{ "uniprot_canonical_ac": "Q6YGZ1-1", "uniprot_ac": "Q6YGZ1", "uniprot_id": "HPSE_MOUSE", "mass": { "chemical_mass": 60066.0, "monoisotopic_mass": 60066.0 }, "refseq": { "ac": "NP_690016", "name": "heparanase preproprotein", "summary": "This gene encodes an endoglucuronidase enzyme that plays an important role in tumor invasion and metastasis. The encoded preproprotein undergoes proteolytic processing to generate an active heterodimeric enzyme that cleaves the heparan sulfate proteoglycans associated with the cell surface and extracellular matrix. Mice lacking the encoded protein do not show any prominent pathological alterations under normal conditions but fail to develop albuminuria and renal damage in response to drug-induced diabetes. [provided by RefSeq, Aug 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690016" }, "gene_names": [ { "name": "Hpse", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q6YGZ1", "id": "Q6YGZ1" }, { "name": "Hpa; Hpr1; HSE1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690016", "id": "NP_690016" }, { "name": "Hpa", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q6YGZ1", "id": "Q6YGZ1" }, { "name": "Hpse", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690016", "id": "NP_690016" } ], "protein_names": [ { "name": "Heparanase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q6YGZ1" }, { "name": "3.2.1.166", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6YGZ1" }, { "name": "Endo-glucoronidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6YGZ1" }, { "name": "endo-glucoronidase; endoglycosidase heparanase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690016", "id": "NP_690016" }, { "name": "heparanase preproprotein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690016", "id": "NP_690016" } ], "function": [ { "annotation": "A full-length heparanase gene was cloned from a mouse embryo cDNA library and determined to encode a protein of 535 amino acids. The full-length mouse gene was stably expressed in NS0 myeloma cells.", "evidence": [ { "database": "RefSeq", "id": "NP_690016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690016" }, { "database": "PubMed", "id": "12460766", "url": "https://glygen.org/publication/PubMed/12460766" } ] }, { "annotation": "Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extracellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1#function" }, { "database": "PubMed", "id": "15677344", "url": "https://glygen.org/publication/PubMed/15677344" }, { "database": "PubMed", "id": "17689495", "url": "https://glygen.org/publication/PubMed/17689495" }, { "database": "PubMed", "id": "18589009", "url": "https://glygen.org/publication/PubMed/18589009" }, { "database": "PubMed", "id": "15793281", "url": "https://glygen.org/publication/PubMed/15793281" } ] }, { "annotation": "Expression of heparanase mRNA and VEGF, and vessel formation in mouse fractured bone", "evidence": [ { "database": "RefSeq", "id": "NP_690016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690016" }, { "database": "PubMed", "id": "14618334", "url": "https://glygen.org/publication/PubMed/14618334" } ] }, { "annotation": "Histone H4 induces heparan sulfate degradation by activating heparanase in chlorine gas-induced acute respiratory distress syndrome. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_690016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690016" }, { "database": "PubMed", "id": "35073921", "url": "https://glygen.org/publication/PubMed/35073921" } ] }, { "annotation": "Implications of Heparanase on Heparin Synthesis and Metabolism in Mast Cells. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_690016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690016" }, { "database": "PubMed", "id": "35563215", "url": "https://glygen.org/publication/PubMed/35563215" } ] }, { "annotation": "This gene encodes an endoglucuronidase enzyme that plays an important role in tumor invasion and metastasis. The encoded preproprotein undergoes proteolytic processing to generate an active heterodimeric enzyme that cleaves the heparan sulfate proteoglycans associated with the cell surface and extracellular matrix. Mice lacking the encoded protein do not show any prominent pathological alterations under normal conditions but fail to develop albuminuria and renal damage in response to drug-induced diabetes. [provided by RefSeq, Aug 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_690016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690016" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Hpse", "url": "https://www.uniprot.org/uniprot/Q6YGZ1", "locus": { "chromosome": "5", "start_pos": 100827350, "end_pos": 100867582, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000035273", "url": "https://www.ensembl.org/id/ENSMUSG00000035273" } ] } } ], "crossref": [ { "id": "ENSMUSG00000035273", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000035273", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "3.2.1.166", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.166&UniProtAcc=Q6YGZ1", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "GH79", "url": "http://www.cazy.org/GH79.html", "database": "CAZy", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL4295872", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL4295872", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "15442", "url": "https://www.ncbi.nlm.nih.gov/gene/15442", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "GPDB0002205", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0002205", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0005896", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0005896", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "IPR005199", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005199", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:15442", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:15442", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1343124", "url": "http://www.informatics.jax.org/marker/MGI:1343124", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "SGFMWLD", "url": "https://omabrowser.org/oma/group/SGFMWLD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1054039at2759", "url": "http://www.orthodb.org/?query=1054039at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46145", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46145", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46145:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46145:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03662", "url": "http://pfam.xfam.org/family/PF03662", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q6YGZ1", "url": "http://purl.obolibrary.org/obo/PR_Q6YGZ1", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-2024096", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2024096", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6798695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_690016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690016", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "D3Z3C3", "url": "https://www.uniprot.org/uniprot/D3Z3C3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z3C3-1", "url": "https://www.uniprot.org/uniprot/D3Z3C3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6YGZ1-1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRLLLLWLWGPLGALAQGAPAGTAPTDDVVDLEFYTKRPLRSVSPSFLSITIDASLATDPRFLTFLGSPRLRALARGLSPAYLRFGGTKTDFLIFDPDKEPTSEERSYWKSQVNHDICRSEPVSAAVLRKLQVEWPFQELLLLREQYQKEFKNSTYSRSSVDMLYSFAKCSGLDLIFGLNALLRTPDLRWNSSNAQLLLDYCSSKGYNISWELGNEPNSFWKKAHILIDGLQLGEDFVELHKLLQRSAFQNAKLYGPDIGQPRGKTVKLLRSFLKAGGEVIDSLTWHHYYLNGRIATKEDFLSSDVLDTFILSVQKILKVTKEITPGKKVWLGETSSAYGGGAPLLSNTFAAGFMWLDKLGLSAQMGIEVVMRQVFFGAGNYHLVDENFEPLPDYWLSLLFKKLVGPRVLLSRVKGPDRSKLRVYLHCTNVYHPRYQEGDLTLYVLNLHNVTKHLKVPPPLFRKPVDTYLLKPSGPDGLLSKSVQLNGQILKMVDEQTLPALTEKPLPAGSALSLPAFSYGFFVIRNAKIAACI", "length": 535, "header": "sp|Q6YGZ1-1|HPSE_MOUSE Isoform 1 of Heparanase OS=Mus musculus OX=10090 GN=Hpse PE=1 SV=3 CANONICAL=Q6YGZ1-1" }, "isoforms": [ { "isoform_ac": "D3Z3C3-1", "url": "", "sequence": { "sequence": "MLRLLLLWLWGPLGALAQGAPAGTAPTDDVVDLEFYTKRPLRSVSPSFLSITIDASLATDPRFLTFLGSPRLRALARGLSPAYLRFGGTKTDFLIFDPDKEPTSEERSYWKSQVNHDICRSEPVSAAVLRKLQVEWPFQELLLLREQYQKEFKNSTYSRSSVDMLYSFAKCSGLDLIFGLNALLRTPDLRWNSSNAQLLLDYCSSKGYNISWELGNEPNSFWKKAHILIDGLQLGEDFVELHKLLQRSAFQNAKLYGPDIGQPRGKTVKLLRSFLKAGGEVIDSLTWHHYYLNGRIATKEDFLSSDVLDTFILSVQKILKVTKEITPGKKVWLGETSSAYGGGAPLLSNTFAAGFMWLDKLGLSAQMGIEVVMRQVFFGAGNYHLVDENFEPLPDYWLSLLFKKLVGPRVLLSRVKGPDRSKLRVYLHCTNVYHPRYQEGDLTLYVLNLHNVTKHLKVPPPLFRKPVDTYLLKPSGPDGLLSK", "length": 483, "header": "tr|D3Z3C3-1|HPSE_MOUSE Computationally mapped isoform of Heparanase OS=Mus musculus OX=10090 GN=Hpse PE=1 SV=1 CANONICAL=Q6YGZ1-1" }, "locus": { "chromosome": "5", "start_pos": 100867460, "end_pos": 100832845, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000112908.2", "url": "https://www.ensembl.org/id/ENSMUST00000112908.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000108529.2", "url": "https://www.ensembl.org/id/ENSMUSP00000108529.2" } ] } }, { "isoform_ac": "Q6YGZ1-1", "url": "", "sequence": { "sequence": "MLRLLLLWLWGPLGALAQGAPAGTAPTDDVVDLEFYTKRPLRSVSPSFLSITIDASLATDPRFLTFLGSPRLRALARGLSPAYLRFGGTKTDFLIFDPDKEPTSEERSYWKSQVNHDICRSEPVSAAVLRKLQVEWPFQELLLLREQYQKEFKNSTYSRSSVDMLYSFAKCSGLDLIFGLNALLRTPDLRWNSSNAQLLLDYCSSKGYNISWELGNEPNSFWKKAHILIDGLQLGEDFVELHKLLQRSAFQNAKLYGPDIGQPRGKTVKLLRSFLKAGGEVIDSLTWHHYYLNGRIATKEDFLSSDVLDTFILSVQKILKVTKEITPGKKVWLGETSSAYGGGAPLLSNTFAAGFMWLDKLGLSAQMGIEVVMRQVFFGAGNYHLVDENFEPLPDYWLSLLFKKLVGPRVLLSRVKGPDRSKLRVYLHCTNVYHPRYQEGDLTLYVLNLHNVTKHLKVPPPLFRKPVDTYLLKPSGPDGLLSKSVQLNGQILKMVDEQTLPALTEKPLPAGSALSLPAFSYGFFVIRNAKIAACI", "length": 535, "header": "sp|Q6YGZ1-1|HPSE_MOUSE Isoform 1 of Heparanase OS=Mus musculus OX=10090 GN=Hpse PE=1 SV=3 CANONICAL=Q6YGZ1-1" }, "locus": { "chromosome": "5", "start_pos": 100867460, "end_pos": 100828740, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000045617", "url": "https://www.ensembl.org/id/ENSMUST00000045617" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000044072", "url": "https://www.ensembl.org/id/ENSMUSP00000044072" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 192, "start_aa": "Asn", "end_pos": 192, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn192", "evidence": [ { "id": "Q6YGZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6YGZ1#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 209, "start_aa": "Asn", "end_pos": 209, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn209", "evidence": [ { "id": "Q6YGZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6YGZ1#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 451, "start_aa": "Asn", "end_pos": 451, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn451", "evidence": [ { "id": "Q6YGZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6YGZ1#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycohydrolase-activity", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis.", "journal": "Nat. Med.", "date": "1999", "authors": "Harris M.J., Hulett M.D., Freeman C., Baker R.T., Hamdorf B.J., Parish C.R.", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "reference": [ { "type": "PubMed", "id": "10395326", "url": "https://glygen.org/publication/PubMed/10395326" } ] }, { "title": "Cloning, expression, and purification of mouse heparanase.", "journal": "Protein Expr. Purif.", "date": "2002", "authors": "Miao HQ, Navarro E, Patel S, Sargent D, Koo H, Wan H, Plata A, Zhou Q, Ludwig D, Bohlen P, Kussie P", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" }, { "database": "RefSeq", "id": "NP_690016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690016" } ], "reference": [ { "type": "PubMed", "id": "12460766", "url": "https://glygen.org/publication/PubMed/12460766" } ] }, { "title": "Processing of macromolecular heparin by heparanase.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Gong F, Jemth P, Escobar Galvis ML, Vlodavsky I, Horner A, Lindahl U, Li JP", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "reference": [ { "type": "PubMed", "id": "12837765", "url": "https://glygen.org/publication/PubMed/12837765" } ] }, { "title": "Heparanase mRNA expression during fracture repair in mice.", "journal": "Histochemistry and cell biology", "date": "2003", "authors": "Saijo M, Kitazawa R, Nakajima M, Kurosaka M, Maeda S, Kitazawa S", "evidence": [ { "database": "RefSeq", "id": "NP_690016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690016" } ], "reference": [ { "type": "PubMed", "id": "14618334", "url": "https://glygen.org/publication/PubMed/14618334" } ] }, { "title": "Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models.", "journal": "FASEB J.", "date": "2005", "authors": "Metzger S., Sarid R., Ilan N., Vlodavsky I., Yacoby-Zeevi O., Zcharia E., Zetser A., Abramovitch R., Casu B., Naggi A., Yaar A., Zilka R.", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "reference": [ { "type": "PubMed", "id": "15677344", "url": "https://glygen.org/publication/PubMed/15677344" } ] }, { "title": "Heparanase regulates murine hair growth.", "journal": "Am. J. Pathol.", "date": "2005", "authors": "Metzger S., Aingorn H., Edovitsky E., Elkin M., Vlodavsky I., Zcharia E., Kleinman H.K., Philp D.", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "reference": [ { "type": "PubMed", "id": "15793281", "url": "https://glygen.org/publication/PubMed/15793281" } ] }, { "title": "Heparanase induces Akt phosphorylation via a lipid raft receptor.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2007", "authors": "Ben-Zaken O., Gingis-Velitski S., Ilan N., Vlodavsky I.", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "reference": [ { "type": "PubMed", "id": "17689495", "url": "https://glygen.org/publication/PubMed/17689495" } ] }, { "title": "Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation.", "journal": "Bone", "date": "2008", "authors": "Brown A.J., Carson D.D., Alicknavitch M., D'Souza S.S., Daikoku T., Farach-Carson M.C., Kirn-Safran C.B., Marchetti D.", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "reference": [ { "type": "PubMed", "id": "18589009", "url": "https://glygen.org/publication/PubMed/18589009" } ] }, { "title": "Histone H4 induces heparan sulfate degradation by activating heparanase in chlorine gas-induced acute respiratory distress syndrome.", "journal": "Respiratory research", "date": "2022", "authors": "Zhang Y, Xu F, Guan L, Chen M, Zhao Y, Guo L, Li X, Zheng Y, Gao A, Li S", "evidence": [ { "database": "RefSeq", "id": "NP_690016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690016" } ], "reference": [ { "type": "PubMed", "id": "35073921", "url": "https://glygen.org/publication/PubMed/35073921" } ] }, { "title": "Implications of Heparanase on Heparin Synthesis and Metabolism in Mast Cells.", "journal": "International journal of molecular sciences", "date": "2022", "authors": "Maccarana M, Jia J, Li H, Zhang X, Vlodavsky I, Li JP", "evidence": [ { "database": "RefSeq", "id": "NP_690016", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_690016" } ], "reference": [ { "type": "PubMed", "id": "35563215", "url": "https://glygen.org/publication/PubMed/35563215" } ] } ], "pathway": [ { "id": "mmu:15442", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:15442", "resource": "KEGG Pathway" }, { "id": "R-MMU-2024096", "name": "HS-GAG degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2024096", "resource": "Reactome", "description": "HS-GAG degradation" }, { "id": "R-MMU-6798695", "name": "Neutrophil degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q71RP1-1", "protein_name": "Heparanase", "gene_name": "Hpse", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRPLLLLWLWGRLGALTQGTPAGTAPTKDVVDLEFYTKRLFQSVSPSFLSITIDASLATDPRFLTFLGSPRLRALARGLSPAYLRFGGTKTDFLIFDPNKEPTSEERSYWQSQDNNDICGSERVSADVLRKLQMEWPFQELLLLREQYQREFKNSTYSRSSVDMLYSFAKCSRLDLIFGLNALLRTPDLRWNSSNAQLLLNYCSSKGYNISWELGNEPNSFWKKAHISIDGLQLGEDFVELHKLLQKSAFQNAKLYGPDIGQPRGKTVKLLRSFLKAGGEVIDSLTWHHYYLNGRVATKEDFLSSDVLDTFILSVQKILKVTKEMTPGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSAQLGIEVVMRQVFFGAGNYHLVDENFEPLPDYWLSLLFKKLVGPKVLMSRVKGPDRSKLRVYLHCTNVYHPRYREGDLTLYVLNLHNVTKHLKLPPPMFSRPVDKYLLKPFGSDGLLSKSVQLNGQTLKMVDEQTLPALTEKPLPAGSSLSVPAFSYGFFVIRNAKIAACI", "length": 536 }, "evidence": [ { "id": "45228849", "url": "http://www.informatics.jax.org/homology/45228849", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9Y251-1", "protein_name": "Heparanase", "gene_name": "HPSE", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVTIDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI", "length": 543 }, "evidence": [ { "id": "45228849", "url": "http://www.informatics.jax.org/homology/45228849", "database": "MGI" }, { "id": "Q6YGZ1", "url": "https://omabrowser.org/oma/group/Q6YGZ1/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 15, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "membrane raft", "id": "GO:0045121", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "autophagosome", "id": "GO:0005776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "lysosomal lumen", "id": "GO:0043202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043202", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "heparanase complex", "id": "GO:1904974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904974", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "hydrolase activity, acting on glycosyl bonds", "id": "GO:0016798", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016798", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "syndecan binding", "id": "GO:0045545", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045545", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "heparanase activity", "id": "GO:0030305", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030305", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "cargo receptor ligand activity", "id": "GO:0140355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140355", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 25, "go_terms": [ { "name": "establishment of endothelial barrier", "id": "GO:0061028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061028", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "inflammatory response", "id": "GO:0006954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "positive regulation of cell population proliferation", "id": "GO:0008284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "positive regulation of cell migration", "id": "GO:0030335", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "positive regulation of protein kinase B signaling", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "positive regulation of vascular endothelial growth factor production", "id": "GO:0010575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010575", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "positive regulation of angiogenesis", "id": "GO:0045766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045766", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "cell-matrix adhesion", "id": "GO:0007160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007160", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "response to organic substance", "id": "GO:0010033", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010033", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "positive regulation of osteoblast proliferation", "id": "GO:0033690", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033690", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "positive regulation of substrate adhesion-dependent cell spreading", "id": "GO:1900026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900026", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "receptor-mediated endocytosis", "id": "GO:0006898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006898", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "positive regulation of autophagy", "id": "GO:0010508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010508", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "positive regulation of blood coagulation", "id": "GO:0030194", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030194", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "wound healing", "id": "GO:0042060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042060", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "vascular wound healing", "id": "GO:0061042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061042", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "positive regulation of hair follicle development", "id": "GO:0051798", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051798", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "heparan sulfate proteoglycan catabolic process", "id": "GO:0030200", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030200", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "angiogenesis involved in wound healing", "id": "GO:0060055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060055", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "heparin metabolic process", "id": "GO:0030202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030202", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "positive regulation of cell-matrix adhesion", "id": "GO:0001954", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001954", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "positive regulation of extracellular matrix disassembly", "id": "GO:0090091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090091", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "protein transmembrane transport", "id": "GO:0071806", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071806", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "Factor XII activation", "id": "GO:0002542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002542", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" }, { "name": "regulation of hair follicle development", "id": "GO:0051797", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051797", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 192, "end_pos": 194, "annotation": "n_glycosylation_sequon" }, { "start_pos": 209, "end_pos": 211, "annotation": "n_glycosylation_sequon" }, { "start_pos": 451, "end_pos": 453, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "N-glycosylated. Glycosylation of the 50 kDa subunit appears to be essential for its solubility.", "evidence": [ { "database": "UniProtKB", "id": "Q6YGZ1", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" }, { "database": "PubMed", "id": "12460766", "url": "https://glygen.org/publication/PubMed/12460766" } ] } ], "interactions": [], "reactions": [ { "id": "R-MMU-1667005", "name": "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "lysosomal lumen", "input_participant_list": [], "output_participant_list": [ "R-ALL-2090033" ], "enzyme_list": [ "Q6YGZ1-1" ], "evidence": [ { "id": "R-MMU-1667005", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1667005" } ] }, { "id": "R-MMU-6798749", "name": "Exocytosis of specific granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, specific granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O70138-1", "Q8VCF1-1", "Q3UP87-1", "Q8K183-1", "Q9JHW2-1", "Q61176-1", "P29351-1", "Q9ERI2-1", "Q8JZQ5-1", "Q9D7Q1-1", "Q6YGZ1-1", "P08071-1", "Q922K9-1", "Q9WUU7-1", "P18242-1", "Q9D7J6-1", "Q9Z0L8-1", "O35657-1", "Q8BND5-1", "Q9CYK2-1", "Q8VCH0-1", "P08905-1" ], "evidence": [ { "id": "R-MMU-6798749", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6798749" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-2090033", "participant_name": "Heparan sulfate chain(1) [lysosomal lumen]", "crossref": [ { "id": "63666", "database": "ChEBI", "url": "" }, { "id": "63666", "database": "ChEBI", "url": "" }, { "id": "63666", "database": "ChEBI", "url": "" }, { "id": "63666", "database": "ChEBI", "url": "" }, { "id": "63666", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "O35657", "gene_name": "Neu1", "activity": [ { "ec_number": "3.2.1.18", "activity": "Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.", "evidence": [ { "id": "O35657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35657" } ] }, { "ec_number": "3.2.1.18", "activity": "", "evidence": [ { "id": "O35657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35657" } ] } ] }, { "uniprot_ac": "O70138", "gene_name": "Mmp8", "activity": [ { "ec_number": "3.4.24.34", "activity": "Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.", "evidence": [ { "id": "O70138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70138" } ] }, { "ec_number": "3.4.24.34", "activity": "", "evidence": [ { "id": "O70138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70138" } ] } ] }, { "uniprot_ac": "P08071", "gene_name": "Ltf", "activity": [ { "ec_number": "3.4.21.-", "activity": "", "evidence": [ { "id": "P08071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08071" } ] } ] }, { "uniprot_ac": "P08905", "gene_name": "Lyz2", "activity": [ { "ec_number": "3.2.1.17", "activity": "Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.", "evidence": [ { "id": "P08905", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08905" } ] }, { "ec_number": "3.2.1.17", "activity": "", "evidence": [ { "id": "P08905", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08905" } ] } ] }, { "uniprot_ac": "P18242", "gene_name": "Ctsd", "activity": [ { "ec_number": "3.4.23.5", "activity": "Specificity similar to, but narrower than, that of pepsin A. Does not cleave the 4-Gln-|-His-5 bond in B chain of insulin.", "evidence": [ { "id": "P18242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18242" } ] }, { "ec_number": "3.4.23.5", "activity": "", "evidence": [ { "id": "P18242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18242" } ] } ] }, { "uniprot_ac": "P29351", "gene_name": "Ptpn6", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P29351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29351" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P29351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29351" } ] } ] }, { "uniprot_ac": "Q3UP87", "gene_name": "Elane", "activity": [ { "ec_number": "3.4.21.37", "activity": "Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.", "evidence": [ { "id": "Q3UP87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UP87" } ] }, { "ec_number": "3.4.21.37", "activity": "", "evidence": [ { "id": "Q3UP87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UP87" } ] } ] }, { "uniprot_ac": "Q61176", "gene_name": "Arg1", "activity": [ { "ec_number": "3.5.3.1", "activity": "H2O + L-arginine = L-ornithine + urea.", "evidence": [ { "id": "Q61176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61176" } ] }, { "ec_number": "3.5.3.1", "activity": "", "evidence": [ { "id": "Q61176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61176" } ] } ] }, { "uniprot_ac": "Q6YGZ1", "gene_name": "Hpse", "activity": [ { "ec_number": "3.2.1.166", "activity": "endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan.", "evidence": [ { "id": "Q6YGZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ] }, { "ec_number": "3.2.1.166", "activity": "", "evidence": [ { "id": "Q6YGZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6YGZ1" } ] } ] }, { "uniprot_ac": "Q8BND5", "gene_name": "Qsox1", "activity": [ { "ec_number": "1.8.3.2", "activity": "O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'.", "evidence": [ { "id": "Q8BND5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BND5" } ] }, { "ec_number": "1.8.3.2", "activity": "", "evidence": [ { "id": "Q8BND5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BND5" } ] } ] }, { "uniprot_ac": "Q8JZQ5", "gene_name": "Aoc1", "activity": [ { "ec_number": "1.4.3.-", "activity": "", "evidence": [ { "id": "Q8JZQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8JZQ5" } ] }, { "ec_number": "1.4.3.22", "activity": "H2O + histamine + O2 = H2O2 + imidazole-4-acetaldehyde + NH4(+).", "evidence": [ { "id": "Q8JZQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8JZQ5" } ] }, { "ec_number": "1.4.3.22", "activity": "", "evidence": [ { "id": "Q8JZQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8JZQ5" } ] } ] }, { "uniprot_ac": "Q8K183", "gene_name": "Pdxk", "activity": [ { "ec_number": "2.7.1.35", "activity": "ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate.", "evidence": [ { "id": "Q8K183", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K183" } ] }, { "ec_number": "2.7.1.35", "activity": "", "evidence": [ { "id": "Q8K183", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K183" } ] } ] }, { "uniprot_ac": "Q8VCF1", "gene_name": "Cant1", "activity": [ { "ec_number": "3.6.1.6", "activity": "ADP + H2O = AMP + H(+) + phosphate.", "evidence": [ { "id": "Q8VCF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCF1" } ] }, { "ec_number": "3.6.1.6", "activity": "", "evidence": [ { "id": "Q8VCF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCF1" } ] } ] }, { "uniprot_ac": "Q8VCH0", "gene_name": "Acaa1b", "activity": [ { "ec_number": "2.3.1.16", "activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "Q8VCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCH0" } ] }, { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "Q8VCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCH0" } ] }, { "ec_number": "2.3.1.155", "activity": "acetyl-CoA + tetradecanoyl-CoA = 3-oxohexadecanoyl-CoA + CoA.", "evidence": [ { "id": "Q8VCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCH0" } ] }, { "ec_number": "2.3.1.9", "activity": "", "evidence": [ { "id": "Q8VCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCH0" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "Q8VCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCH0" } ] }, { "ec_number": "2.3.1.155", "activity": "", "evidence": [ { "id": "Q8VCH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCH0" } ] } ] }, { "uniprot_ac": "Q922K9", "gene_name": "Frk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q922K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922K9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q922K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922K9" } ] } ] }, { "uniprot_ac": "Q9CYK2", "gene_name": "Qpct", "activity": [ { "ec_number": "2.3.2.5", "activity": "N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+).", "evidence": [ { "id": "Q9CYK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CYK2" } ] }, { "ec_number": "2.3.2.5", "activity": "", "evidence": [ { "id": "Q9CYK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CYK2" } ] } ] }, { "uniprot_ac": "Q9D7J6", "gene_name": "Dnase1l1", "activity": [ { "ec_number": "3.1.21.-", "activity": "", "evidence": [ { "id": "Q9D7J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D7J6" } ] } ] }, { "uniprot_ac": "Q9D7Q1", "gene_name": "Chit1", "activity": [ { "ec_number": "3.2.1.14", "activity": "Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.", "evidence": [ { "id": "Q9D7Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D7Q1" } ] }, { "ec_number": "3.2.1.14", "activity": "", "evidence": [ { "id": "Q9D7Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D7Q1" } ] } ] }, { "uniprot_ac": "Q9ERI2", "gene_name": "Rab27a", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "Q9ERI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ERI2" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9ERI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ERI2" } ] } ] }, { "uniprot_ac": "Q9JHW2", "gene_name": "Nit2", "activity": [ { "ec_number": "3.5.1.3", "activity": "a monoamide of a dicarboxylate + H2O = a dicarboxylate + NH4(+).", "evidence": [ { "id": "Q9JHW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHW2" } ] }, { "ec_number": "3.5.1.3", "activity": "", "evidence": [ { "id": "Q9JHW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JHW2" } ] } ] }, { "uniprot_ac": "Q9WUU7", "gene_name": "Ctsz", "activity": [ { "ec_number": "3.4.18.1", "activity": "Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.", "evidence": [ { "id": "Q9WUU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUU7" } ] }, { "ec_number": "3.4.18.1", "activity": "", "evidence": [ { "id": "Q9WUU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WUU7" } ] } ] }, { "uniprot_ac": "Q9Z0L8", "gene_name": "Ggh", "activity": [ { "ec_number": "3.4.19.9", "activity": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate.", "evidence": [ { "id": "Q9Z0L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z0L8" } ] }, { "ec_number": "3.4.19.9", "activity": "", "evidence": [ { "id": "Q9Z0L8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z0L8" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 3 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 3 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }