{ "uniprot_canonical_ac": "Q64232-1", "uniprot_ac": "Q64232", "uniprot_id": "TECR_RAT", "mass": { "chemical_mass": 36123.0, "monoisotopic_mass": 36123.0 }, "refseq": { "ac": "NP_612558", "name": "very-long-chain enoyl-CoA reductase isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612558" }, "gene_names": [ { "name": "Tecr", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q64232", "id": "Q64232" }, { "name": "Gpsn2; SC2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612558", "id": "NP_612558" }, { "name": "Gpsn2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q64232", "id": "Q64232" }, { "name": "Tecr", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612558", "id": "NP_612558" } ], "protein_names": [ { "name": "Very-long-chain enoyl-CoA reductase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q64232" }, { "name": "1.3.1.93", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q64232" }, { "name": "Synaptic glycoprotein SC2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q64232" }, { "name": "TER", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q64232" }, { "name": "Trans-2,3-enoyl-CoA reductase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q64232" }, { "name": "neuroprotective protein 13; TER; glycoprotein, synaptic 2; synaptic glycoprotein SC2; very-long-chain enoyl-CoA reductase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612558", "id": "NP_612558" }, { "name": "very-long-chain enoyl-CoA reductase isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612558", "id": "NP_612558" } ], "function": [ { "annotation": "Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (By similarity). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (By similarity). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (By similarity). This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (By similarity). Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity). Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232#function" }, { "database": "UniProtKB", "id": "Q9NZ01", "url": "https://www.uniprot.org/uniprot/Q9NZ01#function" } ] } ], "disease": [ { "disease_id": "DOID:0050889", "recommended_name": { "id": "DOID:0050889", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050889", "name": "non-syndromic intellectual disability", "description": "An intellectual disability that is characterized by the absence of associated medical and behavioral signs and symptoms." }, "synonyms": [], "evidence": [ { "id": "0050889", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050889" } ] }, { "disease_id": "DOID:0081188", "recommended_name": { "id": "DOID:0081188", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0081188", "name": "autosomal recessive intellectual developmental disorder 14", "description": "An autosomal recessive intellectual developmental disorder that has_material_basis_in homozygous mutation in the TECR gene on chromosome 19p13." }, "synonyms": [ { "id": "MONDO:0013528", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013528", "name": "intellectual disability, autosomal recessive 14", "description": "Any autosomal recessive non-syndromic intellectual disability in which the cause of the disease is a mutation in the TECR gene." }, { "id": "MONDO:0013528", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013528", "name": "TECR autosomal recessive non-syndromic intellectual disability", "description": "" }, { "id": "MONDO:0013528", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013528", "name": "autosomal recessive non-syndromic intellectual disability caused by mutation in TECR", "description": "" }, { "id": "MONDO:0013528", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013528", "name": "intellectual disability, autosomal recessive 14", "description": "" }, { "id": "MONDO:0013528", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013528", "name": "intellectual disability, autosomal recessive type 14", "description": "" }, { "id": "MONDO:0013528", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013528", "name": "mental retardation, autosomal recessive type 14", "description": "" }, { "id": "MONDO:0013528", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013528", "name": "MRT14", "description": "" }, { "id": "MONDO:0013528", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013528", "name": "mental retardation, autosomal recessive 14", "description": "" }, { "id": "MIM:614020", "resource": "MIM", "url": "https://www.omim.org/entry/614020", "name": "Intellectual developmental disorder, autosomal recessive 14", "description": "Intellectual developmental disorder, autosomal recessive 14" } ], "evidence": [ { "id": "0081188", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0081188" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232" } ], "common_name": "Rat" } ], "gene": [ { "name": "Tecr", "url": "https://www.uniprot.org/uniprot/Q64232", "locus": { "chromosome": "19", "start_pos": 24568168, "end_pos": 24541615, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000021808", "url": "https://www.ensembl.org/id/ENSRNOG00000021808" } ] } } ], "crossref": [ { "id": "ENSRNOG00000021808", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000021808", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "1.3.1.93", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.3.1.93&UniProtAcc=Q64232", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "191576", "url": "https://www.ncbi.nlm.nih.gov/gene/191576", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q64232", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q64232*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001104", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001104", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039357", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039357", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:191576", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:191576", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "TVFVIEY", "url": "https://omabrowser.org/oma/group/TVFVIEY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR10556", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10556", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10556:SF31", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10556:SF31", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02544", "url": "http://pfam.xfam.org/family/PF02544", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q64232", "url": "http://purl.obolibrary.org/obo/PR_Q64232", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-75876", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75876", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_612558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612558", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "620376", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=620376", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "14473", "url": "https://www.rhea-db.org/rhea/14473", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "35351", "url": "https://www.rhea-db.org/rhea/35351", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "36143", "url": "https://www.rhea-db.org/rhea/36143", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "39319", "url": "https://www.rhea-db.org/rhea/39319", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "39331", "url": "https://www.rhea-db.org/rhea/39331", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "39467", "url": "https://www.rhea-db.org/rhea/39467", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A8I5ZWG2", "url": "https://www.uniprot.org/uniprot/A0A8I5ZWG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZWG2-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZWG2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AI38", "url": "https://www.uniprot.org/uniprot/A0A8I6AI38", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AI38-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AI38-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AKU7", "url": "https://www.uniprot.org/uniprot/A0A8I6AKU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AKU7-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AKU7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ALN4", "url": "https://www.uniprot.org/uniprot/A0A8I6ALN4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6ALN4-1", "url": "https://www.uniprot.org/uniprot/A0A8I6ALN4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AMG3", "url": "https://www.uniprot.org/uniprot/A0A8I6AMG3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AMG3-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AMG3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AVZ3", "url": "https://www.uniprot.org/uniprot/A0A8I6AVZ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AVZ3-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AVZ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AWG2", "url": "https://www.uniprot.org/uniprot/A0A8I6AWG2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AWG2-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AWG2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6G6D7", "url": "https://www.uniprot.org/uniprot/A0A8I6G6D7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6G6D7-1", "url": "https://www.uniprot.org/uniprot/A0A8I6G6D7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q64232-1", "url": "https://www.uniprot.org/uniprot/Q64232-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKHYEVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHLACMCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGVQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL", "length": 308, "header": "sp|Q64232-1|TECR_RAT Isoform 1 of Very-long-chain enoyl-CoA reductase OS=Rattus norvegicus OX=10116 GN=Tecr PE=1 SV=1 CANONICAL=Q64232-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZWG2-1", "url": "", "sequence": { "sequence": "MKHYEVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKTQGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHLACMCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKVSTLFLSCPLTSSTYGVQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL", "length": 282, "header": "tr|A0A8I5ZWG2-1|TECR_RAT Computationally mapped isoform of Very-long-chain enoyl-CoA reductase OS=Rattus norvegicus OX=10116 GN=Tecr PE=1 SV=1 CANONICAL=Q64232-1" }, "locus": { "chromosome": "19", "start_pos": 24568058, "end_pos": 24541754, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000115783.1", "url": "https://www.ensembl.org/id/ENSRNOT00000115783.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000083676.1", "url": "https://www.ensembl.org/id/ENSRNOP00000083676.1" } ] } }, { "isoform_ac": "A0A8I6AI38-1", "url": "", "sequence": { "sequence": "MDISLSMAAKEAHQGLDGLPMPMPHKAAKKHKKAVLFFEVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKTQGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHLACMCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGVQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL", "length": 327, "header": "tr|A0A8I6AI38-1|TECR_RAT Computationally mapped isoform of Very-long-chain enoyl-CoA reductase OS=Rattus norvegicus OX=10116 GN=Tecr PE=1 SV=1 CANONICAL=Q64232-1" }, "locus": { "chromosome": "19", "start_pos": 24568058, "end_pos": 24565229, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000098878.1", "url": "https://www.ensembl.org/id/ENSRNOT00000098878.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000093730.1", "url": "https://www.ensembl.org/id/ENSRNOP00000093730.1" } ] } }, { "isoform_ac": "A0A8I6AKU7-1", "url": "", "sequence": { "sequence": "MKHYEVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKTQGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHLACMCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPSKWAQTVPLPWICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL", "length": 289, "header": "tr|A0A8I6AKU7-1|TECR_RAT Computationally mapped isoform of Very-long-chain enoyl-CoA reductase OS=Rattus norvegicus OX=10116 GN=Tecr PE=1 SV=1 CANONICAL=Q64232-1" }, "locus": { "chromosome": "19", "start_pos": 24568058, "end_pos": 24541754, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000115881.1", "url": "https://www.ensembl.org/id/ENSRNOT00000115881.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000089376.1", "url": "https://www.ensembl.org/id/ENSRNOP00000089376.1" } ] } }, { "isoform_ac": "A0A8I6ALN4-1", "url": "", "sequence": { "sequence": "MDISLSMAAKEAHQGLDGLPMPMPHKAAKKHKKAVLFFEVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHLACMCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGVQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL", "length": 342, "header": "tr|A0A8I6ALN4-1|TECR_RAT Computationally mapped isoform of Very-long-chain enoyl-CoA reductase OS=Rattus norvegicus OX=10116 GN=Tecr PE=1 SV=1 CANONICAL=Q64232-1" }, "locus": { "chromosome": "19", "start_pos": 24568058, "end_pos": 24565229, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000120184.1", "url": "https://www.ensembl.org/id/ENSRNOT00000120184.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000094888.1", "url": "https://www.ensembl.org/id/ENSRNOP00000094888.1" } ] } }, { "isoform_ac": "A0A8I6AMG3-1", "url": "", "sequence": { "sequence": "MKHYEVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHLACMCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGVQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEFPPPELSPVMPSTYYPCPDVAGQGSPAATIKPA", "length": 325, "header": "tr|A0A8I6AMG3-1|TECR_RAT Computationally mapped isoform of Very-long-chain enoyl-CoA reductase OS=Rattus norvegicus OX=10116 GN=Tecr PE=1 SV=1 CANONICAL=Q64232-1" }, "locus": { "chromosome": "19", "start_pos": 24568160, "end_pos": 24541754, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000102273.1", "url": "https://www.ensembl.org/id/ENSRNOT00000102273.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000095860.1", "url": "https://www.ensembl.org/id/ENSRNOP00000095860.1" } ] } }, { "isoform_ac": "A0A8I6AVZ3-1", "url": "", "sequence": { "sequence": "MKHYEVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHLACMCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGVQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVRDCIFPPSGPLLPGGLHPDDYLGQGQASQLPEGVP", "length": 287, "header": "tr|A0A8I6AVZ3-1|TECR_RAT Computationally mapped isoform of Very-long-chain enoyl-CoA reductase OS=Rattus norvegicus OX=10116 GN=Tecr PE=1 SV=1 CANONICAL=Q64232-1" }, "locus": { "chromosome": "19", "start_pos": 24568015, "end_pos": 24541754, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000103758.1", "url": "https://www.ensembl.org/id/ENSRNOT00000103758.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000097089.1", "url": "https://www.ensembl.org/id/ENSRNOP00000097089.1" } ] } }, { "isoform_ac": "A0A8I6AWG2-1", "url": "", "sequence": { "sequence": "MQRRGRSCASWTRLGAATPDLLLADPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHLACMCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGVQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL", "length": 293, "header": "tr|A0A8I6AWG2-1|TECR_RAT Computationally mapped isoform of Very-long-chain enoyl-CoA reductase OS=Rattus norvegicus OX=10116 GN=Tecr PE=1 SV=1 CANONICAL=Q64232-1" }, "locus": { "chromosome": "19", "start_pos": 24568058, "end_pos": 24565359, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000104728.1", "url": "https://www.ensembl.org/id/ENSRNOT00000104728.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000097514.1", "url": "https://www.ensembl.org/id/ENSRNOP00000097514.1" } ] } }, { "isoform_ac": "A0A8I6G6D7-1", "url": "", "sequence": { "sequence": "MGSVKHHAVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHLACMCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKVSTLFLSCPLTISGPRRSYGVQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL", "length": 304, "header": "tr|A0A8I6G6D7-1|TECR_RAT Computationally mapped isoform of Very-long-chain enoyl-CoA reductase OS=Rattus norvegicus OX=10116 GN=Tecr PE=1 SV=1 CANONICAL=Q64232-1" }, "locus": { "chromosome": "19", "start_pos": 24568058, "end_pos": 24564386, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000096596.1", "url": "https://www.ensembl.org/id/ENSRNOT00000096596.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000080279.1", "url": "https://www.ensembl.org/id/ENSRNOP00000080279.1" } ] } }, { "isoform_ac": "Q64232-1", "url": "", "sequence": { "sequence": "MKHYEVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHLACMCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGVQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL", "length": 308, "header": "sp|Q64232-1|TECR_RAT Isoform 1 of Very-long-chain enoyl-CoA reductase OS=Rattus norvegicus OX=10116 GN=Tecr PE=1 SV=1 CANONICAL=Q64232-1" }, "locus": { "chromosome": "19", "start_pos": 24568058, "end_pos": 24541754, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000037608", "url": "https://www.ensembl.org/id/ENSRNOT00000037608" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000035416", "url": "https://www.ensembl.org/id/ENSRNOP00000035416" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 164, "start_aa": "Asn", "end_pos": 164, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn164", "evidence": [ { "id": "Q64232", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64232#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 247, "start_aa": "Asn", "end_pos": 247, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn247", "evidence": [ { "id": "Q64232", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64232#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 58, "end_pos": 58, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232" }, { "database": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" }, { "database": "iPTMnet", "id": "Q64232", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q64232" } ], "site_lbl": "Ser58" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Molecular cloning of a novel mRNA using an antibody directed against synaptic glycoproteins.", "journal": "J. Neurosci. Res.", "date": "1992", "authors": "Johnston IG, Rush SJ, Gurd JW, Brown IR", "evidence": [ { "database": "UniProtKB", "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232" } ], "reference": [ { "type": "PubMed", "id": "1404491", "url": "https://glygen.org/publication/PubMed/1404491" } ] }, { "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nature communications", "date": "2012", "authors": "Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV", "evidence": [ { "database": "UniProtKB", "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232" }, { "database": "iPTMnet", "id": "Q64232", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q64232" } ], "reference": [ { "type": "PubMed", "id": "22673903", "url": "https://glygen.org/publication/PubMed/22673903" } ] } ], "pathway": [ { "id": "rno:191576", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:191576", "resource": "KEGG Pathway" }, { "id": "R-RNO-75876", "name": "Synthesis of very long-chain fatty acyl-CoAs", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-75876", "resource": "Reactome", "description": "Synthesis of very long-chain fatty acyl-CoAs" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9CY27-1", "protein_name": "Very-long-chain enoyl-CoA reductase", "gene_name": "Tecr", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MKHYEVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHLACMCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGVQQVKLALAVFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAILTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL", "length": 308 }, "evidence": [ { "id": "45230160", "url": "http://www.informatics.jax.org/homology/45230160", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9NZ01-1", "protein_name": "Very-long-chain enoyl-CoA reductase", "gene_name": "TECR", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKHYEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL", "length": 308 }, "evidence": [ { "id": "45230160", "url": "http://www.informatics.jax.org/homology/45230160", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232" } ], "pmid": "" }, { "name": "sphingolipid metabolic process", "id": "GO:0006665", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006665", "evidence": [ { "database": "UniProtKB", "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232" } ], "pmid": "" }, { "name": "fatty acid elongation", "id": "GO:0030497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030497", "evidence": [ { "database": "UniProtKB", "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232" } ], "pmid": "" }, { "name": "very long-chain fatty acid biosynthetic process", "id": "GO:0042761", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042761", "evidence": [ { "database": "UniProtKB", "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232" } ], "pmid": "" }, { "name": "steroid biosynthetic process", "id": "GO:0006694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006694", "evidence": [ { "database": "UniProtKB", "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232" } ], "pmid": "" }, { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "oxidoreductase activity, acting on the CH-CH group of donors", "id": "GO:0016627", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016627", "evidence": [ { "database": "UniProtKB", "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232" } ], "pmid": "" }, { "name": "very-long-chain enoyl-CoA reductase activity", "id": "GO:0102758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102758", "evidence": [ { "database": "UniProtKB", "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232" } ], "pmid": "" }, { "name": "oxidoreductase activity", "id": "GO:0016491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "evidence": [ { "database": "UniProtKB", "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 164, "end_pos": 166, "annotation": "n_glycosylation_sequon" }, { "start_pos": 208, "end_pos": 210, "annotation": "n_glycosylation_sequon" }, { "start_pos": 247, "end_pos": 249, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Glycosylated.", "evidence": [ { "database": "UniProtKB", "id": "Q64232", "url": "https://www.uniprot.org/uniprot/Q64232" }, { "database": "PubMed", "id": "1404491", "url": "https://glygen.org/publication/PubMed/1404491" } ] } ], "interactions": [], "reactions": [ { "id": "14473", "name": "", "equation": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64232-1", "Q9NZ01-1", "Q9CY27-1", "Q99190-1", "Q55C17-1" ], "evidence": [ { "id": "14473", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/14473" } ] }, { "id": "35351", "name": "", "equation": "NADP(+) + octadecanoyl-CoA = (2E)-octadecenoyl-CoA + H(+) + NADPH", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64232-1", "Q9NZ01-1", "Q9CY27-1", "Q99190-1" ], "evidence": [ { "id": "35351", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/35351" } ] }, { "id": "36143", "name": "", "equation": "(2E)-hexadecenoyl-CoA + H(+) + NADPH = hexadecanoyl-CoA + NADP(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64232-1", "Q9NZ01-1", "Q9CY27-1" ], "evidence": [ { "id": "36143", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36143" } ] }, { "id": "39319", "name": "", "equation": "(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H(+) + NADPH = (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64232-1", "Q9NZ01-1", "Q9CY27-1" ], "evidence": [ { "id": "39319", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39319" } ] }, { "id": "39331", "name": "", "equation": "(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H(+) + NADPH = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64232-1", "Q9NZ01-1", "Q9CY27-1" ], "evidence": [ { "id": "39331", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39331" } ] }, { "id": "39467", "name": "", "equation": "(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + H(+) + NADPH = (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q64232-1", "Q9NZ01-1", "Q9CY27-1" ], "evidence": [ { "id": "39467", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/39467" } ] }, { "id": "R-RNO-548831", "name": "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-548809" ], "output_participant_list": [ "R-ALL-428139" ], "enzyme_list": [ "Q64232-1" ], "evidence": [ { "id": "R-RNO-548831", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-548831" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-428139", "participant_name": "ST-CoA [cytosol]", "crossref": [ { "id": "57394", "database": "ChEBI", "url": "" }, { "id": "57394", "database": "ChEBI", "url": "" }, { "id": "57394", "database": "ChEBI", "url": "" }, { "id": "57394", "database": "ChEBI", "url": "" }, { "id": "57394", "database": "ChEBI", "url": "" }, { "id": "57394", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-548809", "participant_name": "TOD-CoA [cytosol]", "crossref": [ { "id": "50570", "database": "ChEBI", "url": "" }, { "id": "HMDB0062633", "database": "HMDB Metabolite", "url": "" }, { "id": "HMDB0062633", "database": "HMDB Metabolite", "url": "" }, { "id": "50570", "database": "ChEBI", "url": "" }, { "id": "50570", "database": "ChEBI", "url": "" }, { "id": "HMDB0062633", "database": "HMDB Metabolite", "url": "" }, { "id": "HMDB0062633", "database": "HMDB Metabolite", "url": "" }, { "id": "50570", "database": "ChEBI", "url": "" }, { "id": "50570", "database": "ChEBI", "url": "" }, { "id": "HMDB0062633", "database": "HMDB Metabolite", "url": "" }, { "id": "50570", "database": "ChEBI", "url": "" }, { "id": "HMDB0062633", "database": "HMDB Metabolite", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q55C17", "gene_name": "gpsn2", "activity": [ { "ec_number": "1.3.1.93", "activity": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "Q55C17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55C17" } ] }, { "ec_number": "1.3.1.93", "activity": "", "evidence": [ { "id": "Q55C17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55C17" } ] } ] }, { "uniprot_ac": "Q64232", "gene_name": "Tecr", "activity": [ { "ec_number": "1.3.1.93", "activity": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "Q64232", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64232" } ] }, { "ec_number": "1.3.1.93", "activity": "", "evidence": [ { "id": "Q64232", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64232" } ] } ] }, { "uniprot_ac": "Q99190", "gene_name": "TSC13", "activity": [ { "ec_number": "1.3.1.93", "activity": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "Q99190", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99190" } ] }, { "ec_number": "1.3.1.93", "activity": "", "evidence": [ { "id": "Q99190", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99190" } ] } ] }, { "uniprot_ac": "Q9CY27", "gene_name": "Tecr", "activity": [ { "ec_number": "1.3.1.93", "activity": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "Q9CY27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CY27" } ] }, { "ec_number": "1.3.1.93", "activity": "", "evidence": [ { "id": "Q9CY27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CY27" } ] } ] }, { "uniprot_ac": "Q9NZ01", "gene_name": "TECR", "activity": [ { "ec_number": "1.3.1.93", "activity": "a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + H(+) + NADPH.", "evidence": [ { "id": "Q9NZ01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NZ01" } ] }, { "ec_number": "1.3.1.93", "activity": "", "evidence": [ { "id": "Q9NZ01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NZ01" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 2 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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