{ "uniprot_canonical_ac": "Q6Y5D8-1", "uniprot_ac": "Q6Y5D8", "uniprot_id": "RHG10_MOUSE", "mass": { "chemical_mass": 89366.0, "monoisotopic_mass": 89366.0 }, "refseq": { "ac": "NP_084389", "name": "rho GTPase-activating protein 10 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084389" }, "gene_names": [ { "name": "Arhgap10", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q6Y5D8", "id": "Q6Y5D8" }, { "name": "A930033B01Rik; PS-GAP; PSGAP; PSGAP-m; PSGAP-s", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084389", "id": "NP_084389" }, { "name": "Arhgap10", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084389", "id": "NP_084389" } ], "protein_names": [ { "name": "Rho GTPase-activating protein 10", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q6Y5D8" }, { "name": "PH and SH3 domain-containing rhoGAP protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6Y5D8" }, { "name": "PS-GAP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6Y5D8" }, { "name": "PSGAP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6Y5D8" }, { "name": "Rho-type GTPase-activating protein 10", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6Y5D8" }, { "name": "rho GTPase-activating protein 10 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084389", "id": "NP_084389" }, { "name": "rho GTPase-activating protein 10; rho-type GTPase-activating protein 10; PH and SH3 domain-containing rhoGAP protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084389", "id": "NP_084389" } ], "function": [ { "annotation": "ARHGAP10 may serve as a tumor suppressor through inactivating Cdc42, as well as inhibiting cell cycle, replication and BER pathways. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_084389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084389" }, { "database": "PubMed", "id": "27010858", "url": "https://glygen.org/publication/PubMed/27010858" } ] }, { "annotation": "GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death.", "evidence": [ { "database": "UniProtKB", "id": "Q6Y5D8", "url": "https://www.uniprot.org/uniprot/Q6Y5D8#function" }, { "database": "PubMed", "id": "11238453", "url": "https://glygen.org/publication/PubMed/11238453" }, { "database": "PubMed", "id": "15471851", "url": "https://glygen.org/publication/PubMed/15471851" } ] }, { "annotation": "Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_084389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084389" }, { "database": "PubMed", "id": "33482876", "url": "https://glygen.org/publication/PubMed/33482876" } ] } ], "disease": [ { "disease_id": "DOID:0080311", "recommended_name": { "id": "DOID:0080311", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080311", "name": "X-linked mental retardation with cerebellar hypoplasia and distinctive facial appearance", "description": "A syndromic X-linked intellectual disability characterized by neonatal hypotonia with motor delay but no obvious ataxia, marked strabismus, early-onset complex partial seizures, and moderate to severe mental retardation and has_material_basis_in mutation in the oligophrenin-1 gene." }, "synonyms": [ { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "X-linked intellectual disability-cerebellar hypoplasia syndrome", "description": "X-linked intellectual deficit-cerebellar hypoplasia, also known as OPHN1 syndrome, is a rare syndromic form of cerebellar dysgenesis characterized by moderate to severe intellectual deficit and cerebellar abnormalities." }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "OPHN1 syndrome", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "Oligophrenin-1 syndrome", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "X-linked intellectual disability-cerebellar hypoplasia syndrome", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "intellectual developmental disorder, X-linked syndromic, Billuart type, X-linked recessive", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "MRX60 (formerly)", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "OPHN1 XLMR", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "OPHN1 XLMR, X-linked intellectual disability", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "OPHN1 deficiency", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "OPHN1- related XLID", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "X-linked intellectual Deficit with cerebellar Hypoplasia", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "intellectual disability X-linked 60 (formerly)", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "intellectual disability X-linked with cerebellar hypoplasia and distinctive facial appearance", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "intellectual disability, X-linked 60", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "intellectual disability, X-linked 60, formerly", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "intellectual disability, X-linked, with cerebellar hypoplasia and distinctive facial appearance", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "mental retardation X-linked 60 (formerly)", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "mental retardation X-linked with cerebellar hypoplasia and distinctive facial appearance", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "mental retardation, X-linked 60", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "mental retardation, X-linked 60, formerly", "description": "" }, { "id": "MONDO:0010337", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010337", "name": "mental retardation, X-linked, with cerebellar hypoplasia and distinctive facial appearance", "description": "" }, { "id": "MIM:300486", "resource": "MIM", "url": "https://www.omim.org/entry/300486", "name": "Intellectual developmental disorder, X-linked, syndromic, Billuart type", "description": "Intellectual developmental disorder, X-linked, syndromic, Billuart type" } ], "evidence": [ { "id": "0080311", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080311" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 418, "end_pos": 418, "sequence_org": "R", "sequence_mut": "Q", "comment": "Inactive. Abolishes GTPase activity in vitro. Greatly diminishes cytoskeletal reorganization.", "evidence": [ { "database": "UniProtKB", "id": "Q6Y5D8", "url": "https://www.uniprot.org/uniprot/Q6Y5D8" }, { "database": "PubMed", "id": "11238453", "url": "https://glygen.org/publication/PubMed/11238453" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q6Y5D8", "url": "https://www.uniprot.org/uniprot/Q6Y5D8" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Arhgap10", "url": "https://www.uniprot.org/uniprot/Q6Y5D8", "locus": { "chromosome": "8", "start_pos": 77976995, "end_pos": 78244582, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000037148", "url": "https://www.ensembl.org/id/ENSMUSG00000037148" } ] } } ], "crossref": [ { "id": "ENSMUSG00000037148", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037148", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd01249", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01249", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd04374", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04374", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12065", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12065", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "78514", "url": "https://www.ncbi.nlm.nih.gov/gene/78514", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q6Y5D8", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q6Y5D8*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000198", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000198", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001849", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004148", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004148", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027267", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035485", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035485", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036028", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047225", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047225", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047234", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047234", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:78514", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:78514", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1925764", "url": "http://www.informatics.jax.org/marker/MGI:1925764", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "MRSPMVQ", "url": "https://omabrowser.org/oma/group/MRSPMVQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5395569at2759", "url": "http://www.orthodb.org/?query=5395569at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12552", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12552", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12552:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12552:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00169", "url": "http://pfam.xfam.org/family/PF00169", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00620", "url": "http://pfam.xfam.org/family/PF00620", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14604", "url": "http://pfam.xfam.org/family/PF14604", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16746", "url": "http://pfam.xfam.org/family/PF16746", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q6Y5D8", "url": "http://purl.obolibrary.org/obo/PR_Q6Y5D8", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-8980692", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8980692", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-9013148", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013148", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-9013149", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013149", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_084389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084389", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q6Y5D8", "url": "https://www.uniprot.org/uniprot/Q6Y5D8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6Y5D8-1", "url": "https://www.uniprot.org/uniprot/Q6Y5D8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6Y5D8-2", "url": "https://www.uniprot.org/uniprot/Q6Y5D8-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6Y5D8-3", "url": "https://www.uniprot.org/uniprot/Q6Y5D8-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6Y5D8-4", "url": "https://www.uniprot.org/uniprot/Q6Y5D8-4", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLISATKSLSAAQRKFAHSLRDFKFEFIGDAETDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLTLSARKKDSHLQEADLQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELSKDFNHYKMELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDQKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKTAKKFNMIPFEHRSGGKLGDGEAFFLKECTKRHMDSTDRRFCFDIEAADRPGVPLTVQAFSEEERKQWLEALGGKEALFHTFNRAIVPRPEGGAQLDKMGFTILRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKMCNELDLENSADWEVKTVTSALKQYLRSLPEPLMTYELHRDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSSHSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILIENHEKIFRTSPDTTFAEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEEGDSPSPLKEDPPSSSQDSLSTPSPTTSAAHGPPGLDGNHLAADGGSCGDATATTPSQTRPSMVQWLNMQSPTTPSSNPAGTPPSPRMSPFPLSPAASIVDKLPECVINRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL", "length": 786, "header": "sp|Q6Y5D8-1|RHG10_MOUSE Isoform 1 of Rho GTPase-activating protein 10 OS=Mus musculus OX=10090 GN=Arhgap10 PE=1 SV=2 CANONICAL=Q6Y5D8-1" }, "isoforms": [ { "isoform_ac": "Q6Y5D8-1", "url": "", "sequence": { "sequence": "MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLISATKSLSAAQRKFAHSLRDFKFEFIGDAETDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLTLSARKKDSHLQEADLQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELSKDFNHYKMELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDQKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKTAKKFNMIPFEHRSGGKLGDGEAFFLKECTKRHMDSTDRRFCFDIEAADRPGVPLTVQAFSEEERKQWLEALGGKEALFHTFNRAIVPRPEGGAQLDKMGFTILRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKMCNELDLENSADWEVKTVTSALKQYLRSLPEPLMTYELHRDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSSHSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILIENHEKIFRTSPDTTFAEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEEGDSPSPLKEDPPSSSQDSLSTPSPTTSAAHGPPGLDGNHLAADGGSCGDATATTPSQTRPSMVQWLNMQSPTTPSSNPAGTPPSPRMSPFPLSPAASIVDKLPECVINRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL", "length": 786, "header": "sp|Q6Y5D8-1|RHG10_MOUSE Isoform 1 of Rho GTPase-activating protein 10 OS=Mus musculus OX=10090 GN=Arhgap10 PE=1 SV=2 CANONICAL=Q6Y5D8-1" }, "locus": { "chromosome": "8", "start_pos": 78244412, "end_pos": 77977551, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000076316", "url": "https://www.ensembl.org/id/ENSMUST00000076316" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000075658", "url": "https://www.ensembl.org/id/ENSMUSP00000075658" } ] } }, { "isoform_ac": "Q6Y5D8-2", "url": "", "sequence": { "sequence": "MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLISATKSLSAAQRKFAHSLRDFKFEFIGDAETDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLTLSARKKDSHLQEADLQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELSKDFNHYKMELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDQKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKTAKKFNMIPFEHRSGGKLGDGEAFFLKECTKRHMDSTDRRFCFDIEAADRPGVPLTVQAFSEEERKQWLEALGGKEALFHTFNRAIVPRPEGGINDQGLYRVVGVSSKVQRLLSMLMDVKMCNELDLENSADWEVKTVTSALKQYLRSLPEPLMTYELHRDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSSHSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILIENHEKIFRTSPDTTFAEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEEGDSPSPLKEDPPSSSQDSLSTPSPTTSAAHGPPGLDGNHLAADGGSCGDATATTPSQTRPSMVQWLNMQSPTTPSSNPAGTPPSPRMSPFPLSPAASIVDKLPECVINRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL", "length": 764, "header": "sp|Q6Y5D8-2|RHG10_MOUSE Isoform 2 of Rho GTPase-activating protein 10 OS=Mus musculus OX=10090 GN=Arhgap10 PE=1 SV=2 CANONICAL=Q6Y5D8-1" }, "locus": { "chromosome": "8", "start_pos": 78244412, "end_pos": 77977551, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000210519", "url": "https://www.ensembl.org/id/ENSMUST00000210519" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000147493", "url": "https://www.ensembl.org/id/ENSMUSP00000147493" } ] } }, { "isoform_ac": "Q6Y5D8-3", "url": "", "sequence": { "sequence": "MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLISATKSLSAAQRKFAHSLRDFKFEFIGDAETDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLTLSARKKDSHLQEADLQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELSKDFNHYKMELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDQKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKTAKKFNMIPFEHRSGGKLGDGEAFFLKECTKRHMDSTDRRFCFDIEAADRPGVPLTVQAFSEEERKQWLEALGGKEALFHTFNRAIVPRPEGGAQLDKMGFTILRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKMCNELDLENSADWEVKTVTSALKQYLRSLPEPLMTYELHRDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSSHSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILIENHEKIFRTSPDTTFAEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEEGDSPSPLKEDPPSSSQDSLSTPSPTTSAAHGPPGLDGNHLAADGGSCGDATATTVINRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL", "length": 735, "header": "sp|Q6Y5D8-3|RHG10_MOUSE Isoform 3 of Rho GTPase-activating protein 10 OS=Mus musculus OX=10090 GN=Arhgap10 PE=1 SV=2 CANONICAL=Q6Y5D8-1" }, "locus": { "chromosome": "8", "start_pos": 78244412, "end_pos": 77977551, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000210922", "url": "https://www.ensembl.org/id/ENSMUST00000210922" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000147485", "url": "https://www.ensembl.org/id/ENSMUSP00000147485" } ] } }, { "isoform_ac": "Q6Y5D8-4", "url": "", "sequence": { "sequence": "MALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLTLSARKKDSHLQEADLQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELSKDFNHYKMELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDQKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKTAKKFNMIPFEHRSGGKLGDGEAFFLKECTKRHMDSTDRRFCFDIEAADRPGVPLTVQAFSEEERKQWLEALGGKEALFHTFNRAIVPRPEGGAQLDKMGFTILRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKMCNELDLENSADWEVKTVTSALKQYLRSLPEPLMTYELHRDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSSHSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILIENHEKIFRTSPDTTFAEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEEGDSPSPLKEDPPSSSQDSLSTPSPTTSAAHGPPGLDGNHLAADGGSCGDATATTPSQTRPSMVQWLNMQSPTTPSSNPAGTPPSPRMSPFPLSPAASIVDKLPECVINRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL", "length": 683, "header": "sp|Q6Y5D8-4|RHG10_MOUSE Isoform 4 of Rho GTPase-activating protein 10 OS=Mus musculus OX=10090 GN=Arhgap10 PE=1 SV=2 CANONICAL=Q6Y5D8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 109, "end_pos": 109, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "Q6Y5D8", "url": "http://phospho.elm.eu.org/byAccession/Q6Y5D8.html" }, { "database": "iPTMnet", "id": "Q6Y5D8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6Y5D8" }, { "database": "PubMed", "id": "17203969", "url": "https://glygen.org/publication/PubMed/17203969" } ], "site_lbl": "Thr109" }, { "start_pos": 111, "end_pos": 111, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "Q6Y5D8", "url": "http://phospho.elm.eu.org/byAccession/Q6Y5D8.html" }, { "database": "iPTMnet", "id": "Q6Y5D8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6Y5D8" }, { "database": "PubMed", "id": "17203969", "url": "https://glygen.org/publication/PubMed/17203969" } ], "site_lbl": "Thr111" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein.", "journal": "J. Cell Biol.", "date": "2001", "authors": "Ren XR, Du QS, Huang YZ, Ao SZ, Mei L, Xiong WC", "evidence": [ { "database": "UniProtKB", "id": "Q6Y5D8", "url": "https://www.uniprot.org/uniprot/Q6Y5D8" } ], "reference": [ { "type": "PubMed", "id": "11238453", "url": "https://glygen.org/publication/PubMed/11238453" } ] }, { "title": "Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2.", "journal": "J. Biol. Chem.", "date": "2004", "authors": "Koeppel MA, McCarthy CC, Moertl E, Jakobi R", "evidence": [ { "database": "UniProtKB", "id": "Q6Y5D8", "url": "https://www.uniprot.org/uniprot/Q6Y5D8" } ], "reference": [ { "type": "PubMed", "id": "15471851", "url": "https://glygen.org/publication/PubMed/15471851" } ] }, { "title": "Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.", "journal": "Journal of proteome research", "date": "2007", "authors": "Dai J, Jin WH, Sheng QH, Shieh CH, Wu JR, Zeng R", "evidence": [ { "database": "iPTMnet", "id": "Q6Y5D8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6Y5D8" } ], "reference": [ { "type": "PubMed", "id": "17203969", "url": "https://glygen.org/publication/PubMed/17203969" } ] }, { "title": "ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells.", "journal": "Cell death & disease", "date": "2016", "authors": "Luo N, Guo J, Chen L, Yang W, Qu X, Cheng Z", "evidence": [ { "database": "RefSeq", "id": "NP_084389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084389" } ], "reference": [ { "type": "PubMed", "id": "27010858", "url": "https://glygen.org/publication/PubMed/27010858" } ] }, { "title": "Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons.", "journal": "Molecular brain", "date": "2021", "authors": "Hada K, Wulaer B, Nagai T, Itoh N, Sawahata M, Sobue A, Mizoguchi H, Mori D, Kushima I, Nabeshima T, Ozaki N, Yamada K", "evidence": [ { "database": "RefSeq", "id": "NP_084389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084389" } ], "reference": [ { "type": "PubMed", "id": "33482876", "url": "https://glygen.org/publication/PubMed/33482876" } ] } ], "pathway": [ { "id": "mmu:78514", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:78514", "resource": "KEGG Pathway" }, { "id": "R-MMU-8980692", "name": "RHOA GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8980692", "resource": "Reactome", "description": "RHOA GTPase cycle" }, { "id": "R-MMU-9013148", "name": "CDC42 GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013148", "resource": "Reactome", "description": "CDC42 GTPase cycle" }, { "id": "R-MMU-9013149", "name": "RAC1 GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9013149", "resource": "Reactome", "description": "RAC1 GTPase cycle" } ], "orthologs": [ { "uniprot_canonical_ac": "A1A4S6-1", "protein_name": "Rho GTPase-activating protein 10", "gene_name": "ARHGAP10", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKFAHSLRDFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKFNMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPPDTTFPEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTPTSSLDSLSSPSPVTTAVPGPPGPDKNHLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATVADKPPESIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL", "length": 786 }, "evidence": [ { "id": "45234020", "url": "http://www.informatics.jax.org/homology/45234020", "database": "MGI" }, { "id": "Q6Y5D8", "url": "https://omabrowser.org/oma/group/Q6Y5D8/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "D4AB50-1", "protein_name": "Rho GTPase activating protein 10", "gene_name": "Arhgap10", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSAAQRKFAHSLRDFKFEFIGDAETDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAEEKKKFDKETERNYSLIDKHLTLSARKKDTHLQEADLQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELSKDFNHYKTELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDQKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKTAKKFNMIPFEHRSGGKLGDGEAFFLKECTKRHIDSTDRRFCFDIEAADRPGVPLTVQAFSEEERKQWLEALGGKEALFHTFNRAIVPRPEGGAQLDKMGFTILRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNELDLENSTDWEVKTVTSALKQYLRSLPEPLMTYELHRDFIVPAKSGSPESRVSAIHFLVHKLPEKNKEMLDILVKHLTNVSSHSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQNIVVEILIENHEKIFRTSPDTTFAEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEEGDSPSPLKEDPPSSSQDSLSTPSPTTSAAHGPPGPDGNHLAADRGNCGDATATTPSQTRPSMVQWLNMQSPTTPSSNPAGTPPSPRMSPFPLSPAASIVDKLPECLINRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL", "length": 784 }, "evidence": [ { "id": "45234020", "url": "http://www.informatics.jax.org/homology/45234020", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "GTPase activator activity", "id": "GO:0005096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "evidence": [ { "database": "UniProtKB", "id": "Q6Y5D8", "url": "https://www.uniprot.org/uniprot/Q6Y5D8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q6Y5D8", "url": "https://www.uniprot.org/uniprot/Q6Y5D8" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q6Y5D8", "url": "https://www.uniprot.org/uniprot/Q6Y5D8" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q6Y5D8", "url": "https://www.uniprot.org/uniprot/Q6Y5D8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q6Y5D8", "url": "https://www.uniprot.org/uniprot/Q6Y5D8" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "Q6Y5D8", "url": "https://www.uniprot.org/uniprot/Q6Y5D8" } ], "pmid": "" }, { "name": "cytoskeleton organization", "id": "GO:0007010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007010", "evidence": [ { "database": "UniProtKB", "id": "Q6Y5D8", "url": "https://www.uniprot.org/uniprot/Q6Y5D8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 141, "end_pos": 143, "annotation": "n_glycosylation_sequon" }, { "start_pos": 519, "end_pos": 521, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }