{
    "uniprot_canonical_ac": "Q66H78-1",
    "uniprot_ac": "Q66H78",
    "uniprot_id": "PXYP1_RAT",
    "mass": {
        "chemical_mass": 54958.0,
        "monoisotopic_mass": 54958.0
    },
    "refseq": {
        "ac": "NP_001007711",
        "name": "2-phosphoxylose phosphatase 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007711"
    },
    "gene_names": [
        {
            "name": "Pxylp1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q66H78",
            "id": "Q66H78"
        },
        {
            "name": "Acpl2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007711",
            "id": "NP_001007711"
        },
        {
            "name": "Acpl2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q66H78",
            "id": "Q66H78"
        },
        {
            "name": "Pxylp1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007711",
            "id": "NP_001007711"
        }
    ],
    "protein_names": [
        {
            "name": "2-phosphoxylose phosphatase 1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q66H78"
        },
        {
            "name": "2-phosphoxylose phosphatase 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007711",
            "id": "NP_001007711"
        },
        {
            "name": "3.1.3.-",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q66H78"
        },
        {
            "name": "Acid phosphatase-like protein 2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q66H78"
        },
        {
            "name": "acid phosphatase-like protein 2; acid phosphatase-like 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007711",
            "id": "NP_001007711"
        }
    ],
    "function": [
        {
            "annotation": "Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q66H78",
                    "url": "https://www.uniprot.org/uniprot/Q66H78#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q8TE99",
                    "url": "https://www.uniprot.org/uniprot/Q8TE99#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q66H78",
                    "url": "https://www.uniprot.org/uniprot/Q66H78"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Pxylp1",
            "url": "https://www.uniprot.org/uniprot/Q66H78",
            "locus": {
                "chromosome": "8",
                "start_pos": 97419776,
                "end_pos": 97485064,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000012480",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000012480"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000012480",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000012480",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd07061",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd07061",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "315939",
            "url": "https://www.ncbi.nlm.nih.gov/gene/315939",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR000560",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000560",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR029033",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029033",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:315939",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:315939",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "HGHPLPC",
            "url": "https://omabrowser.org/oma/group/HGHPLPC/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3403603at2759",
            "url": "http://www.orthodb.org/?query=3403603at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11567",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11567",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR11567:SF125",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11567:SF125",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00328",
            "url": "http://pfam.xfam.org/family/PF00328",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q66H78",
            "url": "http://purl.obolibrary.org/obo/PR_Q66H78",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001007711",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007711",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1359617",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1359617",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "56512",
            "url": "https://www.rhea-db.org/rhea/56512",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "A0A8I6AKD7",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AKD7",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8I6AKD7-1",
            "url": "https://www.uniprot.org/uniprot/A0A8I6AKD7-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q66H78",
            "url": "https://www.uniprot.org/uniprot/Q66H78",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q66H78-1",
            "url": "https://www.uniprot.org/uniprot/Q66H78-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MLYRNRFLVLLALAGLLAFLSLSLQFFHLIPVSTTKNGGSSKSRKRIMPDPVTEPPTVDPVYEALLYCNIPSVAEHSMEGHAPHHYKLVSVHVFIRHGDRYPLYAIPKTKRPEIDCTLVASRKPYHPKLEAFVGHMLKGSGASFESPLGSLPLYPNHPLCEMGELTQTGVVQHLQNGQLLRDIYLRKHKLLPNNWSSDQLYLETTGKSRTLQSGLALLYGFLPEFDWKKVYFKHQPSALFCSGSCYCPLRNQYLEKEQRRQYLLRLKNSDLERTYGEMAKIVDIPTKQLRAANPIDSMLCHFCHNVSFPCSRSGCLGMEHFKVIKTHQIEDERERHEKLLYFGYSLLGAHPILNQTVNRMQRAALGWRDELFTLYSAHDVTLSPILSALGLLEARFPRFAARLVFELWQDRQKPSEHSVRILYNGADVTFHTSFCHDFHKHSPKPMCPLENLVRFVKRDMFVALDGSSTNYYDACHGEGA",
        "length": 480,
        "header": "sp|Q66H78-1|PXYP1_RAT Isoform 1 of 2-phosphoxylose phosphatase 1  OS=Rattus norvegicus OX=10116 GN=Pxylp1 PE=2 SV=1 CANONICAL=Q66H78-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8I6AKD7-1",
            "url": "",
            "sequence": {
                "sequence": "ALNRRHIFSTHCAFFAVHLIPVSTTKNGGSSKSRKRIMPDPVTEPPTVDPVYEALLYCNIPSVAEHSMEGHAPHHYKLVSVHVFIRHGDRYPLYAIPKTKRPEIDCTLVASRKPYHPKLEAFVGHMLKGSGASFESPLGSLPLYPNHPLCEMGELTQTGVVQHLQNGQLLRDIYLRKHKLLPNNWSSDQLYLETTGKSRTLQSGLALLYGFLPEFDWKKVYFKHQPSALFCSGSCYCPLRNQYLEKEQRRQYLLRLKNSDLERTYGEMAKIVDIPTKQLRAANPIDSMLCHFCHNVSFPCSRSGCLGMEHFKVIKTHQIEDERERHEKLLYFGYSLLGAHPILNQTVNRMQRAALGWRDELFTLYSAHDVTLSPILSALGLLEARFPRFAARLVFELWQDRQKPSEHSVRILYNGADVTFHTSFCHDFHKHSPKPMCPLENLVRFVKRDMFVALDGSSTNYYDACHGEGA",
                "length": 470,
                "header": "tr|A0A8I6AKD7-1|A0A8I6AKD7_RAT Computationally mapped isoform of 2-phosphoxylose phosphatase 1  OS=Rattus norvegicus OX=10116 GN=Pxylp1 PE=1 SV=1 CANONICAL=Q66H78-1"
            },
            "locus": {
                "chromosome": "8",
                "start_pos": 97436530,
                "end_pos": 97421066,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000115781.1",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000115781.1"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000093431.1",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000093431.1"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q66H78-1",
            "url": "",
            "sequence": {
                "sequence": "MLYRNRFLVLLALAGLLAFLSLSLQFFHLIPVSTTKNGGSSKSRKRIMPDPVTEPPTVDPVYEALLYCNIPSVAEHSMEGHAPHHYKLVSVHVFIRHGDRYPLYAIPKTKRPEIDCTLVASRKPYHPKLEAFVGHMLKGSGASFESPLGSLPLYPNHPLCEMGELTQTGVVQHLQNGQLLRDIYLRKHKLLPNNWSSDQLYLETTGKSRTLQSGLALLYGFLPEFDWKKVYFKHQPSALFCSGSCYCPLRNQYLEKEQRRQYLLRLKNSDLERTYGEMAKIVDIPTKQLRAANPIDSMLCHFCHNVSFPCSRSGCLGMEHFKVIKTHQIEDERERHEKLLYFGYSLLGAHPILNQTVNRMQRAALGWRDELFTLYSAHDVTLSPILSALGLLEARFPRFAARLVFELWQDRQKPSEHSVRILYNGADVTFHTSFCHDFHKHSPKPMCPLENLVRFVKRDMFVALDGSSTNYYDACHGEGA",
                "length": 480,
                "header": "sp|Q66H78-1|PXYP1_RAT Isoform 1 of 2-phosphoxylose phosphatase 1  OS=Rattus norvegicus OX=10116 GN=Pxylp1 PE=2 SV=1 CANONICAL=Q66H78-1"
            },
            "locus": {
                "chromosome": "8",
                "start_pos": 97452572,
                "end_pos": 97421066,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000017085",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000017085"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000017085",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000017085"
                    }
                ]
            }
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "reported",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 194,
            "start_aa": "Asn",
            "end_pos": 194,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn194",
            "evidence": [
                {
                    "id": "Q66H78",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q66H78#ptm_processing"
                },
                {
                    "id": "PRU00498",
                    "database": "PROSITE-PRORULE",
                    "url": "https://prosite.expasy.org/rule/PRU00498"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 305,
            "start_aa": "Asn",
            "end_pos": 305,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn305",
            "evidence": [
                {
                    "id": "Q66H78",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q66H78#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "reported",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 354,
            "start_aa": "Asn",
            "end_pos": 354,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn354",
            "evidence": [
                {
                    "id": "Q66H78",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q66H78#ptm_processing"
                },
                {
                    "id": "PRU00498",
                    "database": "PROSITE-PRORULE",
                    "url": "https://prosite.expasy.org/rule/PRU00498"
                }
            ]
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme",
        "glycoprotein",
        "glycoprotein_reported",
        "glycoprotein_predicted"
    ],
    "publication": [],
    "pathway": [
        {
            "id": "rno:315939",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:315939",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8BHA9-1",
            "protein_name": "2-phosphoxylose phosphatase 1",
            "gene_name": "Pxylp1",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MLHRNRFLVLLALAGLLAFLSLSLQFFHLIPVSATKNGGSSKSRKRIMPDPVTEPPTVDPVYEALLYCNIPSVAEHSMEGHAPHHYKLVSVHVFIRHGDRYPLYAIPKTKRPEIDCTLVASRKPYHPKLEAFISHMLKGSGASFESPLNSLPLYPNHPLCETGELTQTGVVQHLLNGQLLRDIYLRKHKLLPNNWSSDQLYLESTGKSRTLQSGLALLYGFLPEFDWKKVYFKHQPSALFCSGSCYCPLRNQYLEKEQRRQYLLRLKNSDLERTYGEMAKIVDIPTKQLRAANPIDSMLCHFCHNVSFPCSRSGCLGMEHFKVIKTHQIEDERERHEKLLYFGYSLLGAHPILNQTVNRMQRAASGWRDELFTLYSAHDVTLSPILSALGLLEARFPRFAARLVFELWQDRQKPSEHSVRILYNGADVTFHTSFCHDFHKRSPKPMCPLENLVRFVKRDMFVALDGSSTNYYDACHGEGA",
                "length": 480
            },
            "evidence": [
                {
                    "id": "45232808",
                    "url": "http://www.informatics.jax.org/homology/45232808",
                    "database": "MGI"
                },
                {
                    "id": "Q66H78",
                    "url": "https://omabrowser.org/oma/group/Q66H78/",
                    "database": "OMA"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q8TE99-1",
            "protein_name": "2-phosphoxylose phosphatase 1",
            "gene_name": "PXYLP1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MLFRNRFLLLLALAALLAFVSLSLQFFHLIPVSTPKNGMSSKSRKRIMPDPVTEPPVTDPVYEALLYCNIPSVAERSMEGHAPHHFKLVSVHVFIRHGDRYPLYVIPKTKRPEIDCTLVANRKPYHPKLEAFISHMSKGSGASFESPLNSLPLYPNHPLCEMGELTQTGVVQHLQNGQLLRDIYLKKHKLLPNDWSADQLYLETTGKSRTLQSGLALLYGFLPDFDWKKIYFRHQPSALFCSGSCYCPVRNQYLEKEQRRQYLLRLKNSQLEKTYGEMAKIVDVPTKQLRAANPIDSMLCHFCHNVSFPCTRNGCVDMEHFKVIKTHQIEDERERREKKLYFGYSLLGAHPILNQTIGRMQRATEGRKEELFALYSAHDVTLSPVLSALGLSEARFPRFAARLIFELWQDREKPSEHSVRILYNGVDVTFHTSFCQDHHKRSPKPMCPLENLVRFVKRDMFVALGGSGTNYYDACHREGF",
                "length": 480
            },
            "evidence": [
                {
                    "id": "45232808",
                    "url": "http://www.informatics.jax.org/homology/45232808",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Biological Process",
                "total": 4,
                "go_terms": [
                    {
                        "name": "dephosphorylation",
                        "id": "GO:0016311",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016311",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q66H78",
                                "url": "https://www.uniprot.org/uniprot/Q66H78"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "glycosaminoglycan biosynthetic process",
                        "id": "GO:0006024",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006024",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q66H78",
                                "url": "https://www.uniprot.org/uniprot/Q66H78"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "chondroitin sulfate proteoglycan biosynthetic process",
                        "id": "GO:0050650",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050650",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q66H78",
                                "url": "https://www.uniprot.org/uniprot/Q66H78"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of heparan sulfate proteoglycan biosynthetic process",
                        "id": "GO:0010909",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010909",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q66H78",
                                "url": "https://www.uniprot.org/uniprot/Q66H78"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "Golgi membrane",
                        "id": "GO:0000139",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q66H78",
                                "url": "https://www.uniprot.org/uniprot/Q66H78"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Golgi apparatus",
                        "id": "GO:0005794",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q66H78",
                                "url": "https://www.uniprot.org/uniprot/Q66H78"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "phosphatase activity",
                        "id": "GO:0016791",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016791",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q66H78",
                                "url": "https://www.uniprot.org/uniprot/Q66H78"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 194,
            "end_pos": 196,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 305,
            "end_pos": 307,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 354,
            "end_pos": 356,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "56512",
            "name": "",
            "equation": "3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + phosphate",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "Q66H78-1",
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