{ "uniprot_canonical_ac": "Q71FD5-1", "uniprot_ac": "Q71FD5", "uniprot_id": "ZNRF2_MOUSE", "mass": { "chemical_mass": 23705.0, "monoisotopic_mass": 23705.0 }, "refseq": {}, "gene_names": [ { "name": "Znrf2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q71FD5", "id": "Q71FD5" } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase ZNRF2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q71FD5" }, { "name": "2.3.2.27", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q71FD5" }, { "name": "RING-type E3 ubiquitin transferase ZNRF2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q71FD5" }, { "name": "Zinc/RING finger protein 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q71FD5" } ], "function": [ { "annotation": "E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation. Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases. In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism.", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5#function" }, { "database": "UniProtKB", "id": "Q8NHG8", "url": "https://www.uniprot.org/uniprot/Q8NHG8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Znrf2", "url": "https://www.uniprot.org/uniprot/Q71FD5", "locus": { "chromosome": "6", "start_pos": 54870485, "end_pos": 54793901, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000058446", "url": "https://www.ensembl.org/id/ENSMUSG00000058446" } ] } } ], "crossref": [ { "id": "ENSMUSG00000058446", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000058446", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16695", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16695", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:387524", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:387524", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1196246", "url": "http://www.informatics.jax.org/marker/MGI:1196246", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "RGNDGHR", "url": "https://omabrowser.org/oma/group/RGNDGHR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5474929at2759", "url": "http://www.orthodb.org/?query=5474929at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46661", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46661", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46661:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46661:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13639", "url": "http://pfam.xfam.org/family/PF13639", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q71FD5", "url": "http://purl.obolibrary.org/obo/PR_Q71FD5", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "A0A0N4SVW9", "url": "https://www.uniprot.org/uniprot/A0A0N4SVW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0N4SVW9-1", "url": "https://www.uniprot.org/uniprot/A0A0N4SVW9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6X469", "url": "https://www.uniprot.org/uniprot/F6X469", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6X469-1", "url": "https://www.uniprot.org/uniprot/F6X469-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q71FD5-1", "url": "https://www.uniprot.org/uniprot/Q71FD5-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGAKQSGPAANGRTRAYSGSDLPSGTGSGGGGADGARAARFAAPVSGAQQPSASAGAAAAAAAAASAPAAPRSRSLGGAVGSASGGRAAQSAFSIPSAGGGGGPYGSQDSVHSSPEDSVGARDRDRPAGGGPGGPRLVIGSLPAHLSPHLFGGFKCPVCSKFVPSDEMDLHLVMCLTKPRITYNEDVLSKDTGECAICLEELQQGDTIARLPCLCIYHKGCIDEWFEVNRSCPEHPSD", "length": 238, "header": "sp|Q71FD5-1|ZNRF2_MOUSE Isoform 1 of E3 ubiquitin-protein ligase ZNRF2 OS=Mus musculus OX=10090 GN=Znrf2 PE=1 SV=1 CANONICAL=Q71FD5-1" }, "isoforms": [ { "isoform_ac": "A0A0N4SVW9-1", "url": "", "sequence": { "sequence": "XGRAAQSAFSIPSAGGGGGPYGSQDSVHSSPEDSVGARDRDRPAGGGPGGPRLVIGSLPAHLSPHLFGVLLEPVV", "length": 75, "header": "tr|A0A0N4SVW9-1|ZNRF2_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase ZNRF2 OS=Mus musculus OX=10090 GN=Znrf2 PE=1 SV=1 CANONICAL=Q71FD5-1" }, "locus": { "chromosome": "6", "start_pos": 54819681, "end_pos": 54794255, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000148425.2", "url": "https://www.ensembl.org/id/ENSMUST00000148425.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000145276.2", "url": "https://www.ensembl.org/id/ENSMUSP00000145276.2" } ] } }, { "isoform_ac": "F6X469-1", "url": "", "sequence": { "sequence": "HLSPHLFGGFKCPVCSKFVPSDEMDLHLVMCLTKPRITYNEDVLSKDTGECAICLEELQQGDTIARLPCLCIYHKGCIDEWFEVNRSCPEHPSD", "length": 94, "header": "tr|F6X469-1|F6X469_MOUSE Computationally mapped isoform of Zinc and ring finger 2 OS=Mus musculus OX=10090 GN=Znrf2 PE=1 SV=1 CANONICAL=Q71FD5-1" }, "locus": { "chromosome": "6", "start_pos": 54861804, "end_pos": 54794433, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000127331.2", "url": "https://www.ensembl.org/id/ENSMUST00000127331.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000123316.2", "url": "https://www.ensembl.org/id/ENSMUSP00000123316.2" } ] } }, { "isoform_ac": "Q71FD5-1", "url": "", "sequence": { "sequence": "MGAKQSGPAANGRTRAYSGSDLPSGTGSGGGGADGARAARFAAPVSGAQQPSASAGAAAAAAAAASAPAAPRSRSLGGAVGSASGGRAAQSAFSIPSAGGGGGPYGSQDSVHSSPEDSVGARDRDRPAGGGPGGPRLVIGSLPAHLSPHLFGGFKCPVCSKFVPSDEMDLHLVMCLTKPRITYNEDVLSKDTGECAICLEELQQGDTIARLPCLCIYHKGCIDEWFEVNRSCPEHPSD", "length": 238, "header": "sp|Q71FD5-1|ZNRF2_MOUSE Isoform 1 of E3 ubiquitin-protein ligase ZNRF2 OS=Mus musculus OX=10090 GN=Znrf2 PE=1 SV=1 CANONICAL=Q71FD5-1" }, "locus": { "chromosome": "6", "start_pos": 54861804, "end_pos": 54794001, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000079869", "url": "https://www.ensembl.org/id/ENSMUST00000079869" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000078795", "url": "https://www.ensembl.org/id/ENSMUSP00000078795" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 107, "end_pos": 107, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q71FD5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q71FD5" } ], "site_lbl": "Ser107" }, { "start_pos": 110, "end_pos": 110, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q71FD5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q71FD5" } ], "site_lbl": "Ser110" }, { "start_pos": 113, "end_pos": 113, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "Q71FD5", "url": "http://phospho.elm.eu.org/byAccession/Q71FD5.html" }, { "database": "iPTMnet", "id": "Q71FD5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q71FD5" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ], "site_lbl": "Ser113" }, { "start_pos": 141, "end_pos": 141, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" }, { "database": "PubMed", "id": "19131326", "url": "https://glygen.org/publication/PubMed/19131326" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q71FD5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q71FD5" } ], "site_lbl": "Ser141" }, { "start_pos": 147, "end_pos": 147, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "site_lbl": "Ser147" }, { "start_pos": 189, "end_pos": 189, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "site_lbl": "Ser189" }, { "start_pos": 18, "end_pos": 18, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "Q71FD5", "url": "http://phospho.elm.eu.org/byAccession/Q71FD5.html" }, { "database": "iPTMnet", "id": "Q71FD5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q71FD5" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ], "site_lbl": "Ser18" }, { "start_pos": 20, "end_pos": 20, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q71FD5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q71FD5" } ], "site_lbl": "Ser20" }, { "start_pos": 24, "end_pos": 24, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q71FD5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q71FD5" } ], "site_lbl": "Ser24" }, { "start_pos": 75, "end_pos": 75, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "iPTMnet", "id": "Q71FD5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q71FD5" } ], "site_lbl": "Ser75" }, { "start_pos": 82, "end_pos": 82, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "site_lbl": "Ser82" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases.", "journal": "J. Neurosci.", "date": "2003", "authors": "Araki T, Milbrandt J", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "reference": [ { "type": "PubMed", "id": "14561866", "url": "https://glygen.org/publication/PubMed/14561866" } ] }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" }, { "database": "UniProtKB", "id": "A0A0N4SVW9", "url": "https://www.uniprot.org/uniprot/A0A0N4SVW9" }, { "database": "iPTMnet", "id": "Q71FD5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q71FD5" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] }, { "title": "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" }, { "database": "iPTMnet", "id": "Q71FD5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q71FD5" } ], "reference": [ { "type": "PubMed", "id": "19131326", "url": "https://glygen.org/publication/PubMed/19131326" } ] }, { "title": "The phagosomal proteome in interferon-gamma-activated macrophages.", "journal": "Immunity", "date": "2009", "authors": "Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "reference": [ { "type": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" }, { "database": "iPTMnet", "id": "Q71FD5", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q71FD5" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] } ], "pathway": [ { "id": "mmu:387524", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:387524", "resource": "KEGG Pathway" }, { "id": "R-MMU-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8NHG8-1", "protein_name": "E3 ubiquitin-protein ligase ZNRF2", "gene_name": "ZNRF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGAKQSGPAAANGRTRAYSGSDLPSSSSGGANGTAGGGGGARAAAAGRFPAQVPSAHQPSASGGAAAAAAAPAAPAAPRSRSLGGAVGSVASGARAAQSPFSIPNSSSGPYGSQDSVHSSPEDGGGGRDRPVGGSPGGPRLVIGSLPAHLSPHMFGGFKCPVCSKFVSSDEMDLHLVMCLTKPRITYNEDVLSKDAGECAICLEELQQGDTIARLPCLCIYHKGCIDEWFEVNRSCPEHPSD", "length": 242 }, "evidence": [ { "id": "Q71FD5", "url": "https://omabrowser.org/oma/group/Q71FD5/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 12, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "pmid": "" }, { "name": "fibrillar center", "id": "GO:0001650", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "pmid": "" }, { "name": "cell projection", "id": "GO:0042995", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042995", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "pmid": "" }, { "name": "presynaptic membrane", "id": "GO:0042734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042734", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "pmid": "" }, { "name": "protein K48-linked ubiquitination", "id": "GO:0070936", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070936", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 229, "end_pos": 231, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylated; leading to binding to YWHAE. Phosphorylated by MTOR at Ser-147 and dephosphorylated by PP6C. Ser-147 phosphorylation stimulates vesicle-to-cytosol translocation.", "evidence": [ { "database": "UniProtKB", "id": "Q71FD5", "url": "https://www.uniprot.org/uniprot/Q71FD5" }, { "database": "PubMed", "id": "Q8NHG8", "url": "https://glygen.org/publication/PubMed/Q8NHG8" } ] } ], "interactions": [], "reactions": [ { "id": "R-MMU-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CFI0-1", "Q6P073-1", "Q8CFI2-1", "Q91W82-1", "Q921J4-1", "Q922B6-1", "Q99PQ2-1", "Q9WUD1-1", "Q9WUB0-1", "Q8BM54-1", "Q8C432-1", "Q9DBU5-1", "Q9ET26-1", "Q9JI90-1", "Q7TMY8-1", "Q1PSW8-1", "Q8R516-1", "Q9D074-1", "O55176-3", "Q8BH75-1", "Q99KR6-1", "Q9D0C1-1", "Q9WTV7-1", "G5E870-1", "Q80WG7-1", "Q80X56-1", "Q8CH72-1", "Q3UE37-1", "Q8CCJ3-3", "Q8VDW4-1", "Q06986-1", "P60605-1", "Q3U487-1", "P97868-1", "Q5XPI3-1", "Q6PDX6-1", "Q91YL2-1", "A2A5Z6-1", "Q925F4-1", "Q99ML9-1", "Q9JIY2-1", "Q69ZI1-1", "O08759-1", "P62257-1", "Q6WKZ8-1", "Q6ZPJ3-1", "A2AN08-1", "Q71FD5-1", "Q8CHG5-1", "P61092-1", "Q3UIR3-1", "Q6I6G8-1", "Q05A36-1", "Q9QXP6-1", "A2A7Q9-1", "E9Q555-1", "P50636-1", "Q9QZR0-1", "Q9QZS2-1", "P61089-1", "Q38HM4-1", "Q9ESN2-1", "Q5FWH2-3", "Q8BX13-1", "O70481-1", "P52482-1", "P61080-1", "P61087-1", "P62254-1", "P62838-1", "P63147-1", "P68037-1", "Q6ZWZ2-1", "Q80U95-1", "Q8K2Z8-1", "Q9CY34-1", "Q9D1C1-1", "Q9ES34-1", "Q9JJZ4-1", "Q9QZU9-1", "Q9Z255-1", "Q91V17-1", "Q9CR50-1", "Q3TTA7-1", "Q80TR8-1", "O70263-1", "Q80U04-1", "Q80ZI6-1", "D3YYI7-1", "Q9CQE0-1", "Q8C863-1", "Q9WVS6-1", "Q62191-1", "Q7TPV2-1", "Q3U0D9-1", "Q4U2R1-1", "P46935-1", "F2Z461-1", "P62878-1", "Q8BKD6-1", "Q9CUN6-1", "Q8BZZ3-1", "Q69ZR2-1", "Q6PAV2-1", "Q8CDU6-1", "Q8C7M3-1", "Q8VIG6-1", "E9Q735-1", "P52483-1", "P61079-1", "P61082-1", "Q7TSS2-1", "Q9Z1K6-1", "Q8VEM1-1", "Q6A009-1", "Q5NCC3-1", "Q6PCX9-1", "Q810I2-1", "Q9DBK7-1" ], "evidence": [ { "id": "R-MMU-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983140" } ] }, { "id": "R-MMU-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CFI0-1", "Q922B6-1", "Q99PQ2-1", "Q9WUD1-1", "Q9WUB0-1", "Q8BM54-1", "Q8C432-1", "Q9DBU5-1", "Q9ET26-1", "Q9JI90-1", "Q7TMY8-1", "Q1PSW8-1", "Q8R516-1", "Q9D074-1", "O55176-3", "Q8BH75-1", "Q99KR6-1", "Q9D0C1-1", "Q9WTV7-1", "G5E870-1", "Q80WG7-1", "Q80X56-1", "Q8CH72-1", "Q8CCJ3-3", "Q06986-1", "Q3U487-1", "P97868-1", "Q5XPI3-1", "Q6PDX6-1", "Q91YL2-1", "A2A5Z6-1", "Q925F4-1", "Q99ML9-1", "Q9JIY2-1", "Q69ZI1-1", "O08759-1", "Q6WKZ8-1", "A2AN08-1", "Q71FD5-1", "Q8CHG5-1", "P61092-1", "Q3UIR3-1", "Q6I6G8-1", "Q05A36-1", "Q9QXP6-1", "A2A7Q9-1", "E9Q555-1", "P50636-1", "Q9QZR0-1", "Q9QZS2-1", "Q38HM4-1", "Q9ESN2-1", "Q5FWH2-3", "Q8BX13-1", "O70481-1", "Q80U95-1", "Q9ES34-1", "Q91V17-1", "Q9CR50-1", "Q3TTA7-1", "Q80TR8-1", "O70263-1", "Q80U04-1", "Q80ZI6-1", "D3YYI7-1", "Q9CQE0-1", "Q8C863-1", "Q9WVS6-1", "Q62191-1", "Q7TPV2-1", "Q3U0D9-1", "Q4U2R1-1", "P46935-1", "F2Z461-1", "P62878-1", "Q8BKD6-1", "Q9CUN6-1", "Q8BZZ3-1", "Q69ZR2-1", "Q6PAV2-1", "Q8CDU6-1", "Q8C7M3-1", "Q8VIG6-1", "E9Q735-1", "Q9Z1K6-1", "Q8VEM1-1", "Q6A009-1", "Q5NCC3-1", "Q6PCX9-1", "Q810I2-1" ], "evidence": [ { "id": "R-MMU-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983147" } ] }, { "id": "R-MMU-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CFI0-1", "Q6P073-1", "Q8CFI2-1", "Q91W82-1", "Q921J4-1", "Q922B6-1", "Q99PQ2-1", "Q9WUD1-1", "Q9WUB0-1", "Q8BM54-1", "Q8C432-1", "Q9DBU5-1", "Q9ET26-1", "Q9JI90-1", "Q7TMY8-1", "Q1PSW8-1", "Q8R516-1", "Q9D074-1", "O55176-3", "Q8BH75-1", "Q99KR6-1", "Q9D0C1-1", "Q9WTV7-1", "G5E870-1", "Q80WG7-1", "Q80X56-1", "Q8CH72-1", "Q3UE37-1", "Q8CCJ3-3", "Q8VDW4-1", "Q06986-1", "P60605-1", "Q3U487-1", "P97868-1", "Q5XPI3-1", "Q6PDX6-1", "Q91YL2-1", "A2A5Z6-1", "Q925F4-1", "Q99ML9-1", "Q9JIY2-1", "Q69ZI1-1", "O08759-1", "P62257-1", "Q6WKZ8-1", "Q6ZPJ3-1", "A2AN08-1", "Q71FD5-1", "Q8CHG5-1", "P61092-1", "Q3UIR3-1", "Q6I6G8-1", "Q05A36-1", "Q9QXP6-1", "A2A7Q9-1", "E9Q555-1", "P50636-1", "Q9QZR0-1", "Q9QZS2-1", "P61089-1", "Q38HM4-1", "Q9ESN2-1", "Q5FWH2-3", "Q8BX13-1", "O70481-1", "P52482-1", "P61080-1", "P61087-1", "P62254-1", "P62838-1", "P63147-1", "P68037-1", "Q6ZWZ2-1", "Q80U95-1", "Q8K2Z8-1", "Q9CY34-1", "Q9D1C1-1", "Q9ES34-1", "Q9JJZ4-1", "Q9QZU9-1", "Q9Z255-1", "Q91V17-1", "Q9CR50-1", "Q3TTA7-1", "Q80TR8-1", "O70263-1", "Q80U04-1", "Q80ZI6-1", "D3YYI7-1", "Q9CQE0-1", "Q8C863-1", "Q9WVS6-1", "Q62191-1", "Q7TPV2-1", "Q3U0D9-1", "Q4U2R1-1", "P46935-1", "F2Z461-1", "P62878-1", "Q8BKD6-1", "Q9CUN6-1", "Q8BZZ3-1", "Q69ZR2-1", "Q6PAV2-1", "Q8CDU6-1", "Q8C7M3-1", "Q8VIG6-1", "E9Q735-1", "P52483-1", "P61079-1", "P61082-1", "Q7TSS2-1", "Q9Z1K6-1", "Q8VEM1-1", "Q6A009-1", "Q5NCC3-1", "Q6PCX9-1", "Q810I2-1", "Q9DBK7-1" ], "evidence": [ { "id": "R-MMU-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983156" } ] }, { "id": "R-MMU-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CFI0-1", "Q6P073-1", "Q8CFI2-1", "Q91W82-1", "Q921J4-1", "Q922B6-1", "Q99PQ2-1", "Q9WUD1-1", "Q9WUB0-1", "Q8BM54-1", "Q8C432-1", "Q9DBU5-1", "Q9ET26-1", "Q9JI90-1", "Q7TMY8-1", "Q1PSW8-1", "Q8R516-1", "Q9D074-1", "O55176-3", "Q8BH75-1", "Q99KR6-1", "Q9D0C1-1", "Q9WTV7-1", "G5E870-1", "Q80WG7-1", "Q80X56-1", "Q8CH72-1", "Q3UE37-1", "Q8CCJ3-3", "Q8VDW4-1", "Q06986-1", "P60605-1", "Q3U487-1", "P97868-1", "Q5XPI3-1", "Q6PDX6-1", "Q91YL2-1", "A2A5Z6-1", "Q925F4-1", "Q99ML9-1", "Q9JIY2-1", "Q69ZI1-1", "O08759-1", "P62257-1", "Q6WKZ8-1", "Q6ZPJ3-1", "A2AN08-1", "Q71FD5-1", "Q8CHG5-1", "P61092-1", "Q3UIR3-1", "Q6I6G8-1", "Q05A36-1", "Q9QXP6-1", "A2A7Q9-1", "E9Q555-1", "P50636-1", "Q9QZR0-1", "Q9QZS2-1", "P61089-1", "Q38HM4-1", "Q9ESN2-1", "Q5FWH2-3", "Q8BX13-1", "O70481-1", "P52482-1", "P61080-1", "P61087-1", "P62254-1", "P62838-1", "P63147-1", "P68037-1", "Q6ZWZ2-1", "Q80U95-1", "Q8K2Z8-1", "Q9CY34-1", "Q9D1C1-1", "Q9ES34-1", "Q9JJZ4-1", "Q9QZU9-1", "Q9Z255-1", "Q91V17-1", "Q9CR50-1", "Q3TTA7-1", "Q80TR8-1", "O70263-1", "Q80U04-1", "Q80ZI6-1", "D3YYI7-1", "Q9CQE0-1", "Q8C863-1", "Q9WVS6-1", "Q62191-1", "Q7TPV2-1", "Q3U0D9-1", "Q4U2R1-1", "P46935-1", "F2Z461-1", "P62878-1", "Q8BKD6-1", "Q9CUN6-1", "Q8BZZ3-1", "Q69ZR2-1", "Q6PAV2-1", "Q8CDU6-1", "Q8C7M3-1", "Q8VIG6-1", "E9Q735-1", "P52483-1", "P61079-1", "P61082-1", "Q7TSS2-1", "Q9Z1K6-1", "Q8VEM1-1", "Q6A009-1", "Q5NCC3-1", "Q6PCX9-1", "Q810I2-1", "Q9DBK7-1" ], "evidence": [ { "id": "R-MMU-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A2A5Z6", "gene_name": "Smurf2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A2A5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A5Z6" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A2A5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A5Z6" } ] } ] }, { "uniprot_ac": "A2A7Q9", "gene_name": "Rnf19b", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A2A7Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A7Q9" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A2A7Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A7Q9" } ] } ] }, { "uniprot_ac": "A2AN08", "gene_name": "Ubr4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A2AN08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AN08" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A2AN08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AN08" } ] } ] }, { "uniprot_ac": "D3YYI7", "gene_name": "Rnf217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "D3YYI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YYI7" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "D3YYI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YYI7" } ] } ] }, { "uniprot_ac": "E9Q555", "gene_name": "Rnf213", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] } ] }, { "uniprot_ac": "E9Q735", "gene_name": "Ube4a", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E9Q735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q735" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E9Q735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q735" } ] } ] }, { "uniprot_ac": "F2Z461", "gene_name": "Herc6", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "F2Z461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F2Z461" } ] } ] }, { "uniprot_ac": "G5E870", "gene_name": "Trip12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "G5E870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G5E870" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "G5E870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G5E870" } ] } ] }, { "uniprot_ac": "O08759", "gene_name": "Ube3a", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O08759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08759" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "O08759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08759" } ] } ] }, { "uniprot_ac": "O55176", "gene_name": "Pja1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O55176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55176" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O55176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55176" } ] } ] }, { "uniprot_ac": "O70263", "gene_name": "Lnx1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O70263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70263" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O70263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70263" } ] } ] }, { "uniprot_ac": "O70481", "gene_name": "Ubr1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O70481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70481" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O70481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70481" } ] } ] }, { "uniprot_ac": "P46935", "gene_name": "Nedd4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P46935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46935" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "P46935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46935" } ] } ] }, { "uniprot_ac": "P50636", "gene_name": "Rnf19a", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "P50636", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50636" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "P50636", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50636" } ] } ] }, { "uniprot_ac": "P52482", "gene_name": "Ube2e1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P52482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52482" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P52482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52482" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P52482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52482" } ] } ] }, { "uniprot_ac": "P52483", "gene_name": "Ube2e3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P52483", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52483" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P52483", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52483" } ] } ] }, { "uniprot_ac": "P60605", "gene_name": "Ube2g2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P60605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60605" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P60605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60605" } ] } ] }, { "uniprot_ac": "P61079", "gene_name": "Ube2d3", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61079" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61079" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61079" } ] } ] }, { "uniprot_ac": "P61080", "gene_name": "Ube2d1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61080" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61080" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61080" } ] } ] }, { "uniprot_ac": "P61082", "gene_name": "Ube2m", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "P61082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61082" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "P61082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61082" } ] } ] }, { "uniprot_ac": "P61087", "gene_name": "Ube2k", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61087", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61087" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61087", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61087" } ] } ] }, { "uniprot_ac": "P61089", "gene_name": "Ube2n", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61089" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61089" } ] } ] }, { "uniprot_ac": "P61092", "gene_name": "Siah1a", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61092" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P61092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61092" } ] } ] }, { "uniprot_ac": "P62254", "gene_name": "Ube2g1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62254", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62254" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62254", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62254" } ] } ] }, { "uniprot_ac": "P62257", "gene_name": "Ube2h", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62257" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62257" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62257" } ] } ] }, { "uniprot_ac": "P62838", "gene_name": "Ube2d2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62838" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62838" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62838" } ] } ] }, { "uniprot_ac": "P62878", "gene_name": "Rbx1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62878" } ] }, { "ec_number": "2.3.2.32", "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.", "evidence": [ { "id": "P62878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62878" } ] }, { "ec_number": "2.3.2.32", "activity": "", "evidence": [ { "id": "P62878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62878" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P62878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62878" } ] } ] }, { "uniprot_ac": "P63147", "gene_name": "Ube2b", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P63147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63147" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P63147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63147" } ] } ] }, { "uniprot_ac": "P68037", "gene_name": "Ube2l3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P68037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68037" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P68037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68037" } ] } ] }, { "uniprot_ac": "P97868", "gene_name": "Rbbp6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P97868", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97868" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P97868", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97868" } ] } ] }, { "uniprot_ac": "Q05A36", "gene_name": "Mex3c", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q05A36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05A36" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q05A36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05A36" } ] } ] }, { "uniprot_ac": "Q06986", "gene_name": "Siah2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q06986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06986" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q06986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06986" } ] } ] }, { "uniprot_ac": "Q1PSW8", "gene_name": "Trim71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1PSW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1PSW8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q1PSW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1PSW8" } ] } ] }, { "uniprot_ac": "Q38HM4", "gene_name": "Trim63", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q38HM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q38HM4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q38HM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q38HM4" } ] } ] }, { "uniprot_ac": "Q3TTA7", "gene_name": "Cblb", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3TTA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTA7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q3TTA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTA7" } ] } ] }, { "uniprot_ac": "Q3U0D9", "gene_name": "Hace1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3U0D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U0D9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q3U0D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U0D9" } ] } ] }, { "uniprot_ac": "Q3U487", "gene_name": "Hectd3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3U487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U487" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q3U487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U487" } ] } ] }, { "uniprot_ac": "Q3UE37", "gene_name": "Ube2z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3UE37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UE37" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3UE37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UE37" } ] } ] }, { "uniprot_ac": "Q3UIR3", "gene_name": "Dtx3l", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3UIR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UIR3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q3UIR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UIR3" } ] } ] }, { "uniprot_ac": "Q4U2R1", "gene_name": "Herc2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q4U2R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4U2R1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q4U2R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4U2R1" } ] } ] }, { "uniprot_ac": "Q5FWH2", "gene_name": "Unkl", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q5FWH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FWH2" } ] } ] }, { "uniprot_ac": "Q5NCC3", "gene_name": "Trim41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5NCC3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5NCC3" } ] } ] }, { "uniprot_ac": "Q5XPI3", "gene_name": "Rnf123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5XPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XPI3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5XPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XPI3" } ] } ] }, { "uniprot_ac": "Q62191", "gene_name": "Trim21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q62191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62191" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q62191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62191" } ] } ] }, { "uniprot_ac": "Q69ZI1", "gene_name": "Sh3rf1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q69ZI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZI1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q69ZI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZI1" } ] } ] }, { "uniprot_ac": "Q69ZR2", "gene_name": "Hectd1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q69ZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZR2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q69ZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZR2" } ] } ] }, { "uniprot_ac": "Q6A009", "gene_name": "Ltn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6A009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6A009" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6A009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6A009" } ] } ] }, { "uniprot_ac": "Q6I6G8", "gene_name": "Hecw2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6I6G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6I6G8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q6I6G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6I6G8" } ] } ] }, { "uniprot_ac": "Q6P073", "gene_name": "Ube2j2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q6P073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P073" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q6P073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P073" } ] } ] }, { "uniprot_ac": "Q6PAV2", "gene_name": "Herc4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6PAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PAV2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q6PAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PAV2" } ] } ] }, { "uniprot_ac": "Q6PCX9", "gene_name": "Trim37", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6PCX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCX9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6PCX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCX9" } ] } ] }, { "uniprot_ac": "Q6PDX6", "gene_name": "Rnf220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6PDX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PDX6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6PDX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PDX6" } ] } ] }, { "uniprot_ac": "Q6WKZ8", "gene_name": "Ubr2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6WKZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6WKZ8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6WKZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6WKZ8" } ] } ] }, { "uniprot_ac": "Q6ZPJ3", "gene_name": "Ube2o", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6ZPJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZPJ3" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q6ZPJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZPJ3" } ] } ] }, { "uniprot_ac": "Q6ZWZ2", "gene_name": "Ube2r2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q6ZWZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZWZ2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q6ZWZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZWZ2" } ] } ] }, { "uniprot_ac": "Q71FD5", "gene_name": "Znrf2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q71FD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q71FD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ] } ] }, { "uniprot_ac": "Q7TMY8", "gene_name": "Huwe1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7TMY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TMY8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q7TMY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TMY8" } ] } ] }, { "uniprot_ac": "Q7TPV2", "gene_name": "Dzip3", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7TPV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TPV2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7TPV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TPV2" } ] } ] }, { "uniprot_ac": "Q7TSS2", "gene_name": "Ube2q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q7TSS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TSS2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q7TSS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TSS2" } ] } ] }, { "uniprot_ac": "Q80TR8", "gene_name": "Dcaf1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80TR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80TR8" } ] } ] }, { "uniprot_ac": "Q80U04", "gene_name": "Pja2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80U04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80U04" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q80U04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80U04" } ] } ] }, { "uniprot_ac": "Q80U95", "gene_name": "Ube3c", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80U95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80U95" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q80U95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80U95" } ] } ] }, { "uniprot_ac": "Q80WG7", "gene_name": "Trim36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80WG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80WG7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q80WG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80WG7" } ] } ] }, { "uniprot_ac": "Q80X56", "gene_name": "Trim69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80X56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80X56" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q80X56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80X56" } ] } ] }, { "uniprot_ac": "Q80ZI6", "gene_name": "Lrsam1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80ZI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80ZI6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q80ZI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80ZI6" } ] } ] }, { "uniprot_ac": "Q810I2", "gene_name": "Trim50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q810I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810I2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q810I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810I2" } ] } ] }, { "uniprot_ac": "Q8BH75", "gene_name": "Rnf41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8BH75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BH75" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8BH75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BH75" } ] } ] }, { "uniprot_ac": "Q8BKD6", "gene_name": "Rnf144b", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q8BKD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BKD6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q8BKD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BKD6" } ] } ] }, { "uniprot_ac": "Q8BM54", "gene_name": "Mylip", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8BM54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BM54" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8BM54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BM54" } ] } ] }, { "uniprot_ac": "Q8BX13", "gene_name": "Ube3d", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8BX13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BX13" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8BX13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BX13" } ] } ] }, { "uniprot_ac": "Q8BZZ3", "gene_name": "Wwp1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8BZZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZZ3" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8BZZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZZ3" } ] } ] }, { "uniprot_ac": "Q8C432", "gene_name": "Rnf182", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8C432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C432" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8C432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C432" } ] } ] }, { "uniprot_ac": "Q8C7M3", "gene_name": "Trim9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8C7M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C7M3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8C7M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C7M3" } ] } ] }, { "uniprot_ac": "Q8C863", "gene_name": "Itch", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8C863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C863" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8C863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C863" } ] } ] }, { "uniprot_ac": "Q8CCJ3", "gene_name": "Ufl1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q8CCJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CCJ3" } ] } ] }, { "uniprot_ac": "Q8CDU6", "gene_name": "Hectd2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CDU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CDU6" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8CDU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CDU6" } ] } ] }, { "uniprot_ac": "Q8CFI0", "gene_name": "Nedd4l", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CFI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8CFI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI0" } ] }, { "ec_number": "2.3.2.36", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.", "evidence": [ { "id": "Q8CFI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI0" } ] }, { "ec_number": "2.3.2.36", "activity": "", "evidence": [ { "id": "Q8CFI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI0" } ] } ] }, { "uniprot_ac": "Q8CFI2", "gene_name": "Cdc34", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CFI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8CFI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8CFI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI2" } ] } ] }, { "uniprot_ac": "Q8CH72", "gene_name": "Trim32", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CH72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CH72" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8CH72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CH72" } ] } ] }, { "uniprot_ac": "Q8CHG5", "gene_name": "Arel1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CHG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHG5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8CHG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHG5" } ] } ] }, { "uniprot_ac": "Q8K2Z8", "gene_name": "Ube2q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8K2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K2Z8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8K2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K2Z8" } ] } ] }, { "uniprot_ac": "Q8R516", "gene_name": "Mib2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8R516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R516" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8R516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R516" } ] } ] }, { "uniprot_ac": "Q8VDW4", "gene_name": "Ube2w", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "Q8VDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDW4" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8VDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDW4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8VDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDW4" } ] } ] }, { "uniprot_ac": "Q8VEM1", "gene_name": "Rnf130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8VEM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEM1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8VEM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEM1" } ] } ] }, { "uniprot_ac": "Q8VIG6", "gene_name": "Traip", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8VIG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VIG6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8VIG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VIG6" } ] } ] }, { "uniprot_ac": "Q91V17", "gene_name": "Znrf1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q91V17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91V17" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q91V17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91V17" } ] } ] }, { "uniprot_ac": "Q91W82", "gene_name": "Ube2e2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q91W82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91W82" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q91W82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91W82" } ] } ] }, { "uniprot_ac": "Q91YL2", "gene_name": "Rnf126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q91YL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91YL2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q91YL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91YL2" } ] } ] }, { "uniprot_ac": "Q921J4", "gene_name": "Ube2s", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q921J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q921J4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q921J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q921J4" } ] } ] }, { "uniprot_ac": "Q922B6", "gene_name": "Traf7", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q922B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922B6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q922B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922B6" } ] } ] }, { "uniprot_ac": "Q925F4", "gene_name": "Ubox5", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q925F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925F4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q925F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925F4" } ] } ] }, { "uniprot_ac": "Q99KR6", "gene_name": "Rnf34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q99KR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99KR6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q99KR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99KR6" } ] } ] }, { "uniprot_ac": "Q99ML9", "gene_name": "Rnf111", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q99ML9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q99ML9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML9" } ] } ] }, { "uniprot_ac": "Q99PQ2", "gene_name": "Trim11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q99PQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99PQ2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q99PQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99PQ2" } ] } ] }, { "uniprot_ac": "Q9CQE0", "gene_name": "Rnf138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9CQE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQE0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9CQE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQE0" } ] } ] }, { "uniprot_ac": "Q9CR50", "gene_name": "Rchy1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9CR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CR50" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9CR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CR50" } ] } ] }, { "uniprot_ac": "Q9CUN6", "gene_name": "Smurf1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9CUN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9CUN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ] } ] }, { "uniprot_ac": "Q9CY34", "gene_name": "Ube2f", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q9CY34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CY34" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q9CY34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CY34" } ] } ] }, { "uniprot_ac": "Q9D074", "gene_name": "Mgrn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9D074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D074" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9D074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D074" } ] } ] }, { "uniprot_ac": "Q9D0C1", "gene_name": "Rnf115", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9D0C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D0C1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9D0C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D0C1" } ] } ] }, { "uniprot_ac": "Q9D1C1", "gene_name": "Ube2c", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9D1C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D1C1" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9D1C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D1C1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9D1C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D1C1" } ] } ] }, { "uniprot_ac": "Q9DBK7", "gene_name": "Uba7", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9DBK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBK7" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "Q9DBK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBK7" } ] } ] }, { "uniprot_ac": "Q9DBU5", "gene_name": "Rnf6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9DBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBU5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9DBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBU5" } ] } ] }, { "uniprot_ac": "Q9ES34", "gene_name": "Ube3b", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9ES34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES34" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9ES34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES34" } ] } ] }, { "uniprot_ac": "Q9ESN2", "gene_name": "Trim39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9ESN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESN2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9ESN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESN2" } ] } ] }, { "uniprot_ac": "Q9ET26", "gene_name": "Rnf114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9ET26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ET26" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9ET26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ET26" } ] } ] }, { "uniprot_ac": "Q9JI90", "gene_name": "Rnf14", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9JI90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9JI90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ] } ] }, { "uniprot_ac": "Q9JIY2", "gene_name": "Cbll1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9JIY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JIY2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9JIY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JIY2" } ] } ] }, { "uniprot_ac": "Q9JJZ4", "gene_name": "Ube2j1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9JJZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JJZ4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9JJZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JJZ4" } ] } ] }, { "uniprot_ac": "Q9QXP6", "gene_name": "Mkrn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9QXP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXP6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9QXP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXP6" } ] } ] }, { "uniprot_ac": "Q9QZR0", "gene_name": "Rnf25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9QZR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZR0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9QZR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZR0" } ] } ] }, { "uniprot_ac": "Q9QZS2", "gene_name": "Rnf4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9QZS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZS2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9QZS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZS2" } ] } ] }, { "uniprot_ac": "Q9QZU9", "gene_name": "Ube2l6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9QZU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU9" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9QZU9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU9" } ] } ] }, { "uniprot_ac": "Q9WTV7", "gene_name": "Rlim", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9WTV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTV7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9WTV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTV7" } ] } ] }, { "uniprot_ac": "Q9WUB0", "gene_name": "Rbck1", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9WUB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUB0" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9WUB0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUB0" } ] } ] }, { "uniprot_ac": "Q9WUD1", "gene_name": "Stub1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9WUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUD1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9WUD1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUD1" } ] } ] }, { "uniprot_ac": "Q9WVS6", "gene_name": "Prkn", "activity": [ { "ec_number": "6.3.2.19", "activity": "", "evidence": [ { "id": "Q9WVS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVS6" } ] }, { "ec_number": 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