{
    "uniprot_canonical_ac": "Q68FR3-1",
    "uniprot_ac": "Q68FR3",
    "uniprot_id": "INT12_RAT",
    "mass": {
        "chemical_mass": 48477.0,
        "monoisotopic_mass": 48477.0
    },
    "refseq": {
        "ac": "XP_006233382",
        "name": "integrator complex subunit 12 isoform X1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006233382"
    },
    "gene_names": [
        {
            "name": "Ints12",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q68FR3",
            "id": "Q68FR3"
        },
        {
            "name": "Ints12",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006233382",
            "id": "XP_006233382"
        },
        {
            "name": "Phf22",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006233382",
            "id": "XP_006233382"
        },
        {
            "name": "Phf22",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q68FR3",
            "id": "Q68FR3"
        }
    ],
    "protein_names": [
        {
            "name": "Integrator complex subunit 12",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q68FR3"
        },
        {
            "name": "Int12",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q68FR3"
        },
        {
            "name": "PHD finger protein 22",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q68FR3"
        },
        {
            "name": "int12; PHD finger protein 22",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007641",
            "id": "NP_001007641"
        },
        {
            "name": "integrator complex subunit 12 isoform X1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006233382",
            "id": "XP_006233382"
        },
        {
            "name": "integrator complex subunit 12",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007641",
            "id": "NP_001007641"
        }
    ],
    "function": [
        {
            "annotation": "Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q68FR3",
                    "url": "https://www.uniprot.org/uniprot/Q68FR3#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q96CB8",
                    "url": "https://www.uniprot.org/uniprot/Q96CB8#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q68FR3",
                    "url": "https://www.uniprot.org/uniprot/Q68FR3"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Ints12",
            "url": "https://www.uniprot.org/uniprot/Q68FR3",
            "locus": {
                "chromosome": "2",
                "start_pos": 221609497,
                "end_pos": 221591682,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000011844",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000011844"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000011844",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000011844",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd15501",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15501",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "295448",
            "url": "https://www.ncbi.nlm.nih.gov/gene/295448",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001965",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011011",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013083",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR019786",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR019787",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR039054",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039054",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:295448",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:295448",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "QPMATDE",
            "url": "https://omabrowser.org/oma/group/QPMATDE/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2882290at2759",
            "url": "http://www.orthodb.org/?query=2882290at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13415",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13415",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13415:SF2",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13415:SF2",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00628",
            "url": "http://pfam.xfam.org/family/PF00628",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q68FR3",
            "url": "http://purl.obolibrary.org/obo/PR_Q68FR3",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-RNO-6807505",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6807505",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001007641",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007641",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1359136",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1359136",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "A0A0H2UHJ4",
            "url": "https://www.uniprot.org/uniprot/A0A0H2UHJ4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0H2UHJ4-1",
            "url": "https://www.uniprot.org/uniprot/A0A0H2UHJ4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q68FR3",
            "url": "https://www.uniprot.org/uniprot/Q68FR3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q68FR3-1",
            "url": "https://www.uniprot.org/uniprot/Q68FR3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MAATVNLELDPIFLKALGFLHSKSKDSAEKLKTLLDESLARGIDASYRPAQKDVEPPKISSTKSLSIKQEPKTSSSLPSGSSNGKVLAAEKLKKEAEKRPADKMKDATEGVDVPKKPRLEKPETRSSPITVQTSKDLAMADLSSFEETSADDFAMEMGLACVVCRQMTVASGNQLVECQECHNLYHQDCHKPQVTDKEVNDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPTVVSVAPTVKDPLVKKPETKLKQETTFLAFKRTEVKPSTVISGNSSSNNVSSSVTSGLTGWAAFAAKTSSAGPSTAKLNSTAQNSSGKPAASSASQKPVGLTGLATSSKGGIGSKIGSSNSTSPSVPLKPLPPLTLGKTGLSRSVSCDNVSKVGLPSPSSLVPGGSSQLSGNGNSATAGPTGSITSKTTSETSSSTSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK",
        "length": 461,
        "header": "sp|Q68FR3-1|INT12_RAT Isoform 1 of Integrator complex subunit 12  OS=Rattus norvegicus OX=10116 GN=Ints12 PE=1 SV=1 CANONICAL=Q68FR3-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0H2UHJ4-1",
            "url": "",
            "sequence": {
                "sequence": "MQLVLAMAATVNLELDPIFLKALGFLHSKSKDSAEKLKTLLDESLARGIDASYRPAQKDVEPPKISSTKSLSIKQEPKTSSSLPSGSSNGKVLAAEKLKKEAEKRPADKMKDATEGVDVPKKPRLEKPETRSSPITVQTSKDLAMADLSSFEETSADDFAMEMGLACVVCRQMTVASGNQLVECQECHNLYHQDCHKPQVTDKEVNDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPTVVSVAPTVKDPLVKKPETKLKQETTFLAFKRTEVKPSTVISGNSSSNNVSSSVTSGLTGWAAFAAKTSSAGPSTAKLNSTAQNSSGKPAASSASQKPVGLTGLATSSKGGIGSKIGSSNSTSPSVPLKPLPPLTLGKTGLSRSVSCDNVSKVGLPSPSSLVPGGSSQLSGNGNSATAGPTGSITSKTTSETSSSTSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK",
                "length": 467,
                "header": "tr|A0A0H2UHJ4-1|A0A0H2UHJ4_RAT Computationally mapped isoform of Integrator complex subunit 12  OS=Rattus norvegicus OX=10116 GN=Ints12 PE=1 SV=1 CANONICAL=Q68FR3-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 221607948,
                "end_pos": 221596364,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000016066",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000016066"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000016066",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000016066"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q68FR3-1",
            "url": "",
            "sequence": {
                "sequence": "MAATVNLELDPIFLKALGFLHSKSKDSAEKLKTLLDESLARGIDASYRPAQKDVEPPKISSTKSLSIKQEPKTSSSLPSGSSNGKVLAAEKLKKEAEKRPADKMKDATEGVDVPKKPRLEKPETRSSPITVQTSKDLAMADLSSFEETSADDFAMEMGLACVVCRQMTVASGNQLVECQECHNLYHQDCHKPQVTDKEVNDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPTVVSVAPTVKDPLVKKPETKLKQETTFLAFKRTEVKPSTVISGNSSSNNVSSSVTSGLTGWAAFAAKTSSAGPSTAKLNSTAQNSSGKPAASSASQKPVGLTGLATSSKGGIGSKIGSSNSTSPSVPLKPLPPLTLGKTGLSRSVSCDNVSKVGLPSPSSLVPGGSSQLSGNGNSATAGPTGSITSKTTSETSSSTSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK",
                "length": 461,
                "header": "sp|Q68FR3-1|INT12_RAT Isoform 1 of Integrator complex subunit 12  OS=Rattus norvegicus OX=10116 GN=Ints12 PE=1 SV=1 CANONICAL=Q68FR3-1"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 221607948,
                "end_pos": 221596364,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000016066",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000016066"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000016066",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000016066"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 127,
            "end_pos": 127,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q68FR3",
                    "url": "https://www.uniprot.org/uniprot/Q68FR3"
                }
            ],
            "site_lbl": "Ser127"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.",
            "journal": "Nat. Commun.",
            "date": "2012",
            "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q68FR3",
                    "url": "https://www.uniprot.org/uniprot/Q68FR3"
                },
                {
                    "database": "UniProtKB",
                    "id": "A0A0H2UHJ4",
                    "url": "https://www.uniprot.org/uniprot/A0A0H2UHJ4"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "22673903",
                    "url": "https://glygen.org/publication/PubMed/22673903"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "rno:295448",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:295448",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-RNO-6807505",
            "name": "RNA polymerase II transcribes snRNA genes",
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6807505",
            "resource": "Reactome",
            "description": "RNA polymerase II transcribes snRNA genes"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q96CB8-1",
            "protein_name": "Integrator complex subunit 12",
            "gene_name": "INTS12",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MAATVNLELDPIFLKALGFLHSKSKDSAEKLKALLDESLARGIDSSYRPSQKDVEPPKISSTKNISIKQEPKISSSLPSGNNNGKVLTTEKVKKEAEKRPADKMKSDITEGVDIPKKPRLEKPETQSSPITVQSSKDLPMADLSSFEETSADDFAMEMGLACVVCRQMMVASGNQLVECQECHNLYHRDCHKPQVTDKEANDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPAVVSVTPAVKDPLVKKPETKLKQETTFLAFKRTEVKTSTVISGNSSSASVSSSVTSGLTGWAAFAAKTSSAGPSTAKLSSTTQNNTGKPATSSANQKPVGLTGLATSSKGGIGSKIGSNNSTTPTVPLKPPPPLTLGKTGLSRSVSCDNVSKVGLPSPSSLVPGSSSQLSGNGNSGTSGPSGSTTSKTTSESSSSPSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK",
                "length": 462
            },
            "evidence": [
                {
                    "id": "45238934",
                    "url": "http://www.informatics.jax.org/homology/45238934",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9D168-1",
            "protein_name": "Integrator complex subunit 12",
            "gene_name": "Ints12",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MAATVNLELDPIFLKALGFLHSKSKDSAEKLKALLDESLARGIDSSYRPTQKDVEPPKISSTKSLSIKQEPKTSSSLPSGSSNGKVLTAEKIKKEAEKRPADKMKDVTEGIDVPKKPRLEKPETRSSPITVQTSKDLSMADLSSFEETSADDFAMEMGLACVVCRQMTVASGNQLVECQECHNLYHQDCHKPQVTDKEVNDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPTVVSVTPTVKDPLVKKPETKLKQETTFLAFKRTEVKPSTVISGNSSSNNVSSSVTSGLTGWAAFAAKTSSAGPSTAKLNSAAQNSSGKPAASSSNQKPVGLTGLATSSKGGIGSKIGSGNSTSPSVPLKPLPPLTLGKTGLSRSVSCDNVSKVGLPSPSSLVPGGSSQLSGNGNSATTGPSGSTTSKATSETSSSTSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK",
                "length": 461
            },
            "evidence": [
                {
                    "id": "45238934",
                    "url": "http://www.informatics.jax.org/homology/45238934",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "metal ion binding",
                        "id": "GO:0046872",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q68FR3",
                                "url": "https://www.uniprot.org/uniprot/Q68FR3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "snRNA processing",
                        "id": "GO:0016180",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016180",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q68FR3",
                                "url": "https://www.uniprot.org/uniprot/Q68FR3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "snRNA 3'-end processing",
                        "id": "GO:0034472",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034472",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q68FR3",
                                "url": "https://www.uniprot.org/uniprot/Q68FR3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "integrator complex",
                        "id": "GO:0032039",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032039",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q68FR3",
                                "url": "https://www.uniprot.org/uniprot/Q68FR3"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q68FR3",
                                "url": "https://www.uniprot.org/uniprot/Q68FR3"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 275,
            "end_pos": 277,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 280,
            "end_pos": 282,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 310,
            "end_pos": 312,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 315,
            "end_pos": 317,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 351,
            "end_pos": 353,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 380,
            "end_pos": 382,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
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