{ "uniprot_canonical_ac": "Q6Y7W8-1", "uniprot_ac": "Q6Y7W8", "uniprot_id": "GGYF2_MOUSE", "mass": { "chemical_mass": 149193.0, "monoisotopic_mass": 149193.0 }, "refseq": { "ac": "NP_001103682", "name": "GRB10-interacting GYF protein 2 isoform b", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103682" }, "gene_names": [ { "name": "Gigyf2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q6Y7W8", "id": "Q6Y7W8" }, { "name": "2610016F01Rik; A830080H02Rik; mKIAA0642; Tnrc15", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103682", "id": "NP_001103682" }, { "name": "Gigyf2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103682", "id": "NP_001103682" }, { "name": "Kiaa0642", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q6Y7W8", "id": "Q6Y7W8" }, { "name": "Perq2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q6Y7W8", "id": "Q6Y7W8" }, { "name": "Tnrc15", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q6Y7W8", "id": "Q6Y7W8" } ], "protein_names": [ { "name": "GRB10-interacting GYF protein 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q6Y7W8" }, { "name": "GRB10-interacting GYF protein 2 isoform b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103682", "id": "NP_001103682" }, { "name": "PERQ amino acid-rich with GYF domain-containing protein 2; trinucleotide repeat containing 15", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103682", "id": "NP_001103682" }, { "name": "PERQ amino acid-rich with GYF domain-containing protein 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6Y7W8" }, { "name": "Trinucleotide repeat-containing gene 15 protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6Y7W8" } ], "function": [ { "annotation": "Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function.", "evidence": [ { "database": "RefSeq", "id": "NP_001103682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103682" }, { "database": "PubMed", "id": "37517320", "url": "https://glygen.org/publication/PubMed/37517320" } ] }, { "annotation": "Disruption of the eukaryotic translation initiation factor 4E - Gigyf2 complex leads to increased translation and perinatal lethality in mice.", "evidence": [ { "database": "RefSeq", "id": "NP_001103682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103682" }, { "database": "PubMed", "id": "22751931", "url": "https://glygen.org/publication/PubMed/22751931" } ] }, { "annotation": "Identification of proteins linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling", "evidence": [ { "database": "RefSeq", "id": "NP_001103682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103682" }, { "database": "PubMed", "id": "12771153", "url": "https://glygen.org/publication/PubMed/12771153" } ] }, { "annotation": "Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:26763119). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:26763119). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (By similarity). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). In association with EIF4E2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8#function" }, { "database": "UniProtKB", "id": "Q6Y7W6", "url": "https://www.uniprot.org/uniprot/Q6Y7W6#function" }, { "database": "PubMed", "id": "26763119", "url": "https://glygen.org/publication/PubMed/26763119" }, { "database": "PubMed", "id": "12771153", "url": "https://glygen.org/publication/PubMed/12771153" } ] }, { "annotation": "Negative regulation of Grb10 Interacting GIGYF2 protein on IGF-1 receptor signaling pathway caused diabetic mice cognitive impairment. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001103682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103682" }, { "database": "PubMed", "id": "25268761", "url": "https://glygen.org/publication/PubMed/25268761" } ] }, { "annotation": "Primary cultured embryo fibroblasts from Gigyf2 null mice exhibit decreased IGF1 signaling.", "evidence": [ { "database": "RefSeq", "id": "NP_001103682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103682" }, { "database": "PubMed", "id": "19744960", "url": "https://glygen.org/publication/PubMed/19744960" } ] } ], "disease": [ { "disease_id": "DOID:0060037", "recommended_name": { "id": "DOID:0060037", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060037", "name": "developmental disorder of mental health", "description": "A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development." }, "synonyms": [], "evidence": [ { "id": "0060037", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060037" } ] }, { "disease_id": "DOID:14330", "recommended_name": { "id": "DOID:14330", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14330", "name": "Parkinson's disease", "description": "A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions." }, "synonyms": [ { "id": "DOID:14330", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14330", "name": "Parkinson disease", "description": "" }, { "id": "DOID:14330", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:14330", "name": "paralysis agitans", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late-onset Parkinson disease", "description": "A Parkinson disease that begins after around the age of 50." }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "LOPD", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "PARK", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "PD", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, age of onset, modifier, Multifactorial", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, late-onset", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, late-onset, susceptibility to, Multifactorial", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "Parkinson disease, susceptibility to, Multifactorial", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "autosomal dominant late-onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "hereditary late onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "hereditary late-onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late onset Parkinson disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late onset Parkinson's disease", "description": "" }, { "id": "MONDO:0008199", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008199", "name": "late-onset Parkinson disease", "description": "" }, { "id": "MIM:168600", "resource": "MIM", "url": "https://www.omim.org/entry/168600", "name": "Parkinson disease", "description": "Parkinson disease" } ], "evidence": [ { "id": "14330", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:14330" } ] }, { "disease_id": "DOID:5419", "recommended_name": { "id": "DOID:5419", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5419", "name": "schizophrenia", "description": "A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness." }, "synonyms": [ { "id": "DOID:5419", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5419", "name": "schizophrenia-1", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia", "description": "A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality." }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia 12", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia (disease)", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia-1", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "SCZD", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizoaffective disorder", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia with or without an affective disorder", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia, susceptibility to", "description": "" }, { "id": "MIM:181500", "resource": "MIM", "url": "https://www.omim.org/entry/181500", "name": "Schizophrenia", "description": "Schizophrenia" } ], "evidence": [ { "id": "5419", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5419" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Gigyf2", "url": "https://www.uniprot.org/uniprot/Q6Y7W8", "locus": { "chromosome": "1", "start_pos": 87378518, "end_pos": 87254720, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000048000", "url": "https://www.ensembl.org/id/ENSMUSG00000048000" } ] } } ], "crossref": [ { "id": "ENSMUSG00000048000", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000048000", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00072", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00072", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "227331", "url": "https://www.ncbi.nlm.nih.gov/gene/227331", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q6Y7W8", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q6Y7W8*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003169", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003169", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035445", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035445", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:227331", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:227331", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2138584", "url": "http://www.informatics.jax.org/marker/MGI:2138584", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q6Y7W8", "url": "https://oglcnac.org/atlas/detail/Q6Y7W8", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q6Y7W8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q6Y7W8", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "DRDYGEG", "url": "https://omabrowser.org/oma/group/DRDYGEG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5406906at2759", "url": "http://www.orthodb.org/?query=5406906at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR14445", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14445", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR14445:SF38", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14445:SF38", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02213", "url": "http://pfam.xfam.org/family/PF02213", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q6Y7W8", "url": "http://purl.obolibrary.org/obo/PR_Q6Y7W8", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001103682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103682", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E9Q2M5", "url": "https://www.uniprot.org/uniprot/E9Q2M5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9Q2M5-1", "url": "https://www.uniprot.org/uniprot/E9Q2M5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UWR2", "url": "https://www.uniprot.org/uniprot/G3UWR2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UWR2-1", "url": "https://www.uniprot.org/uniprot/G3UWR2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UWT6", "url": "https://www.uniprot.org/uniprot/G3UWT6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UWT6-1", "url": "https://www.uniprot.org/uniprot/G3UWT6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UXF2", "url": "https://www.uniprot.org/uniprot/G3UXF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UXF2-1", "url": "https://www.uniprot.org/uniprot/G3UXF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UYG6", "url": "https://www.uniprot.org/uniprot/G3UYG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UYG6-1", "url": "https://www.uniprot.org/uniprot/G3UYG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UYH4", "url": "https://www.uniprot.org/uniprot/G3UYH4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UYH4-1", "url": "https://www.uniprot.org/uniprot/G3UYH4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UYR9", "url": "https://www.uniprot.org/uniprot/G3UYR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UYR9-1", "url": "https://www.uniprot.org/uniprot/G3UYR9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UZM3", "url": "https://www.uniprot.org/uniprot/G3UZM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UZM3-1", "url": "https://www.uniprot.org/uniprot/G3UZM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UZS9", "url": "https://www.uniprot.org/uniprot/G3UZS9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UZS9-1", "url": "https://www.uniprot.org/uniprot/G3UZS9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UZW5", "url": "https://www.uniprot.org/uniprot/G3UZW5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UZW5-1", "url": "https://www.uniprot.org/uniprot/G3UZW5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UZX7", "url": "https://www.uniprot.org/uniprot/G3UZX7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3UZX7-1", "url": "https://www.uniprot.org/uniprot/G3UZX7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6Y7W8-1", "url": "https://www.uniprot.org/uniprot/Q6Y7W8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6Y7W8-2", "url": "https://www.uniprot.org/uniprot/Q6Y7W8-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDYKIPFDLLEKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGRPNFEESGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPDGPRSTGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEERSDSDSSHNEEAKEPDKTNRREGEKTDRAGAEASEEVPQTSLSSARPGTPSDHQPQEATQFERKDEPKAEQVEKAEEENRSENSLSAKVPSRGDETVPASQQPSTPLPPDTASPLLILSPPVPTPSSASRPVETAAVEAPGMSSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLTSKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQALKMRMSDQNIIPSVTRSVSVPDTGSIWELQPAASQPAVWEGGSVWDLPLDTTAPGPSLEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELELQRQKDLMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTATCQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQQKLSGWGNVSKPAGTTKSLLEIQQEEARQMQKQQQQQQQQQQQHQQSNRARNSTHSNLHTSLGNSVWGSINTGPSNQWASELVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYTRAYLGDTSEAKEFAKQFLERRAKQKVNQQRQQQQQQQQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETLDDY", "length": 1291, "header": "sp|Q6Y7W8-1|GGYF2_MOUSE Isoform 1 of GRB10-interacting GYF protein 2 OS=Mus musculus OX=10090 GN=Gigyf2 PE=1 SV=2 CANONICAL=Q6Y7W8-1" }, "isoforms": [ { "isoform_ac": "E9Q2M5-1", "url": "", "sequence": { "sequence": "MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDYKIPFDLLEKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGGTVVGAPRGRSSSRGRGRPNFEESGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEERSDSDSSHNEEAKEPDKTNRREGEKTDRAGAEASEEVPQTSLSSARPGTPSDHQPQEATQFERKDEPKAEQVEKAEEENRSENSLSAKVPSRGDETVPASQQPSTPLPPDTASPLLILSPPVPTPSSASRPVETAAVEAPGMSSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLTSKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQALKMRMSDQNIIPSVTRSVSVPDTGSIWELQPAASQPAVWEGGSVWDLPLDTTAPGPSLEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEER", "length": 721, "header": "tr|E9Q2M5-1|E9Q2M5_MOUSE Computationally mapped isoform of GRB10 interacting GYF protein 2 OS=Mus musculus OX=10090 GN=Gigyf2 PE=1 SV=1 CANONICAL=Q6Y7W8-1" }, "locus": { "chromosome": "1", "start_pos": 87352909, "end_pos": 87282168, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000164992.9", "url": "https://www.ensembl.org/id/ENSMUST00000164992.9" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000129046.3", "url": "https://www.ensembl.org/id/ENSMUSP00000129046.3" } ] } }, { "isoform_ac": "G3UWR2-1", "url": "", "sequence": { "sequence": "MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDYKIPFDLLEKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGRPNFEESGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPDGPRSTGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEERSDSDSSHNEEAKEPDKTNRREGEKTDRAGAEASEEVPQTSLSSARPGTPSDHQPQEATQFERKDEPKAEQVEKAEEENRSENSLSAKVPSRGDETVPASQQPSTPLPPDTASPLLILSPPVPTPSSASRPVETAAVEAPGMSSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLTSKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQALKMRMSDQNIIPSVTRSVSVPDTGSIWELQPAASQPAVWEGGSVWDLPLDTTAPGPSLEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELELQRQKDLMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTATCQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQQKLSGWGNVSKPAGTTKSLLEIQQEEARQMQKQQQQQQQQQQQHQQSNRARNSTHSNLHTSLGNSVWGSINTGPSNQWASELVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSSHVCFFLERSGVSL", "length": 1122, "header": "tr|G3UWR2-1|G3UWR2_MOUSE Computationally mapped isoform of GRB10 interacting GYF protein 2 OS=Mus musculus OX=10090 GN=Gigyf2 PE=1 SV=1 CANONICAL=Q6Y7W8-1" }, "locus": { "chromosome": "1", "start_pos": 87371409, "end_pos": 87282168, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000172964.8", "url": "https://www.ensembl.org/id/ENSMUST00000172964.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000133392.2", "url": "https://www.ensembl.org/id/ENSMUSP00000133392.2" } ] } }, { "isoform_ac": "G3UWT6-1", "url": "", "sequence": { "sequence": "MDRIWAEGEEKFQLVKNKQGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEER", "length": 110, "header": "tr|G3UWT6-1|GGYF2_MOUSE Computationally mapped isoform of GRB10-interacting GYF protein 2 OS=Mus musculus OX=10090 GN=Gigyf2 PE=1 SV=8 CANONICAL=Q6Y7W8-1" }, "locus": { "chromosome": "1", "start_pos": 87335086, "end_pos": 87332740, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000173663.2", "url": "https://www.ensembl.org/id/ENSMUST00000173663.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000133416.2", "url": "https://www.ensembl.org/id/ENSMUSP00000133416.2" } ] } }, { "isoform_ac": "G3UXF2-1", "url": "", "sequence": { "sequence": "MISEGRPNFEESGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPDGPRSTGWREHMERRRRFEF", "length": 84, "header": "tr|G3UXF2-1|G3UXF2_MOUSE Computationally mapped isoform of GRB10 interacting GYF protein 2 OS=Mus musculus OX=10090 GN=Gigyf2 PE=1 SV=1 CANONICAL=Q6Y7W8-1" }, "locus": { "chromosome": "1", "start_pos": 87334764, "end_pos": 87314340, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000174334.8", "url": "https://www.ensembl.org/id/ENSMUST00000174334.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000133666.2", "url": "https://www.ensembl.org/id/ENSMUSP00000133666.2" } ] } }, { "isoform_ac": "G3UYG6-1", "url": "", "sequence": { "sequence": "MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDYKIPFDLLEKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGRPNFEESGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEERSDSDSSHNEEAKEPDKTNRREGEKTDRAGAEASEEVPQTSLSSARPGTPSDHQPQEATQFERKDEPKAEQVEKAEEENRSENSLSAKVPSRGDETVPASQQPSTPLPPDTASPLLILSPPVPTPSSASRPVETAAVEAPGMSSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLTSKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQALKMRMSDQNIIPSVTRSVSVPDTGSIWELQPAASQPAVWEGGSVWDLPLDTTAPGPSLEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELELQRQKDLMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTATCQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQQKLSGWGNVSKPAGTTKSLLEIQQEEARQMQKQQQQQQQQQQQHQQSNRARNSTHSNLHTSLGNSVWGSINTGPSNQWASELVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYTRAYLGDTSEAKEFAKQFLERRAKQKVNQQRQQQQQQQQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETLDDY", "length": 1285, "header": "tr|G3UYG6-1|G3UYG6_MOUSE Computationally mapped isoform of GRB10 interacting GYF protein 2 OS=Mus musculus OX=10090 GN=Gigyf2 PE=1 SV=1 CANONICAL=Q6Y7W8-1" }, "locus": { "chromosome": "1", "start_pos": 87376864, "end_pos": 87282168, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000172794.8", "url": "https://www.ensembl.org/id/ENSMUST00000172794.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000134077.2", "url": "https://www.ensembl.org/id/ENSMUSP00000134077.2" } ] } }, { "isoform_ac": "G3UYH4-1", "url": "", "sequence": { "sequence": "MDRIWAEGEEKFQLVKNKQDGPRSTGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEERSDSDSSHNEEAKEPDKTNRREGEKTDRAGAEASEEVPQTSLSSARPGTPSDHQPQE", "length": 172, "header": "tr|G3UYH4-1|G3UYH4_MOUSE Computationally mapped isoform of GRB10 interacting GYF protein 2 OS=Mus musculus OX=10090 GN=Gigyf2 PE=1 SV=1 CANONICAL=Q6Y7W8-1" }, "locus": { "chromosome": "1", "start_pos": 87335333, "end_pos": 87332740, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000173152.2", "url": "https://www.ensembl.org/id/ENSMUST00000173152.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000134086.2", "url": "https://www.ensembl.org/id/ENSMUSP00000134086.2" } ] } }, { "isoform_ac": "G3UYR9-1", "url": "", "sequence": { "sequence": "MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDYKIPFDLLEKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGRPNFEESGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEERSDSDSSHNEEAKEPDKTNRREGEKTDRAGAASEEVPQTSLSSARPGTPSDHQPQEATQFERKDEPKAEQVEKAEEENRSENSLSAKVPSRGDETVPASQQPSTPLPPDTASPLLILSPPVPTPSSASRPVETAAVEAPGMSSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLTSKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQALKMRMSDQNIIPSVTRSVSVPDTGSIWELQPAASQPAVWEGGSVWDLPLDTTAPGPSLEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERK", "length": 877, "header": "tr|G3UYR9-1|G3UYR9_MOUSE Computationally mapped isoform of GRB10 interacting GYF protein 2 OS=Mus musculus OX=10090 GN=Gigyf2 PE=1 SV=1 CANONICAL=Q6Y7W8-1" }, "locus": { "chromosome": "1", "start_pos": 87361521, "end_pos": 87282168, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000173173.8", "url": "https://www.ensembl.org/id/ENSMUST00000173173.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000134193.2", "url": "https://www.ensembl.org/id/ENSMUSP00000134193.2" } ] } }, { "isoform_ac": "G3UZM3-1", "url": "", "sequence": { "sequence": "MDRIWAEGEEKFQLVKNKQDGPRSTGWREHMERRRSAERTYS", "length": 42, "header": "tr|G3UZM3-1|G3UZM3_MOUSE Computationally mapped isoform of GRB10 interacting GYF protein 2 OS=Mus musculus OX=10090 GN=Gigyf2 PE=4 SV=1 CANONICAL=Q6Y7W8-1" }, "locus": { "chromosome": "1", "start_pos": 87335037, "end_pos": 87332740, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000173148.2", "url": "https://www.ensembl.org/id/ENSMUST00000173148.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000134553.2", "url": "https://www.ensembl.org/id/ENSMUSP00000134553.2" } ] } }, { "isoform_ac": "G3UZS9-1", "url": "", "sequence": { "sequence": "RSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPDGPRSTGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEERSDSDSSHNEEAKEPDKTNRREGEKTDRAGAASEEVPQTSLSSARPGTPSDHQPQEATQFERKDEPKAEQVEKAEEENRSENSLSA", "length": 222, "header": "tr|G3UZS9-1|G3UZS9_MOUSE Computationally mapped isoform of GRB10 interacting GYF protein 2 OS=Mus musculus OX=10090 GN=Gigyf2 PE=1 SV=1 CANONICAL=Q6Y7W8-1" }, "locus": { "chromosome": "1", "start_pos": 87335423, "end_pos": 87331448, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000172736.8", "url": "https://www.ensembl.org/id/ENSMUST00000172736.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000134620.2", "url": "https://www.ensembl.org/id/ENSMUSP00000134620.2" } ] } }, { "isoform_ac": "G3UZW5-1", "url": "", "sequence": { "sequence": "XSHNEEAKEPDKTNRREGEKTDRAGAEASEEVPQTSLSSARPGTPSDHQPQEATQFERKDEPKAEQVEKAEEENRSENSLSAKVPSRGDETVPASQQPSTPLPPDTASPLLILSPPVPTPSSASRPVETAAVEAPGMSSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLTSKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGRIGPGTPDQTAGTHCLIPDAAPPVPAVLNPTTVCTGFGSTAESSFVISA", "length": 258, "header": "tr|G3UZW5-1|GGYF2_MOUSE Computationally mapped isoform of GRB10-interacting GYF protein 2 OS=Mus musculus OX=10090 GN=Gigyf2 PE=1 SV=1 CANONICAL=Q6Y7W8-1" }, "locus": { "chromosome": "1", "start_pos": 87348064, "end_pos": 87335101, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000173636.2", "url": "https://www.ensembl.org/id/ENSMUST00000173636.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000134660.2", "url": "https://www.ensembl.org/id/ENSMUSP00000134660.2" } ] } }, { "isoform_ac": "G3UZX7-1", "url": "", "sequence": { "sequence": "XRPNFEESGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPDGPRSTGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEERSDSDSSHNEEAKEPDKTNRREGEKTDRAGAEASEEVPQTSLSSARPGTPSDHQPQEATQFERKDEPKAEQVEKAEEENRSENSLSAKVPSRGDETVPASQQPSTPLPPDTASPLLILSPPVPTPSSASRPVETAAVEAPGMSSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLTSKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQALKMRMSDQNIIPSVTRSVSVPDTGSIWELQPAASQPAVWEGGSVWDLPLDTTAPGPSLEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELELQRQKDLMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTATCQSQATLSLAEIQKLEEERERQLREES", "length": 787, "header": "tr|G3UZX7-1|GGYF2_MOUSE Computationally mapped isoform of GRB10-interacting GYF protein 2 OS=Mus musculus OX=10090 GN=Gigyf2 PE=1 SV=1 CANONICAL=Q6Y7W8-1" }, "locus": { "chromosome": "1", "start_pos": 87368085, "end_pos": 87331389, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000173235.8", "url": "https://www.ensembl.org/id/ENSMUST00000173235.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000134677.2", "url": "https://www.ensembl.org/id/ENSMUSP00000134677.2" } ] } }, { "isoform_ac": "Q6Y7W8-1", "url": "", "sequence": { "sequence": "MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDYKIPFDLLEKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGRPNFEESGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPDGPRSTGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEERSDSDSSHNEEAKEPDKTNRREGEKTDRAGAEASEEVPQTSLSSARPGTPSDHQPQEATQFERKDEPKAEQVEKAEEENRSENSLSAKVPSRGDETVPASQQPSTPLPPDTASPLLILSPPVPTPSSASRPVETAAVEAPGMSSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLTSKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQALKMRMSDQNIIPSVTRSVSVPDTGSIWELQPAASQPAVWEGGSVWDLPLDTTAPGPSLEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELELQRQKDLMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTATCQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQQKLSGWGNVSKPAGTTKSLLEIQQEEARQMQKQQQQQQQQQQQHQQSNRARNSTHSNLHTSLGNSVWGSINTGPSNQWASELVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYTRAYLGDTSEAKEFAKQFLERRAKQKVNQQRQQQQQQQQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETLDDY", "length": 1291, "header": "sp|Q6Y7W8-1|GGYF2_MOUSE Isoform 1 of GRB10-interacting GYF protein 2 OS=Mus musculus OX=10090 GN=Gigyf2 PE=1 SV=2 CANONICAL=Q6Y7W8-1" }, "locus": { "chromosome": "1", "start_pos": 87376864, "end_pos": 87282168, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000027475", "url": "https://www.ensembl.org/id/ENSMUST00000027475" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000027475", "url": "https://www.ensembl.org/id/ENSMUSP00000027475" } ] } }, { "isoform_ac": "Q6Y7W8-2", "url": "", "sequence": { "sequence": "MEEEAARLRHEEEERKRKELELQRQKDLMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTATCQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQQKLSGWGNVSKPAGTTKSLLEIQQEEARQMQKQQQQQQQQQQQHQQSNRARNSTHSNLHTSLGNSVWGSINTGPSNQWASELVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYTRAYLGDTSEAKEFAKQFLERRAKQKVNQQRQQQQQQQQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETLDDY", "length": 423, "header": "sp|Q6Y7W8-2|GGYF2_MOUSE Isoform 2 of GRB10-interacting GYF protein 2 OS=Mus musculus OX=10090 GN=Gigyf2 PE=1 SV=2 CANONICAL=Q6Y7W8-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 672, "start_aa": "Ser", "end_pos": 672, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser672", "evidence": [ { "id": "Q6Y7W8", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q6Y7W8" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 679, "start_aa": "Ser", "end_pos": 679, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser679", "evidence": [ { "id": "Q6Y7W8", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q6Y7W8" }, { "id": "32782141", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32782141" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 681, "start_aa": "Thr", "end_pos": 681, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr681", "evidence": [ { "id": "Q6Y7W8", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q6Y7W8" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" }, { "id": "Q6Y7W8", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q6Y7W8" }, { "id": "32782141", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32782141" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q6Y7W8", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q6Y7W8" }, { "id": "34887587", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34887587" } ] } ], "phosphorylation": [ { "start_pos": 1276, "end_pos": 1276, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "site_lbl": "Ser1276" }, { "start_pos": 140, "end_pos": 140, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "site_lbl": "Ser140" }, { "start_pos": 161, "end_pos": 161, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "site_lbl": "Ser161" }, { "start_pos": 190, "end_pos": 190, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "site_lbl": "Ser190" }, { "start_pos": 19, "end_pos": 19, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "site_lbl": "Ser19" }, { "start_pos": 237, "end_pos": 237, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "site_lbl": "Ser237" }, { "start_pos": 25, "end_pos": 25, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "Q6Y7W8", "url": "http://phospho.elm.eu.org/byAccession/Q6Y7W8.html" }, { "database": "iPTMnet", "id": "Q6Y7W8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6Y7W8" }, { "database": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ], "site_lbl": "Thr25" }, { "start_pos": 26, "end_pos": 26, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q6Y7W8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6Y7W8" } ], "site_lbl": "Ser26" }, { "start_pos": 30, "end_pos": 30, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q6Y7W8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6Y7W8" } ], "site_lbl": "Ser30" }, { "start_pos": 383, "end_pos": 383, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "phospho.ELM", "id": "Q6Y7W8", "url": "http://phospho.elm.eu.org/byAccession/Q6Y7W8.html" }, { "database": "iPTMnet", "id": "Q6Y7W8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6Y7W8" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ], "site_lbl": "Thr383" }, { "start_pos": 594, "end_pos": 594, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "site_lbl": "Ser594" }, { "start_pos": 995, "end_pos": 995, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "site_lbl": "Ser995" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Giovannone B, Lee E, Laviola L, Giorgino F, Cleveland KA, Smith RJ", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" }, { "database": "RefSeq", "id": "NP_001103682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103682" } ], "reference": [ { "type": "PubMed", "id": "12771153", "url": "https://glygen.org/publication/PubMed/12771153" } ] }, { "title": "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.", "journal": "Molecular & cellular proteomics : MCP", "date": "2007", "authors": "Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM", "evidence": [ { "database": "iPTMnet", "id": "Q6Y7W8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6Y7W8" } ], "reference": [ { "type": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ] }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "Q6Y7W8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6Y7W8" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] }, { "title": "The phagosomal proteome in interferon-gamma-activated macrophages.", "journal": "Immunity", "date": "2009", "authors": "Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P", "evidence": [ { "database": "UniProtKB", "id": "G3UZW5", "url": "https://www.uniprot.org/uniprot/G3UZW5" }, { "database": "UniProtKB", "id": "E9Q2M5", "url": "https://www.uniprot.org/uniprot/E9Q2M5" }, { "database": "UniProtKB", "id": "G3UZX7", "url": "https://www.uniprot.org/uniprot/G3UZX7" }, { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" }, { "database": "UniProtKB", "id": "G3UWR2", "url": "https://www.uniprot.org/uniprot/G3UWR2" }, { "database": "UniProtKB", "id": "G3UYG6", "url": "https://www.uniprot.org/uniprot/G3UYG6" } ], "reference": [ { "type": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ] }, { "title": "GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling.", "journal": "Hum. Mol. Genet.", "date": "2009", "authors": "Giovannone B, Tsiaras WG, de la Monte S, Klysik J, Lautier C, Karashchuk G, Goldwurm S, Smith RJ", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" }, { "database": "RefSeq", "id": "NP_001103682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103682" } ], "reference": [ { "type": "PubMed", "id": "19744960", "url": "https://glygen.org/publication/PubMed/19744960" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" }, { "database": "iPTMnet", "id": "Q6Y7W8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6Y7W8" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse.", "journal": "Molecular & cellular proteomics : MCP", "date": "2012", "authors": "Trinidad JC, Barkan DT, Gulledge BF, Thalhammer A, Sali A, Schoepfer R, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q6Y7W8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q6Y7W8" }, { "database": "O-GlcNAc Atlas", "id": "Q6Y7W8", "url": "https://oglcnac.org/atlas/detail/Q6Y7W8" } ], "reference": [ { "type": "PubMed", "id": "22645316", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "title": "A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.", "journal": "Molecular and cellular biology", "date": "2012", "authors": "Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF, Kabuta T, Higashi S, Larsson O, Topisirovic I, Smith RJ, Gingras AC, Sonenberg N", "evidence": [ { "database": "RefSeq", "id": "NP_001103682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103682" } ], "reference": [ { "type": "PubMed", "id": "22751931", "url": "https://glygen.org/publication/PubMed/22751931" } ] }, { "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "journal": "Mol. Cell. Proteomics", "date": "2014", "authors": "Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee KA, Yang V, Aguiar M, Kornhauser J, Jia X, Ren J, Beausoleil SA, Silva JC, Vemulapalli V, Bedford MT, Comb MJ", "evidence": [ { "database": "UniProtKB", "id": "E9Q2M5", "url": "https://www.uniprot.org/uniprot/E9Q2M5" }, { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" }, { "database": "UniProtKB", "id": "G3UWR2", "url": "https://www.uniprot.org/uniprot/G3UWR2" }, { "database": "UniProtKB", "id": "G3UYR9", "url": "https://www.uniprot.org/uniprot/G3UYR9" }, { "database": "UniProtKB", "id": "G3UYG6", "url": "https://www.uniprot.org/uniprot/G3UYG6" } ], "reference": [ { "type": "PubMed", "id": "24129315", "url": "https://glygen.org/publication/PubMed/24129315" } ] }, { "title": "Negative regulation of Grb10 Interacting GYF Protein 2 on insulin-like growth factor-1 receptor signaling pathway caused diabetic mice cognitive impairment.", "journal": "PloS one", "date": "2014", "authors": "Xie J, Wei Q, Deng H, Li G, Ma L, Zeng H", "evidence": [ { "database": "RefSeq", "id": "NP_001103682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103682" } ], "reference": [ { "type": "PubMed", "id": "25268761", "url": "https://glygen.org/publication/PubMed/25268761" } ] }, { "title": "Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements.", "journal": "RNA", "date": "2016", "authors": "Fu R, Olsen MT, Webb K, Bennett EJ, Lykke-Andersen J", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "reference": [ { "type": "PubMed", "id": "26763119", "url": "https://glygen.org/publication/PubMed/26763119" } ] }, { "title": "Cytosolic N-GlcNAc proteins are formed by the action of endo-beta-N-acetylglucosaminidase.", "journal": "Biochemical and biophysical research communications", "date": "2020", "authors": "Maynard JC, Fujihira H, Dolgonos GE, Suzuki T, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "Q6Y7W8", "url": "https://oglcnac.org/atlas/detail/Q6Y7W8" } ], "reference": [ { "type": "PubMed", "id": "32782141", "url": "https://glygen.org/publication/PubMed/32782141" } ] }, { "title": "Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress.", "journal": "Nature chemical biology", "date": "2022", "authors": "Shu XE, Mao Y, Jia L, Qian SB", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q6Y7W8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q6Y7W8" } ], "reference": [ { "type": "PubMed", "id": "34887587", "url": "https://glygen.org/publication/PubMed/34887587" } ] }, { "title": "Defining the Dynamic Regulation of O-GlcNAc Proteome in the Mouse Cortex---the O-GlcNAcylation of Synaptic and Trafficking Proteins Related to Neurodegenerative Diseases.", "journal": "Frontiers in aging", "date": "2021", "authors": "Huynh Van N, Wang Sheng, Ouyang Xiaosen, Wani Willayat Y, Johnson Michelle S, Chacko Balu K, Jegga Anil G, Qian Wei-Jun, Chatham John C, Darley-Usmar Victor M, Zhang Jianhua", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q6Y7W8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q6Y7W8" } ], "reference": [ { "type": "PubMed", "id": "35822049", "url": "https://glygen.org/publication/PubMed/35822049" } ] }, { "title": "Chemoproteomic and Transcriptomic Analysis Reveals that O-GlcNAc Regulates Mouse Embryonic Stem Cell Fate through the Pluripotency Network.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2023-02-27", "authors": "Hao Yi, Li Xiang, Qin Ke, Shi Yujie, He Yanwen, Zhang Che, Cheng Bo, Zhang Xiwen, Hu Guangyu, Liang Shuyu, Tang Qi, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q6Y7W8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q6Y7W8" } ], "reference": [ { "type": "PubMed", "id": "36852467", "url": "https://glygen.org/publication/PubMed/36852467" } ] }, { "title": "Aberrant hyper-expression of the RNA binding protein GIGYF2 in endothelial cells modulates vascular aging and function.", "journal": "Redox biology", "date": "2023-09", "authors": "Niu Fanglin, Li Zhuozhuo, Ren Yuanyuan, Li Zi, Guan Hua, Li Yang, Zhang Yan, Li Yirong, Yang Junle, Qian Lu, Shi Wenzhen, Fan Xiaobin, Li Jinli, Shi Lele, Yu Yi, Xiong Yuyan", "evidence": [ { "database": "RefSeq", "id": "NP_001103682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103682" } ], "reference": [ { "type": "PubMed", "id": "37517320", "url": "https://glygen.org/publication/PubMed/37517320" } ] } ], "pathway": [ { "id": "mmu:227331", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:227331", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6Y7W6-1", "protein_name": "GRB10-interacting GYF protein 2", "gene_name": "GIGYF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPSDLLDKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGRPNFEEGGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPDGPRSAGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEECSDSEGSHNEEAKEPDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPSRGDEMVADVQQPLSQIPSDTASPLLILPPPVPNPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETLDDY", 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"url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "pmid": "" }, { "name": "insulin-like growth factor receptor signaling pathway", "id": "GO:0048009", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048009", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "pmid": "" }, { "name": "mRNA destabilization", "id": "GO:0061157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061157", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "pmid": "" }, { "name": "protein metabolic process", "id": "GO:0019538", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019538", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "pmid": "" }, { "name": "mitotic G1 DNA damage checkpoint signaling", "id": "GO:0031571", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031571", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "pmid": "" }, { "name": "negative regulation of type I interferon-mediated signaling pathway", "id": "GO:0060339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060339", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "pmid": "" }, { "name": "post-transcriptional gene silencing", "id": "GO:0016441", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016441", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "pmid": "" }, { "name": "proline-rich region binding", "id": "GO:0070064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070064", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q6Y7W8", "url": "https://www.uniprot.org/uniprot/Q6Y7W8" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": 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