{ "uniprot_canonical_ac": "Q6AY39-1", "uniprot_ac": "Q6AY39", "uniprot_id": "B3GL1_RAT", "mass": { "chemical_mass": 39215.0, "monoisotopic_mass": 39215.0 }, "refseq": { "ac": "NP_001013176", "name": "UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013176" }, "gene_names": [ { "name": "B3galnt1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q6AY39", "id": "Q6AY39" }, { "name": "B3galnt1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013176", "id": "NP_001013176" }, { "name": "B3galt3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013176", "id": "NP_001013176" }, { "name": "B3galt3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q6AY39", "id": "Q6AY39" } ], "protein_names": [ { "name": "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q6AY39" }, { "name": "2.4.1.79", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6AY39" }, { "name": "Beta-1,3-GalNAc-T1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6AY39" }, { "name": "Beta-1,3-GalTase 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6AY39" }, { "name": "Beta-1,3-galactosyltransferase 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6AY39" }, { "name": "Beta-3-Gx-T3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6AY39" }, { "name": "Beta3Gal-T3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6AY39" }, { "name": "Beta3GalT3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6AY39" }, { "name": "Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6AY39" }, { "name": "Globoside synthase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6AY39" }, { "name": "UDP-GalNAc:beta-1, 3-N-acetylgalactosaminyltransferase 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013176", "id": "NP_001013176" }, { "name": "UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6AY39" }, { "name": "b3Gal-T3; beta3Gal-T3; beta-3-Gx-T3; beta-3-GalNAc-T1; beta-1,3-GalTase 3; globoside synthase; beta-1,3-galactosyltransferase 3; galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase; UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase; beta3GalT3; beta-1,3-GalNAc-T1; UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3; UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013176", "id": "NP_001013176" }, { "name": "b3Gal-T3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q6AY39" } ], "function": [ { "annotation": "Transfers N-acetylgalactosamine onto globotriaosylceramide. Plays a critical role in preimplantation stage embryonic development.", "evidence": [ { "database": "UniProtKB", "id": "Q6AY39", "url": "https://www.uniprot.org/uniprot/Q6AY39#function" }, { "database": "UniProtKB", "id": "Q920V1", "url": "https://www.uniprot.org/uniprot/Q920V1#function" }, { "database": "UniProtKB", "id": "O75752", "url": "https://www.uniprot.org/uniprot/O75752#function" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs3319583095", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3319583095" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 327, "end_pos": 327, "sequence_org": "T", "sequence_mut": "P", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NTT->NPT).", "chr_id": "2", "chr_pos": "153848027", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T327", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs3319513996", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3319513996" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 328, "end_pos": 328, "sequence_org": "T", "sequence_mut": "P", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NTT->NTP).", "chr_id": "2", "chr_pos": "153848024", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T328", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q6AY39", "url": "https://www.uniprot.org/uniprot/Q6AY39" } ], "common_name": "Rat" } ], "gene": [ { "name": "B3galnt1", "url": "https://www.uniprot.org/uniprot/Q6AY39", "locus": { "chromosome": "2", "start_pos": 153846474, "end_pos": 153877332, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000012019", "url": "https://www.ensembl.org/id/ENSRNOG00000012019" } ] } } ], "crossref": [ { "id": "ENSRNOG00000012019", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000012019", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "GT31", "url": "http://www.cazy.org/GT31.html", "database": "CAZy", "categories": [ "Protein Classification" ] }, { "id": "310508", "url": "https://www.ncbi.nlm.nih.gov/gene/310508", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR002659", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002659", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:310508", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:310508", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DICKYRH", "url": "https://omabrowser.org/oma/group/DICKYRH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "532757at2759", "url": "http://www.orthodb.org/?query=532757at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11214", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11214", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11214:SF153", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11214:SF153", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01762", "url": "http://pfam.xfam.org/family/PF01762", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q6AY39", "url": "http://purl.obolibrary.org/obo/PR_Q6AY39", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-9840309", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9840309", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001013176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013176", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1304797", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1304797", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "22252", "url": "https://www.rhea-db.org/rhea/22252", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q6AY39", "url": "https://www.uniprot.org/uniprot/Q6AY39", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q6AY39-1", "url": "https://www.uniprot.org/uniprot/Q6AY39-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPAVLTAIPNRMSLRSLKWSLLLLSLLSFLVIWYLSLPHYNVIERVNWMYFYEYEPIYRQDFQFTLREHSNCSQQNPFLVILVTSRPSDVKARQAIRVTWGEKKTWWGHEVLTFFLLGQEAEREDKVLALSLEDEHALYGDIIRQDFLDTYNNLTLKTIMAFRWVIEFCPNAKYVMKTDTDVFINTGNLVKYLLNLNHSEKFFTGYPLIENYSYRGFFHKNHISYQEYPFKVFPPYCSGLGYIMSGDLVPKIYEMMGHVKPIKFEDVYVGICLNLLKVDIHIPEDTNLFFLFRIHLDVCQLRRVIAAHGFSSKEIITFWQVMLRNTTCHY", "length": 331, "header": "sp|Q6AY39-1|B3GL1_RAT Isoform 1 of UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 OS=Rattus norvegicus OX=10116 GN=B3galnt1 PE=2 SV=1 CANONICAL=Q6AY39-1" }, "isoforms": [ { "isoform_ac": "Q6AY39-1", "url": "", "sequence": { "sequence": "MAPAVLTAIPNRMSLRSLKWSLLLLSLLSFLVIWYLSLPHYNVIERVNWMYFYEYEPIYRQDFQFTLREHSNCSQQNPFLVILVTSRPSDVKARQAIRVTWGEKKTWWGHEVLTFFLLGQEAEREDKVLALSLEDEHALYGDIIRQDFLDTYNNLTLKTIMAFRWVIEFCPNAKYVMKTDTDVFINTGNLVKYLLNLNHSEKFFTGYPLIENYSYRGFFHKNHISYQEYPFKVFPPYCSGLGYIMSGDLVPKIYEMMGHVKPIKFEDVYVGICLNLLKVDIHIPEDTNLFFLFRIHLDVCQLRRVIAAHGFSSKEIITFWQVMLRNTTCHY", "length": 331, "header": "sp|Q6AY39-1|B3GL1_RAT Isoform 1 of UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 OS=Rattus norvegicus OX=10116 GN=B3galnt1 PE=2 SV=1 CANONICAL=Q6AY39-1" }, "locus": { "chromosome": "2", "start_pos": 153849005, "end_pos": 153848013, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000095435", "url": "https://www.ensembl.org/id/ENSRNOT00000095435" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000084772", "url": "https://www.ensembl.org/id/ENSRNOP00000084772" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 154, "start_aa": "Asn", "end_pos": 154, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn154", "evidence": [ { "id": "Q6AY39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AY39#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 198, "start_aa": "Asn", "end_pos": 198, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn198", "evidence": [ { "id": "Q6AY39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AY39#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 212, "start_aa": "Asn", "end_pos": 212, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn212", "evidence": [ { "id": "Q6AY39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AY39#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 326, "start_aa": "Asn", "end_pos": 326, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn326", "evidence": [ { "id": "Q6AY39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AY39#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 72, "start_aa": "Asn", "end_pos": 72, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn72", "evidence": [ { "id": "Q6AY39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AY39#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycosyltransferase-activity", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "rno:310508", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:310508", "resource": "KEGG Pathway" }, { "id": "R-RNO-9840309", "name": "Glycosphingolipid biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9840309", "resource": "Reactome", "description": "Glycosphingolipid biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "O75752-1", "protein_name": "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1", "gene_name": "B3GALNT1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MASALWTVLPSRMSLRSLKWSLLLLSLLSFFVMWYLSLPHYNVIERVNWMYFYEYEPIYRQDFHFTLREHSNCSHQNPFLVILVTSHPSDVKARQAIRVTWGEKKSWWGYEVLTFFLLGQEAEKEDKMLALSLEDEHLLYGDIIRQDFLDTYNNLTLKTIMAFRWVTEFCPNAKYVMKTDTDVFINTGNLVKYLLNLNHSEKFFTGYPLIDNYSYRGFYQKTHISYQEYPFKVFPPYCSGLGYIMSRDLVPRIYEMMGHVKPIKFEDVYVGICLNLLKVNIHIPEDTNLFFLYRIHLDVCQLRRVIAAHGFSSKEIITFWQVMLRNTTCHY", "length": 331 }, "evidence": [ { "id": "45240437", "url": "http://www.informatics.jax.org/homology/45240437", "database": "MGI" }, { "id": "Q6AY39", "url": "https://omabrowser.org/oma/group/Q6AY39/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q920V1-1", "protein_name": "UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1", "gene_name": "B3galnt1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPAVLTALPNRMSLRSLKWSLLLLSLLSFLVIWYLSLPHYNVIERVNWMYFYEYEPIYRQDFRFTLREHSNCSHQNPFLVILVTSRPSDVKARQAIRVTWGEKKSWWGYEVLTFFLLGQQAEREDKTLALSLEDEHVLYGDIIRQDFLDTYNNLTLKTIMAFRWVMEFCPNAKYIMKTDTDVFINTGNLVKYLLNLNHSEKFFTGYPLIDNYSYRGFFHKNHISYQEYPFKVFPPYCSGLGYIMSGDLVPRVYEMMSHVKPIKFEDVYVGICLNLLKVDIHIPEDTNLFFLYRIHLDVCQLRRVIAAHGFSSKEIITFWQVMLRNTTCHY", "length": 331 }, "evidence": [ { "id": "45240437", "url": "http://www.informatics.jax.org/homology/45240437", "database": "MGI" }, { "id": "Q6AY39", "url": "https://omabrowser.org/oma/group/Q6AY39/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q6AY39", "url": "https://www.uniprot.org/uniprot/Q6AY39" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q6AY39", "url": "https://www.uniprot.org/uniprot/Q6AY39" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "Q6AY39", "url": "https://www.uniprot.org/uniprot/Q6AY39" } ], "pmid": "" }, { "name": "protein O-linked glycosylation", "id": "GO:0006493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006493", "evidence": [ { "database": "UniProtKB", "id": "Q6AY39", "url": "https://www.uniprot.org/uniprot/Q6AY39" } ], "pmid": "" }, { "name": "oligosaccharide biosynthetic process", "id": "GO:0009312", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009312", "evidence": [ { "database": "UniProtKB", "id": "Q6AY39", "url": "https://www.uniprot.org/uniprot/Q6AY39" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity", "id": "GO:0008499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008499", "evidence": [ { "database": "UniProtKB", "id": "Q6AY39", "url": "https://www.uniprot.org/uniprot/Q6AY39" } ], "pmid": "" }, { "name": "galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity", "id": "GO:0047273", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047273", "evidence": [ { "database": "UniProtKB", "id": "Q6AY39", "url": "https://www.uniprot.org/uniprot/Q6AY39" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" }, { "start_pos": 212, "end_pos": 214, "annotation": "n_glycosylation_sequon" }, { "start_pos": 326, "end_pos": 328, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "22252", "name": "", "equation": "globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = globoside Gb4Cer (d18:1(4E)) + H(+) + UDP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6AY39-1", "O75752-1", "Q920V1-1" ], "evidence": [ { "id": "22252", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22252" } ] }, { "id": "R-RNO-8878914", "name": "B3GALNT1 transfer GalNAc to Gb3Cer to form Gb4Cer", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [ "R-ALL-8879102" ], "output_participant_list": [ "R-ALL-8879101" ], "enzyme_list": [ "Q6AY39-1" ], "evidence": [ { "id": "R-RNO-8878914", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8878914" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-8879101", "participant_name": "Gb4Cer [Golgi membrane]", "crossref": [ { "id": "88167", "database": "ChEBI", "url": "" }, { "id": "88167", "database": "ChEBI", "url": "" }, { "id": "88167", "database": "ChEBI", "url": "" }, { "id": "88167", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-8879102", "participant_name": "Gb3Cer [Golgi membrane]", "crossref": [ { "id": "88154", "database": "ChEBI", "url": "" }, { "id": "G00093", "database": "COMPOUND", "url": "" }, { "id": "G00093", "database": "COMPOUND", "url": "" }, { "id": "88154", 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