{ "uniprot_canonical_ac": "Q6AZ61-1", "uniprot_ac": "Q6AZ61", "uniprot_id": "LMBD1_RAT", "mass": { "chemical_mass": 61018.0, "monoisotopic_mass": 61018.0 }, "refseq": { "ac": "NP_631928", "name": "lysosomal cobalamin transport escort protein LMBD1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631928" }, "gene_names": [ { "name": "Lmbrd1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q6AZ61", "id": "Q6AZ61" }, { "name": "LMBD1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631928", "id": "NP_631928" }, { "name": "Lmbrd1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631928", "id": "NP_631928" } ], "protein_names": [ { "name": "Lysosomal cobalamin transport escort protein LMBD1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q6AZ61" }, { "name": "LMBD1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6AZ61" }, { "name": "LMBR1 domain-containing protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6AZ61" }, { "name": "lysosomal cobalamin transport escort protein LMBD1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631928", "id": "NP_631928" }, { "name": "probable lysosomal cobalamin transporter; LMBR1 domain-containing protein 1; liver regeneration p-53 related protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631928", "id": "NP_631928" } ], "function": [ { "annotation": "LMBD1 plays an imperative role in mediating and regulating the endocytosis of the IR.", "evidence": [ { "database": "RefSeq", "id": "NP_631928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631928" }, { "database": "PubMed", "id": "24078630", "url": "https://glygen.org/publication/PubMed/24078630" } ] }, { "annotation": "Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q6AZ61", "url": "https://www.uniprot.org/uniprot/Q6AZ61#function" }, { "database": "UniProtKB", "id": "Q9NUN5", "url": "https://www.uniprot.org/uniprot/Q9NUN5#function" }, { "database": "UniProtKB", "id": "Q8K0B2", "url": "https://www.uniprot.org/uniprot/Q8K0B2#function" } ] } ], "disease": [ { "disease_id": "DOID:0050717", "recommended_name": { "id": "DOID:0050717", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050717", "name": "methylmalonic aciduria and homocystinuria type cblF", "description": "A methylmalonic acidemia that is characterized by the accumulation of cobalamin in lysosomes which is then unable to synthesize the cofactors adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl) and that has_material_basis_in homozygous or compound heterozygous mutation in the LMBRD1 gene on chromosome 6q13." }, "synonyms": [ { "id": "DOID:0050717", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050717", "name": "MAHCF", "description": "" }, { "id": "DOID:0050717", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050717", "name": "Cobalamin F deficiency", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "methylmalonic aciduria and homocystinuria type cblF", "description": "A form of methylmalonic acidemia with homocystinuria, an inborn error of vitamin B12 (cobalamin) metabolism characterized by megaloblastic anemia, lethargy, failure to thrive, developmental delay, intellectual deficit and seizures. The disorder is caused by mutations in the LMBRD1 gene (6q13) and is transmitted in an autosomal recessive manner." }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "cblF defect", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "cobalamin F defect", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "cobalamin F deficiency", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "combined defect in adenosylcobalamin and methylcobalamin synthesis, type cblF", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "inherited methylmalonic acidemia and homocystinuria", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "lysosomal membrane cobalamin transporter deficiency", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "methylmalonic aciduria and homocystinuria type cblF", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "methylmalonic aciduria with homocystinuria, type cblF", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "MAHCF", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "cblF methylmalonic acidemia and homocystinuria", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "cobalamin F disease", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "cobalamin locus f variant", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "cobalamin, defect in lysosomal release of", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "methylmalonic acidemia and homocystinuria, cblF type", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "methylmalonic acidemia with homocystinuria type cblF", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "methylmalonic aciduria and homocystinuria, cblF type", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "methylmalonic aciduria due to vitamin B12-release defect", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "vitamin B12 lysosomal release defect", "description": "" }, { "id": "MONDO:0010183", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010183", "name": "vitamin B12 storage disease", "description": "" }, { "id": "MIM:277380", "resource": "MIM", "url": "https://www.omim.org/entry/277380", "name": "Methylmalonic aciduria and homocystinuria, cblF type", "description": "Methylmalonic aciduria and homocystinuria, cblF type" } ], "evidence": [ { "id": "0050717", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050717" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q6AZ61", "url": "https://www.uniprot.org/uniprot/Q6AZ61" } ], "common_name": "Rat" } ], "gene": [ { "name": "Lmbrd1", "url": "https://www.uniprot.org/uniprot/Q6AZ61", "locus": { "chromosome": "9", "start_pos": 27178090, "end_pos": 27096297, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000012178", "url": "https://www.ensembl.org/id/ENSRNOG00000012178" } ] } } ], "crossref": [ { "id": "ENSRNOG00000012178", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000012178", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "246046", "url": "https://www.ncbi.nlm.nih.gov/gene/246046", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR006876", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006876", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:246046", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:246046", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FWAQFVF", "url": "https://omabrowser.org/oma/group/FWAQFVF/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "8533at2759", "url": "http://www.orthodb.org/?query=8533at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16130", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16130", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16130:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16130:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04791", "url": "http://pfam.xfam.org/family/PF04791", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q6AZ61", "url": "http://purl.obolibrary.org/obo/PR_Q6AZ61", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-9758881", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9758881", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-9758890", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9758890", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_631928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631928", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "708471", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=708471", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I5ZJ65", "url": "https://www.uniprot.org/uniprot/A0A8I5ZJ65", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZJ65-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZJ65-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6AZ61", "url": "https://www.uniprot.org/uniprot/Q6AZ61", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6AZ61-1", "url": "https://www.uniprot.org/uniprot/Q6AZ61-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAAAADLVIGWCIFGLLLLAILAFCWVYVRKYQSQRESEVVSTVTAIFSLAVALITSALLPVDIFLVSYMKNQNGTFKDWANANVTVQIENTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDDDDTSKCTQVKTALKYTLGFVVICALLLLVGAFVPLNLPNNNNSTEWEKVKLLFEDLGTGQGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSTAYERLENTEDIEEVEQHIQTIRSKSKDGRPLSARDRRTLKQCEERLRTLRKRERHLEFIENSWWTKFCGALRPLKIIWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIVFGTNLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIESNITSDAHKGNSTLAVPKRCDADAPKDQCTVTRTYVFLHKFWFFSAAYYFGNWAFLVVFLIGLIVSCCKGKKSVIEGVDEDSDLSDDEPSAYSA", "length": 537, "header": "sp|Q6AZ61-1|LMBD1_RAT Isoform 1 of Lysosomal cobalamin transport escort protein LMBD1 OS=Rattus norvegicus OX=10116 GN=Lmbrd1 PE=1 SV=1 CANONICAL=Q6AZ61-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZJ65-1", "url": "", "sequence": { "sequence": "MAAAAADLVIGWCIFGLLLLAILAFCWVYVRKYQSQRESEVVSTVTAIFSLAVALITSALLPVDIFLVSYMKNQNGTFKDWANANVTVQIENTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDDDDTSKCTQVKTALKYTLGFVVICALLLLVGGYEPGSP", "length": 162, "header": "tr|A0A8I5ZJ65-1|LMBD1_RAT Computationally mapped isoform of Lysosomal cobalamin transport escort protein LMBD1 OS=Rattus norvegicus OX=10116 GN=Lmbrd1 PE=1 SV=1 CANONICAL=Q6AZ61-1" }, "locus": { "chromosome": "9", "start_pos": 27128897, "end_pos": 27096475, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000099416.1", "url": "https://www.ensembl.org/id/ENSRNOT00000099416.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000076474.1", "url": "https://www.ensembl.org/id/ENSRNOP00000076474.1" } ] } }, { "isoform_ac": "Q6AZ61-1", "url": "", "sequence": { "sequence": "MAAAAADLVIGWCIFGLLLLAILAFCWVYVRKYQSQRESEVVSTVTAIFSLAVALITSALLPVDIFLVSYMKNQNGTFKDWANANVTVQIENTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDDDDTSKCTQVKTALKYTLGFVVICALLLLVGAFVPLNLPNNNNSTEWEKVKLLFEDLGTGQGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSTAYERLENTEDIEEVEQHIQTIRSKSKDGRPLSARDRRTLKQCEERLRTLRKRERHLEFIENSWWTKFCGALRPLKIIWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIVFGTNLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIESNITSDAHKGNSTLAVPKRCDADAPKDQCTVTRTYVFLHKFWFFSAAYYFGNWAFLVVFLIGLIVSCCKGKKSVIEGVDEDSDLSDDEPSAYSA", "length": 537, "header": "sp|Q6AZ61-1|LMBD1_RAT Isoform 1 of Lysosomal cobalamin transport escort protein LMBD1 OS=Rattus norvegicus OX=10116 GN=Lmbrd1 PE=1 SV=1 CANONICAL=Q6AZ61-1" }, "locus": { "chromosome": "9", "start_pos": 27177244, "end_pos": 27096475, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000016887", "url": "https://www.ensembl.org/id/ENSRNOT00000016887" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000016887", "url": "https://www.ensembl.org/id/ENSRNOP00000016887" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 166, "start_aa": "Asn", "end_pos": 166, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn166", "evidence": [ { "id": "Q6AZ61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AZ61#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 167, "start_aa": "Asn", "end_pos": 167, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn167", "evidence": [ { "id": "Q6AZ61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AZ61#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 344, "start_aa": "Asn", "end_pos": 344, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn344", "evidence": [ { "id": "Q6AZ61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AZ61#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 445, "start_aa": "Asn", "end_pos": 445, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn445", "evidence": [ { "id": "Q6AZ61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AZ61#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 454, "start_aa": "Asn", "end_pos": 454, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn454", "evidence": [ { "id": "Q6AZ61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AZ61#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 75, "start_aa": "Asn", "end_pos": 75, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn75", "evidence": [ { "id": "Q6AZ61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AZ61#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 85, "start_aa": "Asn", "end_pos": 85, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn85", "evidence": [ { "id": "Q6AZ61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AZ61#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 235, "end_pos": 235, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q6AZ61", "url": "https://www.uniprot.org/uniprot/Q6AZ61" } ], "site_lbl": "Thr235" }, { "start_pos": 525, "end_pos": 525, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6AZ61", "url": "https://www.uniprot.org/uniprot/Q6AZ61" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q6AZ61", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6AZ61" } ], "site_lbl": "Ser525" }, { "start_pos": 528, "end_pos": 528, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6AZ61", "url": "https://www.uniprot.org/uniprot/Q6AZ61" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q6AZ61", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6AZ61" } ], "site_lbl": "Ser528" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "Q6AZ61", "url": "https://www.uniprot.org/uniprot/Q6AZ61" }, { "database": "iPTMnet", "id": "Q6AZ61", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6AZ61" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "LMBD1 protein serves as a specific adaptor for insulin receptor internalization.", "journal": "The Journal of biological chemistry", "date": "2013", "authors": "Tseng LT, Lin CL, Tzen KY, Chang SC, Chang MF", "evidence": [ { "database": "RefSeq", "id": "NP_631928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_631928" } ], "reference": [ { "type": "PubMed", "id": "24078630", "url": "https://glygen.org/publication/PubMed/24078630" } ] } ], "pathway": [ { "id": "rno:246046", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:246046", "resource": "KEGG Pathway" }, { "id": "R-RNO-9758881", "name": "Uptake of dietary cobalamins into enterocytes", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9758881", "resource": "Reactome", "description": "Uptake of dietary cobalamins into enterocytes" }, { "id": "R-RNO-9758890", "name": "Transport of RCbl within the body", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9758890", "resource": "Reactome", "description": "Transport of RCbl within the body" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8K0B2-1", "protein_name": "Lysosomal cobalamin transport escort protein LMBD1", "gene_name": "Lmbrd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAAAAELVIGWCIFGLLLLAILAFCWVYVRKYQSQRESEVVSTVTAIFSLAVALITSALLPVDIFLVSYMKNQNGTFKDWADANVTVQIENTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDEDDASKCTQIKTALKYTLGFVVICALLLLVGAFVPLHLPNNNNSTEWEKVKLLFEDLGTGQGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSTAYERLENTEDIEEVEQHIQTIRSKSKDGRPLPARDRRALKQCEERLRTLRKRERHLEFIENSWWTKFCGALRPLKIIWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIIFGTNLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIESNITSDAHKGNSTLAVPKRCDADAPKDQCTVTRTYIFLHKFWFFSAAYYFGNWAFLVVFLIGLIVSCCKGKKSVIEGVDEDSDLSDDEPSAYSA", "length": 537 }, "evidence": [ { "id": "45230265", "url": "http://www.informatics.jax.org/homology/45230265", "database": "MGI" }, { "id": "Q6AZ61", "url": "https://omabrowser.org/oma/group/Q6AZ61/", "database": 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