{ "uniprot_canonical_ac": "Q66HF1-1", "uniprot_ac": "Q66HF1", "uniprot_id": "NDUS1_RAT", "mass": { "chemical_mass": 79412.0, "monoisotopic_mass": 79412.0 }, "refseq": { "ac": "NP_001005550", "name": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005550" }, "gene_names": [ { "name": "Ndufs1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q66HF1", "id": "Q66HF1" }, { "name": "Ndufs1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005550", "id": "NP_001005550" } ], "protein_names": [ { "name": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q66HF1" }, { "name": "7.1.1.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q66HF1" }, { "name": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005550", "id": "NP_001005550" }, { "name": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005550", "id": "NP_001005550" } ], "function": [ { "annotation": "A critical postnatal accumulation of oxidatively damaged respiratory complex I occurs in the cerebellum following prenatal exposure to all-trans retinoic acid.", "evidence": [ { "database": "RefSeq", "id": "NP_001005550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005550" }, { "database": "PubMed", "id": "21752959", "url": "https://glygen.org/publication/PubMed/21752959" } ] }, { "annotation": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (By similarity). Essential for catalysing the entry and efficient transfer of electrons within complex I (By similarity). Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1#function" }, { "database": "UniProtKB", "id": "P28331", "url": "https://www.uniprot.org/uniprot/P28331#function" } ] }, { "annotation": "Down regulation of NDUFS1 is involved in the progression of parenteral-nutrition-associated liver disease by increasing Oxidative stress.", "evidence": [ { "database": "RefSeq", "id": "NP_001005550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005550" }, { "database": "PubMed", "id": "36402252", "url": "https://glygen.org/publication/PubMed/36402252" } ] } ], "disease": [ { "disease_id": "DOID:0060536", "recommended_name": { "id": "DOID:0060536", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060536", "name": "mitochondrial complex I deficiency", "description": "A mitochondrial metabolism disease characterized by a wide range of manifestations including marked and often fatal lactic acidosis, cardiomyopathy, leukoencephalopathy, pure myopathy and hepatopathy with tubulopathy. Among the numerous clinical phenotypes observed are Leigh syndrome, Leber hereditary optic neuropathy and MELAS syndrome. It can have material basis in mutations in multiple different genes, both nuclear-encoded and mitochondrial-encoded." }, "synonyms": [ { "id": "DOID:0060536", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060536", "name": "isolated mitochondrial respiratory chain complex I deficiency", "description": "" }, { "id": "DOID:0060536", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060536", "name": "isolated NADH-CoQ reductase deficiency", "description": "" }, { "id": "DOID:0060536", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060536", "name": "isolated NADH-coenzyme Q reductase deficiency", "description": "" }, { "id": "DOID:0060536", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060536", "name": "isolated NADH-ubiquinone reductase deficiency", "description": "" } ], "evidence": [ { "id": "0060536", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060536" } ] }, { "disease_id": "DOID:0112068", "recommended_name": { "id": "DOID:0112068", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112068", "name": "nuclear type mitochondrial complex I deficiency 5", "description": "A nuclear type mitochondrial complex I deficiency that has_material_basis_in homozygous or compound heterozygous mutation in the NDUFS1 gene on chromosome 2q33.3." }, "synonyms": [ { "id": "DOID:0112068", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112068", "name": "MC1DN5", "description": "" }, { "id": "MONDO:0032610", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032610", "name": "mitochondrial complex 1 deficiency, nuclear type 5", "description": "" }, { "id": "MONDO:0032610", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032610", "name": "MC1DN5", "description": "" }, { "id": "MONDO:0032610", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0032610", "name": "MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 5", "description": "" }, { "id": "MIM:618226", "resource": "MIM", "url": "https://www.omim.org/entry/618226", "name": "Mitochondrial complex I deficiency, nuclear type 5", "description": "Mitochondrial complex I deficiency, nuclear type 5" } ], "evidence": [ { "id": "0112068", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0112068" } ] }, { "disease_id": "DOID:655", "recommended_name": { "id": "DOID:655", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:655", "name": "inherited metabolic disorder", "description": "A disease of metabolism that is characterized by enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to inherited enzyme abnormality." }, "synonyms": [ { "id": "DOID:655", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:655", "name": "Inborn Errors of Metabolism", "description": "" }, { "id": "DOID:655", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:655", "name": "Metabolic hereditary disorder", "description": "" }, { "id": "DOID:655", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:655", "name": "inborn metabolism disorder", "description": "" } ], "evidence": [ { "id": "655", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:655" } ] }, { "disease_id": "DOID:700", "recommended_name": { "id": "DOID:700", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:700", "name": "mitochondrial metabolism disease", "description": "An inherited metabolic disorder that involves mitochondrial metabolism dysfunction." }, "synonyms": [], "evidence": [ { "id": "700", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:700" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "common_name": "Rat" } ], "gene": [ { "name": "Ndufs1", "url": "https://www.uniprot.org/uniprot/Q66HF1", "locus": { "chromosome": "9", "start_pos": 64546225, "end_pos": 64579893, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000011849", "url": "https://www.ensembl.org/id/ENSRNOG00000011849" } ] } } ], "crossref": [ { "id": "ENSRNOG00000011849", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000011849", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00207", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00207", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd02773", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02773", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "301458", "url": "https://www.ncbi.nlm.nih.gov/gene/301458", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q66HF1", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q66HF1*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000283", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000283", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001041", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001041", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006656", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006656", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006963", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006963", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010228", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010228", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015405", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015405", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019574", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019574", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036010", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036010", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:301458", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301458", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q66HF1", "url": "https://oglcnac.org/atlas/detail/Q66HF1", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q66HF1", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q66HF1", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "HKNVGPL", "url": "https://omabrowser.org/oma/group/HKNVGPL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "19999at2759", "url": "http://www.orthodb.org/?query=19999at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR43105", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43105", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR43105:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR43105:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00384", "url": "http://pfam.xfam.org/family/PF00384", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF09326", "url": "http://pfam.xfam.org/family/PF09326", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF10588", "url": "http://pfam.xfam.org/family/PF10588", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13510", "url": "http://pfam.xfam.org/family/PF13510", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q66HF1", "url": "http://purl.obolibrary.org/obo/PR_Q66HF1", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-611105", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-611105", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-6799198", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6799198", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001005550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005550", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "1359670", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1359670", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "29091", "url": "https://www.rhea-db.org/rhea/29091", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A8I5ZXM3", "url": "https://www.uniprot.org/uniprot/A0A8I5ZXM3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZXM3-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZXM3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2Q7K1", "url": "https://www.uniprot.org/uniprot/A0A8L2Q7K1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2Q7K1-1", "url": "https://www.uniprot.org/uniprot/A0A8L2Q7K1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q66HF1-1", "url": "https://www.uniprot.org/uniprot/Q66HF1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLRIPVKRALIGLSKSPKGYVRSTGTAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGSDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVAGMLQSFEGKAVAAIAGGLVDAEALVALKDLLNKVDSDTLCTEEIFPNEGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYRYDHLGDSPKILQDIASGNHEFSKVLNAAKKPMVVLGSSALQRDDGAAILAAVSSIAQKIRVASGAAAEWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKLLFLLGADGGCITRQDLPKDCFIVYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGITLPYDTLDQVRNRLGEVSPNLVRYDDVEEANYFQQASELAKLVDQEFLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPSIC", "length": 727, "header": "sp|Q66HF1-1|NDUS1_RAT Isoform 1 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Rattus norvegicus OX=10116 GN=Ndufs1 PE=1 SV=1 CANONICAL=Q66HF1-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZXM3-1", "url": "", "sequence": { "sequence": "MLRIPVKRALIGLSKSPKGYGKFLLYIHEIFLEIYLCILKYTACEKVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGSDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVAGMLQSFEGKAVAAIAGGLVDAEALVALKDLLNKVDSDTLCTEEIFPNEGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYRYDHLGDSPKILQDIASGNHEFSKVLNAAKKPMVVLGSSALQRDDGAAILAAVSSIAQKIRVASGAAAEWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKLLFLLGADGGCITRQDLPKDCFIVYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGITLPYDTLDQVRNRLGEVSPNLVRYDDVEEANYFQQASELAKLVDQEFLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPSIC", "length": 718, "header": "tr|A0A8I5ZXM3-1|NDUS1_RAT Computationally mapped isoform of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Rattus norvegicus OX=10116 GN=Ndufs1 PE=1 SV=1 CANONICAL=Q66HF1-1" }, "locus": { "chromosome": "9", "start_pos": 64575129, "end_pos": 64546665, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000098172.1", "url": "https://www.ensembl.org/id/ENSRNOT00000098172.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000083908.1", "url": "https://www.ensembl.org/id/ENSRNOP00000083908.1" } ] } }, { "isoform_ac": "A0A8L2Q7K1-1", "url": "", "sequence": { "sequence": "MVEPGTTVLQKVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGSDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVAGMLQSFEGKAVAAIAGGLVDAEALVALKDLLNKVDSDTLCTEEIFPNEGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYRYDHLGDSPKILQDIASGNHEFSKVLNAAKKPMVVLGSSALQRDDGAAILAAVSSIAQKIRVASGAAAEWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKLLFLLGADGGCITRQDLPKDCFIVYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGITLPYDTLDQVRNRLGEVSPNLVRYDDVEEANYFQQASELAKLVDQEFLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPSIC", "length": 683, "header": "tr|A0A8L2Q7K1-1|NDUS1_RAT Computationally mapped isoform of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Rattus norvegicus OX=10116 GN=Ndufs1 PE=1 SV=1 CANONICAL=Q66HF1-1" }, "locus": { "chromosome": "9", "start_pos": 64574413, "end_pos": 64546665, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000015852.6", "url": "https://www.ensembl.org/id/ENSRNOT00000015852.6" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000015851.5", "url": "https://www.ensembl.org/id/ENSRNOP00000015851.5" } ] } }, { "isoform_ac": "Q66HF1-1", "url": "", "sequence": { "sequence": "MLRIPVKRALIGLSKSPKGYVRSTGTAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGSDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVAGMLQSFEGKAVAAIAGGLVDAEALVALKDLLNKVDSDTLCTEEIFPNEGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYRYDHLGDSPKILQDIASGNHEFSKVLNAAKKPMVVLGSSALQRDDGAAILAAVSSIAQKIRVASGAAAEWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKLLFLLGADGGCITRQDLPKDCFIVYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGITLPYDTLDQVRNRLGEVSPNLVRYDDVEEANYFQQASELAKLVDQEFLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPSIC", "length": 727, "header": "sp|Q66HF1-1|NDUS1_RAT Isoform 1 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Rattus norvegicus OX=10116 GN=Ndufs1 PE=1 SV=1 CANONICAL=Q66HF1-1" }, "locus": { "chromosome": "9", "start_pos": 64575129, "end_pos": 64546665, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000104288", "url": "https://www.ensembl.org/id/ENSRNOT00000104288" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000087012", "url": "https://www.ensembl.org/id/ENSRNOP00000087012" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 187, "start_aa": "Ser", "end_pos": 187, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser187", "evidence": [ { "id": "Q66HF1", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q66HF1" }, { "id": "27213235", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27213235" }, { "id": "26446791", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26446791" }, { "id": "18683930", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/18683930" }, { "id": "34502162", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34502162" }, { "id": "Q66HF1", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q66HF1" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 287, "start_aa": "Ser", "end_pos": 287, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser287", "evidence": [ { "id": "Q66HF1", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q66HF1" }, { "id": "27213235", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27213235" }, { "id": "26446791", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26446791" }, { "id": "18683930", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/18683930" }, { 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"https://glygen.org/publication/PubMed/34502162" }, { "id": "Q66HF1", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q66HF1" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 478, "start_aa": "Ser", "end_pos": 478, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser478", "evidence": [ { "id": "Q66HF1", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q66HF1" }, { "id": "27213235", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27213235" }, { "id": "26446791", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26446791" }, { "id": "18683930", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/18683930" }, { "id": "34502162", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34502162" }, { "id": "Q66HF1", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q66HF1" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 494, "start_aa": "Ser", "end_pos": 494, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser494", "evidence": [ { "id": "Q66HF1", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q66HF1" }, { "id": "27213235", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27213235" }, { "id": "26446791", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26446791" }, { "id": "18683930", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/18683930" }, { "id": "34502162", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34502162" }, { "id": "Q66HF1", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q66HF1" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 504, "start_aa": "Ser", "end_pos": 504, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser504", "evidence": [ { "id": "Q66HF1", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q66HF1" }, { "id": "27213235", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27213235" }, { "id": "26446791", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26446791" }, { "id": "18683930", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/18683930" }, { "id": "34502162", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34502162" }, { "id": "Q66HF1", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q66HF1" } ] }, { 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"subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 627, "start_aa": "Ser", "end_pos": 627, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser627", "evidence": [ { "id": "Q66HF1", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q66HF1" }, { "id": "27213235", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27213235" }, { "id": "26446791", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26446791" }, { "id": "18683930", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/18683930" }, { "id": "34502162", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34502162" }, { "id": "Q66HF1", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q66HF1" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins.", "journal": "Journal of the American Chemical Society", "date": "2008", "authors": "Clark PM, Dweck JF, Mason DE, Hart CR, Buck SB, Peters EC, Agnew BJ, Hsieh-Wilson LC", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q66HF1", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q66HF1" } ], "reference": [ { "type": "PubMed", "id": "18683930", "url": "https://glygen.org/publication/PubMed/18683930" } ] }, { "title": "Rat embryo exposure to all-trans retinoic acid results in postnatal oxidative damage of respiratory complex I in the cerebellum.", "journal": "Molecular pharmacology", "date": "2011", "authors": "Signorile A, Sardaro N, De Rasmo D, Scacco S, Papa F, Borracci P, Carratu MR, Papa S", "evidence": [ { "database": "RefSeq", "id": "NP_001005550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005550" } ], "reference": [ { "type": "PubMed", "id": "21752959", "url": "https://glygen.org/publication/PubMed/21752959" } ] }, { "title": "O-GlcNAcomic Profiling Identifies Widespread O-Linked beta-N-Acetylglucosamine Modification (O-GlcNAcylation) in Oxidative Phosphorylation System Regulating Cardiac Mitochondrial Function.", "journal": "The Journal of biological chemistry", "date": "2015", "authors": "Ma J, Liu T, Wei AC, Banerjee P, O'Rourke B, Hart GW", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q66HF1", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q66HF1" }, { "database": "O-GlcNAc Atlas", "id": "Q66HF1", "url": "https://oglcnac.org/atlas/detail/Q66HF1" } ], "reference": [ { "type": "PubMed", "id": "26446791", "url": "https://glygen.org/publication/PubMed/26446791" } ] }, { "title": "Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts.", "journal": "Journal of proteome research", "date": "2016", "authors": "Ma J, Banerjee P, Whelan SA, Liu T, Wei AC, Ramirez-Correa G, McComb ME, Costello CE, O'Rourke B, Murphy A, Hart GW", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q66HF1", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q66HF1" }, { "database": "O-GlcNAc Atlas", "id": "Q66HF1", "url": "https://oglcnac.org/atlas/detail/Q66HF1" } ], "reference": [ { "type": "PubMed", "id": "27213235", "url": "https://glygen.org/publication/PubMed/27213235" } ] }, { "title": "An O-GlcNAcylomic Approach Reveals ACLY as a Potential Target in Sepsis in the Young Rat.", "journal": "International journal of molecular sciences", "date": "2021", "authors": "Denis M, Dupas T, Persello A, Dontaine J, Bultot L, Betus C, Pele T, Dhot J, Erraud A, Maillard A, Montnach J, Leroux AA, Bigot-Corbel E, Vertommen D, Riviere M, Lebreton J, Tessier A, Waard M, Bertrand L, Rozec B, Lauzier B", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q66HF1", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q66HF1" } ], "reference": [ { "type": "PubMed", "id": "34502162", "url": "https://glygen.org/publication/PubMed/34502162" } ] }, { "title": "Down regulation of NDUFS1 is involved in the progression of parenteral-nutrition-associated liver disease by increasing Oxidative stress.", "journal": "The Journal of nutritional biochemistry", "date": "2022-11-17", "authors": "Wan Songlin, Maitiabula Gulisudumu, Wang Peng, Zhang Yupeng, Gao Xuejin, Zhang Li, Gao Tingting, Wang Xinying", "evidence": [ { "database": "RefSeq", "id": "NP_001005550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005550" } ], "reference": [ { "type": "PubMed", "id": "36402252", "url": "https://glygen.org/publication/PubMed/36402252" } ] } ], "pathway": [ { "id": "rno:301458", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301458", "resource": "KEGG Pathway" }, { "id": "R-RNO-611105", "name": "Respiratory electron transport", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-611105", "resource": "Reactome", "description": "Respiratory electron transport" }, { "id": "R-RNO-6799198", "name": "Complex I biogenesis", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6799198", "resource": "Reactome", "description": "Complex I biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "P28331-1", "protein_name": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "gene_name": "NDUFS1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLRIPVRKALVGLSKSPKGCVRTTATAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGNDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVAGMLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMTSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPSIC", "length": 727 }, "evidence": [ { "id": "45235790", "url": "http://www.informatics.jax.org/homology/45235790", "database": "MGI" }, { "id": "Q66HF1", "url": "https://omabrowser.org/oma/group/Q66HF1/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q91VD9-1", "protein_name": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "gene_name": "Ndufs1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLRIPIKRALIGLSNSPKGYVRTTGTAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGSDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNVIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVAGMLQNFEGNAVAAIAGGLVDAEALVALKDLLNKVDSDNLCTEEIFPTEGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYRYDHLGDSPKILQDIASGRHSFCEVLKDAKKPMVVLGSSALQRDDGAAILVAVSNMVQKIRVTTGVAAEWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKMLFLLGADGGCITRQDLPKDCFIVYQGHHGDVGAPMADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGITLPYDTLDQVRNRLEEVSPNLVRYDDIEETNYFQQASELAKLVNQEVLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPSIC", "length": 727 }, "evidence": [ { "id": "45235790", "url": "http://www.informatics.jax.org/homology/45235790", "database": "MGI" }, { "id": "Q66HF1", "url": "https://omabrowser.org/oma/group/Q66HF1/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q94511-1", "protein_name": "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial", "gene_name": "ND-75", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MIRAPLVKALGALGSPTHQMASRAVRTSAMVAQTPAKAPEKIEVFVDDIPVQVVPGTTVLQAAAQIGVEIPRFCYHERLAVAGNCRMCLVEVEKSPKPVAACAMPVMKGWRIKTNSDLTRKAREGVMEFLLMNHPLDCPICDQGGECDLQDQAMAFGSDRSRFTDINYTGKRAVEDKDIGPLVKTIMTRCIHCTRCVRFASEIAGVDDLGTTGRGNDMQIGTYVEKLFLTELSGNVIDLCPVGALTNKPYSFVARPWEIRKVSSIDVLDAVGSNIVVSTRTNEVLRILPRENEDVNEEWLADKSRFACDGLKRQRLVAPMVRMPNGELQAVEWEGALIAVAKAIKAAGGQIAGISGQLADLEAQVALKDLLNRLGSEVVATEQGFIAGGTDNRANYLLNSTIAGLEEADAVLLVGTNPRYEAPLVNTRLRKAYVHNELQIASIGPKIDLSYDHENLGADAALVKDVCSGAHAFSKVLEGAKKPAIIIGADLLERADGAAIHATVAEYCKKLKKPNWNPFNVLQTNAAQVGALDVGYKAGAQTAVKAQPKVLFLLNADAGKVTREQLPKDCFVVYIGSHGDNGASIADAVLPGAAYTEKQGIYVNTEGRPQQTLPGVSPPGMAREDWKILRALSEVVGKPLPYDNLDELRNRLEDVAPHLTRLGQLEPAGDAGAAGTISKSIGGGAIDIKLKELRDYFMTDAISRASPTMAKCISAVNKQQRENEAKQSVAI", "length": 731 }, "evidence": [ { "id": "Q66HF1", "url": "https://omabrowser.org/oma/group/Q66HF1/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "ATP synthesis coupled electron transport", "id": "GO:0042773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042773", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" }, { "name": "regulation of mitochondrial membrane potential", "id": "GO:0051881", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051881", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" }, { "name": "reactive oxygen species metabolic process", "id": "GO:0072593", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072593", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" }, { "name": "mitochondrial electron transport, NADH to ubiquinone", "id": "GO:0006120", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006120", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" }, { "name": "apoptotic mitochondrial changes", "id": "GO:0008637", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008637", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" }, { "name": "ATP metabolic process", "id": "GO:0046034", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046034", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" }, { "name": "cellular respiration", "id": "GO:0045333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045333", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" }, { "name": "respirasome", "id": "GO:0070469", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070469", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" }, { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" }, { "name": "mitochondrial respiratory chain complex I", "id": "GO:0005747", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005747", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" }, { "name": "4 iron, 4 sulfur cluster binding", "id": "GO:0051539", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051539", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" }, { "name": "NADH dehydrogenase (ubiquinone) activity", "id": "GO:0008137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008137", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" }, { "name": "electron transfer activity", "id": "GO:0009055", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009055", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" }, { "name": "2 iron, 2 sulfur cluster binding", "id": "GO:0051537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051537", "evidence": [ { "database": "UniProtKB", "id": "Q66HF1", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 388, "end_pos": 390, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29091", "name": "", "equation": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P05507-1", "P19234-1", "P03889-1", "P11662-1", "Q66HF1-1", "P05506-1", "P05508-1", "P11661-1", "Q641Y2-1", "P03926-1", "Q5XIH3-1", "P49821-1", "P19404-1", "P03901-1", "P03897-1", "P03915-1", "P03923-1", "P03891-1", "P03905-1", "P03886-1", "P28331-1", "O00217-1", "O75306-1", "O75489-1", "O75251-1", "P03888-1", "Q91YT0-1", "Q9D6J6-1", "P03903-1", "Q91VD9-1", "Q91WD5-1", "Q8K3J1-1", "P03899-1", "P03921-1", "P03893-1", "P03911-1", "P03925-1", "Q9DCT2-1", "Q9DC70-1", "Q55CD9-1", "O21047-1", "O21048-1", "P22237-1", "Q34313-1", "Q37312-1", "Q37313-1", "Q37314-1", "Q54F10-1", "Q9XK79-1", "Q23883-1", "Q34312-1", "Q54I90-1", "P18930-1", "P18931-1", "P18932-1", "P18934-1", "Q94511-1", "Q9VF27-1", "Q9VZU4-1", "P03896-1", "P18929-1", "P18933-1", "Q9VMI3-1" ], "evidence": [ { "id": "29091", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29091" } ] }, { "id": "R-RNO-163217", "name": "Complex I oxidises NADH to NAD+, reduces CoQ to QH2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-76633", "R-ALL-163953" ], "enzyme_list": [ "Q66HF1-1", "Q5XIH3-1", "P03926-1", "P05506-1", "P05508-1", "P11661-1", "Q641Y2-1", "P03889-1", "P11662-1", "P19234-1" ], "evidence": [ { "id": "R-RNO-163217", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-163217" } ] }, { "id": "R-RNO-6788523", "name": "NUBPL transfers 4Fe-4S to Complex I subunits", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q66HF1-1", "Q641Y2-1" ], "evidence": [ { "id": "R-RNO-6788523", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6788523" } ] }, { "id": "R-RNO-6799179", "name": "Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q66HF1-1", "Q5XIH3-1", "B1WC61-1", "B2GV71-1", "P03926-1", "P05506-1", "P05508-1", "P11661-1", "Q641Y2-1", "P03889-1", "P11662-1", "P19234-1", "Q5XI79-1" ], "evidence": [ { "id": "R-RNO-6799179", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6799179" } ] }, { "id": "R-RNO-6799196", "name": "The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q66HF1-1", "Q5XIH3-1", "B1WC61-1", "B2GV71-1", "P03926-1", "P05506-1", "P05508-1", "P11661-1", "Q641Y2-1", "P03889-1", "P11662-1", "P19234-1", "Q5XI79-1" ], "evidence": [ { "id": "R-RNO-6799196", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6799196" } ] }, { "id": "R-RNO-6800870", "name": "NDUF subunits bind to form the FP subcomplex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane, mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q66HF1-1", "Q5XIH3-1", "P19234-1" ], "evidence": [ { "id": "R-RNO-6800870", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6800870" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-163953", "participant_name": "H+ [mitochondrial intermembrane space]", "crossref": [ { "id": "C00080", "database": "COMPOUND", "url": "" }, { "id": "15378", "database": "ChEBI", "url": "" }, { "id": "HMDB0059597", "database": "HMDB Metabolite", "url": "" }, { "id": "8145820", "database": "PubChem Substance", "url": "" }, { "id": "C00080", "database": "COMPOUND", "url": "" }, { "id": "15378", "database": "ChEBI", "url": "" }, { "id": "HMDB0059597", "database": "HMDB Metabolite", "url": "" }, { "id": "8145820", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0059597", "database": "HMDB Metabolite", "url": "" }, { "id": "C00080", "database": "COMPOUND", "url": "" }, { "id": "8145820", "database": "PubChem Substance", "url": "" }, { "id": "15378", "database": "ChEBI", "url": "" }, { "id": "C00080", "database": "COMPOUND", "url": "" }, { "id": "15378", "database": "ChEBI", "url": "" }, { "id": "HMDB0059597", "database": "HMDB Metabolite", "url": "" }, { "id": "8145820", "database": "PubChem Substance", "url": "" }, { "id": "C00080", "database": "COMPOUND", "url": "" }, { "id": "15378", "database": "ChEBI", "url": "" }, { "id": "HMDB0059597", "database": "HMDB Metabolite", "url": "" }, { "id": "8145820", "database": "PubChem Substance", "url": "" }, { "id": "C00080", "database": "COMPOUND", "url": "" }, { "id": "15378", "database": "ChEBI", "url": "" }, { "id": "HMDB0059597", "database": "HMDB Metabolite", "url": "" }, { "id": "8145820", "database": "PubChem Substance", "url": "" } ] }, { "participant_id": "R-ALL-76633", "participant_name": "QH2 [mitochondrial inner membrane]", "crossref": [ { "id": "C00390", "database": "COMPOUND", "url": "" }, { "id": "17976", "database": "ChEBI", "url": "" }, { "id": "000002047402", "database": "ZINC", "url": "" }, { "id": "8143934", "database": "PubChem Substance", "url": "" }, { "id": "C00390", "database": "COMPOUND", "url": "" }, { "id": "17976", "database": "ChEBI", "url": "" }, { "id": "000002047402", "database": "ZINC", "url": "" }, { "id": "8143934", "database": "PubChem Substance", "url": "" }, { "id": "C00390", "database": "COMPOUND", "url": "" }, { "id": "17976", "database": "ChEBI", "url": "" }, { "id": "000002047402", "database": "ZINC", "url": "" }, { "id": "8143934", "database": "PubChem Substance", "url": "" }, { "id": "C00390", "database": "COMPOUND", "url": "" }, { "id": "17976", "database": "ChEBI", "url": "" }, { "id": "000002047402", "database": "ZINC", "url": "" }, { "id": "8143934", "database": "PubChem Substance", "url": "" }, { "id": "C00390", "database": "COMPOUND", "url": "" }, { "id": "17976", "database": "ChEBI", "url": "" }, { "id": "000002047402", "database": "ZINC", "url": "" }, { "id": "8143934", "database": "PubChem Substance", "url": "" }, { "id": "C00390", "database": "COMPOUND", "url": "" }, { "id": "17976", "database": "ChEBI", "url": "" }, { "id": "000002047402", "database": "ZINC", "url": "" }, { "id": "8143934", "database": "PubChem Substance", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "B1WC61", "gene_name": "Acad9", "activity": [ { "ec_number": "1.3.8.-", "activity": "", "evidence": [ { "id": "B1WC61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WC61" } ] } ] }, { "uniprot_ac": "B2GV71", "gene_name": "Ndufaf5", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "B2GV71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GV71" } ] }, { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "B2GV71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GV71" } ] } ] }, { "uniprot_ac": "O00217", "gene_name": "NDUFS8", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "O00217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00217" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "O00217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00217" } ] } ] }, { "uniprot_ac": "O21047", "gene_name": "nad4", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "O21047", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O21047" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "O21047", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O21047" } ] } ] }, { "uniprot_ac": "O21048", "gene_name": "nad2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "O21048", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O21048" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "O21048", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O21048" } ] } ] }, { "uniprot_ac": "O75251", "gene_name": "NDUFS7", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "O75251", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75251" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "O75251", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75251" } ] } ] }, { "uniprot_ac": "O75306", "gene_name": "NDUFS2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "O75306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75306" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "O75306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75306" } ] } ] }, { "uniprot_ac": "O75489", "gene_name": "NDUFS3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "O75489", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75489" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "O75489", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75489" } ] } ] }, { "uniprot_ac": "P03886", "gene_name": "MT-ND1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03886", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03886" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03886", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03886" } ] } ] }, { "uniprot_ac": "P03888", "gene_name": "Mtnd1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03888" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03888" } ] } ] }, { "uniprot_ac": "P03889", "gene_name": "Mtnd1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03889", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03889" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03889", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03889" } ] } ] }, { "uniprot_ac": "P03891", "gene_name": "MT-ND2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03891" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03891" } ] } ] }, { "uniprot_ac": "P03893", "gene_name": "mt-Nd2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03893", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03893" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03893", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03893" } ] } ] }, { "uniprot_ac": "P03896", "gene_name": "mt:ND2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03896" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03896" } ] } ] }, { "uniprot_ac": "P03897", "gene_name": "MT-ND3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03897" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03897" } ] } ] }, { "uniprot_ac": "P03899", "gene_name": "mt-Nd3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03899", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03899" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03899", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03899" } ] } ] }, { "uniprot_ac": "P03901", "gene_name": "MT-ND4L", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03901", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03901" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03901", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03901" } ] } ] }, { "uniprot_ac": "P03903", "gene_name": "Mtnd4l", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03903" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03903" } ] } ] }, { "uniprot_ac": "P03905", "gene_name": "MT-ND4", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03905", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03905" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03905", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03905" } ] } ] }, { "uniprot_ac": "P03911", "gene_name": "Mtnd4", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03911" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03911" } ] } ] }, { "uniprot_ac": "P03915", "gene_name": "MT-ND5", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03915" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03915" } ] } ] }, { "uniprot_ac": "P03921", "gene_name": "Mtnd5", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03921" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03921" } ] } ] }, { "uniprot_ac": "P03923", "gene_name": "MT-ND6", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03923" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03923" } ] } ] }, { "uniprot_ac": "P03925", "gene_name": "Mtnd6", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03925" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03925" } ] } ] }, { "uniprot_ac": "P03926", "gene_name": "Mtnd6", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03926", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03926" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03926", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03926" } ] } ] }, { "uniprot_ac": "P05506", "gene_name": "mt-Nd3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P05506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05506" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P05506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05506" } ] } ] }, { "uniprot_ac": "P05507", "gene_name": "Mtnd4l", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P05507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05507" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P05507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05507" } ] } ] }, { "uniprot_ac": "P05508", "gene_name": "Mtnd4", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P05508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05508" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P05508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05508" } ] } ] }, { "uniprot_ac": "P11661", "gene_name": "Mtnd5", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P11661", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11661" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P11661", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11661" } ] } ] }, { "uniprot_ac": "P11662", "gene_name": "mt-Nd2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P11662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11662" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P11662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11662" } ] } ] }, { "uniprot_ac": "P18929", "gene_name": "mt:ND1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P18929", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18929" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P18929", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18929" } ] } ] }, { "uniprot_ac": "P18930", "gene_name": "mt:ND3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P18930", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18930" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P18930", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18930" } ] } ] }, { "uniprot_ac": "P18931", "gene_name": "mt:ND4", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P18931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18931" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P18931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18931" } ] } ] }, { "uniprot_ac": "P18932", "gene_name": "mt:ND5", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P18932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18932" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P18932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18932" } ] } ] }, { "uniprot_ac": "P18933", "gene_name": "mt:ND6", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P18933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18933" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P18933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18933" } ] } ] }, { "uniprot_ac": "P18934", "gene_name": "mt:ND4L", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P18934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18934" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P18934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18934" } ] } ] }, { "uniprot_ac": "P19234", "gene_name": "Ndufv2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P19234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19234" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P19234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19234" } ] } ] }, { "uniprot_ac": "P19404", "gene_name": "NDUFV2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P19404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19404" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P19404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19404" } ] } ] }, { "uniprot_ac": "P22237", "gene_name": "nad9", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P22237", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22237" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P22237", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22237" } ] } ] }, { "uniprot_ac": "P28331", "gene_name": "NDUFS1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P28331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28331" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P28331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28331" } ] } ] }, { "uniprot_ac": "P49821", "gene_name": "NDUFV1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P49821", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49821" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P49821", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49821" } ] } ] }, { "uniprot_ac": "Q23883", "gene_name": "nad7", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q23883", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23883" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q23883", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23883" } ] } ] }, { "uniprot_ac": "Q34312", "gene_name": "nad11", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q34312", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q34312" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q34312", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q34312" } ] } ] }, { "uniprot_ac": "Q34313", "gene_name": "nad5", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q34313", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q34313" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q34313", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q34313" } ] } ] }, { "uniprot_ac": "Q37312", "gene_name": "nad3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q37312", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q37312" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q37312", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q37312" } ] } ] }, { "uniprot_ac": "Q37313", "gene_name": "nad1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q37313", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q37313" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q37313", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q37313" } ] } ] }, { "uniprot_ac": "Q37314", "gene_name": "nad6", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q37314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q37314" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q37314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q37314" } ] } ] }, { "uniprot_ac": "Q54F10", "gene_name": "ndufv2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q54F10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54F10" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q54F10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54F10" } ] } ] }, { "uniprot_ac": "Q54I90", "gene_name": "ndufv1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q54I90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I90" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { 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