{
    "uniprot_canonical_ac": "Q6PE01-1",
    "uniprot_ac": "Q6PE01",
    "uniprot_id": "SNR40_MOUSE",
    "mass": {
        "chemical_mass": 39276.0,
        "monoisotopic_mass": 39276.0
    },
    "refseq": {
        "ac": "NP_079921",
        "name": "U5 small nuclear ribonucleoprotein 40 kDa protein",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079921"
    },
    "gene_names": [
        {
            "name": "Snrnp40",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q6PE01",
            "id": "Q6PE01"
        },
        {
            "name": "0610009C03Rik; Prp8bp; Wdr57",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079921",
            "id": "NP_079921"
        },
        {
            "name": "Snrnp40",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079921",
            "id": "NP_079921"
        },
        {
            "name": "Wdr57",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q6PE01",
            "id": "Q6PE01"
        }
    ],
    "protein_names": [
        {
            "name": "U5 small nuclear ribonucleoprotein 40 kDa protein",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q6PE01"
        },
        {
            "name": "U5 small nuclear ribonucleoprotein 40 kDa protein",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079921",
            "id": "NP_079921"
        },
        {
            "name": "U5 snRNP 40 kDa protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q6PE01"
        },
        {
            "name": "WD repeat domain 57 (U5 snRNP specific); U5 snRNP-specific protein (Prp8-binding); U5 snRNP 40 kDa protein; WD repeat-containing protein 57; small nuclear ribonucleoprotein 40kDa (U5)",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079921",
            "id": "NP_079921"
        },
        {
            "name": "WD repeat-containing protein 57",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q6PE01"
        }
    ],
    "function": [
        {
            "annotation": "Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6PE01",
                    "url": "https://www.uniprot.org/uniprot/Q6PE01#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q96DI7",
                    "url": "https://www.uniprot.org/uniprot/Q96DI7#function"
                }
            ]
        },
        {
            "annotation": "These studies report a new immunodeficiency disorder in mice caused by a viable hypomorphic mutation of Snrnp40",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_079921",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079921"
                },
                {
                    "database": "PubMed",
                    "id": "31427773",
                    "url": "https://glygen.org/publication/PubMed/31427773"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6PE01",
                    "url": "https://www.uniprot.org/uniprot/Q6PE01"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Snrnp40",
            "url": "https://www.uniprot.org/uniprot/Q6PE01",
            "locus": {
                "chromosome": "4",
                "start_pos": 130283819,
                "end_pos": 130253925,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000074088",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000074088"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000074088",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074088",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00200",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "66585",
            "url": "https://www.ncbi.nlm.nih.gov/gene/66585",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q6PE01",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q6PE01*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR001680",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015943",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR019775",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR020472",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036322",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:66585",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:66585",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1913835",
            "url": "http://www.informatics.jax.org/marker/MGI:1913835",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "WDLRKNA",
            "url": "https://omabrowser.org/oma/group/WDLRKNA/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5476798at2759",
            "url": "http://www.orthodb.org/?query=5476798at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR44006",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44006",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR44006:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44006:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00400",
            "url": "http://pfam.xfam.org/family/PF00400",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q6PE01",
            "url": "http://purl.obolibrary.org/obo/PR_Q6PE01",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-72163",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72163",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-72165",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72165",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_079921",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079921",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q6PE01",
            "url": "https://www.uniprot.org/uniprot/Q6PE01",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q6PE01-1",
            "url": "https://www.uniprot.org/uniprot/Q6PE01-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MIEQQKRKGPELPLVPVKRPRHELLLGAAGAGPGAGPQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAVQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRVLYKLPGHAGSINEVAFHPDEPIILSASSDKRLYMGEIQ",
        "length": 358,
        "header": "sp|Q6PE01-1|SNR40_MOUSE Isoform 1 of U5 small nuclear ribonucleoprotein 40 kDa protein  OS=Mus musculus OX=10090 GN=Snrnp40 PE=1 SV=1 CANONICAL=Q6PE01-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q6PE01-1",
            "url": "",
            "sequence": {
                "sequence": "MIEQQKRKGPELPLVPVKRPRHELLLGAAGAGPGAGPQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAVQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRVLYKLPGHAGSINEVAFHPDEPIILSASSDKRLYMGEIQ",
                "length": 358,
                "header": "sp|Q6PE01-1|SNR40_MOUSE Isoform 1 of U5 small nuclear ribonucleoprotein 40 kDa protein  OS=Mus musculus OX=10090 GN=Snrnp40 PE=1 SV=1 CANONICAL=Q6PE01-1"
            },
            "locus": {
                "chromosome": "4",
                "start_pos": 130283383,
                "end_pos": 130253999,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000105994",
                        "url": "https://www.ensembl.org/id/ENSMUST00000105994"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000101616",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000101616"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.",
            "journal": "Mol. Cell. Proteomics",
            "date": "2014",
            "authors": "Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee KA, Yang V, Aguiar M, Kornhauser J, Jia X, Ren J, Beausoleil SA, Silva JC, Vemulapalli V, Bedford MT, Comb MJ",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6PE01",
                    "url": "https://www.uniprot.org/uniprot/Q6PE01"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24129315",
                    "url": "https://glygen.org/publication/PubMed/24129315"
                }
            ]
        },
        {
            "title": "Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40.",
            "journal": "Nature immunology",
            "date": "2019",
            "authors": "Zhang D, Yue T, Choi JH, Nair-Gill E, Zhong X, Wang KW, Zhan X, Li X, Choi M, Tang M, Quan J, Hildebrand S, Moresco EMY, Beutler B",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_079921",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079921"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31427773",
                    "url": "https://glygen.org/publication/PubMed/31427773"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:66585",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:66585",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-72163",
            "name": "mRNA Splicing - Major Pathway",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72163",
            "resource": "Reactome",
            "description": "mRNA Splicing - Major Pathway"
        },
        {
            "id": "R-MMU-72165",
            "name": "mRNA Splicing - Minor Pathway",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-72165",
            "resource": "Reactome",
            "description": "mRNA Splicing - Minor Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q96DI7-1",
            "protein_name": "U5 small nuclear ribonucleoprotein 40 kDa protein",
            "gene_name": "SNRNP40",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ",
                "length": 357
            },
            "evidence": [
                {
                    "id": "45232721",
                    "url": "http://www.informatics.jax.org/homology/45232721",
                    "database": "MGI"
                },
                {
                    "id": "Q6PE01",
                    "url": "https://omabrowser.org/oma/group/Q6PE01/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 5,
                "go_terms": [
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6PE01",
                                "url": "https://www.uniprot.org/uniprot/Q6PE01"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nuclear speck",
                        "id": "GO:0016607",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6PE01",
                                "url": "https://www.uniprot.org/uniprot/Q6PE01"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "catalytic step 2 spliceosome",
                        "id": "GO:0071013",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071013",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6PE01",
                                "url": "https://www.uniprot.org/uniprot/Q6PE01"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "U2-type catalytic step 2 spliceosome",
                        "id": "GO:0071007",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071007",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6PE01",
                                "url": "https://www.uniprot.org/uniprot/Q6PE01"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "U4/U6 x U5 tri-snRNP complex",
                        "id": "GO:0046540",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046540",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6PE01",
                                "url": "https://www.uniprot.org/uniprot/Q6PE01"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "mRNA processing",
                        "id": "GO:0006397",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006397",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6PE01",
                                "url": "https://www.uniprot.org/uniprot/Q6PE01"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA splicing",
                        "id": "GO:0008380",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6PE01",
                                "url": "https://www.uniprot.org/uniprot/Q6PE01"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 203,
            "end_pos": 205,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 78,
            "end_pos": 80,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_predicted",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "phosphorylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "snv_non_disease",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "publication",
            "table_stats": [
                {
                    "field": "total",
                    "count": 2
                }
            ],
            "sort_fields": [
                "title",
                "journal",
                "date",
                "authors"
            ]
        }
    ]
}