{
    "uniprot_canonical_ac": "Q66H23-1",
    "uniprot_ac": "Q66H23",
    "uniprot_id": "MFRN1_RAT",
    "mass": {
        "chemical_mass": 37497.0,
        "monoisotopic_mass": 37497.0
    },
    "refseq": {
        "ac": "NP_001014018",
        "name": "mitoferrin-1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014018"
    },
    "gene_names": [
        {
            "name": "Slc25a37",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q66H23",
            "id": "Q66H23"
        },
        {
            "name": "Mfrn",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q66H23",
            "id": "Q66H23"
        },
        {
            "name": "Mscp; RGD1359361",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014018",
            "id": "NP_001014018"
        },
        {
            "name": "Slc25a37",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014018",
            "id": "NP_001014018"
        }
    ],
    "protein_names": [
        {
            "name": "Mitoferrin-1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q66H23"
        },
        {
            "name": "Mitochondrial iron transporter 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q66H23"
        },
        {
            "name": "Solute carrier family 25 member 37",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q66H23"
        },
        {
            "name": "mitochondrial solute carrier-like protein; mitochondrial iron transporter 1; mitochondrial carrier domain containing protein RGD1359361; solute carrier family 25 (mitochondrial iron transporter), member 37",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014018",
            "id": "NP_001014018"
        },
        {
            "name": "mitoferrin-1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014018",
            "id": "NP_001014018"
        }
    ],
    "function": [
        {
            "annotation": "Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q66H23",
                    "url": "https://www.uniprot.org/uniprot/Q66H23#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q920G8",
                    "url": "https://www.uniprot.org/uniprot/Q920G8#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Rattus norvegicus",
            "taxid": 10116,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q66H23",
                    "url": "https://www.uniprot.org/uniprot/Q66H23"
                }
            ],
            "common_name": "Rat"
        }
    ],
    "gene": [
        {
            "name": "Slc25a37",
            "url": "https://www.uniprot.org/uniprot/Q66H23",
            "locus": {
                "chromosome": "15",
                "start_pos": 44536727,
                "end_pos": 44577199,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSRNOG00000015495",
                        "url": "https://www.ensembl.org/id/ENSRNOG00000015495"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSRNOG00000015495",
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000015495",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "306000",
            "url": "https://www.ncbi.nlm.nih.gov/gene/306000",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR018108",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018108",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR023395",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023395",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "rno:306000",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:306000",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "MYNSQHQ",
            "url": "https://omabrowser.org/oma/group/MYNSQHQ/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5481380at2759",
            "url": "http://www.orthodb.org/?query=5481380at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR45758",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45758",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR45758:SF4",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45758:SF4",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00153",
            "url": "http://pfam.xfam.org/family/PF00153",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q66H23",
            "url": "http://purl.obolibrary.org/obo/PR_Q66H23",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001014018",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014018",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "1359361",
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1359361",
            "database": "RGD",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "28486",
            "url": "https://www.rhea-db.org/rhea/28486",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "A0A8L2QC12",
            "url": "https://www.uniprot.org/uniprot/A0A8L2QC12",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A8L2QC12-1",
            "url": "https://www.uniprot.org/uniprot/A0A8L2QC12-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q66H23",
            "url": "https://www.uniprot.org/uniprot/Q66H23",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q66H23-1",
            "url": "https://www.uniprot.org/uniprot/Q66H23-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MELRRGGVGSQAAGRRMDGDCRDGGCGSKDAGSEDYENLPTSASVSTHMTAGAMAGILEHSIMYPVDSVKTRMQSLNPDPKARYTSIYGALKRIMHTEGFWRPLRGLNVMMMGAGPAHAMYFACYENMKRTLNDVFSHQGNSHLANGIAGSMATLLHDAVMNPAEVVKQRLQMYNSQHQSALSCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQVNPRRDYNPQSHIISGGLAGALAAAATTPLDVCKTLLNTQENMALSLANVSGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEFFKYFLTKRQLENRTLY",
        "length": 338,
        "header": "sp|Q66H23-1|MFRN1_RAT Isoform 1 of Mitoferrin-1  OS=Rattus norvegicus OX=10116 GN=Slc25a37 PE=2 SV=1 CANONICAL=Q66H23-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A8L2QC12-1",
            "url": "",
            "sequence": {
                "sequence": "MCSGQRRHTERWVPSARRTNSAATAGLFFSSYWCFWLLGSTPARHGVSRRNPGEEVPTLRSEVFLPLPLLPTSCRLPRPTGPRMELRRGGVGSQAAGRRMDGDCRDGGCGSKDAGSEDYENLPTSASVSTHMTAGAMAGILEHSIMYPVDSVKTRMQSLNPDPKARYTSIYGALKRIMHTEGFWRPLRGLNVMMMGAGPAHAMYFACYENMKRTLNDVFSHQGNSHLANGIAGSMATLLHDAVMNPAEVVKQRLQMYNSQHQSALSCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQVNPRRDYNPQSHIISGGLAGALAAAATTPLDVCKTLLNTQENMALSLANVSGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEFFKYFLTKRQLENRTLY",
                "length": 421,
                "header": "tr|A0A8L2QC12-1|MFRN1_RAT Computationally mapped isoform of Mitoferrin-1  OS=Rattus norvegicus OX=10116 GN=Slc25a37 PE=2 SV=1 CANONICAL=Q66H23-1"
            },
            "locus": {
                "chromosome": "15",
                "start_pos": 44576806,
                "end_pos": 44537205,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSRNOT00000021636.5",
                        "url": "https://www.ensembl.org/id/ENSRNOT00000021636.5"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSRNOP00000021636.4",
                        "url": "https://www.ensembl.org/id/ENSRNOP00000021636.4"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q66H23-1",
            "url": "",
            "sequence": {
                "sequence": "MELRRGGVGSQAAGRRMDGDCRDGGCGSKDAGSEDYENLPTSASVSTHMTAGAMAGILEHSIMYPVDSVKTRMQSLNPDPKARYTSIYGALKRIMHTEGFWRPLRGLNVMMMGAGPAHAMYFACYENMKRTLNDVFSHQGNSHLANGIAGSMATLLHDAVMNPAEVVKQRLQMYNSQHQSALSCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQVNPRRDYNPQSHIISGGLAGALAAAATTPLDVCKTLLNTQENMALSLANVSGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEFFKYFLTKRQLENRTLY",
                "length": 338,
                "header": "sp|Q66H23-1|MFRN1_RAT Isoform 1 of Mitoferrin-1  OS=Rattus norvegicus OX=10116 GN=Slc25a37 PE=2 SV=1 CANONICAL=Q66H23-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "rno:306000",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:306000",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q920G8-1",
            "protein_name": "Mitoferrin-1",
            "gene_name": "Slc25a37",
            "tax_id": 10090,
            "organism": "Mus musculus",
            "sequence": {
                "sequence": "MELRRGGVGNQAAGRRMDGDCRDGGCGSKDAGSEDYENLPTSASVSTHMTAGAMAGILEHSIMYPVDSVKTRMQSLNPDPKARYTSIYGALKRIMHTEGFWRPLRGLNVMMMGAGPAHAMYFACYENMKRTLNDVFSHQGNSHLANGVAGSMATLLHDAVMNPAEVVKQRLQMYNSQHQSAFSCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQVNPRRDYNPQSHIISGGLAGALAAAATTPLDVCKTLLNTQENMALSLANVSGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEFFKYILTKRQLENRTLY",
                "length": 338
            },
            "evidence": [
                {
                    "id": "45228006",
                    "url": "http://www.informatics.jax.org/homology/45228006",
                    "database": "MGI"
                }
            ],
            "common_name": "Mouse"
        },
        {
            "uniprot_canonical_ac": "Q9NYZ2-1",
            "protein_name": "Mitoferrin-1",
            "gene_name": "SLC25A37",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MELRSGSVGSQAVARRMDGDSRDGGGGKDATGSEDYENLPTSASVSTHMTAGAMAGILEHSVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEGFWRPLRGVNVMIMGAGPAHAMYFACYENMKRTLNDVFHHQGNSHLANGIAGSMATLLHDAVMNPAEVVKQRLQMYNSQHRSAISCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQVNPHRTYNPQSHIISGGLAGALAAAATTPLDVCKTLLNTQENVALSLANISGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEFFKYFLTKRQLENRAPY",
                "length": 338
            },
            "evidence": [
                {
                    "id": "45228006",
                    "url": "http://www.informatics.jax.org/homology/45228006",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 4,
                "go_terms": [
                    {
                        "name": "membrane",
                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q66H23",
                                "url": "https://www.uniprot.org/uniprot/Q66H23"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitochondrion",
                        "id": "GO:0005739",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q66H23",
                                "url": "https://www.uniprot.org/uniprot/Q66H23"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitochondrial inner membrane",
                        "id": "GO:0005743",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q66H23",
                                "url": "https://www.uniprot.org/uniprot/Q66H23"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitochondrial membrane",
                        "id": "GO:0031966",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q66H23",
                                "url": "https://www.uniprot.org/uniprot/Q66H23"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 2,
                "go_terms": [
                    {
                        "name": "iron import into the mitochondrion",
                        "id": "GO:0048250",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048250",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q66H23",
                                "url": "https://www.uniprot.org/uniprot/Q66H23"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of hemoglobin biosynthetic process",
                        "id": "GO:0046985",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046985",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q66H23",
                                "url": "https://www.uniprot.org/uniprot/Q66H23"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 2,
                "go_terms": [
                    {
                        "name": "ferrous iron transmembrane transporter activity",
                        "id": "GO:0015093",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015093",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q66H23",
                                "url": "https://www.uniprot.org/uniprot/Q66H23"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "iron ion transmembrane transporter activity",
                        "id": "GO:0005381",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005381",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q66H23",
                                "url": "https://www.uniprot.org/uniprot/Q66H23"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 274,
            "end_pos": 276,
            "annotation": "n_glycosylation_sequon"
        },
        {
            "start_pos": 334,
            "end_pos": 336,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "28486",
            "name": "",
            "equation": "Fe(2+)(in) = Fe(2+)(out)",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [],
            "evidence": [
                {
                    "id": "28486",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/28486"
                }
            ]
        }
    ],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
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