{ "uniprot_canonical_ac": "Q6NXK9-1", "uniprot_ac": "Q6NXK9", "uniprot_id": "Q6NXK9_MOUSE", "mass": { "chemical_mass": 70723.0, "monoisotopic_mass": 70723.0 }, "refseq": { "ac": "NP_997120", "name": "mannosyl-oligosaccharide 1,2-alpha-mannosidase IC", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997120" }, "gene_names": [ { "name": "Man1c1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q6NXK9", "id": "Q6NXK9" }, { "name": "Man1c1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997120", "id": "NP_997120" } ], "protein_names": [ { "name": "alpha-1,2-Mannosidase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q6NXK9" }, { "name": "3.2.1.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6NXK9" }, { "name": "mannosyl-oligosaccharide 1,2-alpha-mannosidase IC", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997120", "id": "NP_997120" } ], "function": [], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q6NXK9", "url": "https://www.uniprot.org/uniprot/Q6NXK9" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Man1c1", "url": "https://www.uniprot.org/uniprot/Q6NXK9", "locus": { "chromosome": "4", "start_pos": 134289001, "end_pos": 134431601, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000037306", "url": "https://www.ensembl.org/id/ENSMUSG00000037306" } ] } } ], "crossref": [ { "id": "ENSMUSG00000037306", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037306", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "GH47", "url": "http://www.cazy.org/GH47.html", "database": "CAZy", "categories": [ "Protein Classification" ] }, { "id": "230815", "url": "https://www.ncbi.nlm.nih.gov/gene/230815", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001382", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001382", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR012341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR012341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036026", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036026", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:230815", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:230815", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2446214", "url": "http://www.informatics.jax.org/marker/MGI:2446214", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "NICFACL", "url": "https://omabrowser.org/oma/group/NICFACL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "942598at2759", "url": "http://www.orthodb.org/?query=942598at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11742", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11742", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11742:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11742:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01532", "url": "http://pfam.xfam.org/family/PF01532", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-964827", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-964827", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_997120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997120", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q6NXK9", "url": "https://www.uniprot.org/uniprot/Q6NXK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6NXK9-1", "url": "https://www.uniprot.org/uniprot/Q6NXK9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLVRKVPGFVPASPWGLRLPQKFLFLLFLSGLVTLCFGALFLLPHSSRLKRLFSASRTQQPGLEVMAEIAGHHSVSEQEPPPNPAPAAPAPGEDDPSRLVGVLRRKGWLRRTRPTGPREEGNRVAALRPQEESVRFTFDYNGFRSRLRHPVLGTRTDESKESQSLVRAQREKIKEMMRFSWQNYRRYAMGKNELRPLTKDGFEGSMFGGLSGATIIDSLDTLYLMELKEEFQEAKAWVQDSFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFRVKAIKLGEKLLPAFNTPTGIPKGVVNFKSGSWGWATAGSSSILAEFGSLHLEFLHLTELSGNPVFAEKVKHIRKVLREIDKPFGLYPNFLSPTSGNWVQHHVSVGGLGDSFYEYLIKSWLMSAKTDMEAKNMYYEALEAIETYLVNVSPGGLTYIAEWRGGILDHKMGHLACFSGGMIALGADDAKEDKRAYYRELAAQITRTCHESYARSDTKLGPEAFWFNSGREAVATQLSESYYILRPEVVESYMYLWRQTHDPIYREWGWEVVMALEKHCRTEAGFSGIQDVYSSNPNHDNRQQSFFLAETLKYLYLLFSEDNVLSLEDWVFNTEAHPLPVNRSDSFSIAGHPH", "length": 625, "header": "tr|Q6NXK9-1|Q6NXK9_MOUSE Isoform 1 of alpha-1,2-Mannosidase OS=Mus musculus OX=10090 GN=Man1c1 PE=1 SV=1 CANONICAL=Q6NXK9-1" }, "isoforms": [ { "isoform_ac": "Q6NXK9-1", "url": "", "sequence": { "sequence": "MLVRKVPGFVPASPWGLRLPQKFLFLLFLSGLVTLCFGALFLLPHSSRLKRLFSASRTQQPGLEVMAEIAGHHSVSEQEPPPNPAPAAPAPGEDDPSRLVGVLRRKGWLRRTRPTGPREEGNRVAALRPQEESVRFTFDYNGFRSRLRHPVLGTRTDESKESQSLVRAQREKIKEMMRFSWQNYRRYAMGKNELRPLTKDGFEGSMFGGLSGATIIDSLDTLYLMELKEEFQEAKAWVQDSFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFRVKAIKLGEKLLPAFNTPTGIPKGVVNFKSGSWGWATAGSSSILAEFGSLHLEFLHLTELSGNPVFAEKVKHIRKVLREIDKPFGLYPNFLSPTSGNWVQHHVSVGGLGDSFYEYLIKSWLMSAKTDMEAKNMYYEALEAIETYLVNVSPGGLTYIAEWRGGILDHKMGHLACFSGGMIALGADDAKEDKRAYYRELAAQITRTCHESYARSDTKLGPEAFWFNSGREAVATQLSESYYILRPEVVESYMYLWRQTHDPIYREWGWEVVMALEKHCRTEAGFSGIQDVYSSNPNHDNRQQSFFLAETLKYLYLLFSEDNVLSLEDWVFNTEAHPLPVNRSDSFSIAGHPH", "length": 625, "header": "tr|Q6NXK9-1|Q6NXK9_MOUSE Isoform 1 of alpha-1,2-Mannosidase OS=Mus musculus OX=10090 GN=Man1c1 PE=1 SV=1 CANONICAL=Q6NXK9-1" }, "locus": { "chromosome": "4", "start_pos": 134430780, "end_pos": 134291020, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000054096.13", "url": "https://www.ensembl.org/id/ENSMUST00000054096.13" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000050979.7", "url": "https://www.ensembl.org/id/ENSMUSP00000050979.7" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "mmu:230815", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:230815", "resource": "KEGG Pathway" }, { "id": "R-MMU-964827", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-964827", "resource": "Reactome", "description": "Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2" } ], "orthologs": [ { "uniprot_canonical_ac": "D3Z979-1", "protein_name": "alpha-1,2-Mannosidase", "gene_name": "Man1c1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLVRKVPGFVPASSWGLRLPQKFLFLLFLSGLVTLCFGALFLLPHSSRLKRLFSASRTQQPGLEVMAEIAGHHSVSEQEPPPNPAPAAPAPGEDDSGRLVGVLRRKGWLRRTRPTGPREEGNRVSALRPQEESVRFSFDYNSFRSRLRHPVLGTRTDESQESQSLVRAQREKIKEMMRFSWQSYRRYAMGKNELRPLTKDGFEGSMFGGLSGATIIDSLDTLYLMELKEEFQEAKAWVQDSFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFRVKAIKLGEKLLPAFNTPTGIPKGVVNFKSGSWGWATAGSSSILAEFGSLHLEFLHLTELSGNPIFAEKVRNIRKVLREIDKPFGLYPNFLSPVSGNWVQHHVSVGGLGDSFYEYLIKSWLMSAKTDMEAKTMYYEALEAIETYLVNVSPGGLTYIAEWRGGILDHKMGHLACFSGGMIALGAEDAKEDKRAYYRELAAQITRTCHESYARSDTKLGPEAFWFNSGREAVATQLSESYYILRPEVVESYMYLWRQTHDPIYREWGWEVVMALEKHCRTEGGFSGIQDVYSSNPNHDNRQQSFFLAETLKYLYLLFSEDDVLSLEDWVFNTEAHPLPVNRSDSSSVAGHRH", "length": 625 }, "evidence": [ { "id": "45242014", "url": "http://www.informatics.jax.org/homology/45242014", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NR34-1", "protein_name": "Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC", "gene_name": "MAN1C1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLMRKVPGFVPASPWGLRLPQKFLFLLFLSGLVTLCFGALFLLPHSSRLKRLFLAPRTQQPGLEVVAEIAGHAPAREQEPPPNPAPAAPAPGEDDPSSWASPRRRKGGLRRTRPTGPREEATAARGNSIPASRPGDEGVPFRFDFNAFRSRLRHPVLGTRADESQEPQSQVRAQREKIKEMMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFGGLSGATVIDSLDTLYLMELKEEFQEAKAWVGESFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIKAIRLGEKLLPAFNTPTGIPKGVVSFKSGNWGWATAGSSSILAEFGSLHLEFLHLTELSGNQVFAEKVRNIRKVLRKIEKPFGLYPNFLSPVSGNWVQHHVSVGGLGDSFYEYLIKSWLMSGKTDMEAKNMYYEALEAIETYLLNVSPGGLTYIAEWRGGILDHKMGHLACFSGGMIALGAEDAKEEKRAHYRELAAQITKTCHESYARSDTKLGPEAFWFNSGREAVATQLSESYYILRPEVVESYMYLWRQTHNPIYREWGWEVVLALEKYCRTEAGFSGIQDVYSSTPNHDNKQQSFFLAETLKYLYLLFSEDDLLSLEDWVFNTEAHPLPVNHSDSSGRAWGRH", "length": 630 }, "evidence": [ { "id": "45242014", "url": "http://www.informatics.jax.org/homology/45242014", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q6NXK9", "url": "https://www.uniprot.org/uniprot/Q6NXK9" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q6NXK9", "url": "https://www.uniprot.org/uniprot/Q6NXK9" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q6NXK9", "url": "https://www.uniprot.org/uniprot/Q6NXK9" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q6NXK9", "url": "https://www.uniprot.org/uniprot/Q6NXK9" } ], "pmid": "" }, { "name": "mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "id": "GO:0004571", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004571", "evidence": [ { "database": "UniProtKB", "id": "Q6NXK9", "url": "https://www.uniprot.org/uniprot/Q6NXK9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mannose metabolic process", "id": "GO:0006013", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006013", "evidence": [ { "database": "UniProtKB", "id": "Q6NXK9", "url": "https://www.uniprot.org/uniprot/Q6NXK9" } ], "pmid": "" }, { "name": "mannose trimming involved in glycoprotein ERAD pathway", "id": "GO:1904382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904382", "evidence": [ { "database": "UniProtKB", "id": "Q6NXK9", "url": "https://www.uniprot.org/uniprot/Q6NXK9" } ], "pmid": "" }, { "name": "proteoglycan biosynthetic process", "id": "GO:0030166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030166", "evidence": [ { "database": "UniProtKB", "id": "Q6NXK9", "url": "https://www.uniprot.org/uniprot/Q6NXK9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 245, "end_pos": 247, "annotation": "n_glycosylation_sequon" }, { "start_pos": 422, "end_pos": 424, "annotation": "n_glycosylation_sequon" }, { "start_pos": 613, "end_pos": 615, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-MMU-964737", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [ "R-ALL-915149" ], "output_participant_list": [ "R-ALL-964752" ], "enzyme_list": [ "Q6NXK9-1", "P45700-1", "P39098-1" ], "evidence": [ { "id": "R-MMU-964737", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-964737" } ] }, { "id": "R-MMU-964825", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6NXK9-1", "P45700-1", "P39098-1" ], "evidence": [ { "id": "R-MMU-964825", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-964825" } ] }, { "id": "R-MMU-964830", "name": "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [ "R-ALL-964828" ], "output_participant_list": [], "enzyme_list": [ "Q6NXK9-1", "P45700-1", "P39098-1" ], "evidence": [ { "id": "R-MMU-964830", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-964830" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-915149", "participant_name": "(GlcNAc)2 (Man)9 [Golgi lumen]", "crossref": [ { "id": "59092", "database": "ChEBI", "url": "" }, { "id": "59092", "database": "ChEBI", "url": "" }, { "id": "59092", "database": "ChEBI", "url": "" }, { "id": "59092", "database": "ChEBI", "url": "" }, { "id": "59092", "database": "ChEBI", "url": "" }, { "id": "59092", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-964752", "participant_name": "Man [Golgi lumen]", "crossref": [ { "id": "4208", "database": "ChEBI", "url": "" }, { "id": "G70323CJ", "database": "GlyTouCan", "url": "" }, { "id": "C00159", "database": "COMPOUND", "url": "" }, { "id": "000003860903", "database": "ZINC", "url": "" }, { "id": "000003830679", "database": "ZINC", "url": "" }, { "id": "4650", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "4208", "database": "ChEBI", "url": "" }, { "id": "G70323CJ", "database": "GlyTouCan", "url": "" }, { "id": "C00159", "database": "COMPOUND", "url": "" }, { "id": "000003860903", "database": "ZINC", "url": "" }, { "id": "000003830679", "database": "ZINC", "url": "" }, { "id": "4650", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "4208", "database": "ChEBI", "url": "" }, { "id": "G70323CJ", "database": "GlyTouCan", "url": "" }, { "id": "C00159", "database": "COMPOUND", "url": "" }, { "id": "000003860903", "database": "ZINC", "url": "" }, { "id": "000003830679", "database": "ZINC", "url": "" }, { "id": "4650", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "4208", "database": "ChEBI", "url": "" }, { "id": "G70323CJ", "database": "GlyTouCan", "url": "" }, { "id": "C00159", "database": "COMPOUND", "url": "" }, { "id": "000003860903", "database": "ZINC", "url": "" }, { "id": "000003830679", "database": "ZINC", "url": "" }, { "id": "4650", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "C00159", "database": "COMPOUND", "url": "" }, { "id": "000003830679", "database": "ZINC", "url": "" }, { "id": "4650", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "000003860903", "database": "ZINC", "url": "" }, { "id": "4208", "database": "ChEBI", "url": "" }, { "id": "G70323CJ", "database": "GlyTouCan", "url": "" }, { "id": "4208", "database": "ChEBI", "url": "" }, { "id": "G70323CJ", "database": "GlyTouCan", "url": "" }, { "id": "C00159", "database": "COMPOUND", "url": "" }, { "id": "000003860903", "database": "ZINC", "url": "" }, { "id": "000003830679", "database": "ZINC", "url": "" }, { "id": "4650", "database": "Guide to Pharmacology - Ligands", "url": "" } ] }, { "participant_id": "R-ALL-964828", "participant_name": "(GlcNAc)2 (Man)7bc [Golgi lumen]", "crossref": [ { "id": "60637", "database": "ChEBI", "url": "" }, { "id": "60637", "database": "ChEBI", "url": "" }, { "id": "60637", "database": "ChEBI", "url": "" }, { "id": "60637", "database": "ChEBI", "url": "" }, { "id": "60637", "database": "ChEBI", "url": "" }, { "id": "60637", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "P39098", "gene_name": "Man1a2", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "P39098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39098" } ] }, { "ec_number": "3.2.1.113", "activity": "3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2).", "evidence": [ { "id": "P39098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39098" } ] }, { "ec_number": "3.2.1.113", "activity": "", "evidence": [ { "id": "P39098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39098" } ] } ] }, { "uniprot_ac": "P45700", "gene_name": "Man1a1", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "P45700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45700" } ] }, { "ec_number": "3.2.1.113", "activity": "3 H2O + N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) = 3 beta-D-mannose + N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2).", "evidence": [ { "id": "P45700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45700" } ] }, { "ec_number": "3.2.1.113", "activity": "", "evidence": [ { "id": "P45700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45700" } ] } ] }, { "uniprot_ac": "Q6NXK9", "gene_name": "Man1c1", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "Q6NXK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NXK9" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }