLQAQPPPGLVPPPPSAPLPAPAVTAPAAAAAQEPLQDHGQLIPASPEPPLQHHGQLLAQPQPAPSSRVQTPQSPHQHPVAPGAIADKEKERPSSCCAAAGALLQHASPAALGKGVLSRRPENETVLHQFCCPAADTEQKPACSDLASQSDGSCAQAGGGMEDSVVAAVAAGRPSAHAPKAQAPELQQEEERPGAVGSPRAGPLRAASPGRQQPALATALCSHTPAASEYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRAPTAESLVAEKALLEGCGLLGLPLGRSPSLPPTFAGSLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLQESGAYQLHQALHPSAGQPGLETEAAAREPESGPGSGDEAGGLPQGHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTAQATAEPAAAQAEQEDTADQEVSEVPASEQMDPPSEDSEAAESRAQSAQEPAVAQAVVEEAVATEAEEEEEGAKQAGKGAEAEGGDNSEQLSSSSASTKSAKSSSEASAAASKEALQAVILSLPRYHCENPASCRSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSNMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSMPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSFTYTFCKAVGLLGMRFHLFENEYYSHGITLATPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTKTLSVRSAGAQGDPQSKQGSPTAKREAMAGEKAAESSGEVSIHNRLQTSQHSPKLGVERGAPAPSPPTSPPPLPPDPQPSPLREQPPPLPLPPPTPPGTLVQCQQIVKVIVLDKPCLARMEPLLSQALSCYASSSSDSCGSTPLRGPGSPVKVIHQPPLPPPPPPYNHPHQFCPPGSMLLRRRYSSGSRSLV",
                "length": 1195
            },
            "evidence": [
                {
                    "id": "45235289",
                    "url": "http://www.informatics.jax.org/homology/45235289",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9UPP2-1",
            "protein_name": "IQ motif and SEC7 domain-containing protein 3",
            "gene_name": "IQSEC3",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MESLLENPVRAVLYLKELTAIVQNQQSLIHTQRERIDELERRLDELSAENRSLWEHQQLLQAQPPPGLVPPSSAPLPAAPATAPAAAARAQEPLQDQGQRSAAAPHPAPDRPPRQHHGQLLEQPQRGPGSRAHTPQSPHKHLGTQGAVTDKEKERPPSCCAAAGALLQHKSPSALGKGVLSRRPENETVLHQFCCPAADACSDLASQSDGSCTQAGGGMEDSVVAAAAVAAGRPSAHAPKAQAQELQEEEERPGAGAASPRAGPQHKASPGRQQPALATALCPHAPAASDYELSLDLKNKQIEMLEHKYGGHLVSRRAACTIQTAFRQYQLSKNFEKIRNSLLESRLPRRISLRKVRSPTAESLAAEKALMEGYGLVGLPLVRSPSLPPTFAGTLTELEDSFTEQVQSLAKSIDDALSTWSLKTMCSLRESGAYQLHQALQAAAGPPGLEAEGRAPESAGPGPGDDAAETPGLPPAHSGTLMMAFRDVTVQIANQNISVSSSTALSVANCLGAQTVQAPAEPAAGKAEQGETSGREAPEAPAVGREDASAEDSCAEAAASGAADGATAPKTEEEEEEEETAEVGRGAEAEAGDLEQLSSSSTSTKSAKSGSEASASASKDALQAMILSLPRYHCENPASCKSPTLSTDTLRKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKKQFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVVQQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGIYERIQQKELKSNEDHVTYVTKVEKSIVGMKTVLSVPHRRLVCCSRLFEVTDVNKLQKQAAHQREVFLFNDLLVILKLCPKKKSSSTYTFCKSVGLLGMQFQLFENEYYSHGITLVTPLSGSEKKQVLHFCALGSDEMQKFVEDLKESIAEVTELEQIRIEWELEKQQGTKTLSFKPCGAQGDPQSKQGSPTAKREAALRERPAESTVEVSIHNRLQTSQHNSGLGAERGAPVPPPDLQPSPPRQQTPPLPPPPPTPPGTLVQCQQIVKVIVLDKPCLARMEPLLSQALSCYTSSSSDSCGSTPLGGPGSPVKVTHQPPLPPPPPPYNHPHQFCPPGSLLHGHRYSSGSRSLV",
                "length": 1182
            },
            "evidence": [
                {
                    "id": "45235289",
                    "url": "http://www.informatics.jax.org/homology/45235289",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 7,
                "go_terms": [
                    {
                        "name": "GABA-ergic synapse",
                        "id": "GO:0098982",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098982",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q76M68",
                                "url": "https://www.uniprot.org/uniprot/Q76M68"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "postsynaptic density",
                        "id": "GO:0014069",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q76M68",
                                "url": "https://www.uniprot.org/uniprot/Q76M68"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "postsynaptic membrane",
                        "id": "GO:0045211",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q76M68",
                                "url": "https://www.uniprot.org/uniprot/Q76M68"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "inhibitory synapse",
                        "id": "GO:0060077",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060077",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q76M68",
                                "url": "https://www.uniprot.org/uniprot/Q76M68"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "glycinergic synapse",
                        "id": "GO:0098690",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098690",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q76M68",
                                "url": "https://www.uniprot.org/uniprot/Q76M68"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "postsynaptic specialization of symmetric synapse",
                        "id": "GO:0099629",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099629",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q76M68",
                                "url": "https://www.uniprot.org/uniprot/Q76M68"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q76M68",
                                "url": "https://www.uniprot.org/uniprot/Q76M68"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "guanyl-nucleotide exchange factor activity",
                        "id": "GO:0005085",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q76M68",
                                "url": "https://www.uniprot.org/uniprot/Q76M68"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 5,
                "go_terms": [
                    {
                        "name": "regulation of ARF protein signal transduction",
                        "id": "GO:0032012",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032012",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q76M68",
                                "url": "https://www.uniprot.org/uniprot/Q76M68"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of small GTPase mediated signal transduction",
                        "id": "GO:0051056",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051056",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q76M68",
                                "url": "https://www.uniprot.org/uniprot/Q76M68"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "actin cytoskeleton organization",
                        "id": "GO:0030036",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q76M68",
                                "url": "https://www.uniprot.org/uniprot/Q76M68"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "activation of GTPase activity",
                        "id": "GO:0090630",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090630",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q76M68",
                                "url": "https://www.uniprot.org/uniprot/Q76M68"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "postsynapse organization",
                        "id": "GO:0099173",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099173",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q76M68",
                                "url": "https://www.uniprot.org/uniprot/Q76M68"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 180,
            "end_pos": 182,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 489,
            "end_pos": 491,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 50,
            "end_pos": 52,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 1
                },
                {
                    "field": "total_sites",
                    "count": 1
                }
            ],
            "sort_fields": [
                "start_pos",
                "end_pos",
                "kinase_uniprot_canonical_ac",
                "kinase_gene_name",
                "residue",
                "comment",
                "site_lbl"
            ]
        },
        {
            "table_id": "snv",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_non_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 4
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "date",
                "authors"
            ]
        }
    ]
}