{
    "uniprot_canonical_ac": "Q6E0V2-1",
    "uniprot_ac": "Q6E0V2",
    "uniprot_id": "KTNA1_RAT",
    "mass": {
        "chemical_mass": 55844.0,
        "monoisotopic_mass": 55844.0
    },
    "refseq": {
        "ac": "NP_001004217",
        "name": "katanin p60 ATPase-containing subunit A1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004217"
    },
    "gene_names": [
        {
            "name": "Katna1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q6E0V2",
            "id": "Q6E0V2"
        },
        {
            "name": "KATNA1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q6E0V2",
            "id": "Q6E0V2"
        },
        {
            "name": "Katna1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004217",
            "id": "NP_001004217"
        }
    ],
    "protein_names": [
        {
            "name": "Katanin p60 ATPase-containing subunit A1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q6E0V2"
        },
        {
            "name": "5.6.1.1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q6E0V2"
        },
        {
            "name": "Katanin p60 subunit A1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q6E0V2"
        },
        {
            "name": "katanin p60 ATPase-containing subunit A1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004217",
            "id": "NP_001004217"
        },
        {
            "name": "microtubule severing protein; katanin p60 subunit A 1; p60 katanin; katanin p60 subunit A1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004217",
            "id": "NP_001004217"
        },
        {
            "name": "p60 katanin",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q6E0V2"
        }
    ],
    "function": [
        {
            "annotation": "Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Z4YNM2",
                    "url": "https://www.uniprot.org/uniprot/Z4YNM2#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "MF_03023",
                    "url": "https://www.uniprot.org/uniprot/MF_03023#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A8I6GK45",
                    "url": "https://www.uniprot.org/uniprot/A0A8I6GK45#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q6E0V2",
                    "url": "https://www.uniprot.org/uniprot/Q6E0V2#function"
                },
                {
                    "database": "PubMed",
                    "id": "10209026",
                    "url": "https://glygen.org/publication/PubMed/10209026"
                },
                {
                    "database": "PubMed",
                    "id": "15215300",
                    "url": "https://glygen.org/publication/PubMed/15215300"
                }
            ]
        },
        {
            "annotation": "Katanin p60 contributes to microtubule instability around the midbody and facilitates cytokinesis in rat cells. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001004217",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004217"
                },
                {
                    "database": "PubMed",
                    "id": "24303010",
                    "url": "https://glygen.org/publication/PubMed/24303010"
                }
            ]
        },
        {
            "annotation": "RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001004217",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004217"
                },
                {
                    "database": "PubMed",
                    "id": "31963385",
                    "url": "https://glygen.org/publication/PubMed/31963385"
                }
            ]
        },
        {
            "annotation": "The ratio of P60 to P80 varies markedly in different tissues, at different phases of development, and regionally within the neuron. Suggested that the effects on neuronal morphology are dependent on the degree of microtubule severing and loss of polymer",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001004217",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004217"
                },
                {
                    "database": "PubMed",
                    "id": "15944385",
                    "url": "https://glygen.org/publication/PubMed/15944385"
                }
            ]
        },
        {
            "annotation": "WDR47 protects neuronal microtubule minus ends from katanin-mediated severing.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001004217",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004217"
                },
                {
                    "database": "PubMed",
                    "id": "34260930",
                    "url": "https://glygen.org/publication/PubMed/34260930"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [
        {
            "start_pos": 255,
            "end_pos": 255,
            "sequence_org": "K",
            "sequence_mut": "A",
            "comment": "Abolishes ATPase activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6E0V2",
                    "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                },
                {
                    "database": "PubMed",
                    "id": "15215300",
                    "url": "https://glygen.org/publication/PubMed/15215300"
                }
            ]
        }
    ],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6E0V2",
                    "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Katna1",
            "url": "https://www.uniprot.org/uniprot/Q6E0V2",
            "locus": {
                "chromosome": "1",
                "start_pos": 2244131,
                "end_pos": 2202490,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000014996",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000014996"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000014996",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000014996",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "5.6.1.1",
            "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=5.6.1.1&UniProtAcc=Q6E0V2",
            "database": "BRENDA",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "cd19522",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19522",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd21748",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21748",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "292464",
            "url": "https://www.ncbi.nlm.nih.gov/gene/292464",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR003593",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR003959",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003959",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR003960",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003960",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR015415",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR015415",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR027417",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR028596",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR028596",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR041569",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041569",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:292464",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:292464",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "PRDEMHM",
            "url": "https://omabrowser.org/oma/group/PRDEMHM/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "276256at2759",
            "url": "http://www.orthodb.org/?query=276256at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23074",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23074",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23074:SF71",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23074:SF71",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00004",
            "url": "http://pfam.xfam.org/family/PF00004",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF09336",
            "url": "http://pfam.xfam.org/family/PF09336",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF17862",
            "url": "http://pfam.xfam.org/family/PF17862",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q6E0V2",
            "url": "http://purl.obolibrary.org/obo/PR_Q6E0V2",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001004217",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004217",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1303062",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1303062",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A8I6GK45",
            "url": "https://www.uniprot.org/uniprot/A0A8I6GK45",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6GK45-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6GK45-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q6E0V2",
            "url": "https://www.uniprot.org/uniprot/Q6E0V2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q6E0V2-1",
            "url": "https://www.uniprot.org/uniprot/Q6E0V2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Z4YNM2",
            "url": "https://www.uniprot.org/uniprot/Z4YNM2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Z4YNM2-1",
            "url": "https://www.uniprot.org/uniprot/Z4YNM2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MSLLMITENVKLAREYALLGNYDSAMVYYQGVLDQINKYLYSVKDTHLHQKWQQVWQEINVEAKHVKEIMKTLESFKLDSTSLKAAQHELPSSEGEVWSLPVPVERRPLPGPRKRQSTQHSDPKPHSNRPGAVVRAHRPSAQSLHSDRGKAVRSREKKEQSKGREEKNKLPAAVTEPEANKFDSTGYDKDLVEALERDIISQNPNVRWYDIADLVEAKKLLQEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVNLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSREEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIVEFGSC",
        "length": 491,
        "header": "sp|Q6E0V2-1|KTNA1_RAT Isoform 1 of Katanin p60 ATPase-containing subunit A1  OS=Rattus norvegicus OX=10116 GN=Katna1 PE=1 SV=1 CANONICAL=Q6E0V2-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8I6GK45-1",
            "url": "",
            "sequence": {
                "sequence": "MYNTKMSLVSSFLSLRMSMSLLMITENVKLAREYALLGNYDSAMVYYQGVLDQINKYLYSVKDTHLHQKWQQVWQEINVEAKHVKEIMKTLESFKLDSTSLKAAQHELPSSEGEVWSLPVPVERRPLPGPRKRQSTQHSDPKPHSNRPGAVVRAHRPSAQSLHSDRGKAVRSREKKEQSKGREEKNKLPAAVTEPEANKFDSTGYDKDLVEALERDIISQNPNVRWYDIADLVEAKKLLQEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVNLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSREEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIVEFGSC",
                "length": 509,
                "header": "tr|A0A8I6GK45-1|A0A8I6GK45_RAT Computationally mapped isoform of Katanin p60 ATPase-containing subunit A1  OS=Rattus norvegicus OX=10116 GN=Katna1 PE=3 SV=1 CANONICAL=Q6E0V2-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 2243966,
                "end_pos": 2217743,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000099868.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000099868.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000092318.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000092318.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q6E0V2-1",
            "url": "",
            "sequence": {
                "sequence": "MSLLMITENVKLAREYALLGNYDSAMVYYQGVLDQINKYLYSVKDTHLHQKWQQVWQEINVEAKHVKEIMKTLESFKLDSTSLKAAQHELPSSEGEVWSLPVPVERRPLPGPRKRQSTQHSDPKPHSNRPGAVVRAHRPSAQSLHSDRGKAVRSREKKEQSKGREEKNKLPAAVTEPEANKFDSTGYDKDLVEALERDIISQNPNVRWYDIADLVEAKKLLQEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVNLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSREEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIVEFGSC",
                "length": 491,
                "header": "sp|Q6E0V2-1|KTNA1_RAT Isoform 1 of Katanin p60 ATPase-containing subunit A1  OS=Rattus norvegicus OX=10116 GN=Katna1 PE=1 SV=1 CANONICAL=Q6E0V2-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "Z4YNM2-1",
            "url": "",
            "sequence": {
                "sequence": "MSMSLLMITENVKLAREYALLGNYDSAMVYYQGVLDQINKYLYSVKDTHLHQKWQQVWQEINVEAKHVKEIMKTLESFKLDSTSLKAAQHELPSSEGEVWSLPVPVERRPLPGPRKRQSTQHSDPKPHSNRPGAVVRAHRPSAQSLHSDRGKAVRSREKKEQSKGREEKNKLPAAVTEPEANKFDSTGYDKDLVEALERDIISQNPNVRWYDIADLVEAKKLLQEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVNLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSREEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIVEFGSC",
                "length": 493,
                "header": "tr|Z4YNM2-1|Z4YNM2_RAT Computationally mapped isoform of Katanin p60 ATPase-containing subunit A1  OS=Rattus norvegicus OX=10116 GN=Katna1 PE=3 SV=1 CANONICAL=Q6E0V2-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 2243966,
                "end_pos": 2217791,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000020417.7",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000020417.7"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000020417.4",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000020417.4"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 42,
            "end_pos": 42,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine; by DYRK2",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6E0V2",
                    "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                }
            ],
            "site_lbl": "Ser42"
        }
    ],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "An essential role for katanin in severing microtubules in the neuron.",
            "journal": "J. Cell Biol.",
            "date": "1999",
            "authors": "Ahmad FJ, Yu W, McNally FJ, Baas PW",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6E0V2",
                    "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10209026",
                    "url": "https://glygen.org/publication/PubMed/10209026"
                }
            ]
        },
        {
            "title": "Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules.",
            "journal": "J. Neurosci.",
            "date": "2004",
            "authors": "Karabay A, Yu W, Solowska JM, Baird DH, Baas PW",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6E0V2",
                    "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15215300",
                    "url": "https://glygen.org/publication/PubMed/15215300"
                }
            ]
        },
        {
            "title": "Regulation of microtubule severing by katanin subunits during neuronal development.",
            "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience",
            "date": "2005",
            "authors": "Yu W, Solowska JM, Qiang L, Karabay A, Baird D, Baas PW",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001004217",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004217"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "15944385",
                    "url": "https://glygen.org/publication/PubMed/15944385"
                }
            ]
        },
        {
            "title": "Katanin p60 contributes to microtubule instability around the midbody and facilitates cytokinesis in rat cells.",
            "journal": "PloS one",
            "date": "2013",
            "authors": "Matsuo M, Shimodaira T, Kasama T, Hata Y, Echigo A, Okabe M, Arai K, Makino Y, Niwa S, Saya H, Kishimoto T",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001004217",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004217"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "24303010",
                    "url": "https://glygen.org/publication/PubMed/24303010"
                }
            ]
        },
        {
            "title": "RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin.",
            "journal": "Cells",
            "date": "2020",
            "authors": "Tan D, Zhang H, Deng J, Liu J, Wen J, Li L, Wang X, Pan M, Hu X, Guo J",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001004217",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004217"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31963385",
                    "url": "https://glygen.org/publication/PubMed/31963385"
                }
            ]
        },
        {
            "title": "WDR47 protects neuronal microtubule minus ends from katanin-mediated severing.",
            "journal": "Cell reports",
            "date": "2021",
            "authors": "Buijs RR, Hummel JJA, Burute M, Pan X, Cao Y, Stucchi R, Altelaar M, Akhmanova A, Kapitein LC, Hoogenraad CC",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_001004217",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004217"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "34260930",
                    "url": "https://glygen.org/publication/PubMed/34260930"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:292464",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:292464",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "O75449-1",
            "protein_name": "Katanin p60 ATPase-containing subunit A1",
            "gene_name": "KATNA1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFGSC",
                "length": 491
            },
            "evidence": [
                {
                    "id": "45233814",
                    "url": "http://www.informatics.jax.org/homology/45233814",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9WV86-1",
            "protein_name": "Katanin p60 ATPase-containing subunit A1",
            "gene_name": "Katna1",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MSLQMIVENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTHLRQKWQQVWQEINVEAKQVKDIMKTLESFKLDITSLQAAQHELPAAEGEVWSLPVPVERRPLPGPRKRQSSQHSDPKPHSNRPSTVVRAHRPSPQNLHNDRGKAVRSREKKEQSKGREEKNKLPAAVTEPEANKFDGTGYDKDLVEALERDIISQNPNVRWYDIADLVEAKKLLQEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRMKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVNLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSREAMHMPTTMEDFEMALKKISKSVSAADIERYEKWIVEFGSC",
                "length": 491
            },
            "evidence": [
                {
                    "id": "45233814",
                    "url": "http://www.informatics.jax.org/homology/45233814",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 7,
                "go_terms": [
                    {
                        "name": "microtubule severing ATPase activity",
                        "id": "GO:0008568",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008568",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ATP binding",
                        "id": "GO:0005524",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "microtubule binding",
                        "id": "GO:0008017",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008017",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein heterodimerization activity",
                        "id": "GO:0046982",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046982",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ATP hydrolysis activity",
                        "id": "GO:0016887",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "isomerase activity",
                        "id": "GO:0016853",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016853",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "dynein complex binding",
                        "id": "GO:0070840",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070840",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 8,
                "go_terms": [
                    {
                        "name": "microtubule severing",
                        "id": "GO:0051013",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051013",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cell division",
                        "id": "GO:0051301",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cell cycle",
                        "id": "GO:0007049",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007049",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasmic microtubule organization",
                        "id": "GO:0031122",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031122",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "neuron migration",
                        "id": "GO:0001764",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001764",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "negative regulation of neuron projection development",
                        "id": "GO:0010977",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010977",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein localization",
                        "id": "GO:0008104",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "microtubule bundle formation",
                        "id": "GO:0001578",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001578",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 16,
                "go_terms": [
                    {
                        "name": "katanin complex",
                        "id": "GO:0008352",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008352",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasm",
                        "id": "GO:0005737",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "centrosome",
                        "id": "GO:0005813",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "microtubule",
                        "id": "GO:0005874",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "midbody",
                        "id": "GO:0030496",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030496",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitotic spindle pole",
                        "id": "GO:0097431",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097431",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "spindle pole",
                        "id": "GO:0000922",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "lipid droplet",
                        "id": "GO:0005811",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005811",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "spindle",
                        "id": "GO:0005819",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "axon",
                        "id": "GO:0030424",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "growth cone",
                        "id": "GO:0030426",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "neuronal cell body",
                        "id": "GO:0043025",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "microtubule cytoskeleton",
                        "id": "GO:0015630",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Cul3-RING ubiquitin ligase complex",
                        "id": "GO:0031463",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6E0V2",
                                "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 272,
            "end_pos": 274,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 447,
            "end_pos": 449,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [
        {
            "annotation": "Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A8I6GK45",
                    "url": "https://www.uniprot.org/uniprot/A0A8I6GK45"
                },
                {
                    "database": "PubMed",
                    "id": "MF_03023",
                    "url": "https://glygen.org/publication/PubMed/MF_03023"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q6E0V2",
                    "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                },
                {
                    "database": "UniProtKB",
                    "id": "Z4YNM2",
                    "url": "https://www.uniprot.org/uniprot/Z4YNM2"
                }
            ]
        },
        {
            "annotation": "Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A8I6GK45",
                    "url": "https://www.uniprot.org/uniprot/A0A8I6GK45"
                },
                {
                    "database": "PubMed",
                    "id": "MF_03023",
                    "url": "https://glygen.org/publication/PubMed/MF_03023"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q6E0V2",
                    "url": "https://www.uniprot.org/uniprot/Q6E0V2"
                },
                {
                    "database": "UniProtKB",
                    "id": "Z4YNM2",
                    "url": "https://www.uniprot.org/uniprot/Z4YNM2"
                }
            ]
        }
    ],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
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                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
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                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
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                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
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                    "field": "total",
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                },
                {
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                },
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                },
                {
                    "field": "n_linked_glycan_sites",
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                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
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                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported_with_glycan",
            "table_stats": [
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                },
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                {
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                },
                {
                    "field": "n_linked_glycan_sites",
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                },
                {
                    "field": "o_linked_glycans",
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                },
                {
                    "field": "o_linked_glycan_sites",
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            ],
            "sort_fields": []
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        {
            "table_id": "glycosylation_predicted",
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                {
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                {
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                },
                {
                    "field": "o_linked_glycans",
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                },
                {
                    "field": "o_linked_glycan_sites",
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            ],
            "sort_fields": []
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        {
            "table_id": "glycosylation_automatic_literature_mining",
            "table_stats": [
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                    "field": "total",
                    "count": 0
                },
                {
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                },
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                },
                {
                    "field": "n_linked_glycan_sites",
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                },
                {
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