{ "uniprot_canonical_ac": "Q69FB3-1", "uniprot_ac": "Q69FB3", "uniprot_id": "JPH4_RAT", "mass": { "chemical_mass": 66441.0, "monoisotopic_mass": 66441.0 }, "refseq": { "ac": "NP_001003711", "name": "junctophilin-4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003711" }, "gene_names": [ { "name": "Jph4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q69FB3", "id": "Q69FB3" }, { "name": "Jph4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003711", "id": "NP_001003711" }, { "name": "Jphl1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q69FB3", "id": "Q69FB3" } ], "protein_names": [ { "name": "Junctophilin-4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q69FB3" }, { "name": "JP-4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q69FB3" }, { "name": "Junctophilin-like 1 protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q69FB3" }, { "name": "junctophilin-4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003711", "id": "NP_001003711" }, { "name": "junctophilin-like 1 protein; JP-4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003711", "id": "NP_001003711" } ], "function": [ { "annotation": "Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q69FB3", "url": "https://www.uniprot.org/uniprot/Q69FB3#function" } ] } ], "disease": [ { "disease_id": "DOID:0050700", "recommended_name": { "id": "DOID:0050700", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050700", "name": "cardiomyopathy", "description": "A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle." }, "synonyms": [ { "id": "DOID:0050700", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050700", "name": "Cardiomyopathies", "description": "" } ], "evidence": [ { "id": "0050700", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050700" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q69FB3", "url": "https://www.uniprot.org/uniprot/Q69FB3" } ], "common_name": "Rat" } ], "gene": [ { "name": "Jph4", "url": "https://www.uniprot.org/uniprot/Q69FB3", "locus": {} } ], "crossref": [ { "id": "445271", "url": "https://www.ncbi.nlm.nih.gov/gene/445271", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003409", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003409", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017191", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017191", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:445271", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:445271", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "5393283at2759", "url": "http://www.orthodb.org/?query=5393283at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23085", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23085", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23085:SF14", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23085:SF14", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02493", "url": "http://pfam.xfam.org/family/PF02493", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q69FB3", "url": "http://purl.obolibrary.org/obo/PR_Q69FB3", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001003711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003711", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1303170", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1303170", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "Q69FB3", "url": "https://www.uniprot.org/uniprot/Q69FB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q69FB3-1", "url": "https://www.uniprot.org/uniprot/Q69FB3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MHVPLGRKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGKREGLGVERKSRWTYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGVRQSVPYHQAALLRSPRRTSLDSGHSDPPTPPPPLPLPGDEGGSPASGSRGGFVLAGPGDADGASSRKRTPAAGGFFRRSLLLSGLRAGGRRSSLGSKRGSLRSEVSSEVGSTGPPGSEASGPPIPAPPALIEGSATEVYAGEWRADRRSGYGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKEKVDRAVEGARRAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGRRPRQDSGGSDTEPLDEDSPGVYENGLTPSEGSPELPSSPASSHQPWRAPPCRSPLPPGGNWGPFSSPKAWPEEWGGPGEQAEELAGYEAEDEAGMQGPGPRDGSPLLGGCSDSSGSLREEEGEDEESLPQLRAPGGSESEPVTTPVLRGLSSRGPDAGCLTEEFEEPAATERPAQPGAANPLVVGAVALLDLSLAFLFSQLLT", "length": 630, "header": "sp|Q69FB3-1|JPH4_RAT Isoform 1 of Junctophilin-4 OS=Rattus norvegicus OX=10116 GN=Jph4 PE=2 SV=1 CANONICAL=Q69FB3-1" }, "isoforms": [ { "isoform_ac": "Q69FB3-1", "url": "", "sequence": { "sequence": "MHVPLGRKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGKREGLGVERKSRWTYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGVRQSVPYHQAALLRSPRRTSLDSGHSDPPTPPPPLPLPGDEGGSPASGSRGGFVLAGPGDADGASSRKRTPAAGGFFRRSLLLSGLRAGGRRSSLGSKRGSLRSEVSSEVGSTGPPGSEASGPPIPAPPALIEGSATEVYAGEWRADRRSGYGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKEKVDRAVEGARRAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGRRPRQDSGGSDTEPLDEDSPGVYENGLTPSEGSPELPSSPASSHQPWRAPPCRSPLPPGGNWGPFSSPKAWPEEWGGPGEQAEELAGYEAEDEAGMQGPGPRDGSPLLGGCSDSSGSLREEEGEDEESLPQLRAPGGSESEPVTTPVLRGLSSRGPDAGCLTEEFEEPAATERPAQPGAANPLVVGAVALLDLSLAFLFSQLLT", "length": 630, "header": "sp|Q69FB3-1|JPH4_RAT Isoform 1 of Junctophilin-4 OS=Rattus norvegicus OX=10116 GN=Jph4 PE=2 SV=1 CANONICAL=Q69FB3-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "rno:445271", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:445271", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q80WT0-1", "protein_name": "Junctophilin-4", "gene_name": "Jph4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSPGGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGKREGLGVERKSRWTYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGVRQSVPYHQAALLRSPRRTSLDSGHSDPPTPPPPLPLPGDEGGSPASGSRGGFVLAGPGDADGASSRKRTPAAGGFFRRSLLLSGLRAGGRRSSLGSKRGSLRSEVSSEVGSTGPPGSEASGPPIPAPPALIEGSATEVYAGEWRADRRSGYGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKEKVDRAVEGARRAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGRRPRQDSGGSDTEPLDEDSPGVYENGLTPSEGSPELPSSPASSHQPWRAPACRSPLPPGGNWGPFSSPKAWPEEWGGPGEQAEELAGYEAEDEAGVQGPGPRDGSPLLGGCSDSSGSLREEEGEDEESLPQLRAPGGSESEPVTTPVLRGLSSRGPDAGCLTEEVEEPAPTERPAQPGAANPLVVGAVALLDLSLAFLFSQLLT", "length": 628 }, "evidence": [ { "id": "45241663", "url": "http://www.informatics.jax.org/homology/45241663", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q96JJ6-1", "protein_name": "Junctophilin-4", "gene_name": "JPH4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSPGGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGKREGLGVERKSRWTYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGVRQSVPYHQAALLRSPRRTSLDSGHSDPPTPPPPLPLPGDEGGSPASGSRGGFVLAGPGDADGASSRKRTPAAGGFFRRSLLLSGLRAGGRRSSLGSKRGSLRSEVSSEVGSTGPPGSEASGPPAAAPPALIEGSATEVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKEKVDRAVEGARRAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGRRPRQDSEGSDTEPLDEDSPGVYENGLTPSEGSPELPSSPASSRQPWRPPACRSPLPPGGDQGPFSSPKAWPEEWGGAGAQAEELAGYEAEDEAGMQGPGPRDGSPLLGGCSDSSGSLREEEGEDEEPLPPLRAPAGTEPEPIAMLVLRGSSSRGPDAGCLTEELGEPAATERPAQPGAANPLVVGAVALLDLSLAFLFSQLLT", "length": 628 }, "evidence": [ { "id": "45241663", "url": "http://www.informatics.jax.org/homology/45241663", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "smooth endoplasmic reticulum", "id": "GO:0005790", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005790", "evidence": [ { "database": "UniProtKB", "id": "Q69FB3", "url": "https://www.uniprot.org/uniprot/Q69FB3" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q69FB3", "url": "https://www.uniprot.org/uniprot/Q69FB3" } ], "pmid": "" }, { "name": "dendritic shaft", "id": "GO:0043198", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043198", "evidence": [ { "database": "UniProtKB", "id": "Q69FB3", "url": "https://www.uniprot.org/uniprot/Q69FB3" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q69FB3", "url": "https://www.uniprot.org/uniprot/Q69FB3" } ], "pmid": "" }, { "name": "junctional membrane complex", "id": "GO:0030314", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030314", "evidence": [ { "database": "UniProtKB", "id": "Q69FB3", "url": "https://www.uniprot.org/uniprot/Q69FB3" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "learning", "id": "GO:0007612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007612", "evidence": [ { "database": "UniProtKB", "id": "Q69FB3", "url": "https://www.uniprot.org/uniprot/Q69FB3" } ], "pmid": "" }, { "name": "neuromuscular process controlling balance", "id": "GO:0050885", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050885", "evidence": [ { "database": "UniProtKB", "id": "Q69FB3", "url": "https://www.uniprot.org/uniprot/Q69FB3" } ], "pmid": "" }, { "name": "regulation of synaptic plasticity", "id": "GO:0048167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048167", "evidence": [ { "database": "UniProtKB", "id": "Q69FB3", "url": "https://www.uniprot.org/uniprot/Q69FB3" } ], "pmid": "" }, { "name": "regulation of cytokine production", "id": "GO:0001817", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001817", "evidence": [ { "database": "UniProtKB", "id": "Q69FB3", "url": "https://www.uniprot.org/uniprot/Q69FB3" } ], "pmid": "" }, { "name": "regulation of store-operated calcium entry", "id": "GO:2001256", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001256", "evidence": [ { "database": "UniProtKB", "id": "Q69FB3", "url": "https://www.uniprot.org/uniprot/Q69FB3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": 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"total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }