The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-1806276" ], "enzyme_list": [ "D3ZGS3-1", "Q62910-1", "O55207-1" ], "evidence": [ { "id": "R-RNO-1675836", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1675836" } ] }, { "id": "R-RNO-1675988", "name": "PI4P is dephosphorylated to PI by SYNJ at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZGS3-1", "Q62910-1", "O55207-1" ], "evidence": [ { "id": "R-RNO-1675988", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1675988" } ] }, { "id": "R-RNO-1675994", "name": "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-426658" ], "enzyme_list": [ "Q62910-1", "O55207-1", "A0A8I5Y1D5-1", "A0A0G2JXT6-1", "Q5PQT2-1", "Q6AXQ4-1" ], "evidence": [ { "id": "R-RNO-1675994", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1675994" } ] }, { "id": "R-RNO-1676177", "name": "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9JMC1-1", "Q62910-1", "O55207-1" ], "evidence": [ { "id": "R-RNO-1676177", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1676177" } ] }, { "id": "R-RNO-1676203", "name": "PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [ "R-ALL-1806224" ], "output_participant_list": [ "R-ALL-1806240" ], "enzyme_list": [ "Q62910-1", "O55207-1", "A0A8I5Y1D5-1", "A0A0G2JXT6-1", "Q5PQT2-1", "Q6AXQ4-1" ], "evidence": [ { "id": "R-RNO-1676203", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1676203" } ] }, { "id": "R-RNO-1855174", "name": "I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-1629739" ], "enzyme_list": [ "D3ZGS3-1", "Q9JMC1-1", "Q62910-1" ], "evidence": [ { "id": "R-RNO-1855174", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855174" } ] }, { "id": "R-RNO-1855218", "name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZGS3-1", "P97573-1", "Q9JMC1-1", "Q62910-1", "Q9WVR3-1" ], "evidence": [ { "id": "R-RNO-1855218", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1855218" } ] }, { "id": "R-RNO-8868648", "name": "SYNJ hydrolyze PI(4,5)P2 to PI(4)P", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZGS3-1", "P34158-1", "Q08877-1", "P0C1X8-1", "P21575-1", "P39052-1", "Q62910-1", "O55207-1", "P63259-1", "P60711-1", "G3V6K6-1", "A0A8I6G3R2-1" ], "evidence": [ { "id": "R-RNO-8868648", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8868648" } ] }, { "id": "R-RNO-8868651", "name": "Endophilins recruit synaptojanins to the clathrin-coated pit", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZGS3-1", "P34158-1", "Q08877-1", "P0C1X8-1", "P21575-1", "P39052-1", "Q62910-1", "O55207-1", "P63259-1", "P60711-1", "G3V6K6-1", "A0A8I6G3R2-1" ], "evidence": [ { "id": "R-RNO-8868651", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8868651" } ] }, { "id": "R-RNO-8868658", "name": "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "clathrin-coated endocytic vesicle membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZGS3-1", "P34158-1", "Q08877-1", "P63018-1", "P0C1X8-1", "P97874-1", "P21575-1", "P39052-1", "Q62910-1", "O55207-1", "P63259-1", "P60711-1", "G3V6K6-1", "A0A8I6G3R2-1" ], "evidence": [ { "id": "R-RNO-8868658", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8868658" } ] }, { "id": "R-RNO-8868659", "name": "Clathrin recruits auxilins to the clathrin-coated vesicle", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "clathrin-coated endocytic vesicle membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZGS3-1", "P34158-1", "Q08877-1", "P0C1X8-1", "P97874-1", "P21575-1", "P39052-1", "Q62910-1", "O55207-1", "P63259-1", "P60711-1", "G3V6K6-1", "A0A8I6G3R2-1" ], "evidence": [ { "id": "R-RNO-8868659", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8868659" } ] }, { "id": "R-RNO-8868660", "name": "Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "clathrin-coated endocytic vesicle membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZGS3-1", "P34158-1", "Q08877-1", "P63018-1", "P0C1X8-1", "P97874-1", "P21575-1", "P39052-1", "Q62910-1", "O55207-1", "P63259-1", "P60711-1", "G3V6K6-1", "A0A8I6G3R2-1" ], "evidence": [ { "id": "R-RNO-8868660", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8868660" } ] }, { "id": "R-RNO-8868661", "name": "Dynamin-mediated GTP hydrolysis promotes vesicle scission", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane, clathrin-coated endocytic vesicle membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZGS3-1", "P34158-1", "Q08877-1", "P0C1X8-1", "P21575-1", "P39052-1", "Q62910-1", "O55207-1", "P63259-1", "P60711-1", "G3V6K6-1", "A0A8I6G3R2-1" ], "evidence": [ { "id": "R-RNO-8868661", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8868661" } ] }, { "id": "R-RNO-8871193", "name": "Dissociation of AAK1 and dephosphorylation of AP-2 mu2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "clathrin-coated endocytic vesicle membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZGS3-1", "P34158-1", "Q08877-1", "P0C1X8-1", "P97874-1", "P21575-1", "P39052-1", "Q62910-1", "O55207-1", "P63259-1", "P60711-1", "M0RC99-1", "G3V6K6-1", "A0A8I6G3R2-1" ], "evidence": [ { "id": "R-RNO-8871193", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8871193" } ] }, { "id": "R-RNO-8871194", "name": "RAB5 and GAPVD1 bind AP-2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "clathrin-coated endocytic vesicle membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZGS3-1", "P34158-1", "Q08877-1", "P0C1X8-1", "P97874-1", "P21575-1", "P39052-1", "Q62910-1", "O55207-1", "P63259-1", "P60711-1", "M0RC99-1", "G3V6K6-1", "A0A8I6G3R2-1" ], "evidence": [ { "id": "R-RNO-8871194", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8871194" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-1629739", "participant_name": "I(1,4)P2 [cytosol]", "crossref": [ { "id": "C01220", "database": "COMPOUND", "url": "" }, { "id": "17816", "database": "ChEBI", "url": "" }, { "id": "000100016166", "database": "ZINC", "url": "" }, { "id": "HMDB0000968", "database": "HMDB Metabolite", "url": "" }, { "id": "C01220", "database": "COMPOUND", "url": "" }, { "id": "17816", "database": "ChEBI", "url": "" }, { "id": "000100016166", "database": "ZINC", "url": "" }, { "id": "HMDB0000968", "database": "HMDB Metabolite", "url": "" }, { "id": "C01220", "database": "COMPOUND", "url": "" }, { "id": "17816", "database": "ChEBI", "url": "" }, { "id": "000100016166", "database": "ZINC", "url": "" }, { "id": "HMDB0000968", "database": "HMDB Metabolite", "url": "" }, { "id": "C01220", "database": "COMPOUND", "url": "" }, { "id": "17816", "database": "ChEBI", "url": "" }, { "id": "000100016166", "database": "ZINC", "url": "" }, { "id": "HMDB0000968", "database": "HMDB Metabolite", "url": "" }, { "id": "C01220", "database": "COMPOUND", "url": "" }, { "id": "17816", "database": "ChEBI", "url": "" }, { "id": "000100016166", "database": "ZINC", "url": "" }, { "id": "HMDB0000968", "database": "HMDB Metabolite", "url": "" }, { "id": "C01220", "database": "COMPOUND", "url": "" }, { "id": "17816", "database": "ChEBI", "url": "" }, { "id": "000100016166", "database": "ZINC", "url": "" }, { "id": "HMDB0000968", "database": "HMDB Metabolite", "url": "" } ] }, { "participant_id": "R-ALL-1806224", "participant_name": "PI(3,5)P2 [plasma membrane]", "crossref": [ { "id": "57923", "database": "ChEBI", "url": "" }, { "id": "57923", "database": "ChEBI", "url": "" }, { "id": "57923", "database": "ChEBI", "url": "" }, { "id": "57923", "database": "ChEBI", "url": "" }, { "id": "57923", "database": "ChEBI", "url": "" }, { "id": "57923", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1806240", "participant_name": "PI5P [plasma membrane]", "crossref": [ { "id": "57795", "database": "ChEBI", "url": "" }, { "id": "57795", "database": "ChEBI", "url": "" }, { "id": "57795", "database": "ChEBI", "url": "" }, { "id": "57795", "database": "ChEBI", "url": "" }, { "id": "57795", "database": "ChEBI", "url": "" }, { "id": "57795", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-1806276", "participant_name": "PI3P [plasma membrane]", "crossref": [ { "id": "58088", "database": "ChEBI", "url": "" }, { "id": "58088", "database": "ChEBI", "url": "" }, { "id": "58088", "database": "ChEBI", "url": "" }, { "id": "58088", "database": "ChEBI", "url": "" }, { "id": "58088", "database": "ChEBI", "url": "" }, { "id": "58088", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-426658", "participant_name": "PI [plasma membrane]", "crossref": [ { "id": "C01194", "database": "COMPOUND", "url": "" }, { "id": "57880", "database": "ChEBI", "url": "" }, { "id": "C01194", "database": "COMPOUND", "url": "" }, { "id": "57880", "database": "ChEBI", "url": "" }, { "id": "C01194", "database": "COMPOUND", "url": "" }, { "id": "57880", "database": "ChEBI", "url": "" }, { "id": "C01194", "database": "COMPOUND", "url": "" }, { "id": "57880", "database": "ChEBI", "url": "" }, { "id": "C01194", "database": "COMPOUND", "url": "" }, { "id": "57880", "database": "ChEBI", "url": "" }, { "id": "C01194", "database": "COMPOUND", "url": "" }, { "id": "57880", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JXT6", "gene_name": "Mtmr6", "activity": [ { "ec_number": "3.1.3.64", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate.", "evidence": [ { "id": "A0A0G2JXT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JXT6" } ] }, { "ec_number": "3.1.3.64", "activity": "", "evidence": [ { "id": "A0A0G2JXT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JXT6" } ] }, { "ec_number": "3.1.3.95", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate.", "evidence": [ { "id": "A0A0G2JXT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JXT6" } ] } ] }, { "uniprot_ac": "A0A8I5Y1D5", "gene_name": "Mtmr1", "activity": [ { "ec_number": "3.1.3.64", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate.", "evidence": [ { "id": "A0A8I5Y1D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5Y1D5" } ] }, { "ec_number": "3.1.3.95", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate.", "evidence": [ { "id": "A0A8I5Y1D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5Y1D5" } ] }, { "ec_number": "3.1.3.95", "activity": "", "evidence": [ { "id": "A0A8I5Y1D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5Y1D5" } ] }, { "ec_number": "3.1.3.64", "activity": "", "evidence": [ { "id": "A0A8I5Y1D5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5Y1D5" } ] } ] }, { "uniprot_ac": "A0A8I6G3R2", "gene_name": "Cbl", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A8I6G3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G3R2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A8I6G3R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G3R2" } ] } ] }, { "uniprot_ac": "D3ZGS3", "gene_name": "Ocrl", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] }, { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "D3ZGS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZGS3" } ] } ] }, { "uniprot_ac": "G3V6K6", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V6K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6K6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "G3V6K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6K6" } ] } ] }, { "uniprot_ac": "M0RC99", "gene_name": "Rab5a", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "M0RC99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RC99" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "M0RC99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RC99" } ] } ] }, { "uniprot_ac": "O15056", "gene_name": "SYNJ2", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "O15056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15056" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "O15056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15056" } ] } ] }, { "uniprot_ac": "O43426", "gene_name": "SYNJ1", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "O43426", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43426" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "O43426", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43426" } ] } ] }, { "uniprot_ac": "O55207", "gene_name": "Synj2", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "O55207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55207" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "O55207", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55207" } ] } ] }, { "uniprot_ac": "P0C1X8", "gene_name": "Aak1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P0C1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1X8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P0C1X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1X8" } ] } ] }, { "uniprot_ac": "P21575", "gene_name": "Dnm1", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P21575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21575" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "P21575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21575" } ] } ] }, { "uniprot_ac": "P32019", "gene_name": "INPP5B", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "P32019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32019" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "P32019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32019" } ] } ] }, { "uniprot_ac": "P34158", "gene_name": "Cftr", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P34158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34158" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "P34158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34158" } ] } ] }, { "uniprot_ac": "P39052", "gene_name": "Dnm2", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P39052", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39052" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "P39052", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39052" } ] } ] }, { "uniprot_ac": "P40559", "gene_name": "INP51", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "P40559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40559" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "P40559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40559" } ] } ] }, { "uniprot_ac": "P50942", "gene_name": "INP52", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "P50942", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50942" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "P50942", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50942" } ] } ] }, { "uniprot_ac": "P59644", "gene_name": "Inpp5j", "activity": [ { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "P59644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59644" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "P59644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59644" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "P59644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59644" } ] } ] }, { "uniprot_ac": "P60711", "gene_name": "Actb", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60711" } ] } ] }, { "uniprot_ac": "P63018", "gene_name": "Hspa8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P63018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63018" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P63018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63018" } ] } ] }, { "uniprot_ac": "P63259", "gene_name": "Actg1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63259", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63259" } ] } ] }, { "uniprot_ac": "P97573", "gene_name": "Inpp5d", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "P97573", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97573" } ] } ] }, { "uniprot_ac": "P97874", "gene_name": "Gak", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P97874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97874" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P97874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97874" } ] } ] }, { "uniprot_ac": "Q01968", "gene_name": "OCRL", "activity": [ { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "Q01968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01968" } ] }, { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q01968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01968" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q01968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01968" } ] }, { "ec_number": "3.1.3.56", "activity": "", "evidence": [ { "id": "Q01968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01968" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q01968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01968" } ] } ] }, { "uniprot_ac": "Q08227", "gene_name": "INP54", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q08227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08227" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q08227", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08227" } ] } ] }, { "uniprot_ac": "Q08877", "gene_name": "Dnm3", "activity": [ { "ec_number": "3.6.5.5", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "Q08877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08877" } ] }, { "ec_number": "3.6.5.5", "activity": "", "evidence": [ { "id": "Q08877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08877" } ] } ] }, { "uniprot_ac": "Q12271", "gene_name": "INP53", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q12271", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12271" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q12271", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12271" } ] } ] }, { "uniprot_ac": "Q15735", "gene_name": "INPP5J", "activity": [ { "ec_number": "3.1.3.56", "activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.", "evidence": [ { "id": "Q15735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15735" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q15735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15735" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q15735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15735" } ] } ] }, { "uniprot_ac": "Q5PQT2", "gene_name": "Mtmr3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5PQT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQT2" } ] }, { "ec_number": "3.1.3.64", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate.", "evidence": [ { "id": "Q5PQT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQT2" } ] }, { "ec_number": "3.1.3.64", "activity": "", "evidence": [ { "id": "Q5PQT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQT2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5PQT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQT2" } ] }, { "ec_number": "3.1.3.95", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate.", "evidence": [ { "id": "Q5PQT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQT2" } ] } ] }, { "uniprot_ac": "Q5U0V7", "gene_name": "Synj", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q5U0V7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U0V7" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q5U0V7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U0V7" } ] } ] }, { "uniprot_ac": "Q62910", "gene_name": "Synj1", "activity": [ { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q62910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62910" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q62910", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62910" } ] } ] }, { "uniprot_ac": "Q6AXQ4", "gene_name": "Mtm1", "activity": [ { "ec_number": "3.1.3.64", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate.", "evidence": [ { "id": "Q6AXQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AXQ4" } ] }, { "ec_number": "3.1.3.95", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + 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"type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 10 }, { "field": "total_sites", "count": 10 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 9 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }