{
    "uniprot_canonical_ac": "Q6ZSG2-1",
    "uniprot_ac": "Q6ZSG2",
    "uniprot_id": "INSY2_HUMAN",
    "mass": {
        "chemical_mass": 52909.0,
        "monoisotopic_mass": 52909.0
    },
    "refseq": {
        "ac": "NP_001034851",
        "name": "inhibitory synaptic factor 2A",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034851"
    },
    "gene_names": [
        {
            "name": "INSYN2A",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q6ZSG2",
            "id": "Q6ZSG2"
        },
        {
            "name": "C10orf141; FAM196A; INSYN2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034851",
            "id": "NP_001034851"
        },
        {
            "name": "C10orf141",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q6ZSG2",
            "id": "Q6ZSG2"
        },
        {
            "name": "FAM196A",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q6ZSG2",
            "id": "Q6ZSG2"
        },
        {
            "name": "INSYN2A",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034851",
            "id": "NP_001034851"
        },
        {
            "name": "INSYN2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q6ZSG2",
            "id": "Q6ZSG2"
        }
    ],
    "protein_names": [
        {
            "name": "Inhibitory synaptic factor 2A",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q6ZSG2"
        },
        {
            "name": "InSyn2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q6ZSG2"
        },
        {
            "name": "inhibitory synaptic factor 2A",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034851",
            "id": "NP_001034851"
        },
        {
            "name": "protein FAM196A; inhibitory synaptic protein 2; family with sequence similarity 196 member A",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034851",
            "id": "NP_001034851"
        }
    ],
    "function": [
        {
            "annotation": "Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6ZSG2",
                    "url": "https://www.uniprot.org/uniprot/Q6ZSG2#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q3USH1",
                    "url": "https://www.uniprot.org/uniprot/Q3USH1#function"
                }
            ]
        },
        {
            "annotation": "Further refining the critical region of 10q26 microdeletion syndrome: A possible involvement of INSYN2 and NPS in the cognitive phenotype.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001034851",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034851"
                },
                {
                    "database": "PubMed",
                    "id": "34252586",
                    "url": "https://glygen.org/publication/PubMed/34252586"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [
        {
            "tissue": {
                "name": "Adult mammalian kidney",
                "namespace": "UBERON",
                "id": "0000082",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000082"
            },
            "score": "49.59",
            "present": "LOW",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000188916",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188916"
                }
            ]
        },
        {
            "tissue": {
                "name": "Oral cavity",
                "namespace": "UBERON",
                "id": "0000167",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000167"
            },
            "score": "41.27",
            "present": "ABSENT",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000188916",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188916"
                }
            ]
        },
        {
            "tissue": {
                "name": "Stomach",
                "namespace": "UBERON",
                "id": "0000945",
                "url": "http://purl.obolibrary.org/obo/UBERON_0000945"
            },
            "score": "62.71",
            "present": "MEDIUM",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000188916",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188916"
                }
            ]
        },
        {
            "tissue": {
                "name": "Esophagus",
                "namespace": "UBERON",
                "id": "0001043",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001043"
            },
            "score": "48.55",
            "present": "LOW",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000188916",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188916"
                }
            ]
        },
        {
            "tissue": {
                "name": "Rectum",
                "namespace": "UBERON",
                "id": "0001052",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001052"
            },
            "score": "50.01",
            "present": "ABSENT",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000188916",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188916"
                }
            ]
        },
        {
            "tissue": {
                "name": "Urinary bladder",
                "namespace": "UBERON",
                "id": "0001255",
                "url": "http://purl.obolibrary.org/obo/UBERON_0001255"
            },
            "score": "48.91",
            "present": "ABSENT",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000188916",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188916"
                }
            ]
        },
        {
            "tissue": {
                "name": "Thyroid gland",
                "namespace": "UBERON",
                "id": "0002046",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046"
            },
            "score": "50.87",
            "present": "LOW",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000188916",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188916"
                }
            ]
        },
        {
            "tissue": {
                "name": "Liver",
                "namespace": "UBERON",
                "id": "0002107",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002107"
            },
            "score": "58.12",
            "present": "MEDIUM",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000188916",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188916"
                }
            ]
        },
        {
            "tissue": {
                "name": "Prostate gland",
                "namespace": "UBERON",
                "id": "0002367",
                "url": "http://purl.obolibrary.org/obo/UBERON_0002367"
            },
            "score": "57.12",
            "present": "MEDIUM",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000188916",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188916"
                }
            ]
        },
        {
            "tissue": {
                "name": "Thoracic mammary gland",
                "namespace": "UBERON",
                "id": "0005200",
                "url": "http://purl.obolibrary.org/obo/UBERON_0005200"
            },
            "score": "51.7",
            "present": "LOW",
            "evidence": [
                {
                    "database": "Bgee",
                    "id": "ENSG00000188916",
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188916"
                }
            ]
        }
    ],
    "expression_disease": [],
    "species": [
        {
            "name": "Homo sapiens",
            "taxid": 9606,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6ZSG2",
                    "url": "https://www.uniprot.org/uniprot/Q6ZSG2"
                }
            ],
            "common_name": "Human"
        }
    ],
    "gene": [
        {
            "name": "INSYN2A",
            "url": "https://www.uniprot.org/uniprot/Q6ZSG2",
            "locus": {
                "chromosome": "10",
                "start_pos": 127135426,
                "end_pos": 127196591,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSG00000188916",
                        "url": "https://www.ensembl.org/id/ENSG00000188916"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSG00000188916",
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188916",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "INSYN2A",
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=INSYN2A",
            "database": "GeneCards",
            "categories": [
                "Organism-specific",
                "Gene Annotation"
            ]
        },
        {
            "id": "642938",
            "url": "https://www.ncbi.nlm.nih.gov/gene/642938",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "33859",
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=33859",
            "database": "HGNC",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "Q6ZSG2",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q6ZSG2*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR029337",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029337",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "hsa:642938",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:642938",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "617129",
            "url": "http://www.omim.org/entry/617129",
            "database": "MIM",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "NX_Q6ZSG2",
            "url": "https://www.nextprot.org/entry/NX_Q6ZSG2",
            "database": "neXtProt",
            "categories": [
                "Organism-specific",
                "Protein"
            ]
        },
        {
            "id": "WSLCPAE",
            "url": "https://omabrowser.org/oma/group/WSLCPAE/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "4097575at2759",
            "url": "http://www.orthodb.org/?query=4097575at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR28682",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28682",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR28682:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28682:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF15265",
            "url": "http://pfam.xfam.org/family/PF15265",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "Q6ZSG2",
            "url": "https://pharos.nih.gov/targets/Q6ZSG2",
            "database": "PHAROS",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "PR_Q6ZSG2",
            "url": "http://purl.obolibrary.org/obo/PR_Q6ZSG2",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001034851",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034851",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q6ZSG2",
            "url": "https://www.uniprot.org/uniprot/Q6ZSG2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q6ZSG2-1",
            "url": "https://www.uniprot.org/uniprot/Q6ZSG2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q6ZSG2-2",
            "url": "https://www.uniprot.org/uniprot/Q6ZSG2-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MVSKDTGKCILTTSESEVEPAACLALEMKYALDPNRQIKKRNKALQVRFKDICEAQNEQRDTQLSSGQLGEKREAKPVSCRAAYRKYMTVPARRSIPNVTKSTGVQTSPDLKKCYQTFPLDRKKGNLKSLPAADPFKSQNNGFLTDAKEKNEAGPMEEARPCGAGRVHKTTALVFHSNQHMNTVDQPLGVNCTEPCKSPEPLSYGEAALQNSTRPPSEEPDYQLLGRAKQDRGRPNSEEPAPPALRRVFKTEVATVYAPALSARAPEPGLSDSAAASQWSLCPADDERRRATHLNGLQAPSETALACSPPMQCLSPECSEQPSQTHTPPGLGNQPSPTAVAAGEECQRIVPHTEVVDLKAQLQMMENLISSSQETIKVLLGVIQELEKGEAHREGLSYRTGQDTANCDTCRNSACIIYSVELDFKQQEDKLQPVLRKLHPIEETQVIPSPYSQETYSSTPKQKSKTESKKHGRWKLWFL",
        "length": 479,
        "header": "sp|Q6ZSG2-1|INSY2_HUMAN Isoform 1 of Inhibitory synaptic factor 2A  OS=Homo sapiens OX=9606 GN=INSYN2A PE=1 SV=1 CANONICAL=Q6ZSG2-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q6ZSG2-1",
            "url": "",
            "sequence": {
                "sequence": "MVSKDTGKCILTTSESEVEPAACLALEMKYALDPNRQIKKRNKALQVRFKDICEAQNEQRDTQLSSGQLGEKREAKPVSCRAAYRKYMTVPARRSIPNVTKSTGVQTSPDLKKCYQTFPLDRKKGNLKSLPAADPFKSQNNGFLTDAKEKNEAGPMEEARPCGAGRVHKTTALVFHSNQHMNTVDQPLGVNCTEPCKSPEPLSYGEAALQNSTRPPSEEPDYQLLGRAKQDRGRPNSEEPAPPALRRVFKTEVATVYAPALSARAPEPGLSDSAAASQWSLCPADDERRRATHLNGLQAPSETALACSPPMQCLSPECSEQPSQTHTPPGLGNQPSPTAVAAGEECQRIVPHTEVVDLKAQLQMMENLISSSQETIKVLLGVIQELEKGEAHREGLSYRTGQDTANCDTCRNSACIIYSVELDFKQQEDKLQPVLRKLHPIEETQVIPSPYSQETYSSTPKQKSKTESKKHGRWKLWFL",
                "length": 479,
                "header": "sp|Q6ZSG2-1|INSY2_HUMAN Isoform 1 of Inhibitory synaptic factor 2A  OS=Homo sapiens OX=9606 GN=INSYN2A PE=1 SV=1 CANONICAL=Q6ZSG2-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 127176395,
                "end_pos": 127137840,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENST00000522781.6",
                        "url": "https://www.ensembl.org/id/ENST00000522781.6"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSP00000429763.1",
                        "url": "https://www.ensembl.org/id/ENSP00000429763.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q6ZSG2-2",
            "url": "",
            "sequence": {
                "sequence": "MVSKDTGKCILTTSESEVEPAACLALEMKYALDPNRQIKKRNKALQVRFKDICEAQNEQRDTQLSSGQLGEKREAKPVSCRAAYRKYMTVPARRSIPNVTKSTGVQTSPDLKKCYQTFPLDRKKGNLKSLPAADPFKSQNNGFLTDAKEKNEAGPMEEARPCGAGRVHKTTALVFHSNQHMNTVDQPLGVNCTEPCKSPEPLSYGEAALQNSTRPPSEEPDYQLLGRAKQDRGRPNSEEPAPPALRRVFKTEVATVYAPALSARAPEPGLSDSAAASQWSLCPADDERRRATHLNGLQAPSETALACSPPMQCLSPECSEQPSQTHTPPGLGNQPSPTAVAAGEECQRIVPHTEVVDLKAQLQMMENLISSSQETIKVLLGVIQELEKGEAHREGVELDFKQQEDKLQPVLRKLHPIEETQVIPSPYSQETYSSTPKQKSKTESKKHGRWKLWFL",
                "length": 455,
                "header": "sp|Q6ZSG2-2|INSY2_HUMAN Isoform 2 of Inhibitory synaptic factor 2A  OS=Homo sapiens OX=9606 GN=INSYN2A PE=1 SV=1 CANONICAL=Q6ZSG2-1"
            },
            "locus": {
                "chromosome": "10",
                "start_pos": 127176395,
                "end_pos": 127137840,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENST00000424811.2",
                        "url": "https://www.ensembl.org/id/ENST00000424811.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSP00000428730.1",
                        "url": "https://www.ensembl.org/id/ENSP00000428730.1"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 177,
            "end_pos": 177,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6ZSG2",
                    "url": "https://www.uniprot.org/uniprot/Q6ZSG2"
                }
            ],
            "site_lbl": "Ser177"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Further refining the critical region of 10q26 microdeletion syndrome: A possible involvement of INSYN2 and NPS in the cognitive phenotype.",
            "journal": "European journal of medical genetics",
            "date": "2021",
            "authors": "Cherik F, Lepage M, Remerand G, Francannet C, Delabaere A, Salaun G, Pebrel-Richard C, Gouas L, Vago P, Tchirkov A, Goumy C",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001034851",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034851"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "34252586",
                    "url": "https://glygen.org/publication/PubMed/34252586"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "hsa:642938",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:642938",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "D4A4J1-1",
            "protein_name": "Inhibitory synaptic factor 2A",
            "gene_name": "Insyn2a",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MVSKDTGRCILTTPEQEVEPAACLALEMRYALDPNRQIKKRNKALQVRFKDICEAQNEQRDTQLSSGPLGEKREAKAVSCRVAYRKYMTVPARRSIPNVTKSTGVQTSPDLRKCYQTFPLDRKKGSLKGLPAADTFKSQNNGFLADSKEKSEAGPTEDPRPCSAGRIHKTTALVFHSNEHVNALDQPSGVNCAELCKSPDVLGYPEALLQNSRPPSEEPIHQLQGRAKPDRGTLDSEEPTPLTHGRVFKTEVATVYPPAKSTRAPEPGLSNSAAASQWSLCPTEEEQRRAAHLNGLQVSTGSAVACSTPVQCLSPECSEQPLQNQPSPTAGVGDEERQQIVPHTEVVDLKAQLQVMENLISSSQETIKVLLGVIQELEKGEAHREGLSYRTGQDTANCDTCRNSACIIYSVELDFKQQEDKLQPVLRKLHPVEETQVAPLPYTQEAHSSTPKQKSKTESKKHGRWKLWFL",
                "length": 470
            },
            "evidence": [
                {
                    "id": "45230099",
                    "url": "http://www.informatics.jax.org/homology/45230099",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q3USH1-1",
            "protein_name": "Inhibitory synaptic factor 2A",
            "gene_name": "Insyn2a",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MVSKDSGRCILTTPEREVEPAACLALEMRYALDPNRQIKKRNKALQVRFKDICEAQNEQRDTQLSSGPLGEKREAKAVSCRVAYRKYMTVPARRSIPNVTKSTGVQTSPDLRKCYQTFPLDRKKGSLKGLPAADAFKSQNNGFLADSKEKSEAGPMEEPRPCSAGRIHKTTALVFHSNEHVNALGQPSGVNCAELCKSPDVLGYPEAVLQNSRPPSEEPIHQLQGRAKLDRGTLDSEEPAPLTHGRVFKTEVATVYPPAISTRAPEPGLSNSAAASQWSLCPADEEQRRAAHLNGLQASTGSAVACSTPVQYLSPECSEQPLQNQPSPTAGIGDEEHQQIVPHTEVVDLKAQLQVMENLISSSQETIKVLLGVIQELEKGEAHREGLSYRTGQDTANCDTCRNSACIIYRYVNILFPLCYSE",
                "length": 422
            },
            "evidence": [
                {
                    "id": "45230099",
                    "url": "http://www.informatics.jax.org/homology/45230099",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "postsynaptic density",
                        "id": "GO:0014069",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069",
                        "evidence": [
                            {
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