{ "uniprot_canonical_ac": "Q69ZX8-1", "uniprot_ac": "Q69ZX8", "uniprot_id": "ABLM3_MOUSE", "mass": { "chemical_mass": 77630.0, "monoisotopic_mass": 77630.0 }, "refseq": { "ac": "NP_001157963", "name": "actin-binding LIM protein 3 isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157963" }, "gene_names": [ { "name": "Ablim3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q69ZX8", "id": "Q69ZX8" }, { "name": "Ablim3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157963", "id": "NP_001157963" }, { "name": "D930036B08Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157963", "id": "NP_001157963" }, { "name": "Kiaa0843", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q69ZX8", "id": "Q69ZX8" } ], "protein_names": [ { "name": "Actin-binding LIM protein 3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q69ZX8" }, { "name": "Actin-binding LIM protein family member 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q69ZX8" }, { "name": "abLIM-3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q69ZX8" }, { "name": "actin-binding LIM protein 3 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157963", "id": "NP_001157963" }, { "name": "actin-binding LIM protein 3; abLIM-3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157963", "id": "NP_001157963" } ], "function": [ { "annotation": "ABLIM-2 and -3 associate with STARS and directly bind F-actin", "evidence": [ { "database": "RefSeq", "id": "NP_001157963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157963" }, { "database": "PubMed", "id": "17194709", "url": "https://glygen.org/publication/PubMed/17194709" } ] }, { "annotation": "May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "Q69ZX8", "url": "https://www.uniprot.org/uniprot/Q69ZX8#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q69ZX8", "url": "https://www.uniprot.org/uniprot/Q69ZX8" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Ablim3", "url": "https://www.uniprot.org/uniprot/Q69ZX8", "locus": { "chromosome": "18", "start_pos": 61932463, "end_pos": 62044895, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000032735", "url": "https://www.ensembl.org/id/ENSMUSG00000032735" } ] } } ], "crossref": [ { "id": "ENSMUSG00000032735", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000032735", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd09327", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09327", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09328", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09328", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09329", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09329", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd09330", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09330", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "319713", "url": "https://www.ncbi.nlm.nih.gov/gene/319713", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q69ZX8", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q69ZX8*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001781", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001781", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032402", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032402", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036886", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036886", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:319713", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:319713", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2442582", "url": "http://www.informatics.jax.org/marker/MGI:2442582", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q69ZX8", "url": "https://oglcnac.org/atlas/detail/Q69ZX8", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q69ZX8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q69ZX8", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "PTIIQCY", "url": "https://omabrowser.org/oma/group/PTIIQCY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "370973at2759", "url": "http://www.orthodb.org/?query=370973at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24213", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24213", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24213:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24213:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00412", "url": "http://pfam.xfam.org/family/PF00412", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02209", "url": "http://pfam.xfam.org/family/PF02209", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16182", "url": "http://pfam.xfam.org/family/PF16182", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q69ZX8", "url": "http://purl.obolibrary.org/obo/PR_Q69ZX8", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001157963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157963", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q69ZX8", "url": "https://www.uniprot.org/uniprot/Q69ZX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q69ZX8-1", "url": "https://www.uniprot.org/uniprot/Q69ZX8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNTSIPYQQSPYSPRGGSNVIQCYRCGDTCKGEVVRVHNNHFHIRCFTCQVCGCGLAQSGFFFKNQEYICTQDYQQLYGTRCDSCRDFITGEVISALGRTYHPKCFVCSLCRKPFPIGDKVTFSGKECVCQTCSQSMTSSKPIKIRGPSHCAGCKEEIKHGQSLLALDKQWHVSCFKCQTCSVILTGEYISKDGVPYCESDYHSQFGIKCETCDRYISGRVLEAGGKHYHPTCARCVRCHQMFTEGEEMYLTGSEVWHPICKQAARAEKKLKHRRTSETSISPPGSSIGSPNRVICAKVDNEILNYKDLAALPKVKSIYEVQRPDLISYEPHSRYTSDEMLERCGYGESLGTLSPYSQDIYENLDLRQRRASSPGYIDSPTYSRQGMSPTFSRSPHYYRSGPESGRSSPYHSQLDVRSSTPTSYQAPKHFHIPAGESNIYRKPPIYKRHGDLSTATKSKTSEDISQASKYSPAYSPDPYYASESEYWTYHGSPKVPRARRFSSGGEEEDFDRSMHKLQSGIGRLILKEEMKARSSSYADPWTPPRSSTSSREALHTTGYEMSFNGSPRSHYLADSDPLISKSASLPAYRRNGLHRTPSADLFHYDSMNAVNWGMREYKIYPYELLLVTTRGRNRLPKDVDRTRLERHLSQEEFYQVFGMTISEFERLALWKRNELKKQARLF", "length": 682, "header": "sp|Q69ZX8-1|ABLM3_MOUSE Isoform 1 of Actin-binding LIM protein 3 OS=Mus musculus OX=10090 GN=Ablim3 PE=1 SV=2 CANONICAL=Q69ZX8-1" }, "isoforms": [ { "isoform_ac": "Q69ZX8-1", "url": "", "sequence": { "sequence": "MNTSIPYQQSPYSPRGGSNVIQCYRCGDTCKGEVVRVHNNHFHIRCFTCQVCGCGLAQSGFFFKNQEYICTQDYQQLYGTRCDSCRDFITGEVISALGRTYHPKCFVCSLCRKPFPIGDKVTFSGKECVCQTCSQSMTSSKPIKIRGPSHCAGCKEEIKHGQSLLALDKQWHVSCFKCQTCSVILTGEYISKDGVPYCESDYHSQFGIKCETCDRYISGRVLEAGGKHYHPTCARCVRCHQMFTEGEEMYLTGSEVWHPICKQAARAEKKLKHRRTSETSISPPGSSIGSPNRVICAKVDNEILNYKDLAALPKVKSIYEVQRPDLISYEPHSRYTSDEMLERCGYGESLGTLSPYSQDIYENLDLRQRRASSPGYIDSPTYSRQGMSPTFSRSPHYYRSGPESGRSSPYHSQLDVRSSTPTSYQAPKHFHIPAGESNIYRKPPIYKRHGDLSTATKSKTSEDISQASKYSPAYSPDPYYASESEYWTYHGSPKVPRARRFSSGGEEEDFDRSMHKLQSGIGRLILKEEMKARSSSYADPWTPPRSSTSSREALHTTGYEMSFNGSPRSHYLADSDPLISKSASLPAYRRNGLHRTPSADLFHYDSMNAVNWGMREYKIYPYELLLVTTRGRNRLPKDVDRTRLERHLSQEEFYQVFGMTISEFERLALWKRNELKKQARLF", "length": 682, "header": "sp|Q69ZX8-1|ABLM3_MOUSE Isoform 1 of Actin-binding LIM protein 3 OS=Mus musculus OX=10090 GN=Ablim3 PE=1 SV=2 CANONICAL=Q69ZX8-1" }, "locus": { "chromosome": "18", "start_pos": 62044312, "end_pos": 61934369, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000049378", "url": "https://www.ensembl.org/id/ENSMUST00000049378" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000041243", "url": "https://www.ensembl.org/id/ENSMUSP00000041243" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 383, "start_aa": "Ser", "end_pos": 383, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser383", "evidence": [ { "id": "Q69ZX8", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q69ZX8" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "36757814", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36757814" }, { "id": "19458039", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19458039" }, { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" }, { "id": "Q69ZX8", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q69ZX8" }, { "id": "doi.org/10.3389/fragi.2021.757801", "database": "DOI", "url": "https://glygen.org/publication/DOI/doi.org/10.3389/fragi.2021.757801" }, { "id": "32848054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32848054" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 418, "start_aa": "Ser", "end_pos": 418, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser418", "evidence": [ { "id": "Q69ZX8", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q69ZX8" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "36757814", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36757814" }, { "id": "19458039", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19458039" }, { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 419, "start_aa": "Ser", "end_pos": 419, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser419", "evidence": [ { "id": "Q69ZX8", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q69ZX8" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "36757814", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36757814" }, { "id": "19458039", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19458039" }, { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" }, { "id": "Q69ZX8", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q69ZX8" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 420, "start_aa": "Thr", "end_pos": 420, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr420", "evidence": [ { "id": "Q69ZX8", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q69ZX8" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "36757814", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36757814" }, { "id": "19458039", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19458039" }, { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "35822049", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35822049" }, { "id": "Q69ZX8", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q69ZX8" }, { "id": "doi.org/10.3389/fragi.2021.757801", "database": "DOI", "url": "https://glygen.org/publication/DOI/doi.org/10.3389/fragi.2021.757801" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 423, "start_aa": "Ser", "end_pos": 423, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser423", "evidence": [ { "id": "Q69ZX8", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q69ZX8" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "36757814", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36757814" }, { "id": "19458039", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19458039" }, { "id": "22517741", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22517741" }, { "id": "22645316", 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Cell. Proteomics", "date": "2014", "authors": "Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee KA, Yang V, Aguiar M, Kornhauser J, Jia X, Ren J, Beausoleil SA, Silva JC, Vemulapalli V, Bedford MT, Comb MJ", "evidence": [ { "database": "UniProtKB", "id": "Q69ZX8", "url": "https://www.uniprot.org/uniprot/Q69ZX8" } ], "reference": [ { "type": "PubMed", "id": "24129315", "url": "https://glygen.org/publication/PubMed/24129315" } ] }, { "title": "Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2020", "authors": "White CW 3rd, Fan X, Maynard JC, Wheatley EG, Bieri G, Couthouis J, Burlingame AL, Villeda SA", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "Q69ZX8", "url": "https://oglcnac.org/atlas/detail/Q69ZX8" } ], "reference": [ { "type": "PubMed", "id": "32848054", "url": "https://glygen.org/publication/PubMed/32848054" } ] }, { "title": "Novel Antibodies for the Simple and Efficient Enrichment of Native O-GlcNAc Modified Peptides.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Burt RA, Dejanovic B, Peckham HJ, Lee KA, Li X, Ounadjela JR, Rao A, Malaker SA, Carr SA, Myers SA", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q69ZX8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q69ZX8" }, { "database": "O-GlcNAc Atlas", "id": "Q69ZX8", "url": "https://oglcnac.org/atlas/detail/Q69ZX8" } ], "reference": [ { "type": "PubMed", "id": "34678516", "url": "https://glygen.org/publication/PubMed/34678516" } ] }, { "title": "Defining the Dynamic Regulation of O-GlcNAc Proteome in the Mouse Cortex---the O-GlcNAcylation of Synaptic and Trafficking Proteins Related to Neurodegenerative Diseases.", "journal": "Frontiers in aging", "date": "2021", "authors": "Huynh Van N, Wang Sheng, Ouyang Xiaosen, Wani Willayat Y, Johnson Michelle S, Chacko Balu K, Jegga Anil G, Qian Wei-Jun, Chatham John C, Darley-Usmar Victor M, Zhang Jianhua", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q69ZX8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q69ZX8" } ], "reference": [ { "type": "PubMed", "id": "35822049", "url": "https://glygen.org/publication/PubMed/35822049" } ] }, { "title": "O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission.", "journal": "The Journal of clinical investigation", "date": "2023-02-09", "authors": "Fan Jun, Guo Fang, Mo Ran, Chen Liang-Yu, Mo Jiawen, Lu Cheng-Lin, Ren Jing, Zhong Qiuling, Kuang Xiaojing, Wen Youlu, Gu Ting-Ting, Liu Jinming, Li Shuji, Fang Yingying, Zhao Cunyou, Gao Tian-Ming, Cao Xiong", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q69ZX8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q69ZX8" } ], "reference": [ { "type": "PubMed", "id": "36757814", "url": "https://glygen.org/publication/PubMed/36757814" } ] } ], "pathway": [ { "id": "mmu:319713", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:319713", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K875-1", "protein_name": "Actin binding LIM protein family, member 3", "gene_name": "Ablim3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"name": "lamellipodium assembly", "id": "GO:0030032", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030032", "evidence": [ { "database": "UniProtKB", "id": "Q69ZX8", "url": "https://www.uniprot.org/uniprot/Q69ZX8" } ], "pmid": "" }, { "name": "cilium assembly", "id": "GO:0060271", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "evidence": [ { "database": "UniProtKB", "id": "Q69ZX8", "url": "https://www.uniprot.org/uniprot/Q69ZX8" } ], "pmid": "" }, { "name": "transcription by RNA polymerase II", "id": "GO:0006366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "database": "UniProtKB", "id": "Q69ZX8", "url": "https://www.uniprot.org/uniprot/Q69ZX8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q69ZX8", "url": "https://www.uniprot.org/uniprot/Q69ZX8" } ], "pmid": "" 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