{
    "uniprot_canonical_ac": "Q6P6Q9-1",
    "uniprot_ac": "Q6P6Q9",
    "uniprot_id": "MICU1_RAT",
    "mass": {
        "chemical_mass": 54195.0,
        "monoisotopic_mass": 54195.0
    },
    "refseq": {
        "ac": "NP_955444",
        "name": "calcium uptake protein 1, mitochondrial",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955444"
    },
    "gene_names": [
        {
            "name": "Micu1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q6P6Q9",
            "id": "Q6P6Q9"
        },
        {
            "name": "Cbara1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006256483",
            "id": "XP_006256483"
        },
        {
            "name": "Cbara1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q6P6Q9",
            "id": "Q6P6Q9"
        },
        {
            "name": "Micu1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006256483",
            "id": "XP_006256483"
        }
    ],
    "protein_names": [
        {
            "name": "Calcium uptake protein 1, mitochondrial",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q6P6Q9"
        },
        {
            "name": "Calcium-binding atopy-related autoantigen 1 homolog",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q6P6Q9"
        },
        {
            "name": "calcium uptake protein 1, mitochondrial isoform X1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006256482",
            "id": "XP_006256482"
        },
        {
            "name": "calcium uptake protein 1, mitochondrial isoform X2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006256483",
            "id": "XP_006256483"
        },
        {
            "name": "calcium uptake protein 1, mitochondrial isoform X3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006256484",
            "id": "XP_006256484"
        },
        {
            "name": "calcium uptake protein 1, mitochondrial",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955444",
            "id": "NP_955444"
        },
        {
            "name": "calcium-binding atopy-related autoantigen 1 homolog; calcium binding atopy-related autoantigen 1; calcium-binding atopy-related autoantigen 1-like",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955444",
            "id": "NP_955444"
        }
    ],
    "function": [
        {
            "annotation": "In vitro data show that the reconstitution of MICU1 inhibited the apoptosis of cardiomyocytes, induced by high glucose and high fat, through increasing mitochondrial Ca(2+) uptake and subsequently activating the antioxidant system.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_955444",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955444"
                },
                {
                    "database": "PubMed",
                    "id": "28292968",
                    "url": "https://glygen.org/publication/PubMed/28292968"
                }
            ]
        },
        {
            "annotation": "Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6P6Q9",
                    "url": "https://www.uniprot.org/uniprot/Q6P6Q9#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9BPX6",
                    "url": "https://www.uniprot.org/uniprot/Q9BPX6#function"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0111335",
            "recommended_name": {
                "id": "DOID:0111335",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111335",
                "name": "myopathy with extrapyramidal signs",
                "description": "A myopathy characterized by early childhood onset of proximal muscle weakness, with development of progressive extrapyramidal motor signs in most patients, and learning disabilities that has_material_basis_in compound heterozygous or homozygous mutation in the MICU1 gene on chromosome 10q22.1."
            },
            "synonyms": [
                {
                    "id": "DOID:0111335",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111335",
                    "name": "MPXPS",
                    "description": ""
                },
                {
                    "id": "DOID:0111335",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111335",
                    "name": "proximal myopathy with extrapyramidal signs",
                    "description": ""
                },
                {
                    "id": "MONDO:0014300",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014300",
                    "name": "proximal myopathy with extrapyramidal signs",
                    "description": "Proximal myopathy with extrapyramidal signs is a rare, hereditary non-dystrophic myopathy characterized by proximal muscle weakness, delayed motor development, learning difficulties, and progressive extrapyramidal motor signs including chorea, dystonia and tremor. Variable additional features have been reported - ataxia, microcephaly, ophthalmoplegia, ptosis, and optic atrophy."
                },
                {
                    "id": "MONDO:0014300",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014300",
                    "name": "MPXPS",
                    "description": ""
                },
                {
                    "id": "MONDO:0014300",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0014300",
                    "name": "myopathy with extrapyramidal signs",
                    "description": ""
                },
                {
                    "id": "MIM:615673",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/615673",
                    "name": "Myopathy with extrapyramidal signs",
                    "description": "Myopathy with extrapyramidal signs"
                }
            ],
            "evidence": [
                {
                    "id": "0111335",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111335"
                }
            ]
        },
        {
            "disease_id": "DOID:1289",
            "recommended_name": {
                "id": "DOID:1289",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:1289",
                "name": "neurodegenerative disease",
                "description": "A central nervous system disease that results in the progressive deterioration of function or structure of neurons."
            },
            "synonyms": [
                {
                    "id": "DOID:1289",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:1289",
                    "name": "degenerative disease",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "1289",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:1289"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6P6Q9",
                    "url": "https://www.uniprot.org/uniprot/Q6P6Q9"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Micu1",
            "url": "https://www.uniprot.org/uniprot/Q6P6Q9",
            "locus": {
                "chromosome": "20",
                "start_pos": 27814964,
                "end_pos": 27668747,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000043436",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000043436"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000043436",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000043436",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd16173",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16173",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "365567",
            "url": "https://www.ncbi.nlm.nih.gov/gene/365567",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "F1LNV5",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:F1LNV5*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR002048",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011992",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR018247",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR039800",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039800",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:365567",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:365567",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "EVWKAEF",
            "url": "https://omabrowser.org/oma/group/EVWKAEF/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "1020411at2759",
            "url": "http://www.orthodb.org/?query=1020411at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12294",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12294",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12294:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12294:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13202",
            "url": "http://pfam.xfam.org/family/PF13202",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF13833",
            "url": "http://pfam.xfam.org/family/PF13833",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q6P6Q9",
            "url": "http://purl.obolibrary.org/obo/PR_Q6P6Q9",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-RNO-8949215",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8949215",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-RNO-8949664",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8949664",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_955444",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955444",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "735033",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=735033",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A0G2K0T5",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K0T5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2K0T5-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2K0T5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6A7K0",
            "url": "https://www.uniprot.org/uniprot/A0A8I6A7K0",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6A7K0-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6A7K0-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6ACS4",
            "url": "https://www.uniprot.org/uniprot/A0A8I6ACS4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6ACS4-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6ACS4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6AKH4",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AKH4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6AKH4-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AKH4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F1LNV5",
            "url": "https://www.uniprot.org/uniprot/F1LNV5",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F1LNV5-1",
            "url": "https://www.uniprot.org/uniprot/F1LNV5-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q6P6Q9",
            "url": "https://www.uniprot.org/uniprot/Q6P6Q9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q6P6Q9-1",
            "url": "https://www.uniprot.org/uniprot/Q6P6Q9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MFRLNALSALAELAVGSRWYHGTSQPTQTKRRLMLVAFLGASAVTASTGLLWKKAHAESPPSVNSKKTDAGDKGKSKDTREVSSHEGSAADTAAEPYPEEKKKKRSGFRDRKVMEYENRIRAYSTPDKIFRYFATLKVINEPGETEVFMTPQDFVRSITPNEKQPEHLGLDQYIIKRFDGKKIAQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRISERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKDGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQETAWDFALPK",
        "length": 477,
        "header": "sp|Q6P6Q9-1|MICU1_RAT Isoform 1 of Calcium uptake protein 1, mitochondrial  OS=Rattus norvegicus OX=10116 GN=Micu1 PE=2 SV=1 CANONICAL=Q6P6Q9-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2K0T5-1",
            "url": "",
            "sequence": {
                "sequence": "MFRLNALSALAELAMGSRWYHGTSQPTQTKRRLMLVAFLGASAVTASTGLLWKKAHAESPPSVNSKKTDAGDKGKSKDTREVSSHEGSAADTAAEPYPEEKKKKRSGFRDRKVMEYENRIRAYSTPDKIFRYFATLKVINEPGETEVFMTPQDFVRSITPNEKQPEHLGLDQYIIKRFDGKMAKIAQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRISERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKDGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQETAWDFALPK",
                "length": 479,
                "header": "tr|A0A0G2K0T5-1|MICU1_RAT Computationally mapped isoform of Calcium uptake protein 1, mitochondrial  OS=Rattus norvegicus OX=10116 GN=Micu1 PE=2 SV=2 CANONICAL=Q6P6Q9-1"
            },
            "locus": {
                "chromosome": "20",
                "start_pos": 27814199,
                "end_pos": 27695287,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000082734.2",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000082734.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000071575.2",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000071575.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6A7K0-1",
            "url": "",
            "sequence": {
                "sequence": "MFRLNALSALAELAMGSRWYHGTSQPTQTKRRLMLVAFLGASAVTASTGLLWKKAHAESPPSVNSKKTDAGDKGKSKDTREVSSHEGSAADTAAEPYPEEKKKKRSGFRDRKVMEYENRIRAYSTPDKIFRYFATLKVINEPGETEVFMTPQDFVRSITPNEKQPEHLGLDQYIIKRFDGKEFWQTEKIAQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRISERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKDGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQETAWDFALPK",
                "length": 483,
                "header": "tr|A0A8I6A7K0-1|A0A8I6A7K0_RAT Computationally mapped isoform of Mitochondrial calcium uptake 1  OS=Rattus norvegicus OX=10116 GN=Micu1 PE=1 SV=1 CANONICAL=Q6P6Q9-1"
            },
            "locus": {
                "chromosome": "20",
                "start_pos": 27814199,
                "end_pos": 27695287,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000103446.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000103446.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000088284.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000088284.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6ACS4-1",
            "url": "",
            "sequence": {
                "sequence": "MFRLNALSALAELAMGSRWYHGTSQPTQTKRRLMLVAFLGASAVTASTGLLWKKAHAESPPSVNSKKTDAGDKGKSKDTREVSSHEGSAADTAAEPYPEEKKKKRSGFRDRKVMEYENRIRAYSTPDKIFRYFATLKVINEPGETEVFMTPQDFVRSITPNEKQPEHLGLDQYIIKRFDGKEFWQKIAQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRISERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKDGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQETAWDFALPK",
                "length": 481,
                "header": "tr|A0A8I6ACS4-1|MICU1_RAT Computationally mapped isoform of Calcium uptake protein 1, mitochondrial  OS=Rattus norvegicus OX=10116 GN=Micu1 PE=2 SV=1 CANONICAL=Q6P6Q9-1"
            },
            "locus": {
                "chromosome": "20",
                "start_pos": 27814199,
                "end_pos": 27695287,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000098143.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000098143.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000089977.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000089977.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A8I6AKH4-1",
            "url": "",
            "sequence": {
                "sequence": "MFRLNALSALAELAMGSRWYHGTSQPTQTKRRLMLVAFLGASAVTASTGLLWKKAHAESPPSVNSKKTDAGDKGKSKDTREVSSHEGSAADTAAEPYPEEKKKKRSGFRDRKVMEYENRIRAYSTPDKIFRYFATLKVINEPGETEVFMTPQDFVRSITPNEKQPEHLGLDQYIIKRFDGKVSTHKIAQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRISERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKDGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQETAWDFALPK",
                "length": 481,
                "header": "tr|A0A8I6AKH4-1|MICU1_RAT Computationally mapped isoform of Calcium uptake protein 1, mitochondrial  OS=Rattus norvegicus OX=10116 GN=Micu1 PE=2 SV=1 CANONICAL=Q6P6Q9-1"
            },
            "locus": {
                "chromosome": "20",
                "start_pos": 27814199,
                "end_pos": 27695287,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000101745.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000101745.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000094895.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000094895.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F1LNV5-1",
            "url": "",
            "sequence": {
                "sequence": "MFRLNALSALAELAMGSRWYHGTSQPTQTKRRLMLVAFLGASAVTASTGLLWKKAHAESPPSVNSKKTDAGDKGKSKDTREVSSHEGSAADTAAEPYPEEKKKKRSGFRDRKVMEYENRIRAYSTPDKIFRYFATLKVINEPGETEVFMTPQDFVRSITPNEKQPEHLGLDQYIIKRFDGKTEKIAQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRISERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKDGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQETAWDFALPK",
                "length": 479,
                "header": "tr|F1LNV5-1|F1LNV5_RAT Computationally mapped isoform of Mitochondrial calcium uptake 1  OS=Rattus norvegicus OX=10116 GN=Micu1 PE=1 SV=3 CANONICAL=Q6P6Q9-1"
            },
            "locus": {
                "chromosome": "20",
                "start_pos": 27814199,
                "end_pos": 27695287,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000067405.3",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000067405.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000060514.3",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000060514.3"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q6P6Q9-1",
            "url": "",
            "sequence": {
                "sequence": "MFRLNALSALAELAVGSRWYHGTSQPTQTKRRLMLVAFLGASAVTASTGLLWKKAHAESPPSVNSKKTDAGDKGKSKDTREVSSHEGSAADTAAEPYPEEKKKKRSGFRDRKVMEYENRIRAYSTPDKIFRYFATLKVINEPGETEVFMTPQDFVRSITPNEKQPEHLGLDQYIIKRFDGKKIAQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRISERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKDGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQETAWDFALPK",
                "length": 477,
                "header": "sp|Q6P6Q9-1|MICU1_RAT Isoform 1 of Calcium uptake protein 1, mitochondrial  OS=Rattus norvegicus OX=10116 GN=Micu1 PE=2 SV=1 CANONICAL=Q6P6Q9-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca(2+)-Dependent Antioxidant Response.",
            "journal": "Diabetes",
            "date": "2017",
            "authors": "Ji L, Liu F, Jing Z, Huang Q, Zhao Y, Cao H, Li J, Yin C, Xing J, Li F",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_955444",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955444"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28292968",
                    "url": "https://glygen.org/publication/PubMed/28292968"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:365567",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:365567",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-8949215",
            "name": "Mitochondrial calcium ion transport",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8949215",
            "resource": "Reactome",
            "description": "Mitochondrial calcium ion transport"
        },
        {
            "id": "R-RNO-8949664",
            "name": "Processing of SMDT1",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8949664",
            "resource": "Reactome",
            "description": "Processing of SMDT1"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8VCX5-1",
            "protein_name": "Calcium uptake protein 1, mitochondrial",
            "gene_name": "Micu1",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MFRLNTLSALAELAVGSRWYHGASQPTQTKRRLMLVAFLGASAVTASTGLLWKKAHAESPPCVNSKKPDTEDKERNKDSGEVSSREGRAADAAAEPYPEDKKKKRSGFRDRKVMEYENRIRAYSTPDKIFRYFATLKVINEPGETEVFMTPQDFVRSITPNEKQPEHLGLDQYIIKRFDGKKIAQEREKFADEGSIFYSLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRISERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKDGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQETAWDFALPK",
                "length": 477
            },
            "evidence": [
                {
                    "id": "45230784",
                    "url": "http://www.informatics.jax.org/homology/45230784",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9BPX6-1",
            "protein_name": "Calcium uptake protein 1, mitochondrial",
            "gene_name": "MICU1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MFRLNSLSALAELAVGSRWYHGGSQPIQIRRRLMMVAFLGASAVTASTGLLWKRAHAESPPCVDNLKSDIGDKGKNKDEGDVCNHEKKTADLAPHPEEKKKKRSGFRDRKVMEYENRIRAYSTPDKIFRYFATLKVISEPGEAEVFMTPEDFVRSITPNEKQPEHLGLDQYIIKRFDGKKISQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFERHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQETAWDFALPKQ",
                "length": 476
            },
            "evidence": [
                {
                    "id": "45230784",
                    "url": "http://www.informatics.jax.org/homology/45230784",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "calcium ion binding",
                        "id": "GO:0005509",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6P6Q9",
                                "url": "https://www.uniprot.org/uniprot/Q6P6Q9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "identical protein binding",
                        "id": "GO:0042802",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6P6Q9",
                                "url": "https://www.uniprot.org/uniprot/Q6P6Q9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein heterodimerization activity",
                        "id": "GO:0046982",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6P6Q9",
                                "url": "https://www.uniprot.org/uniprot/Q6P6Q9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 7,
                "go_terms": [
                    {
                        "name": "mitochondrial calcium ion transmembrane transport",
                        "id": "GO:0006851",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006851",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6P6Q9",
                                "url": "https://www.uniprot.org/uniprot/Q6P6Q9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein homooligomerization",
                        "id": "GO:0051260",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6P6Q9",
                                "url": "https://www.uniprot.org/uniprot/Q6P6Q9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "calcium import into the mitochondrion",
                        "id": "GO:0036444",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036444",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6P6Q9",
                                "url": "https://www.uniprot.org/uniprot/Q6P6Q9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitochondrial calcium ion homeostasis",
                        "id": "GO:0051560",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051560",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6P6Q9",
                                "url": "https://www.uniprot.org/uniprot/Q6P6Q9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of mitochondrial calcium ion concentration",
                        "id": "GO:0051561",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051561",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6P6Q9",
                                "url": "https://www.uniprot.org/uniprot/Q6P6Q9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "calcium ion import",
                        "id": "GO:0070509",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070509",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6P6Q9",
                                "url": "https://www.uniprot.org/uniprot/Q6P6Q9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "regulation of cellular hyperosmotic salinity response",
                        "id": "GO:1900069",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900069",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6P6Q9",
                                "url": "https://www.uniprot.org/uniprot/Q6P6Q9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 5,
                "go_terms": [
                    {
                        "name": "mitochondrial inner membrane",
                        "id": "GO:0005743",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6P6Q9",
                                "url": "https://www.uniprot.org/uniprot/Q6P6Q9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitochondrial intermembrane space",
                        "id": "GO:0005758",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6P6Q9",
                                "url": "https://www.uniprot.org/uniprot/Q6P6Q9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitochondrial membrane",
                        "id": "GO:0031966",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6P6Q9",
                                "url": "https://www.uniprot.org/uniprot/Q6P6Q9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "calcium channel complex",
                        "id": "GO:0034704",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034704",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6P6Q9",
                                "url": "https://www.uniprot.org/uniprot/Q6P6Q9"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "uniplex complex",
                        "id": "GO:1990246",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990246",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6P6Q9",
                                "url": "https://www.uniprot.org/uniprot/Q6P6Q9"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
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        {
            "table_id": "phosphorylation",
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        {
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}