{ "uniprot_canonical_ac": "Q66JT7-1", "uniprot_ac": "Q66JT7", "uniprot_id": "COQ2_MOUSE", "mass": { "chemical_mass": 40504.0, "monoisotopic_mass": 40504.0 }, "refseq": { "ac": "NP_082254", "name": "4-hydroxybenzoate polyprenyltransferase, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082254" }, "gene_names": [ { "name": "Coq2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q66JT7", "id": "Q66JT7" }, { "name": "2310002F18Rik; PHB:PPT", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082254", "id": "NP_082254" }, { "name": "Coq2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082254", "id": "NP_082254" } ], "protein_names": [ { "name": "4-hydroxybenzoate polyprenyltransferase, mitochondrial", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q66JT7" }, { "name": "2.5.1.39", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q66JT7" }, { "name": "4-HB polyprenyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q66JT7" }, { "name": "4-hydroxybenzoate polyprenyltransferase, mitochondrial precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082254", "id": "NP_082254" }, { "name": "PHB:PPT", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q66JT7" }, { "name": "PHB:polyprenyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q66JT7" }, { "name": "Para-hydroxybenzoate--polyprenyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q66JT7" }, { "name": "para-hydroxybenzoate--polyprenyltransferase, mitochondrial; 4-hydroxybenzoate polyprenyltransferase, mitochondrial; PHB:polyprenyltransferase; 4-HB polyprenyltransferase; coenzyme Q2 homolog, prenyltransferase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082254", "id": "NP_082254" } ], "function": [ { "annotation": "Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues", "evidence": [ { "database": "RefSeq", "id": "NP_082254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082254" }, { "database": "PubMed", "id": "21447381", "url": "https://glygen.org/publication/PubMed/21447381" } ] }, { "annotation": "Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis (PubMed:20526342). Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl donor (such as all-trans-nonaprenyl diphosphate) (PubMed:20526342). The length of the polyprenyl side chain varies depending on the species, in humans, the side chain is comprised of 10 isoprenyls producing CoQ10 (also known as ubiquinone), whereas rodents predominantly generate CoQ9 (PubMed:20526342). However, this specificity is not complete, human tissues have low amounts of CoQ9 and rodent organs contain some CoQ10 (By similarity). Plays a central role in the biosynthesis of CoQ9 (PubMed:20526342). CoQ9 is a vital molecule that transports electrons from mitochondrial respiratory chain complexes (PubMed:20526342). CoQs also function as cofactors for uncoupling protein and play a role as regulators of the extracellularly-induced ceramide-dependent apoptotic pathway (By similarity). Regulates mitochondrial permeability transition pore (mPTP) opening and ROS production (pivotal events in cell death) in a tissue specific manner (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q66JT7", "url": "https://www.uniprot.org/uniprot/Q66JT7#function" }, { "database": "UniProtKB", "id": "Q96H96", "url": "https://www.uniprot.org/uniprot/Q96H96#function" }, { "database": "PubMed", "id": "20526342", "url": "https://glygen.org/publication/PubMed/20526342" }, { "database": "UniProtKB", "id": "Q499N4", "url": "https://www.uniprot.org/uniprot/Q499N4#function" } ] } ], "disease": [ { "disease_id": "DOID:0050730", "recommended_name": { "id": "DOID:0050730", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050730", "name": "coenzyme Q10 deficiency disease", "description": "A mitochondrial metabolism disease that is characterized by a deficiency of CoQ10 resulting from reduced biosynthesis." }, "synonyms": [ { "id": "DOID:0050730", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050730", "name": "COENZYME Q10 DEFICIENCY, PRIMARY", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "coenzyme Q10 deficiency, primary, 1", "description": "Any coenzyme Q10 deficiency in which the cause of the disease is a mutation in the COQ2 gene." }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "COQ2 coenzyme Q10 deficiency", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "coenzyme Q10 deficiency caused by mutation in COQ2", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "coenzyme Q10 deficiency, primary, 1", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "coenzyme Q10 deficiency, primary, type 1", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "COQ10D1", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "CoQ deficiency 1", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "Coq10 deficiency, primary, 1", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "coenzyme Q deficiency 1", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "ubiquinone deficiency 1", "description": "" }, { "id": "MIM:607426", "resource": "MIM", "url": "https://www.omim.org/entry/607426", "name": "Coenzyme Q10 deficiency, primary, 1", "description": "Coenzyme Q10 deficiency, primary, 1" } ], "evidence": [ { "id": "0050730", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050730" } ] }, { "disease_id": "DOID:0070238", "recommended_name": { "id": "DOID:0070238", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070238", "name": "primary coenzyme Q10 deficiency 1", "description": "A primary coenzyme Q10 deficiency that has_material_basis_in an autosomal recessive mutation of the COQ2 gene on chromosome 4q21.22-q21.23." }, "synonyms": [ { "id": "DOID:0070238", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070238", "name": "COQ10D1", "description": "" }, { "id": "DOID:0070238", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070238", "name": "CoQ deficiency 1", "description": "" }, { "id": "DOID:0070238", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070238", "name": "CoQ10 deficiency, primary, 1", "description": "" }, { "id": "DOID:0070238", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070238", "name": "coenzyme Q deficiency 1", "description": "" }, { "id": "DOID:0070238", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070238", "name": "ubiquinone deficiency 1", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "coenzyme Q10 deficiency, primary, 1", "description": "Any coenzyme Q10 deficiency in which the cause of the disease is a mutation in the COQ2 gene." }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "COQ2 coenzyme Q10 deficiency", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "coenzyme Q10 deficiency caused by mutation in COQ2", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "coenzyme Q10 deficiency, primary, 1", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "coenzyme Q10 deficiency, primary, type 1", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "COQ10D1", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "CoQ deficiency 1", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "Coq10 deficiency, primary, 1", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "coenzyme Q deficiency 1", "description": "" }, { "id": "MONDO:0011829", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011829", "name": "ubiquinone deficiency 1", "description": "" }, { "id": "MIM:607426", "resource": "MIM", "url": "https://www.omim.org/entry/607426", "name": "Coenzyme Q10 deficiency, primary, 1", "description": "Coenzyme Q10 deficiency, primary, 1" } ], "evidence": [ { "id": "0070238", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0070238" } ] }, { "disease_id": "DOID:10603", "recommended_name": { "id": "DOID:10603", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10603", "name": "glucose intolerance", "description": "" }, "synonyms": [ { "id": "DOID:10603", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10603", "name": "Malabsorption of glucose", "description": "" }, { "id": "DOID:10603", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10603", "name": "Glucose malabsorption", "description": "" } ], "evidence": [ { "id": "10603", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10603" } ] }, { "disease_id": "DOID:1184", "recommended_name": { "id": "DOID:1184", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1184", "name": "nephrotic syndrome", "description": "A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability." }, "synonyms": [], "evidence": [ { "id": "1184", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1184" } ] }, { "disease_id": "DOID:4752", "recommended_name": { "id": "DOID:4752", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4752", "name": "multiple system atrophy", "description": "" }, "synonyms": [ { "id": "DOID:4752", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4752", "name": "Shy-Drager syndrome", "description": "" } ], "evidence": [ { "id": "4752", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4752" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q66JT7", "url": "https://www.uniprot.org/uniprot/Q66JT7" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Coq2", "url": "https://www.uniprot.org/uniprot/Q66JT7", "locus": { "chromosome": "5", "start_pos": 100802589, "end_pos": 100823006, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000029319", "url": "https://www.ensembl.org/id/ENSMUSG00000029319" } ] } } ], "crossref": [ { "id": "ENSMUSG00000029319", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000029319", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd13959", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13959", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "71883", "url": "https://www.ncbi.nlm.nih.gov/gene/71883", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q66JT7", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q66JT7*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000537", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000537", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006370", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006370", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR030470", "url": "https://www.ebi.ac.uk/interpro/entry/IPR030470", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039653", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039653", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044878", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044878", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:71883", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71883", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1919133", "url": "http://www.informatics.jax.org/marker/MGI:1919133", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "MVVYPYG", "url": "https://omabrowser.org/oma/group/MVVYPYG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "34876at2759", "url": "http://www.orthodb.org/?query=34876at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11048", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11048", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11048:SF28", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11048:SF28", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01040", "url": "http://pfam.xfam.org/family/PF01040", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q66JT7", "url": "http://purl.obolibrary.org/obo/PR_Q66JT7", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-1268020", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1268020", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-2142789", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2142789", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_082254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082254", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17709", "url": "https://www.rhea-db.org/rhea/17709", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "44504", "url": "https://www.rhea-db.org/rhea/44504", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "44564", "url": "https://www.rhea-db.org/rhea/44564", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "D3YZF3", "url": "https://www.uniprot.org/uniprot/D3YZF3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3YZF3-1", "url": "https://www.uniprot.org/uniprot/D3YZF3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z296", "url": "https://www.uniprot.org/uniprot/D3Z296", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3Z296-1", "url": "https://www.uniprot.org/uniprot/D3Z296-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RGA8", "url": "https://www.uniprot.org/uniprot/D6RGA8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RGA8-1", "url": "https://www.uniprot.org/uniprot/D6RGA8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7CDY3", "url": "https://www.uniprot.org/uniprot/F7CDY3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7CDY3-1", "url": "https://www.uniprot.org/uniprot/F7CDY3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q66JT7", "url": "https://www.uniprot.org/uniprot/Q66JT7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q66JT7-1", "url": "https://www.uniprot.org/uniprot/Q66JT7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRWGGAGLARGLRAVRSAWLRGPRGLPLALVRSAGVPGARDRRAPAPGTQRGRALSLSAAAVVNSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIAMGAASLLLVVTYPLVKRITFWPQLALGLTFNWGALLGWSAVKGSCDPAVCLPLYFSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFQENTRQWLSGFGVAMVAALSLAGANNGQTVPYYAAVAAVGAHLAHQIYTVDIHRAEDCWDKFTSNRTVGMLLFLGIVLGNLCKEKTEEAKDAEAVRVGSEQTS", "length": 374, "header": "sp|Q66JT7-1|COQ2_MOUSE Isoform 1 of 4-hydroxybenzoate polyprenyltransferase, mitochondrial OS=Mus musculus OX=10090 GN=Coq2 PE=1 SV=2 CANONICAL=Q66JT7-1" }, "isoforms": [ { "isoform_ac": "D3YZF3-1", "url": "", "sequence": { "sequence": "MGAASLLLVVTYPLVK", "length": 16, "header": "tr|D3YZF3-1|D3YZF3_MOUSE Computationally mapped isoform of Coenzyme Q2 4-hydroxybenzoate polyprenyltransferase OS=Mus musculus OX=10090 GN=Coq2 PE=4 SV=1 CANONICAL=Q66JT7-1" }, "locus": { "chromosome": "5", "start_pos": 100809781, "end_pos": 100809734, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000127811.2", "url": "https://www.ensembl.org/id/ENSMUST00000127811.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000115605.2", "url": "https://www.ensembl.org/id/ENSMUSP00000115605.2" } ] } }, { "isoform_ac": "D3Z296-1", "url": "", "sequence": { "sequence": "MGAASLLLVVTYPLVKRITFWPQLALGLTFNWGALLGWSAVKGSCDPAVCLPLYFSGVMWTLIYDTIYAHQ", "length": 71, "header": "tr|D3Z296-1|D3Z296_MOUSE Computationally mapped isoform of Coenzyme Q2 4-hydroxybenzoate polyprenyltransferase OS=Mus musculus OX=10090 GN=Coq2 PE=4 SV=1 CANONICAL=Q66JT7-1" }, "locus": { "chromosome": "5", "start_pos": 100809781, "end_pos": 100808038, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000135801.3", "url": "https://www.ensembl.org/id/ENSMUST00000135801.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000119410.2", "url": "https://www.ensembl.org/id/ENSMUSP00000119410.2" } ] } }, { "isoform_ac": "D6RGA8-1", "url": "", "sequence": { "sequence": "MLRWGGAGLARGLRAVRSAWLRGPRGLPLALVRSAGVPGARDRRAPAPGTQRGRALSLSAAAVVNSAPRPLQPYLRLMRLDKPIGYKDSKPPNRCWRHFDLPVLRLPWGTADLGTGRSPVFKLLQYSNGSSVLTSCRHLPTSEKNHVLASVGFGIDF", "length": 157, "header": "tr|D6RGA8-1|COQ2_MOUSE Computationally mapped isoform of 4-hydroxybenzoate polyprenyltransferase, mitochondrial OS=Mus musculus OX=10090 GN=Coq2 PE=1 SV=1 CANONICAL=Q66JT7-1" }, "locus": { "chromosome": "5", "start_pos": 100822107, "end_pos": 100808162, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000126981.2", "url": "https://www.ensembl.org/id/ENSMUST00000126981.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000122296.2", "url": "https://www.ensembl.org/id/ENSMUSP00000122296.2" } ] } }, { "isoform_ac": "F7CDY3-1", "url": "", "sequence": { "sequence": "XALVRSAGVPGARDRRAPAPGTQRGRALSLSAAAVVNSAPRPLQPYLRLMRLDKPIGHQTWRRVPALTVSGARGASANHCLCERLTWHITEGLSFPVLRLQGQQTAQSLLETFRPSSPSSSLGDS", "length": 125, "header": "tr|F7CDY3-1|COQ2_MOUSE Computationally mapped isoform of 4-hydroxybenzoate polyprenyltransferase, mitochondrial OS=Mus musculus OX=10090 GN=Coq2 PE=1 SV=1 CANONICAL=Q66JT7-1" }, "locus": { "chromosome": "5", "start_pos": 100822022, "end_pos": 100811488, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000135146.2", "url": "https://www.ensembl.org/id/ENSMUST00000135146.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000122631.2", "url": "https://www.ensembl.org/id/ENSMUSP00000122631.2" } ] } }, { "isoform_ac": "Q66JT7-1", "url": "", "sequence": { "sequence": "MLRWGGAGLARGLRAVRSAWLRGPRGLPLALVRSAGVPGARDRRAPAPGTQRGRALSLSAAAVVNSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIAMGAASLLLVVTYPLVKRITFWPQLALGLTFNWGALLGWSAVKGSCDPAVCLPLYFSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFQENTRQWLSGFGVAMVAALSLAGANNGQTVPYYAAVAAVGAHLAHQIYTVDIHRAEDCWDKFTSNRTVGMLLFLGIVLGNLCKEKTEEAKDAEAVRVGSEQTS", "length": 374, "header": "sp|Q66JT7-1|COQ2_MOUSE Isoform 1 of 4-hydroxybenzoate polyprenyltransferase, mitochondrial OS=Mus musculus OX=10090 GN=Coq2 PE=1 SV=2 CANONICAL=Q66JT7-1" }, "locus": { "chromosome": "5", "start_pos": 100822107, "end_pos": 100803167, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000031262", "url": "https://www.ensembl.org/id/ENSMUST00000031262" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000031262", "url": "https://www.ensembl.org/id/ENSMUSP00000031262" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "4-Nitrobenzoate inhibits coenzyme Q biosynthesis in mammalian cell cultures.", "journal": "Nat. Chem. Biol.", "date": "2010", "authors": "Forsman U., Sindelar P.J., Sjoeberg M., Turunen M.", "evidence": [ { "database": "UniProtKB", "id": "Q66JT7", "url": "https://www.uniprot.org/uniprot/Q66JT7" } ], "reference": [ { "type": "PubMed", "id": "20526342", "url": "https://glygen.org/publication/PubMed/20526342" } ] }, { "title": "Calorie restriction modifies ubiquinone and COQ transcript levels in mouse tissues.", "journal": "Free radical biology & medicine", "date": "2011", "authors": "Parrado-Fernandez C, Lopez-Lluch G, Rodriguez-Bies E, Santa-Cruz S, Navas P, Ramsey JJ, Villalba JM", "evidence": [ { "database": "RefSeq", "id": "NP_082254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082254" } ], "reference": [ { "type": "PubMed", "id": "21447381", "url": "https://glygen.org/publication/PubMed/21447381" } ] } ], "pathway": [ { "id": "mmu:71883", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71883", "resource": "KEGG Pathway" }, { "id": "R-MMU-1268020", "name": "Mitochondrial protein import", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1268020", "resource": "Reactome", "description": "Mitochondrial protein import" }, { "id": "R-MMU-2142789", "name": "Ubiquinol biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2142789", "resource": "Reactome", "description": "Ubiquinol biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "Q499N4-1", "protein_name": "4-hydroxybenzoate polyprenyltransferase, mitochondrial", "gene_name": "Coq2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLRLGGAGLVRGLRVVSPAWLRGPGGLPLALARTTGTSGARDRRAPASGTQRGRALSLSAAAVVNSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAADPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDRDFDKKVERTANRPIAAGDISAFQSFVFLGAQLTLALGVLLHLNYYSIAMGAASLLLVVTYPLMKRVTFWPQLALGLTFNWGALLGWSAVKGSCDPAVCLPLYFSGVMWTLIYDTIYAHQDKKDDALIGLKSTALLFRENTKQWLSGFGVAMVGALSLVGASSGQTLPYYAAVAAVGAHLAHQIYTVDIHRAEDCWEKFTSNRTVGLLLFLGIVLGNLYKDKPDETKGVDAVGEESERTS", "length": 374 }, "evidence": [ { "id": "45238537", "url": "http://www.informatics.jax.org/homology/45238537", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q96H96-1", "protein_name": "4-hydroxybenzoate polyprenyltransferase, mitochondrial", "gene_name": "COQ2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLGSRAAGFARGLRAVALAWLPGWRGRSFALARAAGAPHGGDLQPPACPEPRGRQLSLSAAAVVDSAPRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCDPSVCLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTAPYYAALGAVGAHLTHQIYTLDIHRPEDCWNKFISNRTLGLIVFLGIVLGNLWKEKKTDKTKKGIENKIEN", "length": 371 }, "evidence": [ { "id": "45238537", "url": "http://www.informatics.jax.org/homology/45238537", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VHS7-1", "protein_name": "4-hydroxybenzoate polyprenyltransferase, mitochondrial", "gene_name": "Coq2", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MYALRHLRLQSARHFRSSYAAAATTKHMLPRQPARVLIGDWSTWDKSRLQDVCSRSSSTATEPVKQQTPLQELVSAAKPYAQLMRIDRPIGTYLLFWPCAWSIALSADAGCWPDLTMLGLFGTGALIMRGAGCTINDLWDKDIDAKVERTRLRPLASGQISQFDAIVFLSAQLSLGLLVLVQLNWQSILLGASSLGLVITYPLMKRVTYWPQLVLGMAFNWGALLGWCATQGSVNLAACLPLYLSGVCWTIVYDTIYAHQDKLDDLQIGVKSTALRFGENTKVWLSGFTAAMLTGLSAAGWACDQTVPYYAAVGVVGAHLVQQIYSLNIDNPSDCAKKFISNHQVGLILFLGIVLGTLLKSDESKKQRQSSLTTSTASSYVPALPQKPEVLS", "length": 392 }, "evidence": [ { "id": "Q66JT7", "url": "https://omabrowser.org/oma/group/Q66JT7/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q66JT7", "url": "https://www.uniprot.org/uniprot/Q66JT7" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q66JT7", "url": "https://www.uniprot.org/uniprot/Q66JT7" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q66JT7", "url": "https://www.uniprot.org/uniprot/Q66JT7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "ubiquinone biosynthetic process", "id": "GO:0006744", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006744", "evidence": [ { "database": "UniProtKB", "id": "Q66JT7", "url": "https://www.uniprot.org/uniprot/Q66JT7" } ], "pmid": "" }, { "name": "glycerol metabolic process", "id": "GO:0006071", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006071", "evidence": [ { "database": "UniProtKB", "id": "Q66JT7", "url": "https://www.uniprot.org/uniprot/Q66JT7" } ], "pmid": "" }, { "name": "isoprenoid biosynthetic process", "id": "GO:0008299", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008299", "evidence": [ { "database": "UniProtKB", "id": "Q66JT7", "url": "https://www.uniprot.org/uniprot/Q66JT7" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "prenyltransferase activity", "id": "GO:0004659", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004659", "evidence": [ { "database": "UniProtKB", "id": "Q66JT7", "url": "https://www.uniprot.org/uniprot/Q66JT7" } ], "pmid": "" }, { "name": "4-hydroxybenzoate decaprenyltransferase activity", "id": "GO:0002083", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002083", "evidence": [ { "database": "UniProtKB", "id": "Q66JT7", "url": "https://www.uniprot.org/uniprot/Q66JT7" } ], "pmid": "" }, { "name": "4-hydroxybenzoate nonaprenyltransferase activity", "id": "GO:0047293", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047293", "evidence": [ { "database": "UniProtKB", "id": "Q66JT7", "url": "https://www.uniprot.org/uniprot/Q66JT7" } ], "pmid": "" }, { "name": "4-hydroxybenzoate octaprenyltransferase activity", "id": "GO:0008412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008412", "evidence": [ { "database": "UniProtKB", "id": "Q66JT7", "url": "https://www.uniprot.org/uniprot/Q66JT7" } ], "pmid": "" }, { "name": "transferase activity, transferring alkyl or aryl (other than methyl) groups", "id": "GO:0016765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016765", "evidence": [ { "database": "UniProtKB", "id": "Q66JT7", "url": "https://www.uniprot.org/uniprot/Q66JT7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 336, "end_pos": 338, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17709", "name": "", "equation": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q499N4-1", "Q96H96-1", "Q66JT7-1" ], "evidence": [ { "id": "17709", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17709" } ] }, { "id": "44504", "name": "", "equation": "4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q499N4-1", "Q96H96-1", "Q66JT7-1", "P32378-1", "Q54U71-1", "Q9VHS7-1" ], "evidence": [ { "id": "44504", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44504" } ] }, { "id": "44564", "name": "", "equation": "4-hydroxybenzoate + all-trans-decaprenyl diphosphate = 4-hydroxy-3-all-trans-decaprenylbenzoate + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZG27-1", "Q499N4-1", "Q9Y5Z9-1", "Q96H96-1", "Q9DC60-1", "Q66JT7-1" ], "evidence": [ { "id": "44564", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44564" } ] }, { "id": "R-MMU-2162192", "name": "PHB and all-E-10PrP2 are combined into DHB by COQ2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane, mitochondrial matrix", "input_participant_list": [ "R-ALL-2162213", "R-ALL-2162214" ], "output_participant_list": [ "R-ALL-2162207" ], "enzyme_list": [ "Q66JT7-1" ], "evidence": [ { "id": "R-MMU-2162192", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2162192" } ] }, { "id": "R-MMU-8986181", "name": "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63038-1", "P11725-1", "P56480-1", "Q7TNG8-1", "Q8K411-1", "Q66JT7-1", "O35943-1" ], "evidence": [ { "id": "R-MMU-8986181", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8986181" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-2162207", "participant_name": "DHB [mitochondrial matrix]", "crossref": [ { "id": "HMDB0006251", "database": "HMDB Metabolite", "url": "" }, { "id": "64136", "database": "ChEBI", "url": "" }, { "id": "000085552713", "database": "ZINC", "url": "" }, { "id": "64136", "database": "ChEBI", "url": "" }, { "id": "000085552713", "database": "ZINC", "url": "" }, { "id": "HMDB0006251", "database": "HMDB Metabolite", "url": "" }, { "id": "64136", "database": "ChEBI", "url": "" }, { "id": "000085552713", "database": "ZINC", "url": "" }, { "id": "HMDB0006251", "database": "HMDB Metabolite", "url": "" }, { "id": "64136", "database": "ChEBI", "url": "" }, { "id": "000085552713", "database": "ZINC", "url": "" }, { "id": "HMDB0006251", "database": "HMDB Metabolite", "url": "" }, { "id": "HMDB0006251", "database": "HMDB Metabolite", "url": "" }, { "id": "64136", "database": "ChEBI", "url": "" }, { "id": "000085552713", "database": "ZINC", "url": "" }, { "id": "64136", "database": "ChEBI", "url": "" }, { "id": "000085552713", "database": "ZINC", "url": "" }, { "id": "HMDB0006251", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-2162213", "participant_name": "PHB [mitochondrial matrix]", "crossref": [ { "id": "HMDB0000500", "database": "HMDB Metabolite", "url": "" }, { "id": "C00156", "database": "COMPOUND", "url": "" }, { "id": "000000332752", "database": "ZINC", "url": "" }, { "id": "30763", "database": "ChEBI", "url": "" }, { "id": "000000332752", "database": "ZINC", "url": "" }, { "id": "30763", "database": "ChEBI", "url": "" }, { "id": "C00156", "database": "COMPOUND", "url": "" }, { "id": "HMDB0000500", "database": "HMDB Metabolite", "url": "" }, { "id": "HMDB0000500", "database": "HMDB Metabolite", "url": "" }, { "id": "C00156", "database": "COMPOUND", "url": "" }, { "id": "000000332752", "database": "ZINC", "url": "" }, { "id": "30763", "database": "ChEBI", "url": "" }, { "id": "000000332752", "database": "ZINC", "url": "" }, { "id": "30763", "database": "ChEBI", "url": "" }, { "id": "C00156", "database": "COMPOUND", "url": "" }, { "id": "HMDB0000500", "database": "HMDB Metabolite", "url": "" }, { "id": "30763", "database": "ChEBI", "url": "" }, { "id": "HMDB0000500", "database": "HMDB Metabolite", "url": "" }, { "id": "000000332752", "database": "ZINC", "url": "" }, { "id": "C00156", "database": "COMPOUND", "url": "" }, { "id": "HMDB0000500", "database": "HMDB Metabolite", "url": "" }, { "id": "C00156", "database": "COMPOUND", "url": "" }, { "id": "000000332752", "database": "ZINC", "url": "" }, { "id": "30763", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-2162214", "participant_name": "all-E-10PrP2 [mitochondrial matrix]", "crossref": [ { "id": "61011", "database": "ChEBI", "url": "" }, { "id": "C17432", "database": "COMPOUND", "url": "" }, { "id": "000087520194", "database": "ZINC", "url": "" }, { "id": "61011", "database": "ChEBI", "url": "" }, { "id": "000087520194", "database": "ZINC", "url": "" }, { "id": "C17432", "database": "COMPOUND", "url": "" }, { "id": "61011", "database": "ChEBI", "url": "" }, { "id": "C17432", "database": "COMPOUND", "url": "" }, { "id": "000087520194", "database": "ZINC", "url": "" }, { "id": "000087520194", "database": "ZINC", "url": "" }, { "id": "61011", "database": "ChEBI", "url": "" }, { "id": "C17432", "database": "COMPOUND", "url": "" }, { "id": "61011", "database": "ChEBI", "url": "" }, { "id": "000087520194", "database": "ZINC", "url": "" }, { "id": "C17432", "database": "COMPOUND", "url": "" }, { "id": "000087520194", "database": "ZINC", "url": "" }, { "id": "61011", "database": "ChEBI", "url": "" }, { "id": "C17432", "database": "COMPOUND", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "D3ZG27", "gene_name": "Ubiad1", "activity": [ { "ec_number": "2.5.1.-", "activity": "", "evidence": [ { "id": "D3ZG27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZG27" } ] }, { "ec_number": "2.5.1.39", "activity": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate.", "evidence": [ { "id": "D3ZG27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZG27" } ] }, { "ec_number": "2.5.1.39", "activity": "", "evidence": [ { "id": "D3ZG27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZG27" } ] } ] }, { "uniprot_ac": "O35943", "gene_name": "Fxn", "activity": [ { "ec_number": "1.16.3.1", "activity": "4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O.", "evidence": [ { "id": "O35943", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35943" } ] }, { "ec_number": "1.16.3.1", "activity": "", "evidence": [ { "id": "O35943", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35943" } ] } ] }, { "uniprot_ac": "P11725", "gene_name": "Otc", "activity": [ { "ec_number": "2.1.3.3", "activity": "carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate.", "evidence": [ { "id": "P11725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11725" } ] }, { "ec_number": "2.1.3.3", "activity": "", "evidence": [ { "id": "P11725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11725" } ] } ] }, { "uniprot_ac": "P32378", "gene_name": "COQ2", "activity": [ { "ec_number": "2.5.1.39", "activity": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate.", "evidence": [ { "id": "P32378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32378" } ] }, { "ec_number": "2.5.1.39", "activity": "", "evidence": [ { "id": "P32378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32378" } ] } ] }, { "uniprot_ac": "P56480", "gene_name": "Atp5f1b", "activity": [ { "ec_number": "7.1.2.2", "activity": "ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate.", "evidence": [ { "id": "P56480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56480" } ] }, { "ec_number": "7.1.2.2", "activity": "", "evidence": [ { "id": "P56480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56480" } ] } ] }, { "uniprot_ac": "P63038", "gene_name": "Hspd1", "activity": [ { "ec_number": "5.6.1.7", "activity": "ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.", "evidence": [ { "id": "P63038", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63038" } ] }, { "ec_number": "5.6.1.7", "activity": "", "evidence": [ { "id": "P63038", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63038" } ] } ] }, { "uniprot_ac": "Q499N4", "gene_name": "Coq2", "activity": [ { "ec_number": "2.5.1.39", "activity": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate.", "evidence": [ { "id": "Q499N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q499N4" } ] }, { "ec_number": "2.5.1.39", "activity": "", "evidence": [ { "id": "Q499N4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q499N4" } ] } ] }, { "uniprot_ac": "Q54U71", "gene_name": "coq2", "activity": [ { "ec_number": "2.5.1.39", "activity": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate.", "evidence": [ { "id": "Q54U71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54U71" } ] }, { "ec_number": "2.5.1.39", "activity": "", "evidence": [ { "id": "Q54U71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54U71" } ] } ] }, { "uniprot_ac": "Q66JT7", "gene_name": "Coq2", "activity": [ { "ec_number": "2.5.1.39", "activity": "4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4-hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate.", "evidence": [ { "id": "Q66JT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66JT7" } ] }, { "ec_number": "2.5.1.39", "activity": "", "evidence": [ { "id": "Q66JT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66JT7" } ] } ] }, { "uniprot_ac": "Q7TNG8", "gene_name": "Ldhd", "activity": [ { "ec_number": "1.1.2.4", "activity": "(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + 2 H(+) + pyruvate.", "evidence": [ { "id": "Q7TNG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TNG8" } ] }, { "ec_number": "1.1.2.4", "activity": "", "evidence": [ { "id": "Q7TNG8", "database": "UniProtKB", "url": 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