{
    "uniprot_canonical_ac": "Q6DID7-1",
    "uniprot_ac": "Q6DID7",
    "uniprot_id": "WLS_MOUSE",
    "mass": {
        "chemical_mass": 62188.0,
        "monoisotopic_mass": 62188.0
    },
    "refseq": {
        "ac": "NP_080858",
        "name": "protein wntless homolog isoform 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080858"
    },
    "gene_names": [
        {
            "name": "Wls",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q6DID7",
            "id": "Q6DID7"
        },
        {
            "name": "5031439A09Rik; EVI; Gpr177",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080858",
            "id": "NP_080858"
        },
        {
            "name": "Gpr177",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q6DID7",
            "id": "Q6DID7"
        },
        {
            "name": "Wls",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080858",
            "id": "NP_080858"
        }
    ],
    "protein_names": [
        {
            "name": "Protein wntless homolog",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q6DID7"
        },
        {
            "name": "EVI",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q6DID7"
        },
        {
            "name": "Integral membrane protein GPR177",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q6DID7"
        },
        {
            "name": "Protein evenness interrupted homolog",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q6DID7"
        },
        {
            "name": "integral membrane protein GPR177; protein evenness interrupted homolog; G protein-coupled receptor 177; wntless homolog",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080858",
            "id": "NP_080858"
        },
        {
            "name": "protein wntless homolog isoform 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080858",
            "id": "NP_080858"
        }
    ],
    "function": [
        {
            "annotation": "A reciprocal regulation of Wnt and Gpr177 is essential for the patterning of the anterior-posterior axis during mammalian development.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080858",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080858"
                },
                {
                    "database": "PubMed",
                    "id": "19841259",
                    "url": "https://glygen.org/publication/PubMed/19841259"
                }
            ]
        },
        {
            "annotation": "Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Also plays an important role in establishment of the anterior-posterior body axis formation during development.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6DID7",
                    "url": "https://www.uniprot.org/uniprot/Q6DID7#function"
                },
                {
                    "database": "PubMed",
                    "id": "19841259",
                    "url": "https://glygen.org/publication/PubMed/19841259"
                }
            ]
        },
        {
            "annotation": "These findings suggest a previously unrecognized role for GPR177 in regulating cellular response to opioid agonist drugs, and could create new avenues of investigation regarding the pharmacotherapy of drug dependence. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080858",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080858"
                },
                {
                    "database": "PubMed",
                    "id": "20214800",
                    "url": "https://glygen.org/publication/PubMed/20214800"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [
        {
            "start_pos": 392,
            "end_pos": 392,
            "sequence_org": "Y",
            "sequence_mut": "C",
            "comment": "Knockin mice have several structural anomalies recapitulating the major defects observed in patients with Zaki syndrome.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6DID7",
                    "url": "https://www.uniprot.org/uniprot/Q6DID7"
                },
                {
                    "database": "PubMed",
                    "id": "34587386",
                    "url": "https://glygen.org/publication/PubMed/34587386"
                }
            ]
        },
        {
            "start_pos": 478,
            "end_pos": 478,
            "sequence_org": "Y",
            "sequence_mut": "C",
            "comment": "Knockin mice have several structural anomalies recapitulating the major defects observed in patients with Zaki syndrome.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6DID7",
                    "url": "https://www.uniprot.org/uniprot/Q6DID7"
                },
                {
                    "database": "PubMed",
                    "id": "34587386",
                    "url": "https://glygen.org/publication/PubMed/34587386"
                }
            ]
        }
    ],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6DID7",
                    "url": "https://www.uniprot.org/uniprot/Q6DID7"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Wls",
            "url": "https://www.uniprot.org/uniprot/Q6DID7",
            "locus": {
                "chromosome": "3",
                "start_pos": 159644300,
                "end_pos": 159545309,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000028173",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000028173"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000028173",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000028173",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "68151",
            "url": "https://www.ncbi.nlm.nih.gov/gene/68151",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q6DID7",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q6DID7*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR009551",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009551",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:68151",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68151",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1915401",
            "url": "http://www.informatics.jax.org/marker/MGI:1915401",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "EGQWKWD",
            "url": "https://omabrowser.org/oma/group/EGQWKWD/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3016042at2759",
            "url": "http://www.orthodb.org/?query=3016042at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13449",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13449",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13449:SF2",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13449:SF2",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF06664",
            "url": "http://pfam.xfam.org/family/PF06664",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q6DID7",
            "url": "http://purl.obolibrary.org/obo/PR_Q6DID7",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-3238698",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3238698",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_080858",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080858",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2JEH4",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JEH4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0G2JEH4-1",
            "url": "https://www.uniprot.org/uniprot/A0A0G2JEH4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q6DID7",
            "url": "https://www.uniprot.org/uniprot/Q6DID7",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q6DID7-1",
            "url": "https://www.uniprot.org/uniprot/Q6DID7-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q6DID7-2",
            "url": "https://www.uniprot.org/uniprot/Q6DID7-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAGAIIENMSTKKLCIVGGILLVFQIVAFLVGGLIAPAPTTAVPYTAIKCVDVRKNHHKTRWLAPWGPNKCDKIRDIEEAIPREIEANDIVFSVHIPLPSMEMSPWFQFMLFILQLDIAFKLNNQIRENAEISMDVSLGYRDDMFSEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYNCDVLPFMEIGSVAHKYYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDVGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVSEGHWKWGGVTVQVSSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDLGVHSGEELQLTTTITHVDGPTEIYKLTRKEAQE",
        "length": 541,
        "header": "sp|Q6DID7-1|WLS_MOUSE Isoform 1 of Protein wntless homolog  OS=Mus musculus OX=10090 GN=Wls PE=1 SV=1 CANONICAL=Q6DID7-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0G2JEH4-1",
            "url": "",
            "sequence": {
                "sequence": "MAGAIIENMSTKKLCIVGGILLVFQIVAFLVGGLIGG",
                "length": 37,
                "header": "tr|A0A0G2JEH4-1|A0A0G2JEH4_MOUSE Computationally mapped isoform of Wntless WNT ligand secretion mediator  OS=Mus musculus OX=10090 GN=Wls PE=1 SV=1 CANONICAL=Q6DID7-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 159554206,
                "end_pos": 159545579,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000200191.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000200191.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000142774.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000142774.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q6DID7-1",
            "url": "",
            "sequence": {
                "sequence": "MAGAIIENMSTKKLCIVGGILLVFQIVAFLVGGLIAPAPTTAVPYTAIKCVDVRKNHHKTRWLAPWGPNKCDKIRDIEEAIPREIEANDIVFSVHIPLPSMEMSPWFQFMLFILQLDIAFKLNNQIRENAEISMDVSLGYRDDMFSEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYNCDVLPFMEIGSVAHKYYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDVGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVSEGHWKWGGVTVQVSSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDLGVHSGEELQLTTTITHVDGPTEIYKLTRKEAQE",
                "length": 541,
                "header": "sp|Q6DID7-1|WLS_MOUSE Isoform 1 of Protein wntless homolog  OS=Mus musculus OX=10090 GN=Wls PE=1 SV=1 CANONICAL=Q6DID7-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 159639993,
                "end_pos": 159545579,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000198878",
                        "url": "https://www.ensembl.org/id/ENSMUST00000198878"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000143475",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000143475"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q6DID7-2",
            "url": "",
            "sequence": {
                "sequence": "MEMSPWFQFMLFILQLDIAFKLNNQIRENAEISMDVSLGYRDDMFSEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYNCDVLPFMEIGSVAHKYYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDVGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVSEGHWKWGGVTVQVSSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDLGVHSGEELQLTTTITHVDGPTEIYKLTRKEAQE",
                "length": 441,
                "header": "sp|Q6DID7-2|WLS_MOUSE Isoform 2 of Protein wntless homolog  OS=Mus musculus OX=10090 GN=Wls PE=1 SV=1 CANONICAL=Q6DID7-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation.",
            "journal": "Proc. Natl. Acad. Sci. U.S.A.",
            "date": "2009",
            "authors": "Fu J, Jiang M, Mirando AJ, Yu HM, Hsu W",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6DID7",
                    "url": "https://www.uniprot.org/uniprot/Q6DID7"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_080858",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080858"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "19841259",
                    "url": "https://glygen.org/publication/PubMed/19841259"
                }
            ]
        },
        {
            "title": "Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence.",
            "journal": "BMC neuroscience",
            "date": "2010",
            "authors": "Jin J, Kittanakom S, Wong V, Reyes BA, Van Bockstaele EJ, Stagljar I, Berrettini W, Levenson R",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080858",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080858"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20214800",
                    "url": "https://glygen.org/publication/PubMed/20214800"
                }
            ]
        },
        {
            "title": "Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cells.",
            "journal": "Dev. Dyn.",
            "date": "2010",
            "authors": "Jin J, Morse M, Frey C, Petko J, Levenson R",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6DID7",
                    "url": "https://www.uniprot.org/uniprot/Q6DID7"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "20652957",
                    "url": "https://glygen.org/publication/PubMed/20652957"
                }
            ]
        },
        {
            "title": "A human pleiotropic multiorgan condition caused by deficient Wnt secretion.",
            "journal": "N. Engl. J. Med.",
            "date": "2021",
            "authors": "Chai G, Szenker-Ravi E, Chung C, Li Z, Wang L, Khatoo M, Marshall T, Jiang N, Yang X, McEvoy-Venneri J, Stanley V, Anzenberg P, Lang N, Wazny V, Yu J, Virshup DM, Nygaard R, Mancia F, Merdzanic R, Toralles MBP, Pitanga PML, Puri RD, Hernan R, Chung WK, Bertoli-Avella AM, Al-Sannaa N, Zaki MS, Willert K, Reversade B, Gleeson JG",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q6DID7",
                    "url": "https://www.uniprot.org/uniprot/Q6DID7"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "34587386",
                    "url": "https://glygen.org/publication/PubMed/34587386"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:68151",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68151",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-3238698",
            "name": "WNT ligand biogenesis and trafficking",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3238698",
            "resource": "Reactome",
            "description": "WNT ligand biogenesis and trafficking"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q5T9L3-1",
            "protein_name": "Protein wntless homolog",
            "gene_name": "WLS",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAGAIIENMSTKKLCIVGGILLVFQIIAFLVGGLIAPGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDLGVHSGEELQLTTTITHVDGPTEIYKLTRKEAQE",
                "length": 541
            },
            "evidence": [
                {
                    "id": "45232398",
                    "url": "http://www.informatics.jax.org/homology/45232398",
                    "database": "MGI"
                },
                {
                    "id": "Q6DID7",
                    "url": "https://omabrowser.org/oma/group/Q6DID7/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q6P689-1",
            "protein_name": "Protein wntless homolog",
            "gene_name": "Wls",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MAGAIIENMSTKKLCIVGGILLVFQIVAFLVGGLIAPAPTTAVSYVAAKCVDVRKNHHKTRWLMPWGPNKCNKINDFEEAIPREIEANDIVFSVHIPLPSMEMSPWFQFMLFILQIDIAFKLNNQIRENAEVSMDVSLGYRDDMFSEWTEMAHERVPRKLRCTFTSPKTPEHEGRHYECDVLPFMEIGSVAHKYYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDVGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVSSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDLGVHSGEELQLTTTITHVDGPTEIYKLTRKEAQE",
                "length": 541
            },
            "evidence": [
                {
                    "id": "45232398",
                    "url": "http://www.informatics.jax.org/homology/45232398",
                    "database": "MGI"
                },
                {
                    "id": "Q6DID7",
                    "url": "https://omabrowser.org/oma/group/Q6DID7/",
                    "database": "OMA"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q95ST2-1",
            "protein_name": "Protein wntless",
            "gene_name": "wls",
            "tax_id": 7227,
            "organism": "Drosophila melanogaster",
            "sequence": {
                "sequence": "MSGTILENLSGRKLSILVATLLLCQVLCFLLGGLYAPLPAGHVTVLGSLCREDHARQNDTSFLLYSRGAGACIPVTREEVEQDSTKMANELVHVFQMPLPRDLRDLDYSRWQQNLIGVLQVEFGYDSSSELREPPRELQLTIDMRLAYRNKGDPDNGWKLYAHGVEHRYLDCVTSHVGPTETLYSCDMIPLFELGALHHSFYLLNLRFPLDTPSQMNLQFGHMHDLTLTAIHQNGGFTQIWLLLKTMLFPFVVGIMIWFWRRVHLLQRSPALLEYMLIYLGAALTFLNLPLEYLSLVYEMPYMLLLSDIRQGIFYAMLLTFWLVFAGEHMLIQDAPNKSTIRSRYWKHLSAVVVGCISLFVFDICERGVQLRNPFYSIWTTPLGAKVAMTFIVLAGVSAAIYFLFLCYMIWKVFRNIGDKRTSLPSMSQARRLHYEVPLDQKVEDWAGIVYFYTKAFFFQLHKANESKGLIYRFKFLMLATLVCAALTVAGFIMGQMAEGQWDWNDNVAIQPTSAFLTGVYGMWNIYIFALLILYAPSHKQWPTMHHSDETTQSNENIVASAASEEIEFSHLPSDSNPSEISSLTSFTRKVAFD",
                "length": 594
            },
            "evidence": [
                {
                    "id": "Q6DID7",
                    "url": "https://omabrowser.org/oma/group/Q6DID7/",
                    "database": "OMA"
                }
            ],
            "common_name": "Fruit fly"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 14,
                "go_terms": [
                    {
                        "name": "Golgi membrane",
                        "id": "GO:0000139",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "early endosome",
                        "id": "GO:0005769",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum",
                        "id": "GO:0005783",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Golgi apparatus",
                        "id": "GO:0005794",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytosol",
                        "id": "GO:0005829",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endoplasmic reticulum membrane",
                        "id": "GO:0005789",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "endomembrane system",
                        "id": "GO:0012505",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0012505",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cytoplasmic vesicle",
                        "id": "GO:0031410",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "early endosome membrane",
                        "id": "GO:0031901",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "dendrite cytoplasm",
                        "id": "GO:0032839",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032839",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "trans-Golgi network",
                        "id": "GO:0005802",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "dendrite membrane",
                        "id": "GO:0032590",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032590",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "membrane",
                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 13,
                "go_terms": [
                    {
                        "name": "intracellular protein transport",
                        "id": "GO:0006886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "hindbrain development",
                        "id": "GO:0030902",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030902",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Wnt signaling pathway",
                        "id": "GO:0016055",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016055",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of dendrite morphogenesis",
                        "id": "GO:0050775",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050775",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mesoderm formation",
                        "id": "GO:0001707",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001707",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of canonical Wnt signaling pathway",
                        "id": "GO:0090263",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090263",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cementum mineralization",
                        "id": "GO:0071529",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071529",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of Wnt protein secretion",
                        "id": "GO:0061357",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061357",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "anterior/posterior axis specification",
                        "id": "GO:0009948",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009948",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of Wnt signaling pathway",
                        "id": "GO:0030177",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030177",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "midbrain development",
                        "id": "GO:0030901",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030901",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "exocrine pancreas development",
                        "id": "GO:0031017",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031017",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Wnt protein secretion",
                        "id": "GO:0061355",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061355",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "identical protein binding",
                        "id": "GO:0042802",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Wnt-protein binding",
                        "id": "GO:0017147",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017147",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mu-type opioid receptor binding",
                        "id": "GO:0031852",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031852",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q6DID7",
                                "url": "https://www.uniprot.org/uniprot/Q6DID7"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 406,
            "end_pos": 408,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 8,
            "end_pos": 10,
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    ],
    "ptm_annotation": [
        {
            "annotation": "N-glycosylated.",
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                {
                    "database": "UniProtKB",
                    "id": "Q6DID7",
                    "url": "https://www.uniprot.org/uniprot/Q6DID7"
                },
                {
                    "database": "PubMed",
                    "id": "20652957",
                    "url": "https://glygen.org/publication/PubMed/20652957"
                }
            ]
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    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
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        }
    ],
    "section_stats": [
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        {
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        {
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}