{ "uniprot_canonical_ac": "Q6AYS6-1", "uniprot_ac": "Q6AYS6", "uniprot_id": "SNX17_RAT", "mass": { "chemical_mass": 52882.0, "monoisotopic_mass": 52882.0 }, "refseq": { "ac": "NP_001011981", "name": "sorting nexin-17", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011981" }, "gene_names": [ { "name": "Snx17", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q6AYS6", "id": "Q6AYS6" }, { "name": "Snx17", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011981", "id": "NP_001011981" } ], "protein_names": [ { "name": "Sorting nexin-17", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q6AYS6" }, { "name": "sorting nexin-17", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011981", "id": "NP_001011981" } ], "function": [ { "annotation": "Abnormal down-regulation of SNX17 contributes to ischemic damages of cardiac electrophysiology and contractile function.", "evidence": [ { "database": "RefSeq", "id": "NP_001011981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011981" }, { "database": "PubMed", "id": "30025651", "url": "https://glygen.org/publication/PubMed/30025651" } ] }, { "annotation": "Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6#function" }, { "database": "UniProtKB", "id": "Q8BVL3", "url": "https://www.uniprot.org/uniprot/Q8BVL3#function" }, { "database": "UniProtKB", "id": "Q15036", "url": "https://www.uniprot.org/uniprot/Q15036#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "common_name": "Rat" } ], "gene": [ { "name": "Snx17", "url": "https://www.uniprot.org/uniprot/Q6AYS6", "locus": { "chromosome": "6", "start_pos": 25177391, "end_pos": 25183030, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000026884", "url": "https://www.ensembl.org/id/ENSRNOG00000026884" } ] } } ], "crossref": [ { "id": "ENSRNOG00000026884", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000026884", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd06885", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06885", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd13337", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13337", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16121", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16121", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd17109", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17109", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "298836", "url": "https://www.ncbi.nlm.nih.gov/gene/298836", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q6AYS6", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q6AYS6*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000159", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000159", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001683", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001683", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028666", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028666", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036871", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037831", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037831", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037836", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037836", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040842", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040842", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:298836", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:298836", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "RRHCVGV", "url": "https://omabrowser.org/oma/group/RRHCVGV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5487301at2759", "url": "http://www.orthodb.org/?query=5487301at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12431", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12431", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12431:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12431:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00787", "url": "http://pfam.xfam.org/family/PF00787", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF18116", "url": "http://pfam.xfam.org/family/PF18116", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q6AYS6", "url": "http://purl.obolibrary.org/obo/PR_Q6AYS6", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001011981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011981", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1306424", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306424", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2JXV4", "url": "https://www.uniprot.org/uniprot/A0A0G2JXV4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JXV4-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JXV4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AGG0", "url": "https://www.uniprot.org/uniprot/A0A8I6AGG0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AGG0-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AGG0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AMM3", "url": "https://www.uniprot.org/uniprot/A0A8I6AMM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AMM3-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AMM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GA49", "url": "https://www.uniprot.org/uniprot/A0A8I6GA49", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GA49-1", "url": "https://www.uniprot.org/uniprot/A0A8I6GA49-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1LMM2", "url": "https://www.uniprot.org/uniprot/F1LMM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1LMM2-1", "url": "https://www.uniprot.org/uniprot/F1LMM2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6AYS6-1", "url": "https://www.uniprot.org/uniprot/Q6AYS6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHFSIPETESRSGDSGGSTYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSDGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIEHGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGTSTPSRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGNLRRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGSPSTDASASAVHGNFAFEGIGDEDL", "length": 470, "header": "sp|Q6AYS6-1|SNX17_RAT Isoform 1 of Sorting nexin-17 OS=Rattus norvegicus OX=10116 GN=Snx17 PE=1 SV=1 CANONICAL=Q6AYS6-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JXV4-1", "url": "", "sequence": { "sequence": "TQETQQVPTEEVSLEVLLSDGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIEHGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGTSTPSRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGNLRRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGSPSTDASASAVHGNFAFEGIGDEDL", "length": 365, "header": "tr|A0A0G2JXV4-1|SNX17_RAT Computationally mapped isoform of Sorting nexin-17 OS=Rattus norvegicus OX=10116 GN=Snx17 PE=1 SV=2 CANONICAL=Q6AYS6-1" }, "locus": { "chromosome": "6", "start_pos": 25180564, "end_pos": 25177923, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000091264.2", "url": "https://www.ensembl.org/id/ENSRNOT00000091264.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000070417.2", "url": "https://www.ensembl.org/id/ENSRNOP00000070417.2" } ] } }, { "isoform_ac": "A0A8I6AGG0-1", "url": "", "sequence": { "sequence": "MHFSIPETESRSGDSGGSTYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSDGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIEHGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGTSTPSRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGNLRRSDSQQAVKSPPLLESPDASRESMVKLSVSYRVGEVDCRGLTGCHPLTCFPPLLQSKLSAVSLRGIGSPSTDASASAVHGNFAFEGIGDEDL", "length": 497, "header": "tr|A0A8I6AGG0-1|A0A8I6AGG0_RAT Computationally mapped isoform of Sorting nexin-17 OS=Rattus norvegicus OX=10116 GN=Snx17 PE=1 SV=1 CANONICAL=Q6AYS6-1" }, "locus": { "chromosome": "6", "start_pos": 25182896, "end_pos": 25177923, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000118822.1", "url": "https://www.ensembl.org/id/ENSRNOT00000118822.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000091898.1", "url": "https://www.ensembl.org/id/ENSRNOP00000091898.1" } ] } }, { "isoform_ac": "A0A8I6AMM3-1", "url": "", "sequence": { "sequence": "MHFSIPETESRSGDSGGSTYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSDGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKRSGLSLNTEEGMGWRAGLHTETVSDIEHGWILVTKEQHRQLKSLQEKFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVPLPSGGTSTPSRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGNLRRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGSPSTDASASAVHGNFAFEGIGDEDL", "length": 458, "header": "tr|A0A8I6AMM3-1|A0A8I6AMM3_RAT Computationally mapped isoform of Sorting nexin-17 OS=Rattus norvegicus OX=10116 GN=Snx17 PE=1 SV=1 CANONICAL=Q6AYS6-1" }, "locus": { "chromosome": "6", "start_pos": 25182896, "end_pos": 25177923, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000118894.1", "url": "https://www.ensembl.org/id/ENSRNOT00000118894.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000095437.1", "url": "https://www.ensembl.org/id/ENSRNOP00000095437.1" } ] } }, { "isoform_ac": "A0A8I6GA49-1", "url": "", "sequence": { "sequence": "MSQLPTEVTPSSNRFFGRLLLPARPRLLWWWALLSSLGGRLPHKRPSFLLTGSSVWNPDLGENTGSIPGSLGALLRRICLATSGQVSVGKRWFGLRPLSVCLFLCPQAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSDGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIEHGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGTSTPSRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGNLRRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGSPSTDASASAVHGNFAFEGIGDEDL", "length": 556, "header": "tr|A0A8I6GA49-1|SNX17_RAT Computationally mapped isoform of Sorting nexin-17 OS=Rattus norvegicus OX=10116 GN=Snx17 PE=1 SV=1 CANONICAL=Q6AYS6-1" }, "locus": { "chromosome": "6", "start_pos": 25182734, "end_pos": 25177923, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000115042.1", "url": "https://www.ensembl.org/id/ENSRNOT00000115042.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000082948.1", "url": "https://www.ensembl.org/id/ENSRNOP00000082948.1" } ] } }, { "isoform_ac": "F1LMM2-1", "url": "", "sequence": { "sequence": "LLSDGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKRSGLSLNTEEGMGWRAGLHTEVHGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGTSTPSRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGNLRRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGSPSTDASASAVHGNFAFEGIGDEDL", "length": 341, "header": "tr|F1LMM2-1|SNX17_RAT Computationally mapped isoform of Sorting nexin-17 OS=Rattus norvegicus OX=10116 GN=Snx17 PE=1 SV=4 CANONICAL=Q6AYS6-1" }, "locus": { "chromosome": "6", "start_pos": 25180516, "end_pos": 25177923, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000030518.7", "url": "https://www.ensembl.org/id/ENSRNOT00000030518.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000029617.7", "url": "https://www.ensembl.org/id/ENSRNOP00000029617.7" } ] } }, { "isoform_ac": "Q6AYS6-1", "url": "", "sequence": { "sequence": "MHFSIPETESRSGDSGGSTYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSDGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIEHGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGTSTPSRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGNLRRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGSPSTDASASAVHGNFAFEGIGDEDL", "length": 470, "header": "sp|Q6AYS6-1|SNX17_RAT Isoform 1 of Sorting nexin-17 OS=Rattus norvegicus OX=10116 GN=Snx17 PE=1 SV=1 CANONICAL=Q6AYS6-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 407, "end_pos": 407, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "site_lbl": "Ser407" }, { "start_pos": 409, "end_pos": 409, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "site_lbl": "Ser409" }, { "start_pos": 415, "end_pos": 415, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q6AYS6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6AYS6" } ], "site_lbl": "Ser415" }, { "start_pos": 421, "end_pos": 421, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q6AYS6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6AYS6" } ], "site_lbl": "Ser421" }, { "start_pos": 437, "end_pos": 437, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "phospho.ELM", "id": "Q6AYS6", "url": "http://phospho.elm.eu.org/byAccession/Q6AYS6.html" }, { "database": "iPTMnet", "id": "Q6AYS6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6AYS6" }, { "database": "PubMed", "id": "16396499", "url": "https://glygen.org/publication/PubMed/16396499" } ], "site_lbl": "Ser437" }, { "start_pos": 440, "end_pos": 440, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "phospho.ELM", "id": "Q6AYS6", "url": "http://phospho.elm.eu.org/byAccession/Q6AYS6.html" }, { "database": "iPTMnet", "id": "Q6AYS6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6AYS6" }, { "database": "PubMed", "id": "16396499", "url": "https://glygen.org/publication/PubMed/16396499" } ], "site_lbl": "Ser440" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS.", "journal": "Journal of proteome research", "date": "2006", "authors": "Moser K, White FM", "evidence": [ { "database": "iPTMnet", "id": "Q6AYS6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6AYS6" } ], "reference": [ { "type": "PubMed", "id": "16396499", "url": "https://glygen.org/publication/PubMed/16396499" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" }, { "database": "UniProtKB", "id": "A0A0G2JXV4", "url": "https://www.uniprot.org/uniprot/A0A0G2JXV4" }, { "database": "UniProtKB", "id": "F1LMM2", "url": "https://www.uniprot.org/uniprot/F1LMM2" }, { "database": "iPTMnet", "id": "Q6AYS6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q6AYS6" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] }, { "title": "SNX17 produces anti-arrhythmic effects by preserving functional SERCA2a protein in myocardial infarction.", "journal": "International journal of cardiology", "date": "2018", "authors": "Zhao D, Li X, Liang H, Zheng N, Pan Z, Zhou Y, Liu X, Qian M, Xu B, Zhang Y, Feng Y, Qili M, Wu Q, Yang B, Shan H", "evidence": [ { "database": "RefSeq", "id": "NP_001011981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011981" } ], "reference": [ { "type": "PubMed", "id": "30025651", "url": "https://glygen.org/publication/PubMed/30025651" } ] } ], "pathway": [ { "id": "rno:298836", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:298836", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q15036-1", "protein_name": "Sorting nexin-17", "gene_name": "SNX17", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDATRESMVKLSSKLSAVSLRGIGSPSTDASASDVHGNFAFEGIGDEDL", "length": 470 }, "evidence": [ { "id": "45227877", "url": "http://www.informatics.jax.org/homology/45227877", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BVL3-1", "protein_name": "Sorting nexin-17", "gene_name": "Snx17", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVVPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVTVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIEHGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGTSSPSRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGSPSTDASASAVHGNFAFEGIGDEDL", "length": 470 }, "evidence": [ { "id": "45227877", "url": "http://www.informatics.jax.org/homology/45227877", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 10, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "endosome", "id": "GO:0005768", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "cytoplasmic vesicle membrane", "id": "GO:0030659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 9, "go_terms": [ { "name": "intracellular protein transport", "id": "GO:0006886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "kidney development", "id": "GO:0001822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001822", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "receptor-mediated endocytosis", "id": "GO:0006898", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006898", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "aorta development", "id": "GO:0035904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035904", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "coronary vasculature development", "id": "GO:0060976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060976", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "endocytic recycling", "id": "GO:0032456", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032456", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "cardiac septum development", "id": "GO:0003279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003279", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "vesicle-mediated transport", "id": "GO:0016192", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "low-density lipoprotein particle receptor binding", "id": "GO:0050750", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050750", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" }, { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "Q6AYS6", "url": "https://www.uniprot.org/uniprot/Q6AYS6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }