{ "uniprot_canonical_ac": "Q6UWP2-1", "uniprot_ac": "Q6UWP2", "uniprot_id": "DHR11_HUMAN", "mass": { "chemical_mass": 28308.0, "monoisotopic_mass": 28308.0 }, "refseq": { "ac": "NP_077284", "name": "dehydrogenase/reductase SDR family member 11 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077284" }, "gene_names": [ { "name": "DHRS11", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q6UWP2", "id": "Q6UWP2" }, { "name": "ARPG836; SDR24C1; spDHRS11", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077284", "id": "NP_077284" }, { "name": "DHRS11", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077284", "id": "NP_077284" }, { "name": "PRO1774", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q6UWP2", "id": "Q6UWP2" }, { "name": "SDR24C1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q6UWP2", "id": "Q6UWP2" } ], "protein_names": [ { "name": "Dehydrogenase/reductase SDR family member 11", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q6UWP2" }, { "name": "1.1.1.270", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6UWP2" }, { "name": "1.1.1.62", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6UWP2" }, { "name": "17-beta-hydroxysteroid dehydrogenase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6UWP2" }, { "name": "3-beta-hydroxysteroid 3-dehydrogenase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6UWP2" }, { "name": "Estradiol 17-beta-dehydrogenase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6UWP2" }, { "name": "Short-chain dehydrogenase/reductase family 24C member 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6UWP2" }, { "name": "dehydrogenase/reductase SDR family member 11 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077284", "id": "NP_077284" }, { "name": "short-chain dehydrogenase/reductase family 24C member 1; dehydrogenase/reductase (SDR family) member 11; estradiol 17-beta-dehydrogenase; 17-beta-hydroxysteroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077284", "id": "NP_077284" } ], "function": [ { "annotation": "Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones.", "evidence": [ { "database": "UniProtKB", "id": "Q6UWP2", "url": "https://www.uniprot.org/uniprot/Q6UWP2#function" }, { "database": "PubMed", "id": "26920053", "url": "https://glygen.org/publication/PubMed/26920053" } ] }, { "annotation": "Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C19-steroids.", "evidence": [ { "database": "RefSeq", "id": "NP_077284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077284" }, { "database": "PubMed", "id": "31926269", "url": "https://glygen.org/publication/PubMed/31926269" } ] }, { "annotation": "The recombinant protein (DHRS11) efficiently catalyzed the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5alpha-androstanes into their 17beta-hydroxyl metabolites with NADPH as a coenzyme.", "evidence": [ { "database": "RefSeq", "id": "NP_077284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077284" }, { "database": "PubMed", "id": "26920053", "url": "https://glygen.org/publication/PubMed/26920053" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "80.49", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000278535", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000278535" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "70.75", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000278535", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000278535" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "73.37", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000278535", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000278535" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000278535", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000278535" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "79.21", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000278535", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000278535" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "97.72", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000278535", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000278535" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "94.77", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000278535", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000278535" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "75.39", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000278535", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000278535" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "83.81", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000278535", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000278535" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "47.6", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000278535", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000278535" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "74.98", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000278535", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000278535" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "82.12", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000278535", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000278535" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "79.63", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000278535", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000278535" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "Q6UWP2", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q6UWP2" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", 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"https://www.uniprot.org/uniprot/Q6UWP2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6UWP2-2", "url": "https://www.uniprot.org/uniprot/Q6UWP2-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6UWP2-3", "url": "https://www.uniprot.org/uniprot/Q6UWP2-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVLSTPAHIQIGDIQMRPTEQVT", "length": 260, "header": "sp|Q6UWP2-1|DHR11_HUMAN Isoform 1 of Dehydrogenase/reductase SDR family member 11 OS=Homo sapiens OX=9606 GN=DHRS11 PE=1 SV=1 CANONICAL=Q6UWP2-1" }, "isoforms": [ { "isoform_ac": "A0A087WYV4-1", "url": "", "sequence": { "sequence": "MARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEM", "length": 50, "header": "tr|A0A087WYV4-1|A0A087WYV4_HUMAN Computationally mapped isoform of Dehydrogenase/reductase SDR family member 11 OS=Homo sapiens OX=9606 GN=DHRS11 PE=1 SV=1 CANONICAL=Q6UWP2-1" }, "locus": { "chromosome": "17", "start_pos": 36595029, "end_pos": 36592010, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000612538.1", "url": "https://www.ensembl.org/id/ENST00000612538.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000482124.1", "url": "https://www.ensembl.org/id/ENSP00000482124.1" } ] } }, { "isoform_ac": "A0A087WZN3-1", "url": "", "sequence": { "sequence": "MFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKP", "length": 150, "header": "tr|A0A087WZN3-1|A0A087WZN3_HUMAN Computationally mapped isoform of Dehydrogenase/reductase SDR family member 11 OS=Homo sapiens OX=9606 GN=DHRS11 PE=1 SV=1 CANONICAL=Q6UWP2-1" }, "locus": { "chromosome": "CHR_HSCHR17_7_CTG4", "start_pos": 36600945, "end_pos": 36596024, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000632185.1", "url": "https://www.ensembl.org/id/ENST00000632185.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000488451.1", "url": "https://www.ensembl.org/id/ENSP00000488451.1" } ] } }, { "isoform_ac": "A0A087X0R1-1", "url": "", "sequence": { "sequence": "NVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHIRATCLKPEDVAEAVIYVLSTPAHIQIGDIQMRPTEQVT", "length": 109, "header": "tr|A0A087X0R1-1|A0A087X0R1_HUMAN Computationally mapped isoform of Dehydrogenase/reductase SDR family member 11 OS=Homo sapiens OX=9606 GN=DHRS11 PE=1 SV=1 CANONICAL=Q6UWP2-1" }, "locus": { "chromosome": "17", "start_pos": 36600200, "end_pos": 36598166, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000621871.1", "url": "https://www.ensembl.org/id/ENST00000621871.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000483596.1", "url": "https://www.ensembl.org/id/ENSP00000483596.1" } ] } }, { "isoform_ac": "Q6UWP2-1", "url": "", "sequence": { "sequence": "MARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVLSTPAHIQIGDIQMRPTEQVT", "length": 260, "header": "sp|Q6UWP2-1|DHR11_HUMAN Isoform 1 of Dehydrogenase/reductase SDR family member 11 OS=Homo sapiens OX=9606 GN=DHRS11 PE=1 SV=1 CANONICAL=Q6UWP2-1" }, "locus": { "chromosome": "17", "start_pos": 36600200, "end_pos": 36592010, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000618403.5", "url": "https://www.ensembl.org/id/ENST00000618403.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000482704.1", "url": "https://www.ensembl.org/id/ENSP00000482704.1" } ] } }, { "isoform_ac": "Q6UWP2-2", "url": "", "sequence": { "sequence": "MFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVLSTPAHIQIGDIQMRPTEQVT", "length": 181, "header": "sp|Q6UWP2-2|DHR11_HUMAN Isoform 2 of Dehydrogenase/reductase SDR family member 11 OS=Homo sapiens OX=9606 GN=DHRS11 PE=1 SV=1 CANONICAL=Q6UWP2-1" }, "locus": { "chromosome": "17", "start_pos": 36600200, "end_pos": 36595061, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000611337.4", "url": "https://www.ensembl.org/id/ENST00000611337.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000477603.1", "url": "https://www.ensembl.org/id/ENSP00000477603.1" } ] } }, { "isoform_ac": "Q6UWP2-3", "url": "", "sequence": { "sequence": "MARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHIRATCLKPEDVAEAVIYVLSTPAHIQIGDIQMRPTEQVT", "length": 229, "header": "sp|Q6UWP2-3|DHR11_HUMAN Isoform 3 of Dehydrogenase/reductase SDR family member 11 OS=Homo sapiens OX=9606 GN=DHRS11 PE=1 SV=1 CANONICAL=Q6UWP2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.", "journal": "Genome Res.", "date": "2003", "authors": "Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A", "evidence": [ { "database": "UniProtKB", "id": "Q6UWP2", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ], "reference": [ { "type": "PubMed", "id": "12975309", "url": "https://glygen.org/publication/PubMed/12975309" } ] }, { "title": "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.", "journal": "Chem. Biol. Interact.", "date": "2009", "authors": "Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U", "evidence": [ { "database": "UniProtKB", "id": "Q6UWP2", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ], "reference": [ { "type": "PubMed", "id": "19027726", "url": "https://glygen.org/publication/PubMed/19027726" } ] }, { "title": "Human dehydrogenase/reductase (SDR family) member 11 is a novel type of 17beta-hydroxysteroid dehydrogenase.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2016", "authors": "Endo S, Miyagi N, Matsunaga T, Hara A, Ikari A", "evidence": [ { "database": "UniProtKB", "id": "Q6UWP2", "url": "https://www.uniprot.org/uniprot/Q6UWP2" }, { "database": "RefSeq", "id": "NP_077284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077284" } ], "reference": [ { "type": "PubMed", "id": "26920053", "url": "https://glygen.org/publication/PubMed/26920053" } ] }, { "title": "Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C19-steroids.", "journal": "The Journal of steroid biochemistry and molecular biology", "date": "2020", "authors": "Endo S, Morikawa Y, Kudo Y, Suenami K, Matsunaga T, Ikari A, Hara A", "evidence": [ { "database": "RefSeq", "id": "NP_077284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077284" } ], "reference": [ { "type": "PubMed", "id": "31926269", "url": "https://glygen.org/publication/PubMed/31926269" } ] } ], "pathway": [ { "id": "hsa:79154", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:79154", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q3U0B3-1", "protein_name": "Dehydrogenase/reductase SDR family member 11", "gene_name": "Dhrs11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTRAGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLSNEEDILSMFSAVRSQHSGVDICINNAGMARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNIDDGHIININSMCGHRVPPQSVIHFYSATKYAVTALTEGLRQELLEAQTHIRATCISPGLVETQFAFKLHDKDPGEAAATYEHIKCLRPEDVAEAVIYVLSTPPHVQVGDIQMRPTEQVT", "length": 260 }, "evidence": [ { "id": "45232749", "url": "http://www.informatics.jax.org/homology/45232749", "database": "MGI" }, { "id": "Q6UWP2", "url": "https://omabrowser.org/oma/group/Q6UWP2/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "Q6UWP2", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ], "pmid": "" }, { "name": "17-beta-ketosteroid reductase activity", "id": "GO:0072555", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072555", "evidence": [ { "database": "UniProtKB", "id": "Q6UWP2", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ], "pmid": "" }, { "name": "17-beta-hydroxysteroid dehydrogenase (NADP+) activity", "id": "GO:0072582", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072582", "evidence": [ { "database": "UniProtKB", "id": "Q6UWP2", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ], "pmid": "" }, { "name": "nucleotide binding", "id": "GO:0000166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000166", "evidence": [ { "database": "UniProtKB", "id": "Q6UWP2", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ], "pmid": "" }, { "name": "estradiol 17-beta-dehydrogenase [NAD(P)] activity", "id": "GO:0004303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004303", "evidence": [ { "database": "UniProtKB", "id": "Q6UWP2", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ], "pmid": "" }, { "name": "3-keto sterol reductase activity", "id": "GO:0000253", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000253", "evidence": [ { "database": "UniProtKB", "id": "Q6UWP2", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ], "pmid": "" }, { "name": "cycloeucalenone reductase activity", "id": "GO:0102176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102176", "evidence": [ { "database": "UniProtKB", "id": "Q6UWP2", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q6UWP2", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "steroid biosynthetic process", "id": "GO:0006694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006694", "evidence": [ { "database": "UniProtKB", "id": "Q6UWP2", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ], "pmid": "" }, { "name": "estrogen biosynthetic process", "id": "GO:0006703", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006703", "evidence": [ { "database": "UniProtKB", "id": "Q6UWP2", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "24612", "name": "", "equation": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q5M875-1", "Q62730-1", "Q6MGB5-1", "Q6P7R8-1", "Q6AYS8-1", "O54753-1", "P51657-1", "O70351-1", "Q8NBQ5-1", "Q6UWP2-1", "P14061-1", "Q53GQ0-1", "Q92506-1", "P37059-1", "O14756-1", "P52895-1", "P17516-1", "Q04828-1", "P42330-1", "Q7Z5P4-1", "Q5T2L2-1", "Q9BPX1-1", "Q99714-1", "P50171-1", "P51656-1", "P51658-1", "O70503-1", "Q3U0B3-1", "Q9EQ06-1", "Q9R092-1", "O08756-1", "Q8VCR2-1", "O18404-1" ], "evidence": [ { "id": "24612", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24612" } ] }, { "id": "24616", "name": "", "equation": "17beta-estradiol + NADP(+) = estrone + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6P7R8-1", "Q62904-1", "Q6AYS8-1", "O54753-1", "P51657-1", "O54939-1", "C9JRZ8-1", "Q8NBQ5-1", "Q6UWP2-1", "P14061-1", "Q53GQ0-1", "P56937-1", "O14756-1", "P52895-1", "P17516-1", "Q04828-1", "P42330-1", "Q5T2L2-1", "P37058-1", "P51656-1", "O70503-1", "O88736-1", "Q3U0B3-1", "Q9EQ06-1", "Q9R092-1", "P70385-1" ], "evidence": [ { "id": "24616", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/24616" } ] }, { "id": "34787", "name": "", "equation": "a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P22071-1", "P27364-1", "Q62904-1", "P14060-1", "Q6UWP2-1", "P56937-1", "P24815-1", "Q61694-1", "Q61767-1", "O88736-1", "Q3U0B3-1" ], "evidence": [ { "id": "34787", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/34787" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "C9JRZ8", "gene_name": "AKR1B15", "activity": [ { "ec_number": "1.1.1.300", "activity": "all-trans-retinol + NADP(+) = all-trans-retinal + H(+) + NADPH.", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.54", "activity": "allyl alcohol + NADP(+) = acrolein + H(+) + NADPH.", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.216", "activity": "(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + H(+) + NADPH.", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.300", "activity": "", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] }, { "ec_number": "1.1.1.54", "activity": "", "evidence": [ { "id": "C9JRZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C9JRZ8" } ] } ] }, { "uniprot_ac": "O08756", "gene_name": "Hsd17b10", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.178", "activity": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.159", "activity": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH.", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "O08756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08756" } ] } ] }, { "uniprot_ac": "O14756", "gene_name": "HSD17B6", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.239", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O14756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14756" } ] } ] }, { "uniprot_ac": "O18404", "gene_name": "scu", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.201", "activity": "a 7beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.36", "activity": "a (3R)-3-hydroxyacyl-CoA + NADP(+) = a 3-oxoacyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "O18404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18404" } ] } ] }, { "uniprot_ac": "O54753", "gene_name": "Hsd17b6", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.105", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] }, { "ec_number": "1.1.1.239", "activity": "", "evidence": [ { "id": "O54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54753" } ] } ] }, { "uniprot_ac": "O54939", "gene_name": "Hsd17b3", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O54939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54939" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "O54939", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54939" } ] } ] }, { "uniprot_ac": "O70351", "gene_name": "Hsd17b10", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.178", "activity": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.159", "activity": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH.", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "O70351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70351" } ] } ] }, { "uniprot_ac": "O70503", "gene_name": "Hsd17b12", "activity": [ { "ec_number": "1.1.1.330", "activity": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "O70503", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70503" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O70503", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70503" } ] }, { "ec_number": "1.1.1.330", "activity": "", "evidence": [ { "id": "O70503", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70503" } ] } ] }, { "uniprot_ac": "O88736", "gene_name": "Hsd17b7", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "O88736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88736" } ] }, { "ec_number": "1.1.1.270", "activity": "", "evidence": [ { "id": "O88736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88736" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "O88736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88736" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "O88736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88736" } ] } ] }, { "uniprot_ac": "P14060", "gene_name": "HSD3B1", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "P14060", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14060" } ] }, { "ec_number": "1.1.1.145", "activity": "3beta-hydroxyandrost-5-en-17-one + NAD(+) = androst-5-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P14060", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14060" } ] }, { "ec_number": "5.3.3.1", "activity": "a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid.", "evidence": [ { "id": "P14060", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14060" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P14060", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14060" } ] } ] }, { "uniprot_ac": "P14061", "gene_name": "HSD17B1", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P14061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14061" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P14061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14061" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P14061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14061" } ] }, { "ec_number": "1.1.1.51", "activity": "", "evidence": [ { "id": "P14061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14061" } ] } ] }, { "uniprot_ac": "P17516", "gene_name": "AKR1C4", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.225", "activity": "chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.357", "activity": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.51", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] }, { "ec_number": "1.1.1.210", "activity": "", "evidence": [ { "id": "P17516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17516" } ] } ] }, { "uniprot_ac": "P22071", "gene_name": "Hsd3b1", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "P22071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22071" } ] }, { "ec_number": "1.1.1.145", "activity": "3beta-hydroxyandrost-5-en-17-one + NAD(+) = androst-5-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P22071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22071" } ] }, { "ec_number": "5.3.3.1", "activity": "a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid.", "evidence": [ { "id": "P22071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22071" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P22071", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22071" } ] } ] }, { "uniprot_ac": "P24815", "gene_name": "Hsd3b1", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "P24815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24815" } ] }, { "ec_number": "1.1.1.145", "activity": "3beta-hydroxyandrost-5-en-17-one + NAD(+) = androst-5-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P24815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24815" } ] }, { "ec_number": "5.3.3.1", "activity": "a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid.", "evidence": [ { "id": "P24815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24815" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P24815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24815" } ] } ] }, { "uniprot_ac": "P27364", "gene_name": "Hsd3b5", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "P27364", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27364" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P27364", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27364" } ] } ] }, { "uniprot_ac": "P37058", "gene_name": "HSD17B3", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P37058", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37058" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P37058", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37058" } ] } ] }, { "uniprot_ac": "P37059", "gene_name": "HSD17B2", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P37059", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37059" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P37059", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P37059" } ] } ] }, { "uniprot_ac": "P42330", "gene_name": "AKR1C3", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.357", "activity": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.188", "activity": "NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin D2.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.210", "activity": "", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P42330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42330" } ] } ] }, { "uniprot_ac": "P50171", "gene_name": "Hsd17b8", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P50171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50171" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P50171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50171" } ] }, { "ec_number": "1.1.1.n12", "activity": "a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "P50171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50171" } ] }, { "ec_number": "1.1.1.n12", "activity": "", "evidence": [ { "id": "P50171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50171" } ] } ] }, { "uniprot_ac": "P51656", "gene_name": "Hsd17b1", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P51656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51656" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P51656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51656" } ] }, { "ec_number": "1.1.1.51", "activity": "", "evidence": [ { "id": "P51656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51656" } ] } ] }, { "uniprot_ac": "P51657", "gene_name": "Hsd17b1", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P51657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51657" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P51657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51657" } ] } ] }, { "uniprot_ac": "P51658", "gene_name": "Hsd17b2", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P51658", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51658" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "P51658", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51658" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P51658", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51658" } ] } ] }, { "uniprot_ac": "P52895", "gene_name": "AKR1C2", "activity": [ { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.357", "activity": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.112", "activity": "(S)-indan-1-ol + NAD(+) = H(+) + indan-1-one + NADH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.3.1.20", "activity": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.3.1.20", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] }, { "ec_number": "1.1.1.112", "activity": "", "evidence": [ { "id": "P52895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52895" } ] } ] }, { "uniprot_ac": "P56937", "gene_name": "HSD17B7", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "P56937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56937" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P56937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56937" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "P56937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56937" } ] } ] }, { "uniprot_ac": "P70385", "gene_name": "Hsd17b3", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "P70385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70385" } ] }, { "ec_number": "1.1.1.64", "activity": "NADP(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "P70385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70385" } ] } ] }, { "uniprot_ac": "Q04828", "gene_name": "AKR1C1", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.357", "activity": "a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + H(+) + NADPH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.112", "activity": "(S)-indan-1-ol + NAD(+) = H(+) + indan-1-one + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.149", "activity": "(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + H(+) + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.3.1.20", "activity": "(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + H(+) + NADPH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.51", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.210", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.112", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.357", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.51", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.3.1.20", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.53", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "Q04828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04828" } ] } ] }, { "uniprot_ac": "Q3U0B3", "gene_name": "Dhrs11", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q3U0B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U0B3" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q3U0B3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U0B3" } ] } ] }, { "uniprot_ac": "Q53GQ0", "gene_name": "HSD17B12", "activity": [ { "ec_number": "1.1.1.330", "activity": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "Q53GQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53GQ0" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q53GQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53GQ0" } ] }, { "ec_number": "1.1.1.330", "activity": "", "evidence": [ { "id": "Q53GQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53GQ0" } ] } ] }, { "uniprot_ac": "Q5M875", "gene_name": "Hsd17b13", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q5M875", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5M875" } ] } ] }, { "uniprot_ac": "Q5T2L2", "gene_name": "AKR1C8", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q5T2L2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T2L2" } ] } ] }, { "uniprot_ac": "Q61694", "gene_name": "Hsd3b5", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q61694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61694" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q61694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61694" } ] } ] }, { "uniprot_ac": "Q61767", "gene_name": "Hsd3b4", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q61767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61767" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q61767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61767" } ] } ] }, { "uniprot_ac": "Q62730", "gene_name": "Hsd17b2", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q62730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62730" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q62730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62730" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q62730", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62730" } ] } ] }, { "uniprot_ac": "Q62904", "gene_name": "Hsd17b7", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q62904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62904" } ] }, { "ec_number": "1.1.1.270", "activity": "", "evidence": [ { "id": "Q62904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62904" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q62904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62904" } ] }, { "ec_number": "1.1.1.210", "activity": "5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q62904", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62904" } ] } ] }, { "uniprot_ac": "Q6AYS8", "gene_name": "Hsd17b11", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q6AYS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYS8" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q6AYS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYS8" } ] } ] }, { "uniprot_ac": "Q6MGB5", "gene_name": "Hsd17b8", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q6MGB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MGB5" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q6MGB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MGB5" } ] }, { "ec_number": "1.1.1.n12", "activity": "a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "Q6MGB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MGB5" } ] }, { "ec_number": "1.1.1.n12", "activity": "", "evidence": [ { "id": "Q6MGB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MGB5" } ] } ] }, { "uniprot_ac": "Q6P7R8", "gene_name": "Hsd17b12", "activity": [ { "ec_number": "1.1.1.330", "activity": "a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "Q6P7R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7R8" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q6P7R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7R8" } ] }, { "ec_number": "1.1.1.330", "activity": "", "evidence": [ { "id": "Q6P7R8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7R8" } ] } ] }, { "uniprot_ac": "Q6UWP2", "gene_name": "DHRS11", "activity": [ { "ec_number": "1.1.1.270", "activity": "4alpha-methyl-5alpha-cholest-7-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + H(+) + NADPH.", "evidence": [ { "id": "Q6UWP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q6UWP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6UWP2" } ] } ] }, { "uniprot_ac": "Q7Z5P4", "gene_name": "HSD17B13", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q7Z5P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z5P4" } ] } ] }, { "uniprot_ac": "Q8NBQ5", "gene_name": "HSD17B11", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q8NBQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NBQ5" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q8NBQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NBQ5" } ] } ] }, { "uniprot_ac": "Q8VCR2", "gene_name": "Hsd17b13", "activity": [ { "ec_number": "1.1.1.-", "activity": "", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q8VCR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCR2" } ] } ] }, { "uniprot_ac": "Q92506", "gene_name": "HSD17B8", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q92506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92506" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q92506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92506" } ] }, { "ec_number": "1.1.1.n12", "activity": "a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "Q92506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92506" } ] }, { "ec_number": "1.1.1.n12", "activity": "", "evidence": [ { "id": "Q92506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92506" } ] } ] }, { "uniprot_ac": "Q99714", "gene_name": "HSD17B10", "activity": [ { "ec_number": "1.1.1.35", "activity": "a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH.", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] }, { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] }, { "ec_number": "1.1.1.178", "activity": "(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD(+) = 2-methyl-3-oxobutanoyl-CoA + H(+) + NADH.", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] }, { "ec_number": "1.1.1.159", "activity": "cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH.", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] }, { "ec_number": "1.1.1.35", "activity": "", "evidence": [ { "id": "Q99714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99714" } ] } ] }, { "uniprot_ac": "Q9BPX1", "gene_name": "HSD17B14", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q9BPX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BPX1" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q9BPX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BPX1" } ] } ] }, { "uniprot_ac": "Q9EQ06", "gene_name": "Hsd17b11", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q9EQ06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EQ06" } ] }, { "ec_number": "1.1.1.62", "activity": "", "evidence": [ { "id": "Q9EQ06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EQ06" } ] } ] }, { "uniprot_ac": "Q9R092", "gene_name": "Hsd17b6", "activity": [ { "ec_number": "1.1.1.62", "activity": "17beta-estradiol + NAD(+) = estrone + H(+) + NADH.", "evidence": [ { "id": "Q9R092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R092" } ] }, { "ec_number": "1.1.1.239", "activity": "NAD(+) + testosterone = androst-4-ene-3,17-dione + H(+) + NADH.", "evidence": [ { "id": "Q9R092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R092" } ] }, { "ec_number": "1.1.1.105", "activity": "all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH.", "evidence": [ { "id": "Q9R092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R092" } ] }, { "ec_number": "1.1.1.209", "activity": "androsterone + NADP(+) = 5alpha-androstan-3,17-dione + H(+) + NADPH.", "evidence": [ { "id": "Q9R092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R092" } ] }, { "ec_number": "1.1.1.53", "activity": "5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADH.", "evidence": [ { "id": "Q9R092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R092" } ] }, { "ec_number": "1.1.1.209", "activity": "", "evidence": [ { "id": "Q9R092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9R092" } ] }, { "ec_number": 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