{ "uniprot_canonical_ac": "Q68FV3-1", "uniprot_ac": "Q68FV3", "uniprot_id": "FUT11_RAT", "mass": { "chemical_mass": 56000.0, "monoisotopic_mass": 56000.0 }, "refseq": { "ac": "NP_775430", "name": "alpha-(1,3)-fucosyltransferase 11 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775430" }, "gene_names": [ { "name": "Fut11", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q68FV3", "id": "Q68FV3" }, { "name": "Fut11", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775430", "id": "NP_775430" } ], "protein_names": [ { "name": "Alpha-(1,3)-fucosyltransferase 11", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q68FV3" }, { "name": "2.4.1.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q68FV3" }, { "name": "Fuc-TXI", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q68FV3" }, { "name": "FucT-XI", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q68FV3" }, { "name": "Fucosyltransferase 11", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q68FV3" }, { "name": "Fucosyltransferase XI", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q68FV3" }, { "name": "Galactoside 3-L-fucosyltransferase 11", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q68FV3" }, { "name": "alpha-(1,3)-fucosyltransferase 11 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775430", "id": "NP_775430" }, { "name": "alpha-(1,3)-fucosyltransferase 11; fuc-TXI; fucT-XI; fucosyltransferase XI; galactoside 3-L-fucosyltransferase 11; alpha3-fucosyltransferase 11; fucosyltransferase 11 (alpha (1,3) fucosyltransferase)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775430", "id": "NP_775430" } ], "function": [ { "annotation": "Has fucosyltransferase activity toward biantennary N-glycan acceptors. Does not fucosylate GlcNAc residue within type 2 lactosamine unit.", "evidence": [ { "database": "UniProtKB", "id": "Q68FV3", "url": "https://www.uniprot.org/uniprot/Q68FV3#function" }, { "database": "UniProtKB", "id": "Q495W5", "url": "https://www.uniprot.org/uniprot/Q495W5#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q68FV3", "url": "https://www.uniprot.org/uniprot/Q68FV3" } ], "common_name": "Rat" } ], "gene": [ { "name": "Fut11", "url": "https://www.uniprot.org/uniprot/Q68FV3", "locus": { "chromosome": "15", "start_pos": 3598758, "end_pos": 3602356, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000009274", "url": "https://www.ensembl.org/id/ENSRNOG00000009274" } ] } } ], "crossref": [ { "id": "ENSRNOG00000009274", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000009274", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "GT10", "url": "http://www.cazy.org/GT10.html", "database": "CAZy", "categories": [ "Protein Classification" ] }, { "id": "286971", "url": "https://www.ncbi.nlm.nih.gov/gene/286971", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001503", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001503", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017176", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017176", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031481", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031481", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038577", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038577", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:286971", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:286971", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "EHREWGV", "url": "https://omabrowser.org/oma/group/EHREWGV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1331128at2759", "url": "http://www.orthodb.org/?query=1331128at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11929", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11929", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11929:SF198", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11929:SF198", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00852", "url": "http://pfam.xfam.org/family/PF00852", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17039", "url": "http://pfam.xfam.org/family/PF17039", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q68FV3", "url": "http://purl.obolibrary.org/obo/PR_Q68FV3", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-9037629", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9037629", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_775430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775430", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "628731", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=628731", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "Q68FV3", "url": "https://www.uniprot.org/uniprot/Q68FV3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q68FV3-1", "url": "https://www.uniprot.org/uniprot/Q68FV3-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAARYTEAVLAALGVLSVCSASSSSGSGASGKAGGEAEWAEPWDGAVFRPPAALGAVGMTRGLGSPPPGNAETVDLPVLLWWSPGLFPHFPGDSERIECALGACVASRDRRARADPRTRALLFYGTDFRAADAPLPRLAHQSWALLHEESPLNNFLLSHGPGIRLFNLTATFSRHSDYPLPLQWLPGAAYLRRPAPPLRERAEWRRRGYAPLLYLQSHCDVPSDRDRYVRELMRYIPVDSYGKCLQNREPPTVRLQDTATATTEDPELMAFLSRYKFHLAMENAICNDYMTEKLWRPMHLGAVPVYRGSPSVRDWMPNNHSVILIDDFESPQKLAEFIDFLDKNDEEYMKYLAYKQPGGITNQFLLDNLEHREWGVNDPMLPNYLNGFECFVCDHELARLDAEKAHESSPRDIPVLEPHIAQLSHMDCPVPTPGFGKVEEIPENDSWKEMWLQDYWQGLYQGEALTAMIHNNETQQSKFWDYVHEIFMKRNKNL", "length": 494, "header": "sp|Q68FV3-1|FUT11_RAT Isoform 1 of Alpha-(1,3)-fucosyltransferase 11 OS=Rattus norvegicus OX=10116 GN=Fut11 PE=2 SV=1 CANONICAL=Q68FV3-1" }, "isoforms": [ { "isoform_ac": "Q68FV3-1", "url": "", "sequence": { "sequence": "MAARYTEAVLAALGVLSVCSASSSSGSGASGKAGGEAEWAEPWDGAVFRPPAALGAVGMTRGLGSPPPGNAETVDLPVLLWWSPGLFPHFPGDSERIECALGACVASRDRRARADPRTRALLFYGTDFRAADAPLPRLAHQSWALLHEESPLNNFLLSHGPGIRLFNLTATFSRHSDYPLPLQWLPGAAYLRRPAPPLRERAEWRRRGYAPLLYLQSHCDVPSDRDRYVRELMRYIPVDSYGKCLQNREPPTVRLQDTATATTEDPELMAFLSRYKFHLAMENAICNDYMTEKLWRPMHLGAVPVYRGSPSVRDWMPNNHSVILIDDFESPQKLAEFIDFLDKNDEEYMKYLAYKQPGGITNQFLLDNLEHREWGVNDPMLPNYLNGFECFVCDHELARLDAEKAHESSPRDIPVLEPHIAQLSHMDCPVPTPGFGKVEEIPENDSWKEMWLQDYWQGLYQGEALTAMIHNNETQQSKFWDYVHEIFMKRNKNL", "length": 494, "header": "sp|Q68FV3-1|FUT11_RAT Isoform 1 of Alpha-(1,3)-fucosyltransferase 11 OS=Rattus norvegicus OX=10116 GN=Fut11 PE=2 SV=1 CANONICAL=Q68FV3-1" }, "locus": { "chromosome": "15", "start_pos": 3602311, "end_pos": 3598776, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000012300", "url": "https://www.ensembl.org/id/ENSRNOT00000012300" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000012300", "url": "https://www.ensembl.org/id/ENSRNOP00000012300" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 167, "start_aa": "Asn", "end_pos": 167, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn167", "evidence": [ { "id": "Q68FV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68FV3#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycosyltransferase-activity", "glycoprotein", "glycoprotein_predicted" ], "publication": [], "pathway": [ { "id": "rno:286971", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:286971", "resource": "KEGG Pathway" }, { "id": "R-RNO-9037629", "name": "Lewis blood group biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9037629", "resource": "Reactome", "description": "Lewis blood group biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "Q495W5-1", "protein_name": "Alpha-(1,3)-fucosyltransferase 11", "gene_name": "FUT11", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MAAGPIRVVLVLLGVLSVCAASGHGSVAEREAGGEAEWAEPWDGAVFRPPSALGAVGVTRSSGTPRPGREEAGDLPVLLWWSPGLFPHFPGDSERIECARGACVASRNRRALRDSRTRALLFYGTDFRASAAPLPRLAHQSWALLHEESPLNNFLLSHGPGIRLFNLTSTFSRHSDYPLSLQWLPGTAYLRRPVPPPMERAEWRRRGYAPLLYLQSHCDVPADRDRYVRELMRHIPVDSYGKCLQNRELPTARLQDTATATTEDPELLAFLSRYKFHLALENAICNDYMTEKLWRPMHLGAVPVYRGSPSVRDWMPNNHSVILIDDFESPQKLAEFIDFLDKNDEEYMKYLAYKQPGGITNQFLLDSLKHREWGVNDPLLPNYLNGFECFVCDYELARLDAEKAHAASPGDSPVFEPHIAQPSHMDCPVPTPGFGNVEEIPENDSWKEMWLQDYWQGLDQGEALTAMIHNNETEQTKFWDYLHEIFMKRQHL", "length": 492 }, "evidence": [ { "id": "45239090", "url": "http://www.informatics.jax.org/homology/45239090", "database": "MGI" }, { "id": "Q68FV3", "url": "https://omabrowser.org/oma/group/Q68FV3/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q8BHC9-1", "protein_name": "Alpha-(1,3)-fucosyltransferase 11", "gene_name": "Fut11", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAARCTEAVLAALGVLSVCSASSSGSEASGEAEREEPWDGAVFRPPAALGAVGIARGPGSPPPGNREAVDLPVLLWWSPGLFPHFPGDSERIQCAHGACVASRDRRARADPRTRALLFYGTDFRAADAPLPRLAHQSWALLHEESPLNNFLLSHGPGIRLFNLTATFSRHSDYPLPLQWLPGAAYLRRPAPPPRERAEWRRRGYAPLLYLQSHCDVPSDRDRYVRELMRYIPVDSYGKCLQNREPPTVRLQDTATATTEDPELMAFLSRYKFHLALENAICNDYMTEKLWRPMHLGAVPVYRGSPSVRDWMPNNHSVILIDDFESPQKLAEFIDFLDKNDDEYMKYLAYKQPGGITNQFLLDNLEHREWGVNDPMLPNYLNGFECFVCDHELARLNAEKAHASSHGDIPVPEPRIAQSSHMNCPVPTPGFGKVEEIPENDSWKEMWLQDYWQGLYQGEALTAMIHNNETQQRKFWDYVHEIFMKRNKNL", "length": 489 }, "evidence": [ { "id": "45239090", "url": "http://www.informatics.jax.org/homology/45239090", "database": "MGI" }, { "id": "Q68FV3", "url": "https://omabrowser.org/oma/group/Q68FV3/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "N-glycan fucosylation", "id": "GO:0036071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036071", "evidence": [ { "database": "UniProtKB", "id": "Q68FV3", "url": "https://www.uniprot.org/uniprot/Q68FV3" } ], "pmid": "" }, { "name": "fucosylation", "id": "GO:0036065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036065", "evidence": [ { "database": "UniProtKB", "id": "Q68FV3", "url": "https://www.uniprot.org/uniprot/Q68FV3" } ], "pmid": "" }, { "name": "protein glycosylation", "id": "GO:0006486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006486", "evidence": [ { "database": "UniProtKB", "id": "Q68FV3", "url": "https://www.uniprot.org/uniprot/Q68FV3" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q68FV3", "url": "https://www.uniprot.org/uniprot/Q68FV3" } ], "pmid": "" }, { "name": "Golgi cisterna membrane", "id": "GO:0032580", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032580", "evidence": [ { "database": "UniProtKB", "id": "Q68FV3", "url": "https://www.uniprot.org/uniprot/Q68FV3" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "fucosyltransferase activity", "id": "GO:0008417", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008417", "evidence": [ { "database": "UniProtKB", "id": "Q68FV3", "url": "https://www.uniprot.org/uniprot/Q68FV3" } ], "pmid": "" }, { "name": "alpha-(1->3)-fucosyltransferase activity", "id": "GO:0046920", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046920", "evidence": [ { "database": "UniProtKB", "id": "Q68FV3", "url": "https://www.uniprot.org/uniprot/Q68FV3" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 167, "end_pos": 169, "annotation": "n_glycosylation_sequon" }, { "start_pos": 319, "end_pos": 321, "annotation": "n_glycosylation_sequon" }, { "start_pos": 444, "end_pos": 446, "annotation": "n_glycosylation_sequon" }, { "start_pos": 472, "end_pos": 474, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-RNO-9603984", "name": "FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-9605593" ], "enzyme_list": [ "Q5F2L1-1", "Q62994-1", "Q68FV3-1", "Q99JB3-1" ], "evidence": [ { "id": "R-RNO-9603984", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9603984" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-9605593", "participant_name": "LeX [Golgi lumen]", "crossref": [ { "id": "140911", "database": "ChEBI", "url": "" }, { "id": "140911", "database": "ChEBI", "url": "" }, { "id": "140911", "database": "ChEBI", "url": "" }, { "id": "140911", "database": "ChEBI", "url": "" }, { "id": "140911", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q5F2L1", "gene_name": "Fut10", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q5F2L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5F2L1" } ] } ] }, { "uniprot_ac": "Q62994", "gene_name": "Fut4", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q62994", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62994" } ] }, { "ec_number": "2.4.1.152", "activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+).", "evidence": [ { "id": "Q62994", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62994" } ] } ] }, { "uniprot_ac": "Q68FV3", "gene_name": "Fut11", "activity": [ { "ec_number": "2.4.1.-", "activity": "", "evidence": [ { "id": "Q68FV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68FV3" } ] } ] }, { "uniprot_ac": "Q99JB3", "gene_name": "Fut9", "activity": [ { "ec_number": "2.4.1.152", "activity": "a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = a beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl derivative + GDP + H(+).", "evidence": [ { "id": "Q99JB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99JB3" } ] }, { "ec_number": "2.4.1.152", "activity": "", "evidence": [ { "id": "Q99JB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99JB3" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }