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"PF04969", "url": "http://pfam.xfam.org/family/PF04969", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q68EJ0", "url": "http://purl.obolibrary.org/obo/PR_Q68EJ0", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-1237044", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1237044", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_596918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596918", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "621834", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=621834", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "46680", "url": "https://www.rhea-db.org/rhea/46680", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0G2JSK2", "url": "https://www.uniprot.org/uniprot/A0A0G2JSK2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JSK2-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JSK2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A4B1", "url": "https://www.uniprot.org/uniprot/A0A8I6A4B1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A4B1-1", "url": "https://www.uniprot.org/uniprot/A0A8I6A4B1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ABY9", "url": "https://www.uniprot.org/uniprot/A0A8I6ABY9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ABY9-1", "url": "https://www.uniprot.org/uniprot/A0A8I6ABY9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GKQ4", "url": "https://www.uniprot.org/uniprot/A0A8I6GKQ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6GKQ4-1", "url": "https://www.uniprot.org/uniprot/A0A8I6GKQ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q68EJ0-1", "url": "https://www.uniprot.org/uniprot/Q68EJ0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q68EJ0-2", "url": "https://www.uniprot.org/uniprot/Q68EJ0-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLNVPSQAFPAPGSQQRVASQGRSKVPLKQGRSLMDWFRLTKSGKDFTGLKGGLIEVTEEELKKHNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGADGTDLFNEVHRWVNYESMLKECLVGRMAVKPAVPKDCHEGKRVLNGMLPKSQVTDTLPREGPSSPSYDWFQTESSVTIVIYTKQKNINLDSVIVDLQDDSLRAEAVIKDHSYLIHIGLSHEVQENFSVRVIENVGKIEIVLQKKETVSWKCLGDPLEKHDSFIPKKDTGLYYRQCQLISKEDVTHDTRLFCLMLPPSTHLQVPVGQHVYLKLSVTGAEIVKPYTPVSESLLSDFKEPVLSPNKYIYFLIKIYPAGLFTPELDRLQIGDFVSVSGPEGNFKVSKLQEVEDLFLLAAGTGFTPMVTVLNHALTHMSSLRKVKLMFFNKTEDDIIWRCQLEKLALKDKRFHVEYVLSAPSPEWNGKQGHVSRALLSEFLQRSLENSKVFLCICGPTPFTDEGIRLLHDLNFSDDEIHGFTA", "length": 520, "header": "sp|Q68EJ0-1|NB5R4_RAT Isoform 1 of Cytochrome b5 reductase 4 OS=Rattus norvegicus OX=10116 GN=Cyb5r4 PE=1 SV=2 CANONICAL=Q68EJ0-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JSK2-1", "url": "", "sequence": { "sequence": "MLNVPSQAFPAPGSQQRVASQGRSKVPLKQGRSLMDWIRLTKSGKDFTGLKGGLIEVTEEELKKHNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGADGTDLFNEVHRWVNYESMLKECLVGRMAVKPAVPKDCHEGKRVLNGMLPKSQVTDTLPREGPSSPSYDWFQTESSVTIVIYTKQKNINLDSVIVDLQDDSLRAEAVIKDHSYLIHIGLSHEVQENFSVRVIENVGKIEIVLQKKETVSWKCLGDPLEKHDSFIPKKDTGLYYRQCQLISKEDVTHDTRLFCLMLPPSTHLQVPVGQHVYLKLSVTGAEIVKPYTPVSESLLSDFKEPVLSPNKYIYFLIKIYPAGLFTPELDRLQIGDFVSVSGPEGNFKVSKLQEVEDLFLLAAGTGFTPMVTVLNHALTHMSSLRKVKLMFFNKTEDDIIWRCQLEKLALKDKRFHVEYVLSAPSPEWNGKQGHVSRALLSEFLQRSLENSKVFLCICGPTPFTDEGIRLLHDLNFSDDEIHGFTA", "length": 520, "header": "tr|A0A0G2JSK2-1|NB5R4_RAT Computationally mapped isoform of Cytochrome b5 reductase 4 OS=Rattus norvegicus OX=10116 GN=Cyb5r4 PE=1 SV=1 CANONICAL=Q68EJ0-1" }, "locus": { "chromosome": "8", "start_pos": 88045303, "end_pos": 87981267, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000013908.6", "url": "https://www.ensembl.org/id/ENSRNOT00000013908.6" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000013909.4", "url": "https://www.ensembl.org/id/ENSRNOP00000013909.4" } ] } }, { "isoform_ac": "A0A8I6A4B1-1", "url": "", "sequence": { "sequence": "MLNVPSQAFPAPGSQQRVASQGRSKVPLKQGRSLMDWIRLTKSGKDFTGLKGGLIEVTEEELKKHNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGADGTDLFNEVHRWVNYESMLKECLVGRMAVKPAVPKGMLPKSQVTDTLPREGPSSPSYDWFQTESSVTIVIYTKQKNINLDSVIVDLQDDSLRAEAVIKDHSYLIHIGLSHEVQENFSVRVIENVGKIEIVLQKKETVSWKCLGDPLEKHDSFIPKKDTGLYYRQCQLISKEDVTHDTRLFCLMLPPSTHLQVPVGQHVYLKLSVTGAEIVKPYTPVSESLLSDFKEPVLSPNKYIYFLIKIYPAGLFTPELDRLQIGDFVSVSGPEGNFKVSKLQEVEDLFLLAAGTGFTPMVTVLNHALTHMSSLRKVKLMFFNKTEDDIIWRCQLEKLALKDKRFHVEYVLSAPSPEWNGKQGHVSRALLSEFLQRSLENSKVFLCICGPTPFTDEGIRLLHDLNFSDDEIHGFTA", "length": 510, "header": "tr|A0A8I6A4B1-1|NB5R4_RAT Computationally mapped isoform of Cytochrome b5 reductase 4 OS=Rattus norvegicus OX=10116 GN=Cyb5r4 PE=1 SV=1 CANONICAL=Q68EJ0-1" }, "locus": { "chromosome": "8", "start_pos": 88045303, "end_pos": 87981267, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000119185.1", "url": "https://www.ensembl.org/id/ENSRNOT00000119185.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000085891.1", "url": "https://www.ensembl.org/id/ENSRNOP00000085891.1" } ] } }, { "isoform_ac": "A0A8I6ABY9-1", "url": "", "sequence": { "sequence": "MLNVPSQAFPAPGSQQRVASQGRSKVPLKQGRSLMDWIRLTKSGKDFTGLKGGLIEVTEEELKKHNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGADGTDLFNEVHRWVNYESMLKECLVGRMAVKPAVPKDCHEGKRVLNGMLPKSQVTDTLPREGPSSPSYDWFQTESSVTIVIYTKQKNINLDSVIVDLQDDSLRAEAVIKDHSYLIHIVRVIENVGKIEIVLQKKETVSWKCLGDPLEKHDSFIPKKDTGLYYRQCQLISKEDVTHDTRLFCLMLPPSTHLQVPVGQHVYLKLSVTGAEIVKPYTPVSESLLSDFKEPVLSPNKYIYFLIKIYPAGLFTPELDRLQIGDFVSVSGPEGNFKVSKLQEVEDLFLLAAGTGFTPMVTVLNHALTHMSSLRKVKLMFFNKTEDDIIWRCQLEKLALKDKRFHVEYVLSAPSPEWNGKQGHVSRALLSEFLQRSLENSKVFLCICGPTPFTDEGIRLLHDLNFSDDEIHGFTA", "length": 509, "header": "tr|A0A8I6ABY9-1|A0A8I6ABY9_RAT Computationally mapped isoform of Cytochrome b5 reductase 4 OS=Rattus norvegicus OX=10116 GN=Cyb5r4 PE=1 SV=1 CANONICAL=Q68EJ0-1" }, "locus": { "chromosome": "8", "start_pos": 88045303, "end_pos": 87981267, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000119351.1", "url": "https://www.ensembl.org/id/ENSRNOT00000119351.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000091593.1", "url": "https://www.ensembl.org/id/ENSRNOP00000091593.1" } ] } }, { "isoform_ac": "A0A8I6GKQ4-1", "url": "", "sequence": { "sequence": "MLNVPSQAFPAPGSQQRVASQGRSKVPLKQGRSLMDWIRLTKSGKDFTGLKGGLIEVTEEELKKHNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGADGTDLFNEVHRWVNYESMLKECLVGRMAVKPAVPKDCHEGKRVLNGMLPKSQVTDTLPREGPSSPSYDWFQTESSVTIVIYTKQKNINLDSVIVDLQDDSLRAEAVIKDHSYLIHIGLSHEVQENFSVRVIENVGKIEIVLQKKETVSWKCLGDPLEKHDSFIPKKDTGLYYRQCQLISKEDVTHDTRLFCLMLPPSTHLQVPVGQHVYLKLSVTGDFVSVSGPEGNFKVSKLQEVEDLFLLAAGTGFTPMVTVLNHALTHMSSLRKVKLMFFNKTEDDIIWRCQLEKLALKDKRFHVEYVLSAPSPEWNGKQGHVSRALLSEFLQRSLENSKVFLCICGPTPFTDEGIRLLHDLNFSDDEIHGFTA", "length": 469, "header": "tr|A0A8I6GKQ4-1|NB5R4_RAT Computationally mapped isoform of Cytochrome b5 reductase 4 OS=Rattus norvegicus OX=10116 GN=Cyb5r4 PE=1 SV=1 CANONICAL=Q68EJ0-1" }, "locus": { "chromosome": "8", "start_pos": 88045303, "end_pos": 87981267, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000111365.1", "url": "https://www.ensembl.org/id/ENSRNOT00000111365.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000093571.1", "url": "https://www.ensembl.org/id/ENSRNOP00000093571.1" } ] } }, { "isoform_ac": "Q68EJ0-1", "url": "", "sequence": { "sequence": "MLNVPSQAFPAPGSQQRVASQGRSKVPLKQGRSLMDWFRLTKSGKDFTGLKGGLIEVTEEELKKHNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGADGTDLFNEVHRWVNYESMLKECLVGRMAVKPAVPKDCHEGKRVLNGMLPKSQVTDTLPREGPSSPSYDWFQTESSVTIVIYTKQKNINLDSVIVDLQDDSLRAEAVIKDHSYLIHIGLSHEVQENFSVRVIENVGKIEIVLQKKETVSWKCLGDPLEKHDSFIPKKDTGLYYRQCQLISKEDVTHDTRLFCLMLPPSTHLQVPVGQHVYLKLSVTGAEIVKPYTPVSESLLSDFKEPVLSPNKYIYFLIKIYPAGLFTPELDRLQIGDFVSVSGPEGNFKVSKLQEVEDLFLLAAGTGFTPMVTVLNHALTHMSSLRKVKLMFFNKTEDDIIWRCQLEKLALKDKRFHVEYVLSAPSPEWNGKQGHVSRALLSEFLQRSLENSKVFLCICGPTPFTDEGIRLLHDLNFSDDEIHGFTA", "length": 520, "header": "sp|Q68EJ0-1|NB5R4_RAT Isoform 1 of Cytochrome b5 reductase 4 OS=Rattus norvegicus OX=10116 GN=Cyb5r4 PE=1 SV=2 CANONICAL=Q68EJ0-1" }, "locus": {} }, { "isoform_ac": "Q68EJ0-2", "url": "", "sequence": { "sequence": "MLNVPSQAFPAPGSQQRVASQGRSKVPLKQGRSLMDWFRLTKSGKDFTGLKGGLIEVTEEELKKHNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGADGTDLFNEVHRWVNYESMLKECLVGRMAVKPAVPKDCHEGKRVLNGMLPKSQVTDTLPREGPSSPSYDWFQTESSVTIVIYTKQKNINLDSVIVDLQDDSLRAEAVIKDHSYLIHIGLSHEVQENFSVRVIENVGKIEIVLQKKETVSWKCLGDPLEKHDSFIPKKDTGLYYRQCQLISKEDVTHDTRLFCLMLPPSTHLQVPVGQHVYLKLSVTGDFVSVSGPEGNFKVSKLQEVEDLFLLAAGTGFTPMVTVLNHALTHMSSLRKVKLMFFNKTEDDIIWRCQLEKLALKDKRFHVEYVLSAPSPEWNGKQGHVSRALLSEFLQRSLENSKVFLCICGPTPFTDEGIRLLHDLNFSDDEIHGFTA", "length": 469, "header": "sp|Q68EJ0-2|NB5R4_RAT Isoform 2 of Cytochrome b5 reductase 4 OS=Rattus norvegicus OX=10116 GN=Cyb5r4 PE=1 SV=2 CANONICAL=Q68EJ0-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Heterologous expression of an endogenous rat cytochrome b(5)/cytochrome b(5) reductase fusion protein: identification of histidines 62 and 85 as the heme axial ligands.", "journal": "Arch. Biochem. Biophys.", "date": "2002", "authors": "Davis CA, Dhawan IK, Johnson MK, Barber MJ", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "reference": [ { "type": "PubMed", "id": "11913972", "url": "https://glygen.org/publication/PubMed/11913972" } ] }, { "title": "Identification and characterization of a novel splice variant of mouse and rat cytochrome b5/cytochrome b5 reductase.", "journal": "Genomics", "date": "2004", "authors": "Curry BJ, Roman SD, Wallace CA, Scott R, Miriami E, Aitken RJ", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "reference": [ { "type": "PubMed", "id": "14962668", "url": "https://glygen.org/publication/PubMed/14962668" } ] }, { "title": "Mutagenesis of Glycine 179 modulates both catalytic efficiency and reduced pyridine nucleotide specificity in cytochrome b5 reductase.", "journal": "Biochemistry", "date": "2005", "authors": "Roma GW, Crowley LJ, Davis CA, Barber MJ", "evidence": [ { "database": "RefSeq", "id": "NP_596918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_596918" } ], "reference": [ { "type": "PubMed", "id": "16216070", "url": "https://glygen.org/publication/PubMed/16216070" } ] } ], "pathway": [ { "id": "rno:171015", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:171015", "resource": "KEGG Pathway" }, { "id": "R-RNO-1237044", "name": "Erythrocytes take up carbon dioxide and release oxygen", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1237044", "resource": "Reactome", "description": "Erythrocytes take up carbon dioxide and release oxygen" } ], "orthologs": [ { "uniprot_canonical_ac": "Q3TDX8-4", "protein_name": "Cytochrome b5 reductase 4", "gene_name": "Cyb5r4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLNVPSQAFPAPGSQQRVSSQGRSKVPLKQGRSLMDWIRLTKSGKDLTGLKGGLIEVTEEELKKHNKKEDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGADGTDLFNEVHRWVNYESMLKECLVGRMAVKPAVPKDCHEGKRVLNGMLPKSQMSDTLPRDVTDTLPREDLSSPSYDWFQTESSVTIVVYTKQKNISLDSVIVDLQDDSLRAEAVIKDHSYLVHVGLSHEVQENFSVRVIENVGKIEIVLQKKESVSWQCLGDHLEKHDSFIPKKDTGLYYRRCQLISKEDVTHDTRLFCLMLPPSTHLQVPVGQHVYLKLSVTGAEIVKPYTPVSDSLLSDFKEPVLSPNKYICFLIKIYPAGLFTPELDRLQIGDFISVSGPEGDFKVSKLQEVEDLFLLAAGTGFTPMVTVLNYALSHMSSLRKVKLMFFNKTEDDIIWRCQLEKLALREKRFDVEFVLSAPSPEWNGKQGHISRALLSEFLQRSSENSRAFLCICGPTPFTDEGIRLLHDLNFSDDEIHGFTA", "length": 528 }, "evidence": [ { "id": "45233742", "url": "http://www.informatics.jax.org/homology/45233742", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q7L1T6-1", "protein_name": "Cytochrome b5 reductase 4", "gene_name": "CYB5R4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLNVPSQSFPAPRSQQRVASGGRSKVPLKQGRSLMDWIRLTKSGKDLTGLKGRLIEVTEEELKKHNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGSDGTELFDQVHRWVNYESMLKECLVGRMAIKPAVLKDYREEEKKVLNGMLPKSQVTDTLAKEGPSYPSYDWFQTDSLVTIAIYTKQKDINLDSIIVDHQNDSFRAETIIKDCLYLIHIGLSHEVQEDFSVRVVESVGKIEIVLQKKENTSWDFLGHPLKNHNSLIPRKDTGLYYRKCQLISKEDVTHDTRLFCLMLPPSTHLQVPIGQHVYLKLPITGTEIVKPYTPVSGSLLSEFKEPVLPNNKYIYFLIKIYPTGLFTPELDRLQIGDFVSVSSPEGNFKISKFQELEDLFLLAAGTGFTPMVKILNYALTDIPSLRKVKLMFFNKTEDDIIWRSQLEKLAFKDKRLDVEFVLSAPISEWNGKQGHISPALLSEFLKRNLDKSKVLVCICGPVPFTEQGVRLLHDLNFSKNEIHSFTA", "length": 521 }, "evidence": [ { "id": "45233742", "url": "http://www.informatics.jax.org/homology/45233742", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "pmid": "" }, { "name": "heme binding", "id": "GO:0020037", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor", "id": "GO:0016653", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016653", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "pmid": "" }, { "name": "flavin adenine dinucleotide binding", "id": "GO:0050660", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050660", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "pmid": "" }, { "name": "NAD(P)H oxidase H2O2-forming activity", "id": "GO:0016174", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016174", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "pmid": "" }, { "name": "NADPH-hemoprotein reductase activity", "id": "GO:0003958", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003958", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "pmid": "" }, { "name": "cytochrome-b5 reductase activity, acting on NAD(P)H", "id": "GO:0004128", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004128", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "NADP metabolic process", "id": "GO:0006739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006739", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "pmid": "" }, { "name": "generation of precursor metabolites and energy", "id": "GO:0006091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006091", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "pmid": "" }, { "name": "glucose homeostasis", "id": "GO:0042593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "pmid": "" }, { "name": "response to antibiotic", "id": "GO:0046677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046677", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "pmid": "" }, { "name": "reactive oxygen species metabolic process", "id": "GO:0072593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072593", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "pmid": "" }, { "name": "insulin secretion", "id": "GO:0030073", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030073", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "pmid": "" }, { "name": "cell development", "id": "GO:0048468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048468", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "pmid": "" }, { "name": "superoxide metabolic process", "id": "GO:0006801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006801", "evidence": [ { "database": "UniProtKB", "id": "Q68EJ0", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 427, "end_pos": 429, "annotation": "n_glycosylation_sequon" }, { "start_pos": 509, "end_pos": 511, "annotation": "n_glycosylation_sequon" }, { "start_pos": 81, "end_pos": 83, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "46680", "name": "", "equation": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6AY12-1", "Q68EJ0-1", "P20070-1", "Q5EB81-1", "Q7L1T6-1", "Q9UHQ9-1", "Q6IPT4-1", "P00387-1", "Q6BCY4-1", "Q9DB73-1", "B1AS42-1", "Q3TDX8-4", "Q3KNK3-1", "Q9DCN2-1", "P38626-1", "P36060-1", "Q12746-1", "Q54NC1-1", "X2JGK6-1" ], "evidence": [ { "id": "46680", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/46680" } ] }, { "id": "R-RNO-6806831", "name": "CYB5Rs reduce MetHb to HbA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q68EJ0-1", "Q6AY12-1", "D3ZZ05-1", "Q5EB81-1" ], "evidence": [ { "id": "R-RNO-6806831", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6806831" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "B1AS42", "gene_name": "Cyb5rl", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "B1AS42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AS42" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "B1AS42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AS42" } ] } ] }, { "uniprot_ac": "D3ZZ05", "gene_name": "Cyb5rl", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "D3ZZ05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZ05" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "D3ZZ05", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZ05" } ] } ] }, { "uniprot_ac": "P00387", "gene_name": "CYB5R3", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "P00387", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00387" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "P00387", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00387" } ] } ] }, { "uniprot_ac": "P20070", "gene_name": "Cyb5r3", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "P20070", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20070" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "P20070", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20070" } ] } ] }, { "uniprot_ac": "P36060", "gene_name": "MCR1", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "P36060", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36060" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "P36060", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36060" } ] } ] }, { "uniprot_ac": "P38626", "gene_name": "CBR1", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "P38626", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38626" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "P38626", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38626" } ] } ] }, { "uniprot_ac": "Q12746", "gene_name": "PGA3", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "Q12746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12746" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q12746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12746" } ] } ] }, { "uniprot_ac": "Q3KNK3", "gene_name": "Cyb5r2", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "Q3KNK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3KNK3" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q3KNK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3KNK3" } ] } ] }, { "uniprot_ac": "Q3TDX8", "gene_name": "Cyb5r4", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "Q3TDX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TDX8" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q3TDX8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TDX8" } ] } ] }, { "uniprot_ac": "Q54NC1", "gene_name": "cyb5r1", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "Q54NC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54NC1" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q54NC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54NC1" } ] } ] }, { "uniprot_ac": "Q5EB81", "gene_name": "Cyb5r1", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "Q5EB81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5EB81" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q5EB81", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5EB81" } ] } ] }, { "uniprot_ac": "Q68EJ0", "gene_name": "Cyb5r4", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "Q68EJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q68EJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68EJ0" } ] } ] }, { "uniprot_ac": "Q6AY12", "gene_name": "Cyb5r2", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "Q6AY12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AY12" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q6AY12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AY12" } ] } ] }, { "uniprot_ac": "Q6BCY4", "gene_name": "CYB5R2", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "Q6BCY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6BCY4" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q6BCY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6BCY4" } ] } ] }, { "uniprot_ac": "Q6IPT4", "gene_name": "CYB5RL", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "Q6IPT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6IPT4" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q6IPT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6IPT4" } ] } ] }, { "uniprot_ac": "Q7L1T6", "gene_name": "CYB5R4", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "Q7L1T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7L1T6" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q7L1T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7L1T6" } ] } ] }, { "uniprot_ac": "Q9DB73", "gene_name": "Cyb5r1", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "Q9DB73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DB73" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q9DB73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DB73" } ] } ] }, { "uniprot_ac": "Q9DCN2", "gene_name": "Cyb5r3", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "Q9DCN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DCN2" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q9DCN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DCN2" } ] } ] }, { "uniprot_ac": "Q9UHQ9", "gene_name": "CYB5R1", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "Q9UHQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UHQ9" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q9UHQ9", "database": "UniProtKB", "url": 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