{ "uniprot_canonical_ac": "Q6P9Q4-1", "uniprot_ac": "Q6P9Q4", "uniprot_id": "FHOD1_MOUSE", "mass": { "chemical_mass": 129600.0, "monoisotopic_mass": 129600.0 }, "refseq": { "ac": "NP_808367", "name": "FH1/FH2 domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808367" }, "gene_names": [ { "name": "Fhod1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q6P9Q4", "id": "Q6P9Q4" }, { "name": "FHOS; FHOS1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808367", "id": "NP_808367" }, { "name": "Fhod1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808367", "id": "NP_808367" }, { "name": "Fhos1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q6P9Q4", "id": "Q6P9Q4" } ], "protein_names": [ { "name": "FH1/FH2 domain-containing protein 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q6P9Q4" }, { "name": "FH1/FH2 domain-containing protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808367", "id": "NP_808367" }, { "name": "FHOS", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6P9Q4" }, { "name": "Formin homolog overexpressed in spleen 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6P9Q4" }, { "name": "Formin homology 2 domain-containing protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6P9Q4" }, { "name": "formin homolog overexpressed in spleen 1; formin homology 2 domain-containing protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808367", "id": "NP_808367" } ], "function": [ { "annotation": "FHOD1 is regulated by ROCK for cytoplasm actin assembly and spindle migration during mouse oocyte meiosis.", "evidence": [ { "database": "RefSeq", "id": "NP_808367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808367" }, { "database": "PubMed", "id": "28708292", "url": "https://glygen.org/publication/PubMed/28708292" } ] }, { "annotation": "Fhod1 appears to be dispensable for normal development and function of the mouse heart, even if a marginal amount of Fhod1 is expressed in the heart.", "evidence": [ { "database": "RefSeq", "id": "NP_808367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808367" }, { "database": "PubMed", "id": "31008549", "url": "https://glygen.org/publication/PubMed/31008549" } ] }, { "annotation": "Letter: G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho kinase in platelets.", "evidence": [ { "database": "RefSeq", "id": "NP_808367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808367" }, { "database": "PubMed", "id": "21605332", "url": "https://glygen.org/publication/PubMed/21605332" } ] }, { "annotation": "Report FODH1 expression in cardiomyocytes.", "evidence": [ { "database": "RefSeq", "id": "NP_808367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808367" }, { "database": "PubMed", "id": "25125170", "url": "https://glygen.org/publication/PubMed/25125170" } ] }, { "annotation": "Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Fhod1", "url": "https://www.uniprot.org/uniprot/Q6P9Q4", "locus": { "chromosome": "8", "start_pos": 106055795, "end_pos": 106074585, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000014778", "url": "https://www.ensembl.org/id/ENSMUSG00000014778" } ] } } ], "crossref": [ { "id": "ENSMUSG00000014778", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000014778", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "234686", "url": "https://www.ncbi.nlm.nih.gov/gene/234686", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q6P9Q4", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q6P9Q4*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014768", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014768", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015425", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015425", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:234686", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:234686", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2679008", "url": "http://www.informatics.jax.org/marker/MGI:2679008", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q6P9Q4", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q6P9Q4", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "VRVMQFC", "url": "https://omabrowser.org/oma/group/VRVMQFC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2918313at2759", "url": "http://www.orthodb.org/?query=2918313at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45920", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45920", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45920:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45920:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02181", "url": "http://pfam.xfam.org/family/PF02181", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF18382", "url": "http://pfam.xfam.org/family/PF18382", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q6P9Q4", "url": "http://purl.obolibrary.org/obo/PR_Q6P9Q4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_808367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808367", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6P9Q4-1", "url": "https://www.uniprot.org/uniprot/Q6P9Q4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGEEERGDGDPVSVVTVRVQYLEDTDPFACANFPEPRRAPTCSLDGALPLSAQIPALHRLLGAPLKLEDCALQVSPSGYYLDPELSLEEQREMLEGFYEEISKGRKPTLILRTQLSVRVNAILEKLYGSSGPELRRSLFSLKQIFQEDKDLVPEFVHSEGLSCLIRVGAAADHNYQSYILRALGQLMLFVDGMLGVVAHSETVQWLYTLCASLSRLVVKTALKLLLVFVEYSENNAPLFIQAVNAVASATGTLPWANLVSILEEKNGADAELLVYTVTLINKTLAALPDQDSFYDVTDALEQQGMEALVQRFLGTAGTDVDLRTQLTLYESALRLEDGDMEEAAAAAAAGGRRERRKPSSEEGKRSRRSLEGGGCPVRAPEPGSTGSASPVGSTPSTGSAPPTNPAFSSTGPASGLLRTSVNLFPTISVGPSVDSSCERSVYKARFLENVAAAETEKQAALAQGRAETLAGATVDDTDGSSGTRELWDSPEPASAPRTPQSPVSRILLRTQRSLEPEPKKPVSPPSPKAEPIQEPPTCVPKLCIGDLDFSDLGEDEDQDTLNVESVEAGKASPFLSSLSPSLSGGPPPPPPPPPPITGSCPPPPPPPLPPPATGSCPPPPPPPPPPIIGSCPPPPPLAAPFTHSALDGPRHPTKRKTVKLFWRELKLTGGPGCSRSRFGPCPTLWASLEPVSVDTARLEHLFESRAKDVLPTKKAGEGRRTMTVVLDPKRSNAINIGLTTLPPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDVPLGPAENFLMTLASIGGLAARLQLWAFKLDYESMEREIAEPLFDLKVGMEQLVHNATFRCILATLLAVGNFLNGSQSSGFELSYLEKVSEVKDTVRRQSLLYHLCSLVLQTRPDSSDLYSEIPALTRCAKVDFEQLTENLGQLECRSQAAEDSLRSLAKHELSPALRARLTHFLAQCTRRVAMLRVVHRRVCNRFHAFLLYLGYTPQAARDVRIMQFCHTLREFALEYRTCRERVLQQQQKRATYRERNKTRGRMITETEKFSGVAGEAPNNLSVPVAVGSGPGQGDTDNHASMKSLLTSRPEDATHSRRSRGMVQSSSPVSHTAVGPSAASPEETAASGLPTDTSDEIMDLLVQSVTKSGPRALAARERKRSRGNRKSLRRTLKSGLGDDLVQALGLSKAPGLEV", "length": 1197, "header": "sp|Q6P9Q4-1|FHOD1_MOUSE Isoform 1 of FH1/FH2 domain-containing protein 1 OS=Mus musculus OX=10090 GN=Fhod1 PE=1 SV=3 CANONICAL=Q6P9Q4-1" }, "isoforms": [ { "isoform_ac": "Q6P9Q4-1", "url": "", "sequence": { "sequence": "MAGEEERGDGDPVSVVTVRVQYLEDTDPFACANFPEPRRAPTCSLDGALPLSAQIPALHRLLGAPLKLEDCALQVSPSGYYLDPELSLEEQREMLEGFYEEISKGRKPTLILRTQLSVRVNAILEKLYGSSGPELRRSLFSLKQIFQEDKDLVPEFVHSEGLSCLIRVGAAADHNYQSYILRALGQLMLFVDGMLGVVAHSETVQWLYTLCASLSRLVVKTALKLLLVFVEYSENNAPLFIQAVNAVASATGTLPWANLVSILEEKNGADAELLVYTVTLINKTLAALPDQDSFYDVTDALEQQGMEALVQRFLGTAGTDVDLRTQLTLYESALRLEDGDMEEAAAAAAAGGRRERRKPSSEEGKRSRRSLEGGGCPVRAPEPGSTGSASPVGSTPSTGSAPPTNPAFSSTGPASGLLRTSVNLFPTISVGPSVDSSCERSVYKARFLENVAAAETEKQAALAQGRAETLAGATVDDTDGSSGTRELWDSPEPASAPRTPQSPVSRILLRTQRSLEPEPKKPVSPPSPKAEPIQEPPTCVPKLCIGDLDFSDLGEDEDQDTLNVESVEAGKASPFLSSLSPSLSGGPPPPPPPPPPITGSCPPPPPPPLPPPATGSCPPPPPPPPPPIIGSCPPPPPLAAPFTHSALDGPRHPTKRKTVKLFWRELKLTGGPGCSRSRFGPCPTLWASLEPVSVDTARLEHLFESRAKDVLPTKKAGEGRRTMTVVLDPKRSNAINIGLTTLPPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDVPLGPAENFLMTLASIGGLAARLQLWAFKLDYESMEREIAEPLFDLKVGMEQLVHNATFRCILATLLAVGNFLNGSQSSGFELSYLEKVSEVKDTVRRQSLLYHLCSLVLQTRPDSSDLYSEIPALTRCAKVDFEQLTENLGQLECRSQAAEDSLRSLAKHELSPALRARLTHFLAQCTRRVAMLRVVHRRVCNRFHAFLLYLGYTPQAARDVRIMQFCHTLREFALEYRTCRERVLQQQQKRATYRERNKTRGRMITETEKFSGVAGEAPNNLSVPVAVGSGPGQGDTDNHASMKSLLTSRPEDATHSRRSRGMVQSSSPVSHTAVGPSAASPEETAASGLPTDTSDEIMDLLVQSVTKSGPRALAARERKRSRGNRKSLRRTLKSGLGDDLVQALGLSKAPGLEV", "length": 1197, "header": "sp|Q6P9Q4-1|FHOD1_MOUSE Isoform 1 of FH1/FH2 domain-containing protein 1 OS=Mus musculus OX=10090 GN=Fhod1 PE=1 SV=3 CANONICAL=Q6P9Q4-1" }, "locus": { "chromosome": "8", "start_pos": 106074485, "end_pos": 106056032, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000014922", "url": "https://www.ensembl.org/id/ENSMUST00000014922" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000014922", "url": "https://www.ensembl.org/id/ENSMUSP00000014922" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q6P9Q4", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q6P9Q4" }, { "id": "28528544", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28528544" }, { "id": "34887587", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34887587" } ] } ], "phosphorylation": [ { "start_pos": 370, "end_pos": 370, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "iPTMnet", "id": "Q6P9Q4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6P9Q4" } ], "site_lbl": "Ser370" }, { "start_pos": 490, "end_pos": 490, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "site_lbl": "Ser490" }, { "start_pos": 499, "end_pos": 499, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "site_lbl": "Thr499" }, { "start_pos": 502, "end_pos": 502, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "site_lbl": "Ser502" }, { "start_pos": 524, "end_pos": 524, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q6P9Q4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6P9Q4" } ], "site_lbl": "Ser524" }, { "start_pos": 527, "end_pos": 527, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q6P9Q4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6P9Q4" } ], "site_lbl": "Ser527" }, { "start_pos": 722, "end_pos": 722, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "site_lbl": "Thr722" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Fhos2, a novel formin-related actin-organizing protein, probably associates with the nestin intermediate filament.", "journal": "Genes Cells", "date": "2005", "authors": "Jing N., Takeuchi K., Watanabe N., Sumimoto H., Takeya R., Kanaya H.", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "reference": [ { "type": "PubMed", "id": "15966898", "url": "https://glygen.org/publication/PubMed/15966898" } ] }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" }, { "database": "iPTMnet", "id": "Q6P9Q4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6P9Q4" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" }, { "database": "iPTMnet", "id": "Q6P9Q4", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6P9Q4" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho kinase in platelets.", "journal": "Journal of thrombosis and haemostasis : JTH", "date": "2011", "authors": "Thomas SG, Calaminus SD, Machesky LM, Alberts AS, Watson SP", "evidence": [ { "database": "RefSeq", "id": "NP_808367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808367" } ], "reference": [ { "type": "PubMed", "id": "21605332", "url": "https://glygen.org/publication/PubMed/21605332" } ] }, { "title": "The formin FHOD1 in cardiomyocytes.", "journal": "Anatomical record (Hoboken, N.J. : 2007)", "date": "2014", "authors": "Dwyer J, Pluess M, Iskratsch T, Dos Remedios CG, Ehler E", "evidence": [ { "database": "RefSeq", "id": "NP_808367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808367" } ], "reference": [ { "type": "PubMed", "id": "25125170", "url": "https://glygen.org/publication/PubMed/25125170" } ] }, { "title": "The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8.", "journal": "Journal of the American Chemical Society", "date": "2017", "authors": "Chuh KN, Batt AR, Zaro BW, Darabedian N, Marotta NP, Brennan CK, Amirhekmat A, Pratt MR", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q6P9Q4", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q6P9Q4" } ], "reference": [ { "type": "PubMed", "id": "28528544", "url": "https://glygen.org/publication/PubMed/28528544" } ] }, { "title": "FHOD1 regulates cytoplasmic actin-based spindle migration for mouse oocyte asymmetric cell division.", "journal": "Journal of cellular physiology", "date": "2018", "authors": "Pan MH, Wang F, Lu Y, Tang F, Duan X, Zhang Y, Xiong B, Sun SC", "evidence": [ { "database": "RefSeq", "id": "NP_808367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808367" } ], "reference": [ { "type": "PubMed", "id": "28708292", "url": "https://glygen.org/publication/PubMed/28708292" } ] }, { "title": "Fhod1, an actin-organizing formin family protein, is dispensable for cardiac development and function in mice.", "journal": "Cytoskeleton (Hoboken, N.J.)", "date": "2019", "authors": "Sanematsu F, Kanai A, Ushijima T, Shiraishi A, Abe T, Kage Y, Sumimoto H, Takeya R", "evidence": [ { "database": "RefSeq", "id": "NP_808367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808367" } ], "reference": [ { "type": "PubMed", "id": "31008549", "url": "https://glygen.org/publication/PubMed/31008549" } ] }, { "title": "Dynamic eIF3a O-GlcNAcylation controls translation reinitiation during nutrient stress.", "journal": "Nature chemical biology", "date": "2022", "authors": "Shu XE, Mao Y, Jia L, Qian SB", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q6P9Q4", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q6P9Q4" } ], "reference": [ { "type": "PubMed", "id": "34887587", "url": "https://glygen.org/publication/PubMed/34887587" } ] } ], "pathway": [ { "id": "mmu:234686", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:234686", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JZ38-1", "protein_name": "Formin homology 2 domain containing 1", "gene_name": "Fhod1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGEEERGDGDPVSVVTVRVQYLEDTDPFACANFPEPRRAPTCSLDGALPLSAQIPALHRLLGAPLKLEDCALQVSPSGYYLDPELSLEEQREMLEGFYEEISKGRKPTLILRTQLSVRVNAILEKLYGSSGPELRRSLFSLKQIFQEDKDLVPEFVHSEGLSCLIRVGAAADHNYQSYILRALGQLMLFVDGMLGVVAHSETVQWLYTLCASLSRLVVKTALKLLLVFVEYSENNAPLFIQAVNAVASNTGTLPWANLVSILEEKNGVDPELLVYTVTLINKTLAALPDQDSFYDVTDAFEQQGMEALVQRLLGTAGTDVDLRTQLTLYESALRLEDGDMEEAAAAAAAGGRRERRKPSSEEGKRSRRSLEGGGCPVRTPEPGPTGSASPVGSASFTDSTSPTSSAFSPTGPASGLHTSVNLFPTISVGPSVDTSCERSVYKARFLENVAAAETEKQAALAQGRAETLAGATVDETDESSGTRELWDSSEPASAPRPPQSPVSPIVLRTQRSLEPEPKEPVSPRSPKTEPVQELPTHVPKLCIGDLDFSDLGEDEDQDTLNVESVEAGKASLVLSLPPSSFSGGPPPPPPPPPPIIVSCPPPPPPPPPPIMGSCLPPPPLAAPFPHSALDGPRHPTKRKTVKLFWRELKPTGSPGCSRSRFGPCPTLWASLEPVSVDTARLEHLFESRAKDVLPTKKAGEGRRTMTIVLDPKRSNAINIGLTTLPPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDVPLGPAENFLMTLASIGGLAARLQLWAFKLDYESMEREIAEPLFDLKVGMEQLVHNATFRCILATLLAVGNFLNGSQSSGFELSYLEKVSEVKDTVRRQSLLYHLCSLVLQTRPDSSDLYSEIPALTRCAKVDFEQLTENLGQLECRSQAAEDSLRSLAKHELSPALRARLTHFLAQCTRRVAMLRVVHRRVCNRFHAFLLYLGYTAQAAREVRIMQFCHTLREFALEYRTCRERVLQQQQKRATYRERNKTRGRMITETEKFSGVAGEVPSNLSVPVAVGSGPGRGDADNHASMKSLLTSRPEDATHSRRSRGMVQSSSPVTHTTVGPFTASPEETAASGLPSDTSDEIMDLLVQSVTKSSPRALAARERKRSRGNRKSLRRTLKSGLGDDLVQALGLSKAPGLEV", "length": 1180 }, "evidence": [ { "id": "45231279", "url": "http://www.informatics.jax.org/homology/45231279", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9Y613-1", "protein_name": "FH1/FH2 domain-containing protein 1", "gene_name": "FHOD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAGGEDRGDGEPVSVVTVRVQYLEDTDPFACANFPEPRRAPTCSLDGALPLGAQIPAVHRLLGAPLKLEDCALQVSPSGYYLDTELSLEEQREMLEGFYEEISKGRKPTLILRTQLSVRVNAILEKLYSSSGPELRRSLFSLKQIFQEDKDLVPEFVHSEGLSCLIRVGAAADHNYQSYILRALGQLMLFVDGMLGVVAHSDTIQWLYTLCASLSRLVVKTALKLLLVFVEYSENNAPLFIRAVNSVASTTGAPPWANLVSILEEKNGADPELLVYTVTLINKTLAALPDQDSFYDVTDALEQQGMEALVQRHLGTAGTDVDLRTQLVLYENALKLEDGDIEEAPGAGGRRERRKPSSEEGKRSRRSLEGGGCPARAPEPGPTGPASPVGPTSSTGPALLTGPASSPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKARFLENVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAEPIWELPTRAPRLSIGDLDFSDLGEDEDQDMLNVESVEAGKDIPAPSPPLPLLSGVPPPPPLPPPPPIKGPFPPPPPLPLAAPLPHSVPDSSALPTKRKTVKLFWRELKLAGGHGVSASRFGPCATLWASLDPVSVDTARLEHLFESRAKEVLPSKKAGEGRRTMTTVLDPKRSNAINIGLTTLPPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDIPLGPAENFLMTLASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGSQSSGFELSYLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQLERRSRAAEESLRSLAKHELAPALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPQAAREVRIMQFCHTLREFALEYRTCRERVLQQQQKQATYRERNKTRGRMITETEKFSGVAGEAPSNPSVPVAVSSGPGRGDADSHASMKSLLTSRPEDTTHNRRSRGMVQSSSPIMPTVGPSTASPEEPPGSSLPSDTSDEIMDLLVQSVTKSSPRALAARERKRSRGNRKSLRRTLKSGLGDDLVQALGLSKGPGLEV", "length": 1164 }, "evidence": [ { "id": "45231279", "url": "http://www.informatics.jax.org/homology/45231279", "database": "MGI" }, { "id": "Q6P9Q4", "url": "https://omabrowser.org/oma/group/Q6P9Q4/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" }, { "name": "intercalated disc", "id": "GO:0014704", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014704", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" }, { "name": "stress fiber", "id": "GO:0001725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001725", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" }, { "name": "bleb", "id": "GO:0032059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032059", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "protein domain specific binding", "id": "GO:0019904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" }, { "name": "protein self-association", "id": "GO:0043621", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043621", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" }, { "name": "positive regulation of stress fiber assembly", "id": "GO:0051496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051496", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" }, { "name": "cortical actin cytoskeleton organization", "id": "GO:0030866", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030866", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" }, { "name": "regulation of stress fiber assembly", "id": "GO:0051492", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051492", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" }, { "name": "nuclear migration", "id": "GO:0007097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007097", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" }, { "name": "establishment of centrosome localization", "id": "GO:0051660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051660", "evidence": [ { "database": "UniProtKB", "id": "Q6P9Q4", "url": "https://www.uniprot.org/uniprot/Q6P9Q4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1040, "end_pos": 1042, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1063, "end_pos": 1065, "annotation": "n_glycosylation_sequon" }, { "start_pos": 282, "end_pos": 284, "annotation": "n_glycosylation_sequon" }, { "start_pos": 846, "end_pos": 848, "annotation": "n_glycosylation_sequon" }, { "start_pos": 864, "end_pos": 866, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { 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