{ "uniprot_canonical_ac": "Q64127-1", "uniprot_ac": "Q64127", "uniprot_id": "TIF1A_MOUSE", "mass": { "chemical_mass": 116657.0, "monoisotopic_mass": 116657.0 }, "refseq": { "ac": "NP_001258993", "name": "transcription intermediary factor 1-alpha isoform 2", "summary": "The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which are typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. This protein, which also contains a PHD/TTC finger and bromodomain important for regulating nuclear receptors and binding chromatin, has important roles in differentiation, development, and tissue homeostasis. This protein has been reported to regulate the activity of the tumor suppressor p53 and of the retinoic acid receptor. A translocation event between this gene and Braf transforming gene, which results in the fusion protein T18, has been reported in hepatocellular carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258993" }, "gene_names": [ { "name": "Trim24", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q64127", "id": "Q64127" }, { "name": "A130082H20Rik; D430004I05Rik; TIF1; TIF1-alpha; Tif1a; TIF1alpha", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258993", "id": "NP_001258993" }, { "name": "Tif1a", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q64127", "id": "Q64127" }, { "name": "Tif1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q64127", "id": "Q64127" }, { "name": "Trim24", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258993", "id": "NP_001258993" } ], "protein_names": [ { "name": "Transcription intermediary factor 1-alpha", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q64127" }, { "name": "2.3.2.27", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q64127" }, { "name": "E3 ubiquitin-protein ligase Trim24", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q64127" }, { "name": "RING-type E3 ubiquitin transferase TIF1-alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q64127" }, { "name": "TIF1-alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q64127" }, { "name": "Tripartite motif-containing protein 24", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q64127" }, { "name": "transcription intermediary factor 1-alpha isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258993", "id": "NP_001258993" }, { "name": "transcription intermediary factor 1-alpha isoform 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259005", "id": "NP_001259005" }, { "name": "transcriptional intermediary factor 1, alpha; transcription intermediary factor 1-alpha; tripartite motif-containing protein 24; E3 ubiquitin-protein ligase Trim24; RING-type E3 ubiquitin transferase TIF1-alpha", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259005", "id": "NP_001259005" } ], "function": [ { "annotation": "Decrease in Tripartite Motif Containing 24 suppresses hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells via the AKT/mammalian target of rapamycin complex 1 pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_001258993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258993" }, { "database": "PubMed", "id": "35653796", "url": "https://glygen.org/publication/PubMed/35653796" }, { "database": "RefSeq", "id": "NP_001259005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259005" } ] }, { "annotation": "Loss of TRIM24 promotes IL-10 expression via CBP/p300-dependent IFNbeta1 transcription during macrophage activation.", "evidence": [ { "database": "RefSeq", "id": "NP_001258993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258993" }, { "database": "PubMed", "id": "37326695", "url": "https://glygen.org/publication/PubMed/37326695" }, { "database": "RefSeq", "id": "NP_001259005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259005" } ] }, { "annotation": "Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001258993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258993" }, { "database": "PubMed", "id": "34508101", "url": "https://glygen.org/publication/PubMed/34508101" }, { "database": "RefSeq", "id": "NP_001259005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259005" } ] }, { "annotation": "TRIM24 is an insulin-responsive regulator of P-bodies. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001258993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258993" }, { "database": "PubMed", "id": "35803934", "url": "https://glygen.org/publication/PubMed/35803934" }, { "database": "RefSeq", "id": "NP_001259005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259005" } ] }, { "annotation": "The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which are typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. This protein, which also contains a PHD/TTC finger and bromodomain important for regulating nuclear receptors and binding chromatin, has important roles in differentiation, development, and tissue homeostasis. This protein has been reported to regulate the activity of the tumor suppressor p53 and of the retinoic acid receptor. A translocation event between this gene and Braf transforming gene, which results in the fusion protein T18, has been reported in hepatocellular carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013].", "evidence": [ { "database": "RefSeq", "id": "NP_001258993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258993" }, { "database": "RefSeq", "id": "NP_001259005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259005" } ] }, { "annotation": "Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (By similarity). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). Participates also in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway. Additionally, negatively regulates NLRP3/CASP1/IL-1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127#function" }, { "database": "UniProtKB", "id": "O15164", "url": "https://www.uniprot.org/uniprot/O15164#function" }, { "database": "PubMed", "id": "16880268", "url": "https://glygen.org/publication/PubMed/16880268" }, { "database": "PubMed", "id": "19556538", "url": "https://glygen.org/publication/PubMed/19556538" }, { "database": "PubMed", "id": "16322096", "url": "https://glygen.org/publication/PubMed/16322096" }, { "database": "PubMed", "id": "10610177", "url": "https://glygen.org/publication/PubMed/10610177" }, { "database": "PubMed", "id": "18026104", "url": "https://glygen.org/publication/PubMed/18026104" }, { "database": "PubMed", "id": "19909775", "url": "https://glygen.org/publication/PubMed/19909775" }, { "database": "PubMed", "id": "7744009", "url": "https://glygen.org/publication/PubMed/7744009" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs3396667849", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3396667849" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 199, "end_pos": 199, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DHT->NHT).", "chr_id": "6", "chr_pos": "37885263", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D199", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 724, "end_pos": 724, "sequence_org": "K", "sequence_mut": "R", "comment": "Loss of sumoylation; when associated with R-742.", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" }, { "database": "PubMed", "id": "11313457", "url": "https://glygen.org/publication/PubMed/11313457" } ] }, { "start_pos": 742, "end_pos": 742, "sequence_org": "K", "sequence_mut": "R", "comment": "Loss of sumoylation; when associated with R-724.", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" }, { "database": "PubMed", "id": "11313457", "url": "https://glygen.org/publication/PubMed/11313457" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Trim24", "url": "https://www.uniprot.org/uniprot/Q64127", "locus": { "chromosome": "6", "start_pos": 37943231, "end_pos": 37847746, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000029833", "url": "https://www.ensembl.org/id/ENSMUSG00000029833" } ] } } ], "crossref": [ { "id": "ENSMUSG00000029833", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000029833", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd05502", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05502", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15624", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15624", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16764", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16764", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19828", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19828", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd19845", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19845", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "21848", "url": "https://www.ncbi.nlm.nih.gov/gene/21848", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q64127", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q64127*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000315", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000315", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001487", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001487", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003649", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003649", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018359", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018359", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036427", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036427", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:21848", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:21848", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "109275", "url": "http://www.informatics.jax.org/marker/MGI:109275", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q64127", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q64127", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "HMAGRGR", "url": "https://omabrowser.org/oma/group/HMAGRGR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "56754at2759", "url": "http://www.orthodb.org/?query=56754at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45915", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45915", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45915:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45915:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00439", "url": "http://pfam.xfam.org/family/PF00439", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00628", "url": "http://pfam.xfam.org/family/PF00628", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00643", "url": "http://pfam.xfam.org/family/PF00643", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q64127", "url": "http://purl.obolibrary.org/obo/PR_Q64127", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001258993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258993", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E9Q1U8", "url": "https://www.uniprot.org/uniprot/E9Q1U8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9Q1U8-1", "url": "https://www.uniprot.org/uniprot/E9Q1U8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q64127-1", "url": "https://www.uniprot.org/uniprot/Q64127-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q64127-2", "url": "https://www.uniprot.org/uniprot/Q64127-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEVAVEKAAAAAAPAGGPAAAAPSGENEAESRQGPDSESGGEASRLNLLDTCAVCHQNIQSRVPKLLPCLHSFCQRCLPAPQRYLMLTAPALGSAETPPPAPAPAPAPGSPAGGPSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKYTGNQIQNRIIEINQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNTTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQSSQPPGGLPSNQLSKFPTQISLAQLRLQHIQQQVMAQRQQVQRRPAPVGLPNPRMQGPIQQPSISHQHPPPRLINFQNHSPKPNGPVLPPYPQQLRYSPSQNVPRQTTIKPNPLQMAFLAQQAIKQWQISSVQAPPTTASSSSSTPSSPTITSAAGYDGKAFSSPMIDLSAPVGGSYNLPSLPDIDCSSTIMLDNIARKDTGVDHAQPRPPSNRTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNTNYPRSILTSLLLNSSQSSASEETVLRSDAPDSTGDQPGLHQENSSNGKSEWSDASQKSPVHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHLTCHVPTLTNFPSGEWICTFCRDLSKPEVDYDCDVPSHHSEKRKSEGLTKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYCMYTKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLESYFEELLKNLYPEKRFPKVEFRHEAEDCKFSDDSDDDFVQPRKKRLKSTEDRQLLK", "length": 1051, "header": "sp|Q64127-1|TIF1A_MOUSE Isoform 1 of Transcription intermediary factor 1-alpha OS=Mus musculus OX=10090 GN=Trim24 PE=1 SV=1 CANONICAL=Q64127-1" }, "isoforms": [ { "isoform_ac": "E9Q1U8-1", "url": "", "sequence": { "sequence": "MADIFDYTFIGGCGDACPTCACGSQRITWKSQFFPSCVRPMDKTAVTGDEQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKYTGNQIQNRIIEINQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNTTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQSSQPPGGLPSNQLSKFPTQISLAQLRLQHIQQQVMAQRQQVQRRPAPVGLPNPRMQGPIQQPSISHQHPPPRLINFQNHSPKPNGPVLPPYPQQLRYSPSQNVPRQTTIKPNPLQMAFLAQQAIKQWQISSVQAPPTTASSSSSTPSSPTITSAAGYDGKAFSSPMIDLSAPVGGSYNLPSLPDIDCSSTIMLDNIARKDTGVDHAQPRPPSNRTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNTNYPRSILTSLLLNSSQSSASEETVLRSDAPDSTGDQPGLHQENSSNGKSEWSDASQKSPVHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHLTCHVPTLTNFPSGEWICTFCRDLSKPEVDYDCDVPSHHSEKRKSEGLTKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYCMYTKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLESYFEELLKNLYPEKRFPKVEFRHEAEDCKFSDDSDDDFVQPRKKRLKSTEDRQLLK", "length": 981, "header": "tr|E9Q1U8-1|E9Q1U8_MOUSE Computationally mapped isoform of Tripartite motif-containing 24 OS=Mus musculus OX=10090 GN=Trim24 PE=1 SV=1 CANONICAL=Q64127-1" }, "locus": { "chromosome": "6", "start_pos": 37942642, "end_pos": 37877512, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000120238.2", "url": "https://www.ensembl.org/id/ENSMUST00000120238.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000114001.2", "url": "https://www.ensembl.org/id/ENSMUSP00000114001.2" } ] } }, { "isoform_ac": "Q64127-1", "url": "", "sequence": { "sequence": "MEVAVEKAAAAAAPAGGPAAAAPSGENEAESRQGPDSESGGEASRLNLLDTCAVCHQNIQSRVPKLLPCLHSFCQRCLPAPQRYLMLTAPALGSAETPPPAPAPAPAPGSPAGGPSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSNQVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQRPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITKLMEKTKYIKYTGNQIQNRIIEINQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRARCDASPVTNTTIQFHCDPSFWAQNIINLGSLVIEDKESQPQMPKQNPVVEQSSQPPGGLPSNQLSKFPTQISLAQLRLQHIQQQVMAQRQQVQRRPAPVGLPNPRMQGPIQQPSISHQHPPPRLINFQNHSPKPNGPVLPPYPQQLRYSPSQNVPRQTTIKPNPLQMAFLAQQAIKQWQISSVQAPPTTASSSSSTPSSPTITSAAGYDGKAFSSPMIDLSAPVGGSYNLPSLPDIDCSSTIMLDNIARKDTGVDHAQPRPPSNRTVQSPNSSVPSPGLAGPVTMTSVHPPIRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIVKQESDEESRPQNTNYPRSILTSLLLNSSQSSASEETVLRSDAPDSTGDQPGLHQENSSNGKSEWSDASQKSPVHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHLTCHVPTLTNFPSGEWICTFCRDLSKPEVDYDCDVPSHHSEKRKSEGLTKLTPIDKRKCERLLLFLYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYCMYTKPEDFVADFRLIFQNCAEFNEPDSEVANAGIKLESYFEELLKNLYPEKRFPKVEFRHEAEDCKFSDDSDDDFVQPRKKRLKSTEDRQLLK", "length": 1051, "header": "sp|Q64127-1|TIF1A_MOUSE Isoform 1 of Transcription intermediary factor 1-alpha OS=Mus musculus OX=10090 GN=Trim24 PE=1 SV=1 CANONICAL=Q64127-1" }, "locus": { "chromosome": "6", "start_pos": 37942642, "end_pos": 37848046, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000031859", "url": "https://www.ensembl.org/id/ENSMUST00000031859" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000031859", "url": "https://www.ensembl.org/id/ENSMUSP00000031859" } ] } }, { "isoform_ac": "Q64127-2", "url": "", "sequence": { "sequence": 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"database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 581, "start_aa": "Thr", "end_pos": 581, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr581", "evidence": [ { "id": "Q64127", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q64127" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 583, "start_aa": "Ser", "end_pos": 583, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser583", "evidence": [ { "id": "Q64127", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q64127" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 676, "start_aa": "Thr", "end_pos": 676, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr676", "evidence": [ { "id": "Q64127", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q64127" }, { "id": "34678516", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34678516" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" } ] } ], "phosphorylation": [ { "start_pos": 1026, "end_pos": 1026, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "iPTMnet", "id": "Q64127", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q64127" } ], "site_lbl": "Ser1026" }, { "start_pos": 1029, "end_pos": 1029, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "site_lbl": "Ser1029" }, { "start_pos": 1043, "end_pos": 1043, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "site_lbl": "Ser1043" }, { "start_pos": 110, "end_pos": 110, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "site_lbl": "Ser110" }, { "start_pos": 655, "end_pos": 655, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "site_lbl": "Ser655" }, { "start_pos": 661, "end_pos": 661, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q64127", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q64127" } ], "site_lbl": "Ser661" }, { "start_pos": 668, "end_pos": 668, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q64127", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q64127" } ], "site_lbl": "Ser668" }, { "start_pos": 745, "end_pos": 745, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "site_lbl": "Ser745" }, { "start_pos": 769, "end_pos": 769, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "site_lbl": "Ser769" }, { "start_pos": 809, "end_pos": 809, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "site_lbl": "Ser809" }, { "start_pos": 812, "end_pos": 812, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q64127", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q64127" } ], "site_lbl": "Ser812" }, { "start_pos": 819, "end_pos": 819, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "site_lbl": "Thr819" }, { "start_pos": 97, "end_pos": 97, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "site_lbl": "Thr97" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins.", "journal": "Nat. Genet.", "date": "1999", "authors": "Zhang H., Kalantry S., Zhong S., Delva L., Pandolfi P.P., Cenciarelli C., Freedman L.P., Rachez C., Gandini D.", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "reference": [ { "type": "PubMed", "id": "10610177", "url": "https://glygen.org/publication/PubMed/10610177" } ] }, { "title": "Common properties of nuclear protein SP100 and TIF1alpha chromatin factor: role of SUMO modification.", "journal": "Mol. Cell. Biol.", "date": "2001", "authors": "Seeler JS, Marchio A, Losson R, Desterro JM, Hay RT, Chambon P, Dejean A", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "reference": [ { "type": "PubMed", "id": "11313457", "url": "https://glygen.org/publication/PubMed/11313457" } ] }, { "title": "Transcriptional intermediary factor 1alpha mediates physical interaction and functional synergy between the coactivator-associated arginine methyltransferase 1 and glucocorticoid receptor-interacting protein 1 nuclear receptor coactivators.", "journal": "Mol. Endocrinol.", "date": "2006", "authors": "Stallcup M.R., Losson R., Teyssier C., Ou C.Y., Khetchoumian K.", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "reference": [ { "type": "PubMed", "id": "16322096", "url": "https://glygen.org/publication/PubMed/16322096" } ] }, { "title": "Role of TIF1alpha as a modulator of embryonic transcription in the mouse zygote.", "journal": "J. Cell Biol.", "date": "2006", "authors": "Torres-Padilla ME, Zernicka-Goetz M", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "reference": [ { "type": "PubMed", "id": "16880268", "url": "https://glygen.org/publication/PubMed/16880268" } ] }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" }, { "database": "UniProtKB", "id": "E9Q1U8", "url": "https://www.uniprot.org/uniprot/E9Q1U8" }, { "database": "iPTMnet", "id": "Q64127", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q64127" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] }, { "title": "Characterization of three growth hormone-responsive transcription factors preferentially expressed in adult female liver.", "journal": "Endocrinology", "date": "2007", "authors": "Laz EV, Holloway MG, Chen CS, Waxman DJ", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "reference": [ { "type": "PubMed", "id": "17412818", "url": "https://glygen.org/publication/PubMed/17412818" } ] }, { "title": "Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha.", "journal": "Nat. Genet.", "date": "2007", "authors": "Thibault C., Chambon P., Losson R., Mark M., Zucman-Rossi J., Metzger D., Khetchoumian K., Lerouge T., Teletin M., Cammas F., Herquel B., Ignat M., Tisserand J.", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "reference": [ { "type": "PubMed", "id": "18026104", "url": "https://glygen.org/publication/PubMed/18026104" } ] }, { "title": "Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alpha.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2008", "authors": "Chambon P., Losson R., Mark M., Khetchoumian K., Teletin M., Dennefeld C., Ignat M., Tisserand J.", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "reference": [ { "type": "PubMed", "id": "18287084", "url": "https://glygen.org/publication/PubMed/18287084" } ] }, { "title": "Trim24 targets endogenous p53 for degradation.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2009", "authors": "Allton K, Jain AK, Herz HM, Tsai WW, Jung SY, Qin J, Bergmann A, Johnson RL, Barton MC", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "reference": [ { "type": "PubMed", "id": "19556538", "url": "https://glygen.org/publication/PubMed/19556538" } ] }, { "title": "TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells.", "journal": "Biochim. Biophys. Acta", "date": "2009", "authors": "Miyajima N., Watanabe M., Kikuchi M., Hatakeyama S., Imamura M., Okumura F., Tanaka J., Tsukiyama T.", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "reference": [ { "type": "PubMed", "id": "19909775", "url": "https://glygen.org/publication/PubMed/19909775" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" }, { "database": "iPTMnet", "id": "Q64127", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q64127" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "journal": "Mol. Cell. Proteomics", "date": "2014", "authors": "Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee KA, Yang V, Aguiar M, Kornhauser J, Jia X, Ren J, Beausoleil SA, Silva JC, Vemulapalli V, Bedford MT, Comb MJ", "evidence": [ { "database": "UniProtKB", "id": "E9Q1U8", "url": "https://www.uniprot.org/uniprot/E9Q1U8" }, { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "reference": [ { "type": "PubMed", "id": "24129315", "url": "https://glygen.org/publication/PubMed/24129315" } ] }, { "title": "Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer.", "journal": "Nature communications", "date": "2021", "authors": "Shah VV, Duncan AD, Jiang S, Stratton SA, Allton KL, Yam C, Jain A, Krause PM, Lu Y, Cai S, Tu Y, Zhou X, Zhang X, Jiang Y, Carroll CL, Kang Z, Liu B, Shen J, Gagea M, Manu SM, Huo L, Gilcrease M, Powell RT, Guo L, Stephan C, Davies PJ, Parker-Thornburg J, Lozano G, Behringer RR, Piwnica-Worms H, Chang JT, Moulder SL, Barton MC", "evidence": [ { "database": "RefSeq", "id": "NP_001259005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259005" }, { "database": "RefSeq", "id": "NP_001258993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258993" } ], "reference": [ { "type": "PubMed", "id": "34508101", "url": "https://glygen.org/publication/PubMed/34508101" } ] }, { "title": "Novel Antibodies for the Simple and Efficient Enrichment of Native O-GlcNAc Modified Peptides.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Burt RA, Dejanovic B, Peckham HJ, Lee KA, Li X, Ounadjela JR, Rao A, Malaker SA, Carr SA, Myers SA", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q64127", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q64127" } ], "reference": [ { "type": "PubMed", "id": "34678516", "url": "https://glygen.org/publication/PubMed/34678516" } ] }, { "title": "Decrease in Tripartite Motif Containing 24 suppresses hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells via the AKT/mammalian target of rapamycin complex 1 pathway.", "journal": "Bioengineered", "date": "2022", "authors": "Xu J, Zhong Y, Wang Z", "evidence": [ { "database": "RefSeq", "id": "NP_001259005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259005" }, { "database": "RefSeq", "id": "NP_001258993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258993" } ], "reference": [ { "type": "PubMed", "id": "35653796", "url": "https://glygen.org/publication/PubMed/35653796" } ] }, { "title": "TRIM24 is an insulin-responsive regulator of P-bodies.", "journal": "Nature communications", "date": "2022", "authors": "Wei W, Chen Q, Liu M, Sheng Y, OuYang Q, Feng W, Yang X, Ding L, Su S, Zhang J, Fang L, Vidal-Puig A, Wang HY, Chen S", "evidence": [ { "database": "RefSeq", "id": "NP_001258993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258993" }, { "database": "RefSeq", "id": "NP_001259005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259005" } ], "reference": [ { "type": "PubMed", "id": "35803934", "url": "https://glygen.org/publication/PubMed/35803934" } ] }, { "title": "Chemoproteomic and Transcriptomic Analysis Reveals that O-GlcNAc Regulates Mouse Embryonic Stem Cell Fate through the Pluripotency Network.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2023-02-27", "authors": "Hao Yi, Li Xiang, Qin Ke, Shi Yujie, He Yanwen, Zhang Che, Cheng Bo, Zhang Xiwen, Hu Guangyu, Liang Shuyu, Tang Qi, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q64127", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q64127" } ], "reference": [ { "type": "PubMed", "id": "36852467", "url": "https://glygen.org/publication/PubMed/36852467" } ] }, { "title": "Loss of TRIM24 promotes IL-10 expression via CBP/p300-dependent IFN\u03b21 transcription during macrophage activation.", "journal": "Inflammation research : official journal of the European Histamine Research Society ... [et al.]", "date": "2023-07", "authors": "Hui Zhaoyuan, Fu Yuanzheng, Chen Yunyun, Yin Jie, Fang Hui, Tu Yifan, Gu Ying, Zhang Jiawei", "evidence": [ { "database": "RefSeq", "id": "NP_001259005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259005" }, { "database": "RefSeq", "id": "NP_001258993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258993" } ], "reference": [ { "type": "PubMed", "id": "37326695", "url": "https://glygen.org/publication/PubMed/37326695" } ] }, { "title": "The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.", "journal": "EMBO J.", "date": "1995", "authors": "Le Douarin B, Zechel C, Garnier JM, Lutz Y, Tora L, Pierrat P, Heery D, Gronemeyer H, Chambon P, Losson R", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "reference": [ { "type": "PubMed", "id": "7744009", "url": "https://glygen.org/publication/PubMed/7744009" } ] }, { "title": "A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.", "journal": "EMBO J.", "date": "1996", "authors": "Le Douarin B, Nielsen AL, Garnier JM, Ichinose H, Jeanmougin F, Losson R, Chambon P", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "reference": [ { "type": "PubMed", "id": "8978696", "url": "https://glygen.org/publication/PubMed/8978696" } ] } ], "pathway": [ { "id": "mmu:21848", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:21848", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AI80-1", "protein_name": "Tripartite motif-containing 24", "gene_name": "Trim24", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"length": 1050 }, "evidence": [ { "id": "45236745", "url": "http://www.informatics.jax.org/homology/45236745", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "O15164-1", "protein_name": "Transcription intermediary factor 1-alpha", "gene_name": "TRIM24", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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"https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "male germ cell nucleus", "id": "GO:0001673", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001673", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "euchromatin", "id": "GO:0000791", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000791", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 11, "go_terms": [ { "name": "estrogen response element binding", "id": "GO:0034056", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034056", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "transcription coactivator activity", "id": "GO:0003713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "protein kinase activity", "id": "GO:0004672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "sequence-specific DNA binding", "id": "GO:0043565", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "lysine-acetylated histone binding", "id": "GO:0070577", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070577", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "p53 binding", "id": "GO:0002039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002039", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "nuclear receptor binding", "id": "GO:0016922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016922", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 16, "go_terms": [ { "name": "protein phosphorylation", "id": "GO:0006468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "negative regulation of epithelial cell proliferation", "id": "GO:0050680", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050680", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "regulation of signal transduction by p53 class mediator", "id": "GO:1901796", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901796", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "protein autophosphorylation", "id": "GO:0046777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046777", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "regulation of protein stability", "id": "GO:0031647", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "response to peptide hormone", "id": "GO:0043434", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043434", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "protein catabolic process", "id": "GO:0030163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030163", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "calcium ion homeostasis", "id": "GO:0055074", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055074", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": "https://www.uniprot.org/uniprot/Q64127" } ], "pmid": "" }, { "name": "cellular response to estrogen stimulus", "id": "GO:0071391", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071391", "evidence": [ { "database": "UniProtKB", "id": "Q64127", "url": 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