{ "uniprot_canonical_ac": "Q6NR09-1", "uniprot_ac": "Q6NR09", "uniprot_id": "EGRAP_DROME", "mass": { "chemical_mass": 46099.0, "monoisotopic_mass": 46099.0 }, "refseq": { "ac": "NP_001163352", "name": "EGFR adaptor protein, isoform B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163352" }, "gene_names": [ { "name": "Egfrap", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q6NR09", "id": "Q6NR09" }, { "name": "CG13289; CG13290; CG33993; Dmel\\CG33993; EGFRAP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163352", "id": "NP_001163352" }, { "name": "CG33993", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q6NR09", "id": "Q6NR09" }, { "name": "Egfrap", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163352", "id": "NP_001163352" } ], "protein_names": [ { "name": "EGFR adapter protein", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q6NR09" }, { "name": "CG33993-PB; Egfrap-PB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163352", "id": "NP_001163352" }, { "name": "EGFR adaptor protein, isoform B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163352", "id": "NP_001163352" } ], "function": [ { "annotation": "Involved in the negative regulation of the Egfr/Ras signaling pathway (PubMed:34411095). During wing morphogenesis, may function redundantly with PVRAP to inhibit Egfr activity and prevent uncontrolled cell growth (PubMed:34411095).", "evidence": [ { "database": "UniProtKB", "id": "Q6NR09", "url": "https://www.uniprot.org/uniprot/Q6NR09#function" }, { "database": "PubMed", "id": "34411095", "url": "https://glygen.org/publication/PubMed/34411095" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q6NR09", "url": "https://www.uniprot.org/uniprot/Q6NR09" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "Egfrap", "url": "https://www.uniprot.org/uniprot/Q6NR09", "locus": { "chromosome": "3L", "start_pos": 5933036, "end_pos": 5950658, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0053993", "url": "https://www.ensembl.org/id/FBgn0053993" } ] } } ], "crossref": [ { "id": "FBgn0053993", "url": "https://bgee.org/?page=gene&gene_id=FBgn0053993", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00173", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00173", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "FBgn0053993", "url": "https://flybase.org/reports/FBgn0053993", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "3885637", "url": "https://www.ncbi.nlm.nih.gov/gene/3885637", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q6NR09", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q6NR09*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000980", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000980", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036860", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036860", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG33993", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG33993", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q6NR09", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q6NR09", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "AMQDIRL", "url": "https://omabrowser.org/oma/group/AMQDIRL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3681543at2759", "url": "http://www.orthodb.org/?query=3681543at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45734", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45734", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45734:SF7", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45734:SF7", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00017", "url": "http://pfam.xfam.org/family/PF00017", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q6NR09", "url": "http://purl.obolibrary.org/obo/PR_Q6NR09", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001163352", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163352", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q6NR09", "url": "https://www.uniprot.org/uniprot/Q6NR09", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6NR09-1", "url": "https://www.uniprot.org/uniprot/Q6NR09-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6NR09-2", "url": "https://www.uniprot.org/uniprot/Q6NR09-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MIMQDIRLRLEPQHSKATFISSSSASSSSSQTAETTLIETAEKSPASEAAAGTVTTTSPQHFFHHHHPPAHPHPPRQQPHPHSHSHPHPHPQLQRRPVEQLHLLHSHHDVQELSGQEHPHPQPGSHPHPHHLRSPSSEEDNSPTEMNNCRRLVDKPPLVKRLTMGIGLLRGTEDSRPLMHSTCGSSLTSGSGCGSTQTISDGYVNEAICEPDKYVASKFGDSCRQSLSALESATQRLQVELPAASKKYLRETCSANSSPKLFPGHSALRLDNLSLAEQQELKGAAWFQAGIPREISLEALSRQSPGAFLVRQSSTKPGCFALSLRVPPPSPRVAHYLILRTQRGYKIKGFTKEFSSLKALITHHSVMPELLPVPLTLPRPPSTRSQRSQGAYAGGTGNGGADFEMYGSLNDFRKMMADLNV", "length": 421, "header": "sp|Q6NR09-1|EGRAP_DROME Isoform 1 of EGFR adapter protein OS=Drosophila melanogaster OX=7227 GN=Egfrap PE=1 SV=1 CANONICAL=Q6NR09-1" }, "isoforms": [ { "isoform_ac": "Q6NR09-1", "url": "", "sequence": { "sequence": "MIMQDIRLRLEPQHSKATFISSSSASSSSSQTAETTLIETAEKSPASEAAAGTVTTTSPQHFFHHHHPPAHPHPPRQQPHPHSHSHPHPHPQLQRRPVEQLHLLHSHHDVQELSGQEHPHPQPGSHPHPHHLRSPSSEEDNSPTEMNNCRRLVDKPPLVKRLTMGIGLLRGTEDSRPLMHSTCGSSLTSGSGCGSTQTISDGYVNEAICEPDKYVASKFGDSCRQSLSALESATQRLQVELPAASKKYLRETCSANSSPKLFPGHSALRLDNLSLAEQQELKGAAWFQAGIPREISLEALSRQSPGAFLVRQSSTKPGCFALSLRVPPPSPRVAHYLILRTQRGYKIKGFTKEFSSLKALITHHSVMPELLPVPLTLPRPPSTRSQRSQGAYAGGTGNGGADFEMYGSLNDFRKMMADLNV", "length": 421, "header": "sp|Q6NR09-1|EGRAP_DROME Isoform 1 of EGFR adapter protein OS=Drosophila melanogaster OX=7227 GN=Egfrap PE=1 SV=1 CANONICAL=Q6NR09-1" }, "locus": { "chromosome": "3L", "start_pos": 5937968, "end_pos": 5933773, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0100046", "url": "https://www.ensembl.org/id/FBtr0100046" }, { "database": "Ensembl Peptide", "id": "FBpp0099403", "url": "https://www.ensembl.org/id/FBpp0099403" } ] } }, { "isoform_ac": "Q6NR09-2", "url": "", "sequence": { "sequence": "MGIGLLRGTEDSRPLMHSTCGSSLTSGSGCGSTQTISDGYVNEAICEPDKYVASKFGDSCRQSLSALESATQRLQVELPAASKKYLRETCSANSSPKLFPGHSALRLDNLSLAEQQELKGAAWFQAGIPREISLEALSRQSPGAFLVRQSSTKPGCFALSLRVPPPSPRVAHYLILRTQRGYKIKGFTKEFSSLKALITHHSVMPELLPVPLTLPRPPSTRSQRSQGAYAGGTGNGGADFEMYGSLNDFRKMMADLNV", "length": 258, "header": "sp|Q6NR09-2|EGRAP_DROME Isoform 2 of EGFR adapter protein OS=Drosophila melanogaster OX=7227 GN=Egfrap PE=1 SV=1 CANONICAL=Q6NR09-1" }, "locus": { "chromosome": "3L", "start_pos": 5934678, "end_pos": 5933773, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0301034", "url": "https://www.ensembl.org/id/FBtr0301034" }, { "database": "Ensembl Peptide", "id": "FBpp0290256", "url": "https://www.ensembl.org/id/FBpp0290256" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q6NR09", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q6NR09" }, { "id": "28604694", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28604694" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "Q6NR09", "url": "https://www.uniprot.org/uniprot/Q6NR09" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "Q6NR09", "url": "https://www.uniprot.org/uniprot/Q6NR09" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "A mutant O-GlcNAcase enriches Drosophila developmental regulators.", "journal": "Nature chemical biology", "date": "2017", "authors": "Selvan N, Williamson R, Mariappa D, Campbell DG, Gourlay R, Ferenbach AT, Aristotelous T, Hopkins-Navratilova I, Trost M, van Aalten DMF", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q6NR09", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q6NR09" } ], "reference": [ { "type": "PubMed", "id": "28604694", "url": "https://glygen.org/publication/PubMed/28604694" } ] }, { "title": "EGFRAP encodes a new negative regulator of the EGFR acting in both normal and oncogenic EGFR/Ras-driven tissue morphogenesis.", "journal": "PLoS Genet.", "date": "2021", "authors": "Soler Beatty J, Molnar C, Luque CM, de Celis JF, Martin-Bermudo MD", "evidence": [ { "database": "UniProtKB", "id": "Q6NR09", "url": "https://www.uniprot.org/uniprot/Q6NR09" } ], "reference": [ { "type": "PubMed", "id": "34411095", "url": "https://glygen.org/publication/PubMed/34411095" } ] } ], "pathway": [ { "id": "dme:Dmel_CG33993", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG33993", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "apical cortex", "id": "GO:0045179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045179", "evidence": [ { "database": "UniProtKB", "id": "Q6NR09", "url": "https://www.uniprot.org/uniprot/Q6NR09" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "Q6NR09", "url": "https://www.uniprot.org/uniprot/Q6NR09" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "receptor tyrosine kinase binding", "id": "GO:0030971", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030971", "evidence": [ { "database": "UniProtKB", "id": "Q6NR09", "url": "https://www.uniprot.org/uniprot/Q6NR09" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "negative regulation of epidermal growth factor receptor signaling pathway", "id": "GO:0042059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042059", "evidence": [ { "database": "UniProtKB", "id": "Q6NR09", "url": "https://www.uniprot.org/uniprot/Q6NR09" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 256, "end_pos": 258, "annotation": "n_glycosylation_sequon" }, { "start_pos": 272, "end_pos": 274, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }